HK1011680A1 - Indol derivatives for the treatment of migraine - Google Patents
Indol derivatives for the treatment of migraineInfo
- Publication number
- HK1011680A1 HK1011680A1 HK98112654A HK98112654A HK1011680A1 HK 1011680 A1 HK1011680 A1 HK 1011680A1 HK 98112654 A HK98112654 A HK 98112654A HK 98112654 A HK98112654 A HK 98112654A HK 1011680 A1 HK1011680 A1 HK 1011680A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- image
- alkyl group
- migraine
- treatment
- indol derivatives
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title abstract 2
- 206010027599 migraine Diseases 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- HCUARRIEZVDMPT-UHFFFAOYSA-N indolyl-2-carboxylic acid Natural products C1=CC=C2NC(C(=O)O)=CC2=C1 HCUARRIEZVDMPT-UHFFFAOYSA-N 0.000 abstract 1
- -1 methoxy benzyl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Processing Of Solid Wastes (AREA)
- Fertilizers (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929216009A GB9216009D0 (en) | 1992-07-28 | 1992-07-28 | New indol derivatives |
| PCT/EP1993/001901 WO1994002460A1 (fr) | 1992-07-28 | 1993-07-19 | Derives d'indole utilises dans le traitement de la migraine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1011680A1 true HK1011680A1 (en) | 1999-07-16 |
Family
ID=10719423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98112654A HK1011680A1 (en) | 1992-07-28 | 1998-12-02 | Indol derivatives for the treatment of migraine |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5565447A (fr) |
| EP (1) | EP0605697B1 (fr) |
| JP (1) | JP2716585B2 (fr) |
| KR (1) | KR100191830B1 (fr) |
| CN (1) | CN1035179C (fr) |
| AT (1) | ATE177080T1 (fr) |
| BR (2) | BR9305589A (fr) |
| CA (1) | CA2120028C (fr) |
| CZ (1) | CZ282659B6 (fr) |
| DE (2) | DE69323712T2 (fr) |
| DK (1) | DK0605697T3 (fr) |
| EC (1) | ECSP930953A (fr) |
| EG (1) | EG20340A (fr) |
| FI (1) | FI109998B (fr) |
| GB (1) | GB9216009D0 (fr) |
| GR (1) | GR3029915T3 (fr) |
| HK (1) | HK1011680A1 (fr) |
| HU (2) | HUT70518A (fr) |
| IL (1) | IL106387A (fr) |
| LU (1) | LU90758I2 (fr) |
| MX (1) | MX9304524A (fr) |
| MY (1) | MY113266A (fr) |
| NL (1) | NL300053I2 (fr) |
| NO (1) | NO180231C (fr) |
| NZ (1) | NZ254152A (fr) |
| PL (1) | PL174352B1 (fr) |
| RU (1) | RU2117667C1 (fr) |
| SG (1) | SG48708A1 (fr) |
| TW (1) | TW235297B (fr) |
| UA (1) | UA27818C2 (fr) |
| UY (1) | UY23624A1 (fr) |
| WO (1) | WO1994002460A1 (fr) |
| ZA (1) | ZA935316B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2712591B1 (fr) * | 1993-11-19 | 1996-02-09 | Pf Medicament | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. |
| FR2731224B1 (fr) * | 1995-03-02 | 1997-05-30 | Pf Medicament | Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments |
| GB9523462D0 (en) * | 1995-11-16 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
| US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| US6066637A (en) * | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2006129190A1 (fr) * | 2005-06-03 | 2006-12-07 | Glenmark Pharmaceuticals Limited | Procede de preparation de l'almotriptan |
| US20070112055A1 (en) * | 2005-09-30 | 2007-05-17 | Glenmark Pharmaceuticals Limited | Crystalline forms of almotriptan and processes for their preparation |
