HK1050197A1 - Dipeptide nitrile cathepsin k inhibitors. - Google Patents

Dipeptide nitrile cathepsin k inhibitors.

Info

Publication number
HK1050197A1
HK1050197A1 HK03102397A HK03102397A HK1050197A1 HK 1050197 A1 HK1050197 A1 HK 1050197A1 HK 03102397 A HK03102397 A HK 03102397A HK 03102397 A HK03102397 A HK 03102397A HK 1050197 A1 HK1050197 A1 HK 1050197A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
dipeptide nitrile
nitrile cathepsin
cathepsin
dipeptide
Prior art date
Application number
HK03102397A
Other languages
English (en)
Inventor
Martin Missbach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1050197A1 publication Critical patent/HK1050197A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK03102397A 2000-02-10 2003-04-03 Dipeptide nitrile cathepsin k inhibitors. HK1050197A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0003111.2A GB0003111D0 (en) 2000-02-10 2000-02-10 Organic compounds
PCT/EP2001/001359 WO2001058886A1 (en) 2000-02-10 2001-02-08 Dipeptide nitrile cathepsin k inhibitors

Publications (1)

Publication Number Publication Date
HK1050197A1 true HK1050197A1 (en) 2003-06-13

Family

ID=9885359

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03102397A HK1050197A1 (en) 2000-02-10 2003-04-03 Dipeptide nitrile cathepsin k inhibitors.

Country Status (31)

Country Link
US (4) US6642239B2 (no)
EP (1) EP1254124B1 (no)
JP (1) JP3942895B2 (no)
KR (1) KR100544553B1 (no)
CN (2) CN1183122C (no)
AR (1) AR029466A1 (no)
AT (1) ATE402930T1 (no)
AU (1) AU764334B2 (no)
BR (1) BR0108118A (no)
CA (1) CA2396158C (no)
CO (1) CO5261578A1 (no)
CZ (1) CZ20022721A3 (no)
DE (1) DE60135087D1 (no)
ES (1) ES2310177T3 (no)
GB (1) GB0003111D0 (no)
HK (1) HK1050197A1 (no)
HU (1) HUP0300148A3 (no)
IL (1) IL150406A0 (no)
MX (1) MXPA02007768A (no)
MY (1) MY122826A (no)
NO (1) NO20023780D0 (no)
NZ (1) NZ519940A (no)
PE (1) PE20020220A1 (no)
PL (1) PL200119B1 (no)
PT (1) PT1254124E (no)
RU (2) RU2293732C2 (no)
SK (1) SK11462002A3 (no)
TR (1) TR200201752T2 (no)
TW (1) TWI258473B (no)
WO (1) WO2001058886A1 (no)
ZA (1) ZA200206218B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9723407D0 (en) * 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
DK1178958T3 (da) 1999-03-15 2004-06-21 Axys Pharm Inc N-cyanomethylamider som proteaseinhibitorer
GB0003111D0 (en) * 2000-02-10 2000-03-29 Novartis Ag Organic compounds
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
CA2460125A1 (en) 2001-09-14 2003-03-27 Aventis Pharmaceuticals Inc. Novel compounds and compositions as cathepsin inhibitors
WO2003042197A1 (en) 2001-11-14 2003-05-22 Aventis Pharmaceuticals Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
KR100975784B1 (ko) * 2002-03-05 2010-08-17 머크 프로스트 캐나다 리미티드 카텝신 시스테인 프로테아제 억제제
WO2004052921A1 (en) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
JP4690319B2 (ja) * 2003-06-30 2011-06-01 メルク フロスト カナダ リミテツド カテプシンシステインプロテアーゼ阻害剤
MXPA06000790A (es) * 2003-07-21 2006-04-07 Novartis Ag Combinaciones de un inhibidor de catepsina k y un bisfofonato en el tratamiento de metastasis osea, crecimiento de tumor y perdida osea inducida por tumor.
US20070135448A1 (en) * 2003-11-19 2007-06-14 Martin Missbach Use of cathepsin k inhibitors for treating of severe bone loss diseases
US7915300B2 (en) 2004-01-08 2011-03-29 Medivir Ab Cysteine protease inhibitors
CN101065137A (zh) * 2004-09-16 2007-10-31 加利福尼亚大学董事会 用于改善动脉粥样硬化和其它病变的g型多肽和其它剂
AU2005314043A1 (en) * 2004-12-06 2006-06-15 The Regents Of The University Of California Methods for improving the structure and function of arterioles
GB0427380D0 (en) * 2004-12-14 2005-01-19 Novartis Ag Organic compounds
US20080125442A1 (en) * 2005-01-19 2008-05-29 Michael David Percival Cathepsin K Inhibitors and Atherosclerosis
EP1841419A4 (en) * 2005-01-19 2009-02-25 Merck Frosst Canada Ltd INHIBITORS OF CATHEPSIN K AND OBESITY
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
GB0517637D0 (en) * 2005-08-30 2005-10-05 Novartis Ag Organic compounds
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
JP3975226B2 (ja) * 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
AU2007205578B2 (en) * 2006-01-11 2012-06-28 Seikagaku Corporation Cycloalkylcarbonylamino acid ester derivative and process for producing the same
JP2010503610A (ja) * 2006-05-22 2010-02-04 ベルキュラ セラピューティクス インコーポレイティッド 骨産生におけるカテプシンｋアンタゴニストの使用
GB0614044D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614046D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614053D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
WO2008149971A1 (ja) 2007-06-08 2008-12-11 Kyoto University 脳動脈瘤の治療または予防薬
BRPI0702541A2 (pt) 2007-06-21 2009-02-10 Petroleo Brasileiro Sa processo de craqueamento catalÍtico para produÇço de diesel a partir de sementes de oleaginosas
US7893067B2 (en) 2007-06-27 2011-02-22 Medivir Ab Cysteine protease inhibitors
US20100331545A1 (en) 2007-10-24 2010-12-30 Nippon Chemiphar Co., Ltd. Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient
WO2009076490A1 (en) * 2007-12-12 2009-06-18 Velcura Therapeutics, Inc. Use of cathepsin l antagonists in the treatment of bone disease
EP2240491B1 (en) 2008-01-09 2015-07-15 Amura Therapeutics Limited TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES
WO2009103432A2 (en) * 2008-02-21 2009-08-27 Sanofi-Aventis Covalently binding imaging probes
GB0817425D0 (en) * 2008-09-24 2008-10-29 Medivir Ab Protease inhibitors
US20100298507A1 (en) * 2009-05-19 2010-11-25 Menschig Klaus R Polyisobutylene Production Process With Improved Efficiencies And/Or For Forming Products Having Improved Characteristics And Polyisobutylene Products Produced Thereby
SG194842A1 (en) 2011-05-16 2013-12-30 Bayer Ip Gmbh Use of cathepsin k inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure
EP2537532A1 (en) 2011-06-22 2012-12-26 J. Stefan Institute Cathepsin-binding compounds bound to a nanodevice and their diagnostic and therapeutic use
US9593138B2 (en) 2012-10-05 2017-03-14 Wayne State University Nitrile-containing enzyme inhibitors and ruthenium complexes thereof
WO2014199644A1 (ja) 2013-06-14 2014-12-18 生化学工業株式会社 α－オキソアシルアミノカプロラクタム誘導体
EP3009425B1 (en) 2013-06-14 2018-06-06 Seikagaku Corporation Alpha-oxoacylaminocaprolactam

