HK1053300A1 - Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. - Google Patents

Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril.

Info

Publication number
HK1053300A1
HK1053300A1 HK03105540A HK03105540A HK1053300A1 HK 1053300 A1 HK1053300 A1 HK 1053300A1 HK 03105540 A HK03105540 A HK 03105540A HK 03105540 A HK03105540 A HK 03105540A HK 1053300 A1 HK1053300 A1 HK 1053300A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
carboxybutylü
perindopril
alanine esters
alanine
Prior art date
Application number
HK03105540A
Other languages
English (en)
Inventor
Jean-Claude Souvie
Alain Renaud
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1053300A1 publication Critical patent/HK1053300A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK03105540A 2000-04-11 2003-08-01 Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. HK1053300A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004610A FR2807430B1 (fr) 2000-04-11 2000-04-11 Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
PCT/FR2001/001088 WO2001056972A1 (fr) 2000-04-11 2001-04-10 Nouveau procede de synthese des esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (1)

Publication Number Publication Date
HK1053300A1 true HK1053300A1 (en) 2003-10-17

Family

ID=8849107

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03105540A HK1053300A1 (en) 2000-04-11 2003-08-01 Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril.

Country Status (36)

Country Link
US (1) US6774259B2 (de)
EP (1) EP1272454B1 (de)
JP (1) JP3872344B2 (de)
KR (1) KR100520700B1 (de)
CN (1) CN1176903C (de)
AP (1) AP1417A (de)
AR (1) AR027782A1 (de)
AT (1) ATE362913T1 (de)
AU (2) AU2001250467B2 (de)
BG (1) BG65833B1 (de)
BR (1) BR0109963A (de)
CA (1) CA2405466C (de)
CY (1) CY1106720T1 (de)
CZ (1) CZ302603B6 (de)
DE (1) DE60128554T2 (de)
DK (1) DK1272454T3 (de)
EA (1) EA004265B1 (de)
EE (1) EE05030B1 (de)
ES (1) ES2287114T3 (de)
FR (1) FR2807430B1 (de)
GE (1) GEP20063798B (de)
HK (1) HK1053300A1 (de)
HR (1) HRP20020887B1 (de)
HU (1) HU229189B1 (de)
ME (1) ME00442B (de)
MX (1) MXPA02009888A (de)
NO (1) NO327970B1 (de)
NZ (1) NZ521846A (de)
OA (1) OA12246A (de)
PL (1) PL346553A1 (de)
PT (1) PT1272454E (de)
RS (1) RS50240B (de)
SK (1) SK287067B6 (de)
UA (1) UA72040C2 (de)
WO (1) WO2001056972A1 (de)
ZA (1) ZA200207689B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DK1603558T3 (da) 2003-02-28 2008-09-01 Servier S A Lab Fremgangsmåde til fremstilling af perindopril og salte deraf
DK1362845T3 (da) * 2003-09-01 2010-01-18 Servier Lab Ny fremgangsmåde til fremstilling af estere af N-((S)-1-carboxybutyl)-(S)-alanin og deres anvendelse ved fremstilling af perindopril
SI1400531T1 (sl) * 2003-09-30 2006-04-30 Servier Lab Postopek za sintezo n-((s)-1-karbetoksibutil)-(s)-alanina in uporaba pri sintezi perindoprila
DE60300806T2 (de) * 2003-09-30 2006-03-23 Les Laboratoires Servier Verfahren zur Herstellung von N-((S)-1-(Ethoxycarbonyl)butyl)-(S)-alanin und Verwendung in der Synthese von Perindopril
ES2603856T3 (es) * 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
EP1792896A1 (de) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren zur Herstellung von Perindopril und deren Salze
FI126564B (fi) 2011-02-28 2017-02-15 Andritz Oy Menetelmä ja laitteisto meesan polttamiseksi
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Also Published As

Publication number Publication date
BG65833B1 (bg) 2010-02-26
HRP20020887B1 (en) 2011-03-31
HUP0101337A2 (hu) 2001-11-28
KR20020093902A (ko) 2002-12-16
HRP20020887A2 (en) 2004-02-29
AP1417A (en) 2005-05-24
ES2287114T3 (es) 2007-12-16
RS50240B (sr) 2009-07-15
CZ20023323A3 (cs) 2003-01-15
BG107250A (bg) 2003-06-30
CA2405466A1 (fr) 2001-08-09
YU76702A (sh) 2006-05-25
EP1272454A1 (de) 2003-01-08
KR100520700B1 (ko) 2005-10-17
WO2001056972A1 (fr) 2001-08-09
AU2001250467B2 (en) 2005-02-17
SK287067B6 (sk) 2009-11-05
ATE362913T1 (de) 2007-06-15
NO20024811L (no) 2002-10-04
EE05030B1 (et) 2008-06-16
CN1176903C (zh) 2004-11-24
EA200201049A1 (ru) 2003-02-27
ZA200207689B (en) 2003-09-25
DK1272454T3 (da) 2007-09-17
GEP20063798B (en) 2006-04-25
JP3872344B2 (ja) 2007-01-24
CZ302603B6 (cs) 2011-08-03
PL346553A1 (en) 2001-09-10
SK14572002A3 (sk) 2003-02-04
MXPA02009888A (es) 2004-09-06
UA72040C2 (en) 2005-01-17
PT1272454E (pt) 2007-08-01
HU229189B1 (hu) 2013-09-30
EP1272454B1 (de) 2007-05-23
AR027782A1 (es) 2003-04-09
CA2405466C (fr) 2005-02-15
ME00442B (me) 2011-10-10
DE60128554D1 (de) 2007-07-05
HU0101337D0 (en) 2001-06-28
JP2003521530A (ja) 2003-07-15
EA004265B1 (ru) 2004-02-26
EE200200586A (et) 2004-04-15
US20030109743A1 (en) 2003-06-12
NZ521846A (en) 2004-07-30
AU5046701A (en) 2001-08-14
US6774259B2 (en) 2004-08-10
DE60128554T2 (de) 2008-02-21
CN1422245A (zh) 2003-06-04
NO327970B1 (no) 2009-11-02
NO20024811D0 (no) 2002-10-04
CY1106720T1 (el) 2012-05-23
OA12246A (en) 2003-12-08
HUP0101337A3 (en) 2002-11-28
FR2807430A1 (fr) 2001-10-12
FR2807430B1 (fr) 2002-05-17
BR0109963A (pt) 2003-08-05
AP2002002639A0 (en) 2002-09-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180410