HK1045334A1 - 缩氨酸受体结紮方法 - Google Patents
缩氨酸受体结紮方法 Download PDFInfo
- Publication number
- HK1045334A1 HK1045334A1 HK02106728.4A HK02106728A HK1045334A1 HK 1045334 A1 HK1045334 A1 HK 1045334A1 HK 02106728 A HK02106728 A HK 02106728A HK 1045334 A1 HK1045334 A1 HK 1045334A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- peptide acceptor
- ligation methods
- acceptor ligation
- methods
- peptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14583499P | 1999-07-27 | 1999-07-27 | |
| US145834P | 1999-07-27 | ||
| PCT/US2000/019653 WO2001007657A1 (en) | 1999-07-27 | 2000-07-19 | Peptide acceptor ligation methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1045334A1 true HK1045334A1 (zh) | 2002-11-22 |
Family
ID=22514769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02106728.4A HK1045334A1 (zh) | 1999-07-27 | 2000-07-19 | 缩氨酸受体结紮方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6429300B1 (https=) |
| EP (2) | EP1870417B9 (https=) |
| JP (2) | JP4766808B2 (https=) |
| KR (1) | KR20020033743A (https=) |
| AT (2) | ATE360706T1 (https=) |
| AU (2) | AU781783B2 (https=) |
| CA (2) | CA2377468C (https=) |
| CY (1) | CY1113185T1 (https=) |
| DE (1) | DE60034566T2 (https=) |
| DK (2) | DK1196637T3 (https=) |
| ES (2) | ES2284508T3 (https=) |
| HK (1) | HK1045334A1 (https=) |
| IL (1) | IL147037A0 (https=) |
| NO (1) | NO20020348D0 (https=) |
| PT (2) | PT1196637E (https=) |
| WO (1) | WO2001007657A1 (https=) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1196637T3 (da) * | 1999-07-27 | 2007-07-30 | Adnexus Therapeutics Inc | Peptidacceptor-ligeringsmetoder |
| CA2397091A1 (en) | 2000-01-11 | 2001-07-19 | Markus Schweitzer | Biomolecules having multiple attachment moieties for binding to a substrate surface |
| WO2001072998A2 (de) * | 2000-03-31 | 2001-10-04 | Memorec Stoffel Gmbh | Verfahren zur extraktion von nukleinsäuren |
| US20040229271A1 (en) * | 2000-05-19 | 2004-11-18 | Williams Richard B. | Compositions and methods for the identification and selection of nucleic acids and polypeptides |
| WO2003044194A1 (en) * | 2001-11-16 | 2003-05-30 | Proteonova, Inc. | Selection and evolution of nucleic acids and polypeptides |
| US6962781B1 (en) * | 2000-05-19 | 2005-11-08 | Proteonova, Inc. | In vitro evolution of nucleic acids and encoded polypeptide |
| US7410761B2 (en) * | 2000-05-19 | 2008-08-12 | Proteonova, Inc. | System for rapid identification and selection of nucleic acids and polypeptides, and method thereof |
| WO2005072087A2 (en) * | 2003-12-12 | 2005-08-11 | Proteonova, Inc. | System and methods for nucleic acid and polypeptide selection |
| EP1309730B1 (en) * | 2000-08-11 | 2008-11-26 | Nanogen Recognomics GmbH | New hydrazide building blocks and hydrazide modified biomolecules |
| US7129229B2 (en) | 2000-08-11 | 2006-10-31 | Nanogen Recognomics Gmbh | Hydrazide building blocks and hydrazide modified biomolecules |
| JP4963142B2 (ja) * | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
| US20060234231A1 (en) * | 2001-06-20 | 2006-10-19 | Nuevolution A/S | Microarrays displaying encoded molecules |
| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
| US20030027194A1 (en) * | 2001-07-31 | 2003-02-06 | Markus Kurz | Modular assembly of nucleic acid-protein fusion multimers |
| DE10147074A1 (de) * | 2001-09-25 | 2003-05-08 | Beru Ag | Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung |
| AU2002365404A1 (en) | 2001-11-27 | 2003-06-10 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
| DE20200926U1 (de) * | 2002-01-23 | 2002-04-18 | Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz | Festwalzgerät einer Festwalzmaschine für Kurbelwellen |