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3467691A (en) 1964-04-22 1969-09-16 Tsutomu Irikura N-(n-acylaminoacyl)-aminoacetonitriles
US5206249A (en) 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
EP0547699A1 (en) 1991-12-19 1993-06-23 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
JP3283114B2 (ja) 1992-09-07 2002-05-20 クミアイ化学工業株式会社 縮合ヘテロ環誘導体及び農園芸用殺菌剤
JP2848232B2 (ja) 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体
EP0648740B1 (en) 1993-04-28 1997-10-08 Kumiai Chemical Industry Co., Ltd. Amino acid amide derivative, agrohorticultural bactericide, and production process
JPH09501420A (ja) * 1993-07-30 1997-02-10 スミスクライン・ビーチャム・コーポレイション ３−シアノ−３−（３，４−二置換）フェニルシクロヘキシル−１−カルボキシレート類
CA2173875A1 (en) 1993-11-01 1995-05-11 Hideyuki Saika Endothelin receptor antagonists
US5486623A (en) * 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
IL112759A0 (en) * 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
WO1995024382A1 (en) 1994-03-10 1995-09-14 G.D. Searle & Co. L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
US5614649A (en) * 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5977075A (en) * 1995-04-21 1999-11-02 Novartis Ag N-aroylamino acid amides as endothelin inhibitors
WO1997027200A1 (en) 1996-01-26 1997-07-31 Smithkline Beecham Plc Thienoxazinone derivatives useful as antiviral agents
WO1998001133A1 (fr) 1996-07-08 1998-01-15 Yamanouchi Pharmaceutical Co., Ltd. Inhibiteurs de la resorption osseuse
AU729133B2 (en) 1996-11-22 2001-01-25 Elan Pharmaceuticals, Inc. N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
ID24931A (id) 1997-11-05 2000-08-31 Novartis Ag Dipeptida nitril
GB9723407D0 (en) * 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
US6355678B1 (en) * 1998-06-29 2002-03-12 Parker Hughes Institute Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
WO2000049007A1 (en) 1999-02-20 2000-08-24 Astrazeneca Ab Acetamido acetonitrile derivatives as inhibitors of cathepsin l and/or cathepsin s
AU2560000A (en) 1999-02-20 2000-09-04 Astrazeneca Ab Di- and tripeptide nitrile derivatives as inhibitors of cathepsin l and cathepsin
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
DK1178958T3 (da) * 1999-03-15 2004-06-21 Axys Pharm Inc N-cyanomethylamider som proteaseinhibitorer
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
WO2001019796A1 (en) * 1999-09-16 2001-03-22 Axys Pharmaceuticals, Inc. Compounds and pharmaceutical compositions as cathepsin s inhibitors
JP2001139320A (ja) * 1999-11-05 2001-05-22 Asahi Glass Co Ltd 球状シリカゲルの製造方法
DE60030768T2 (de) * 1999-12-24 2007-11-08 F. Hoffmann-La Roche Ag Nitrilderivate als cathepsin k hemmer
AU779855B2 (en) * 2000-01-06 2005-02-17 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
GB0003111D0 (en) * 2000-02-10 2000-03-29 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
WO2001058886A1 (en) 2001-08-16
HUP0300148A3 (en) 2005-04-28
NZ519940A (en) 2004-02-27
NO20023780L (no) 2002-08-09
DE60135087D1 (de) 2008-09-11
SK11462002A3 (sk) 2003-01-09
KR100544553B1 (ko) 2006-01-24
ZA200206218B (en) 2003-08-05
BR0108118A (pt) 2003-02-25
ES2310177T3 (es) 2009-01-01
CN1636980A (zh) 2005-07-13
US6642239B2 (en) 2003-11-04
RU2265601C2 (ru) 2005-12-10
PL357901A1 (en) 2004-07-26
US20070191392A1 (en) 2007-08-16
US20010016207A1 (en) 2001-08-23
EP1254124A1 (en) 2002-11-06
PL200119B1 (pl) 2008-12-31
TR200201752T2 (tr) 2002-10-21
MY122826A (en) 2006-05-31
CA2396158C (en) 2010-02-02
GB0003111D0 (en) 2000-03-29
RU2005108133A (ru) 2006-09-10
EP1254124B1 (en) 2008-07-30
TWI258473B (en) 2006-07-21
ATE402930T1 (de) 2008-08-15
US20050267129A1 (en) 2005-12-01
MXPA02007768A (es) 2002-10-11
US20030203919A1 (en) 2003-10-30
CZ20022721A3 (cs) 2002-11-13
IL150406A0 (en) 2002-12-01
CA2396158A1 (en) 2001-08-16
HUP0300148A2 (en) 2003-05-28
AR029466A1 (es) 2003-07-02
RU2293732C2 (ru) 2007-02-20
CN1398260A (zh) 2003-02-19
PT1254124E (pt) 2008-11-03
AU764334B2 (en) 2003-08-14
NO20023780D0 (no) 2002-08-09
CN1183122C (zh) 2005-01-05
CO5261578A1 (es) 2003-03-31
JP3942895B2 (ja) 2007-07-11
KR20020072310A (ko) 2002-09-14
PE20020220A1 (es) 2002-03-25
RU2002123350A (ru) 2004-01-10
AU4642601A (en) 2001-08-20
JP2003522764A (ja) 2003-07-29

