HK1048982A1 - 邻氯甲基苯基二羟乙酸衍生物的制备方法 - Google Patents

邻氯甲基苯基二羟乙酸衍生物的制备方法 Download PDF

Info

Publication number
HK1048982A1
HK1048982A1 HK03101145.9A HK03101145A HK1048982A1 HK 1048982 A1 HK1048982 A1 HK 1048982A1 HK 03101145 A HK03101145 A HK 03101145A HK 1048982 A1 HK1048982 A1 HK 1048982A1
Authority
HK
Hong Kong
Prior art keywords
formula
mol
reaction
alkyl
group
Prior art date
Application number
HK03101145.9A
Other languages
English (en)
Chinese (zh)
Inventor
J-M‧阿瑟克
H-D‧施奈德
A‧普菲弗纳
W‧普法夫
A‧普菲弗納
Original Assignee
拜尔公开股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27171705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1048982(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 拜尔公开股份有限公司 filed Critical 拜尔公开股份有限公司
Publication of HK1048982A1 publication Critical patent/HK1048982A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/52—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HK03101145.9A 1996-01-03 2003-02-18 邻氯甲基苯基二羟乙酸衍生物的制备方法 HK1048982A1 (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH196 1996-01-03
CH1/96 1996-01-03
CH1112/96 1996-05-02
CH111296 1996-05-02
CH1874/96 1996-07-26
CH187496 1996-07-26

Publications (1)

Publication Number Publication Date
HK1048982A1 true HK1048982A1 (zh) 2003-04-25

Family

ID=27171705

Family Applications (2)

Application Number Title Priority Date Filing Date
HK03101145.9A HK1048982A1 (zh) 1996-01-03 2003-02-18 邻氯甲基苯基二羟乙酸衍生物的制备方法
HK03101146.8A HK1048983A1 (zh) 1996-01-03 2003-02-18 邻氯甲基苯基二羟乙酸衍生物的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK03101146.8A HK1048983A1 (zh) 1996-01-03 2003-02-18 邻氯甲基苯基二羟乙酸衍生物的制备方法

Country Status (23)

Country Link
US (2) US5756811A (enExample)
EP (1) EP0782982B1 (enExample)
JP (1) JP4621308B2 (enExample)
KR (2) KR100540153B1 (enExample)
CN (3) CN1073554C (enExample)
AR (1) AR005362A1 (enExample)
AT (1) ATE193010T1 (enExample)
AU (1) AU714429B2 (enExample)
BR (1) BR9700009A (enExample)
CA (1) CA2194203C (enExample)
CZ (1) CZ290146B6 (enExample)
DE (1) DE59605241D1 (enExample)
DK (1) DK0782982T3 (enExample)
ES (1) ES2147357T3 (enExample)
GR (1) GR3033714T3 (enExample)
HK (2) HK1048982A1 (enExample)
HU (1) HUP9603547A1 (enExample)
IL (1) IL119922A (enExample)
MX (1) MX9700003A (enExample)
PL (1) PL184464B1 (enExample)
PT (1) PT782982E (enExample)
SK (1) SK168996A3 (enExample)
TW (1) TW477785B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990036612A (ko) * 1997-10-08 1999-05-25 고사이 아끼오 벤질 브로마이드 유도체의 제조 방법
GB9908530D0 (en) * 1999-04-14 1999-06-09 Novartis Ag Organic compounds
EP2134673A1 (en) * 2007-04-12 2009-12-23 DSM Fine Chemicals Austria Nfg GmbH & Co KG Improved process for preparing o-chloromethylphenylglyoxylic esters, improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters, and novel intermediates for their preparation
WO2009037230A2 (en) * 2007-09-17 2009-03-26 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters
CN108358797A (zh) * 2018-04-20 2018-08-03 南京农业大学 一种烷基甘氨酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ213630A (en) 1984-10-19 1990-02-26 Ici Plc Acrylic acid derivatives and fungicidal compositions
GB8617648D0 (en) 1986-07-18 1986-08-28 Ici Plc Fungicides
DE3835028A1 (de) * 1988-10-14 1990-04-19 Basf Ag Oximether-derivate, verfahren zu ihrer herstellung und diese enthaltende fungizide
DE3843439A1 (de) * 1988-12-23 1990-06-28 Basf Ag Schwefelhaltige oximether und diese enthaltende fungizide
DE3932542A1 (de) * 1989-09-29 1991-04-11 Basf Ag Neue anilinderivate und diese enthaltende fungizide
DK0585751T3 (da) * 1992-08-29 1996-11-18 Basf Ag N-methylamider, fremgangsmåder og mellemprodukter til deres fremstilling samt fremgangsmåder til bekæmpelse af skadelige organismer
DE4305502A1 (de) * 1993-02-23 1994-08-25 Basf Ag Ortho-substituierte 2-Methoxyiminophenylessigsäuremethylamide
HU219157B (hu) * 1994-01-05 2001-02-28 Novartis Ag. Peszticid hatású [dioxa-diaza/vagy oxa-triaza/-heptadienil-fenil]-akrilsav- és glioxilsav-származékok, előállításuk és alkalmazásuk
ES2150550T3 (es) * 1994-02-04 2000-12-01 Basf Ag Derivados de acido fenilacetico, procedimientos y productos intermedios para su obtencion, y agentes que los contienen.
RU2146247C1 (ru) * 1994-06-10 2000-03-10 Басф Акциенгезельшафт СПОСОБЫ И ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ ДЛЯ ПОЛУЧЕНИЯ МЕТИЛАМИДОВ α-МЕТОКСИИМИНОКАРБОНОВЫХ КИСЛОТ
US5583249A (en) * 1994-08-19 1996-12-10 Ciba-Geigy Corporation Pesticides