| WO2003078627A2 (en) * | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block capable of functional entity transfer to nucleophil |
| WO2003078050A2 (en) * | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c bond upon reaction |
| US10731151B2 (en) | 2002-03-15 | 2020-08-04 | Nuevolution A/S | Method for synthesising templated molecules |
| US20050247001A1 (en) * | 2002-03-15 | 2005-11-10 | Nuevolution A/S | Building block forming a c-c or a c-hetero atom bond uponreaction |
| AU2003214031A1 (en) * | 2002-03-15 | 2003-09-29 | Nuevolution A/S | An improved method for synthesising templated molecules |
| EP1539980B1 (en) * | 2002-08-01 | 2016-02-17 | Nuevolution A/S | Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules |
| WO2004015075A2 (en) * | 2002-08-08 | 2004-02-19 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
| EP2348124B1 (en) * | 2002-10-30 | 2013-12-11 | Nuevolution A/S | Synthesis of a bifunctional complex |
| WO2004056994A2 (en) * | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
| US20070026397A1 (en) | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
| WO2004074501A2 (en) * | 2003-02-21 | 2004-09-02 | Nuevolution A/S | A method for obtaining structural information about an encoded molecule |
| US7915201B2 (en) * | 2003-03-20 | 2011-03-29 | Nuevolution A/S | Ligational encoding of small molecules |
| WO2004110964A2 (en) * | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
| WO2005074417A2 (en) * | 2003-09-03 | 2005-08-18 | Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| US11118215B2 (en) | 2003-09-18 | 2021-09-14 | Nuevolution A/S | Method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
| KR101337320B1 (ko) * | 2003-11-20 | 2013-12-06 | 사노피 파스퇴르 인크 | 백일해 독소의 정제방법 및 이에 유용한 펩타이드 |
| EP1711196A4 (en) | 2003-12-05 | 2011-09-14 | Bristol Myers Squibb Co | INHIBITORS OF TYPE-2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS |
| WO2005078122A2 (en) * | 2004-02-17 | 2005-08-25 | Nuevolution A/S | Method for enrichment involving elimination by mismatch hybridisation |
| DE602005017370D1 (de) * | 2004-03-22 | 2009-12-10 | Nuevolution As | Ligationscodierung unter verwendung von oligonukleotidbausteinen |
| CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
| WO2006041194A1 (ja) | 2004-10-15 | 2006-04-20 | Japan Science And Technology Agency | mRNA-ピューロマイシン-タンパク質連結体作製用リンカー |
| US20080199499A1 (en) | 2005-01-12 | 2008-08-21 | Proteonova, Inc. | Method for Making Targeted Therapeutic Agents |
| US10206998B2 (en) | 2005-01-12 | 2019-02-19 | Proteonova, Inc. | Modular targeted therapeutic agents and methods of making same |
| DK2339014T3 (en) | 2005-11-16 | 2015-07-20 | Ambrx Inc | Methods and compositions comprising non-natural amino acids |
| PT3305900T (pt) | 2005-12-01 | 2021-10-27 | Nuevolution As | Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes |
| US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
| MX2009005466A (es) | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
| EP2118344B1 (en) | 2007-02-12 | 2014-07-23 | Proteonova, Inc. | GENERATION OF LIBRARY OF SOLUBLE RANDOM POLYPEPTIDES LINKED TO mRNA |
| US7951559B2 (en) * | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
| US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
| US7678883B2 (en) * | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
| US7794963B2 (en) | 2007-11-02 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins |
| US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| AU2009213141A1 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind EGFR |