Similar Documents

Publication Publication Date Title
HK1050197A1 (en) Dipeptide nitrile cathepsin k inhibitors.
EP1272467A4 (en) Cathepsin cysteine PROTEASE INHIBITORS
MXPA03001832A (es) Derivados de hidroxamato utiles como inhibidores de desacetilasa.
MXPA03001780A (es) Inhibidores de proteasa peptidomimeticos.
ZA200204397B (en) Nitrile derivatives as cathepsin K inhibitors.
MXPA03005838A (es) Inhibidores de antigenos de aparicion muy tardia-4.
AP2002002593A0 (en) Protease inhibitors
GB0125445D0 (en) Protease Inhibitors
MXPA03008177A (es) Inhibidores de metaloproteinasa..
MXPA03008180A (es) Inhibidores de metaloproteinasa.
MXPA03009647A (es) Heterociclildicarbamidas como inhibidores de caspasa.
MXPA03008187A (es) Inhibidores de metaloproteinasas.
IL153421A0 (en) Protease inhibitors
MXPA03000512A (es) Oxiguanidina-pirazinonas ciclicas como inhibidores de proteasas.
IL151087A0 (en) Protease inhibitors
AU2002242500A1 (en) Cathepsin cysteine protease inhibitors
EP1401453A4 (en) PROTEASE INHIBITORS
IL155961A0 (en) Cysteine protease inhibitors
MXPA03004542A (es) Inhibidores de proteasa.
ZA200207478B (en) Protease inhibitors.
ZA200003399B (en) Inhibitors.
ZA200003398B (en) Inhibitors.
AU2001296247A1 (en) Cysteine protease inhibitors
GB0009123D0 (en) Protease inhibitor
ZA200208909B (en) Peptide deformylase inhibitors.

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090208