Also Published As

Publication number Publication date
AR005362A1 (es) 1999-04-28
IL119922A0 (en) 1997-03-18
CN1167756A (zh) 1997-12-17
CN1073554C (zh) 2001-10-24
PL184464B1 (pl) 2002-11-29
US5756811A (en) 1998-05-26
KR100540153B1 (ko) 2006-04-20
AU714429B2 (en) 2000-01-06
PT782982E (pt) 2000-10-31
PL317751A1 (en) 1997-07-07
HUP9603547A1 (hu) 1998-01-28
US6124493A (en) 2000-09-26
HU9603547D0 (en) 1997-02-28
CA2194203A1 (en) 1997-07-04
AU1000397A (en) 1997-07-10
HK1048983A1 (zh) 2003-04-25
KR100540148B1 (ko) 2005-12-29
EP0782982B1 (de) 2000-05-17
CN1368497A (zh) 2002-09-11
ATE193010T1 (de) 2000-06-15
JP4621308B2 (ja) 2011-01-26
EP0782982A1 (de) 1997-07-09
CN1185208C (zh) 2005-01-19
TW477785B (en) 2002-03-01
DK0782982T3 (da) 2000-10-09
MX9700003A (es) 1997-12-31
ES2147357T3 (es) 2000-09-01
SK168996A3 (en) 1998-02-04
DE59605241D1 (de) 2000-06-21
CZ290146B6 (cs) 2002-06-12
CZ397A3 (cs) 1998-07-15
JPH09227486A (ja) 1997-09-02
BR9700009A (pt) 1998-11-10
KR970059162A (ko) 1997-08-12
IL119922A (en) 2004-07-25
CN1368498A (zh) 2002-09-11
CN1185209C (zh) 2005-01-19
GR3033714T3 (en) 2000-10-31
CA2194203C (en) 2005-04-26

Similar Documents

Publication Publication Date Title
US7985879B2 (en) Process for making galantamine
HK1048982A1 (zh) 邻氯甲基苯基二羟乙酸衍生物的制备方法
US7087798B2 (en) Process for preparation of spirofluorenols
US6790977B2 (en) Process for preparing 3,4-dihydroxy-benzonitrile
EP1281707B1 (en) Process for the preparation of 5-subtituted isobenzofurans
US20040199002A1 (en) Process for producing(2-nitrophenyl)acetonitrile derivative and intermediate therefor
CZ257593A3 (en) Derivatives of phenylacetic acid esters and process for preparing thereof
US10562834B2 (en) Process for preparing substituted crotonic acids
JP4032861B2 (ja) β−オキソニトリル誘導体又はそのアルカリ金属塩の製法
RU2177472C2 (ru) Способ получения производных о-хлорметилфенилглиоксиловой кислоты
JP4187777B2 (ja) フェニルグリオキシル酸エステル類
JP4196572B2 (ja) アミノナフトキノン類の製造方法
JP2000256244A (ja) ４−メチルテトラフルオロベンジルアルコール誘導体の製造法
JP4663105B2 (ja) ２−スルホニル−４−オキシピリジン誘導体の製造方法
JP4267107B2 (ja) ピリジン誘導体およびその製造方法
JP4104697B2 (ja) フェニルグリオキシル酸エステル類の製造法、それを用いたメトキシイミノアセトアミド誘導体の製造法およびそれらの中間体
WO2001032617A1 (en) Process for the preparation of 7-azabicyclo[4.1.0]-hept-3-ene-3-carboxylic acid esters
CN1399628A (zh) 制备2－(2－羟基苯基)－2－(烷氧基亚氨基)－n－甲基乙酰胺衍生物的方法
JPH08283222A (ja) 置換アミンの製造方法
JP2002363171A (ja) ４−置換−３−アミノイソオキサゾール誘導体の製法
HK1051848A (en) Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-n-methylacetamide derivatives
US20020049350A1 (en) Process for preparing thrombin receptor antagonist building blocks
JP2004210752A (ja) エノールエーテルの新規製造法