| CA2723265C (en) * | 2008-05-02 | 2015-11-24 | Epicentre Technologies Corporation | Selective 5' ligation tagging of rna |
| EA201001734A1 (ru) | 2008-05-02 | 2011-10-31 | Новартис Аг | Улучшенные связывающие молекулы на основе фибронектина и их применение |
| WO2009142773A2 (en) | 2008-05-22 | 2009-11-26 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
| EP2316030B1 (en) | 2008-07-25 | 2019-08-21 | Wagner, Richard W. | Protein screeing methods |
| KR20110076906A (ko) * | 2008-09-30 | 2011-07-06 | 아보트 러보러터리즈 | 개선된 rna 디스플레이 방법 |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
| US20100158846A1 (en) * | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
| US20100158822A1 (en) * | 2008-12-18 | 2010-06-24 | E .I. Du Pont De Nemours And Company | Peptides that bind to silica-coated particles |
| US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
| US8481678B2 (en) | 2009-03-30 | 2013-07-09 | E I Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
| JP2012522057A (ja) * | 2009-03-30 | 2012-09-20 | ジヨンソン・アンド・ジヨンソン・コンシユーマー・カンパニーズ・インコーポレーテツド | 化粧用剤の送達のためのペプチドに基づく系 |
| JP5733784B2 (ja) * | 2009-09-24 | 2015-06-10 | 国立大学法人埼玉大学 | cDNA/mRNA−タンパク質連結体の効率的合成法 |
| WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
| WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
| WO2011092233A1 (en) | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
| US20120296403A1 (en) | 2010-02-10 | 2012-11-22 | Novartis Ag | Methods and compounds for muscle growth |
| WO2011126370A1 (en) * | 2010-04-09 | 2011-10-13 | Universiteit Utrecht Holding B.V. | Recombinant multimeric influenza proteins |
| EP3540059A1 (en) | 2010-04-16 | 2019-09-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| JP6023703B2 (ja) | 2010-05-26 | 2016-11-09 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 改善された安定性を有するフィブロネクチンをベースとする足場タンパク質 |
| CN107903321A (zh) | 2010-07-30 | 2018-04-13 | 诺华有限公司 | 纤连蛋白摇篮分子和其库 |
| DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
| ES2926988T3 (es) | 2011-03-15 | 2022-10-31 | X Body Inc | Métodos de cribado de anticuerpos |
| CN103732738A (zh) | 2011-04-28 | 2014-04-16 | 小利兰斯坦福大学托管委员会 | 与样品相关的多核苷酸的鉴定 |
| US9422550B2 (en) | 2011-08-01 | 2016-08-23 | The General Hospital Corporation | Protein and peptide libraries |
| EP3753567A1 (en) | 2011-10-11 | 2020-12-23 | Viela Bio, Inc. | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
| AU2012347972B2 (en) | 2011-12-05 | 2018-05-10 | X-Body, Inc. | PDGF receptor beta binding polypeptides |
| JP6020865B2 (ja) * | 2013-03-13 | 2016-11-02 | 国立大学法人 東京大学 | 核酸リンカー |
| MY191368A (en) | 2013-06-28 | 2022-06-20 | X Body Inc | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
| CN103382579B (zh) * | 2013-07-06 | 2015-10-21 | 中国科学院成都生物研究所 | 一种体外筛选多肽的方法 |
| EP3779440A1 (en) | 2013-09-23 | 2021-02-17 | X-Body, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
| US20150184214A1 (en) * | 2013-12-31 | 2015-07-02 | Roche Nimblegen, Inc. | Enrichment of full length oligonucleotides via transcription/translation mediated purification |
| WO2015120058A2 (en) | 2014-02-05 | 2015-08-13 | Molecular Templates, Inc. | Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity |
| ES2736127T3 (es) | 2014-03-20 | 2019-12-26 | Bristol Myers Squibb Co | Dominios de tipo III de fibronectina de unión a seroalbúmina |
| JP6478392B2 (ja) * | 2014-12-26 | 2019-03-06 | 国立研究開発法人産業技術総合研究所 | 核酸リンカー |
| AU2016228806B2 (en) | 2015-03-12 | 2020-10-22 | Medimmune, Llc | Method of purifying albumin-fusion proteins |
| CN108290941A (zh) | 2015-09-23 | 2018-07-17 | 百时美施贵宝公司 | 快解离速率的血清白蛋白结合性纤连蛋白iii型结构域 |
| EP3452591B1 (en) | 2016-05-02 | 2023-08-16 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| CN109790565A (zh) * | 2016-06-15 | 2019-05-21 | 基因捕获公司 | 包含茎-环捕获分子的组合物、方法和装置 |
| US20200182884A1 (en) | 2016-06-27 | 2020-06-11 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
| EP3475706B1 (en) | 2016-06-27 | 2021-08-11 | Juno Therapeutics, Inc. | Mhc-e restricted epitopes, binding molecules and related methods and uses |
| RU2731211C1 (ru) | 2017-03-21 | 2020-08-31 | Фуджифилм Корпорэйшн | Пептидное соединение и способ его получения, композиция для скринингового использования и способ отбора пептидного соединения |
| JP7390027B2 (ja) | 2017-10-31 | 2023-12-01 | エンコディア, インコーポレイテッド | 核酸エンコーディングおよび/または標識を使用する解析のためのキット |
| WO2019109046A1 (en) | 2017-11-30 | 2019-06-06 | Arrakis Therapeutics, Inc. | Nucleic acid-binding photoprobes and uses thereof |
| CN111971292B (zh) | 2018-02-02 | 2024-12-13 | 波纹疗法公司 | 包含类固醇二聚体的玻璃制剂及其用途 |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| JP6817493B2 (ja) * | 2018-03-30 | 2021-01-20 | 住友化学株式会社 | 一本鎖rnaの製造方法 |
| WO2019236644A1 (en) * | 2018-06-05 | 2019-12-12 | Arrakis Therapeutics, Inc. | Encoded libraries and methods of use for screening nucleic acid targets |
| WO2020154815A1 (en) | 2019-02-01 | 2020-08-06 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| US12509469B2 (en) | 2019-08-07 | 2025-12-30 | Ripple Therapeutics Corporation | Compositions and methods for the treatment of pain and dependence disorders |
| WO2021220061A2 (en) | 2020-05-01 | 2021-11-04 | Ripple Therapeutics Corporation | Heterodimer compositions and methods for the treatment of ocular disorders |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5391723A (en) * | 1989-05-31 | 1995-02-21 | Neorx Corporation | Oligonucleotide conjugates |
| US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
| WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| DE19646372C1 (de) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Genotyp und Phänotyp koppelnde Verbindung |
| DK0862656T3 (da) * | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
| US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5842701A (en) * | 1996-10-08 | 1998-12-01 | Smith International, Inc. | Dual functioning seal for rock bits |
| EP0932693A1 (en) | 1996-10-10 | 1999-08-04 | Henrik Garoff | Alphavirus-retrovirus vectors |
| DE69730157T2 (de) * | 1996-10-17 | 2005-07-28 | Mitsubishi Chemical Corp. | Molekül, welches genotyp und phänotyp zusammenführt und dessen anwendungen |
| ATE332368T1 (de) | 1997-01-21 | 2006-07-15 | Gen Hospital Corp | Selektion von proteinen mittels rns-protein fusionen |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| US5935791A (en) * | 1997-09-23 | 1999-08-10 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
| WO1999032644A2 (en) * | 1997-12-22 | 1999-07-01 | Genset | Prostate cancer gene |
| US5985575A (en) * | 1998-05-20 | 1999-11-16 | Wisconsin Alumni Research Foundation | Tethered function assay for protein function |
| DK1196637T3 (da) * | 1999-07-27 | 2007-07-30 | Adnexus Therapeutics Inc | Peptidacceptor-ligeringsmetoder |
| US6436665B1 (en) * | 1999-08-27 | 2002-08-20 | Phylos, Inc | Methods for encoding and sorting in vitro translated proteins |
-
2000
- 2000-07-19 DK DK00947524T patent/DK1196637T3/da active
- 2000-07-19 PT PT00947524T patent/PT1196637E/pt unknown
- 2000-07-19 AT AT00947524T patent/ATE360706T1/de active
- 2000-07-19 EP EP07005917A patent/EP1870417B9/en not_active Expired - Lifetime
- 2000-07-19 EP EP00947524A patent/EP1196637B1/en not_active Expired - Lifetime
- 2000-07-19 CA CA2377468A patent/CA2377468C/en not_active Expired - Lifetime
- 2000-07-19 DE DE60034566T patent/DE60034566T2/de not_active Expired - Lifetime
- 2000-07-19 CA CA2693274A patent/CA2693274C/en not_active Expired - Lifetime
- 2000-07-19 PT PT07005917T patent/PT1870417E/pt unknown
- 2000-07-19 ES ES00947524T patent/ES2284508T3/es not_active Expired - Lifetime
- 2000-07-19 DK DK07005917.5T patent/DK1870417T3/da active
- 2000-07-19 AU AU61112/00A patent/AU781783B2/en not_active Expired
- 2000-07-19 JP JP2001512922A patent/JP4766808B2/ja not_active Expired - Lifetime
- 2000-07-19 US US09/619,103 patent/US6429300B1/en not_active Expired - Lifetime
- 2000-07-19 AT AT07005917T patent/ATE551352T1/de active
- 2000-07-19 KR KR1020027001058A patent/KR20020033743A/ko not_active Withdrawn
- 2000-07-19 ES ES07005917T patent/ES2383332T3/es not_active Expired - Lifetime
- 2000-07-19 IL IL14703700A patent/IL147037A0/xx unknown
- 2000-07-19 HK HK02106728.4A patent/HK1045334A1/zh unknown
- 2000-07-19 WO PCT/US2000/019653 patent/WO2001007657A1/en not_active Ceased
-
2002
- 2002-01-23 NO NO20020348A patent/NO20020348D0/no not_active Application Discontinuation
- 2002-07-30 US US10/208,357 patent/US7078197B2/en not_active Expired - Lifetime
-
2005
- 2005-09-15 AU AU2005211548A patent/AU2005211548B2/en not_active Expired
-
2006
- 2006-07-10 US US11/483,495 patent/US7790421B2/en not_active Expired - Fee Related
-
2010
- 2010-08-24 JP JP2010186725A patent/JP5512463B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-08 CY CY20121100522T patent/CY1113185T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1045334A1 (zh) | 缩氨酸受体结紮方法 | |
| WO1999057325A3 (en) | Enzymes mixture | |
| WO2003012119A3 (en) | Nucleic acid amplification method | |
| AU2002336367A1 (en) | Adamts13 genes and proteins and variants, and uses thereof | |
| AU2001279134A1 (en) | Nucleotide incorporating enzymes | |
| AU2002366285A1 (en) | Ides, an igg-degrading enzyme of streptococcus pyogenes | |
| AU2002365122A1 (en) | A method for engineering strand-specific, sequence-specific, dna-nicking enzymes | |
| AU6114700A (en) | Novel system for the sequential, directional cloning of multiple dna sequences | |
| AU2001244609A1 (en) | Novel protein, dna thereof and process for producing the same | |
| WO2004087735A3 (en) | Proteolytic and covalent antibodies | |
| WO1995006764A3 (en) | Oligonucleotides with rna cleavage activity | |
| AU3425700A (en) | Non-ribosomal peptide synthetases, method for producing same and the use thereof | |
| HK1045309A1 (zh) | 取代的哌啶-4-酮的制备 | |
| AU2002243235A1 (en) | Novel nucleic acids, methods and transformed cells for the modulation of gibberellin production | |
| AU1908100A (en) | Isothermal nucleic acid amplification methods | |
| AU2003248117A1 (en) | Novel enzyme forming peptide, microorganism producing the same and process for producing dipeptide using them | |
| AU2003245663A1 (en) | Process for the enzymatic resolution of 1,3-dioxolane-4-carboxylates | |
| AU2626699A (en) | Self-replicating vector for dna immunization against hiv | |
| AU2001252390A1 (en) | Nucleic acid immunization | |
| AU2001293697A1 (en) | N-substituted-1-amino-1,1-dialkylcarboxylic acid derivatives | |
| AU2438501A (en) | Expression of proteins from amplified, immobilized nucleic acids | |
| AU2002306218A1 (en) | Saponin-digesting enzymes, genes thereof and soyasapogenol B mass production system | |
| AU1558200A (en) | 1-hydroxy-3-sulfonoalkane-1,1-diphosphonous acids | |
| AU4692501A (en) | Laminaribiose phosphorylase, process for producing the same and process for producing laminarioligosaccharide by using the enzyme | |
| WO2004003169A3 (en) | Recombinant genes for polyketide modifying enzymes |