| DE102006027229A1 (de) * | 2006-06-09 | 2007-12-20 | Grünenthal GmbH | 1,3-Disubstituierte 4-Methyl-1H-pyrrol-2-carbonsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| CA2666149A1 (fr) * | 2006-10-19 | 2008-04-24 | Auspex Pharmaceuticals, Inc. | Indoles substitues |
| TWI321616B (en) | 2007-03-27 | 2010-03-11 | Coretronic Corp | Centrifugal blower |
| CZ302424B6 (cs) * | 2007-06-13 | 2011-05-11 | Zentiva, A. S. | Zpusob prípravy almotriptanu o vysoké cistote |
| EP2170824A1 (fr) * | 2007-08-02 | 2010-04-07 | Generics Ýuk¨Limited | Nouveau procédé |
| CN103724252A (zh) * | 2012-10-12 | 2014-04-16 | 苏州四同医药科技有限公司 | 一种阿莫曲坦的制备方法 |
| EP3766483A1 (fr) | 2019-07-19 | 2021-01-20 | BioPharma Synergies, S. L. | Composition de poudre orodispersible comprenant un triptane |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2082175B (en) * | 1980-08-12 | 1984-05-02 | Glaxo Group Ltd | Heterocyclic compounds |
| IT1170387B (it) * | 1982-06-07 | 1987-06-03 | Glaxo Group Ltd | Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono |
| GB2162532B (en) * | 1984-08-04 | 1988-08-03 | Ritchie Swanson John | Decontaminant wash composition |
| GB8431426D0 (en) * | 1984-12-13 | 1985-01-23 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| MC2210A1 (fr) * | 1990-06-07 | 1992-11-26 | Wellcome Found | Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer |
-
1992
- 1992-07-28 GB GB929216009A patent/GB9216009D0/en active Pending
-
1993
- 1993-07-19 CA CA002120028A patent/CA2120028C/fr not_active Expired - Lifetime
- 1993-07-19 DK DK93915953T patent/DK0605697T3/da active
- 1993-07-19 IL IL106387A patent/IL106387A/xx not_active IP Right Cessation
- 1993-07-19 DE DE69323712T patent/DE69323712T2/de not_active Expired - Lifetime
- 1993-07-19 JP JP6504146A patent/JP2716585B2/ja not_active Expired - Lifetime
- 1993-07-19 DE DE2001199016 patent/DE10199016I2/de active Active
- 1993-07-19 AT AT93915953T patent/ATE177080T1/de active
- 1993-07-19 NZ NZ254152A patent/NZ254152A/en not_active IP Right Cessation
- 1993-07-19 PL PL93302917A patent/PL174352B1/pl unknown
- 1993-07-19 EP EP93915953A patent/EP0605697B1/fr not_active Expired - Lifetime
- 1993-07-19 WO PCT/EP1993/001901 patent/WO1994002460A1/fr active IP Right Grant
- 1993-07-19 BR BR9305589A patent/BR9305589A/pt not_active Application Discontinuation
- 1993-07-19 RU RU94020400A patent/RU2117667C1/ru active
- 1993-07-19 HU HU9400869A patent/HUT70518A/hu unknown
- 1993-07-19 UA UA94005336A patent/UA27818C2/uk unknown
- 1993-07-19 CZ CZ94664A patent/CZ282659B6/cs not_active IP Right Cessation
- 1993-07-19 KR KR1019940700865A patent/KR100191830B1/ko not_active IP Right Cessation
- 1993-07-19 SG SG1996000062A patent/SG48708A1/en unknown
- 1993-07-21 TW TW082105804A patent/TW235297B/zh not_active IP Right Cessation
- 1993-07-22 ZA ZA935316A patent/ZA935316B/xx unknown
- 1993-07-26 EC EC1993000953A patent/ECSP930953A/es unknown
- 1993-07-27 MX MX9304524A patent/MX9304524A/es active IP Right Grant
- 1993-07-28 EG EG47893A patent/EG20340A/xx active
- 1993-07-28 UY UY23624A patent/UY23624A1/es not_active IP Right Cessation
- 1993-07-28 CN CN93109364A patent/CN1035179C/zh not_active Expired - Lifetime
- 1993-07-28 MY MYPI93001483A patent/MY113266A/en unknown
-
1994
- 1994-03-22 NO NO941019A patent/NO180231C/no not_active IP Right Cessation
- 1994-03-25 FI FI941413A patent/FI109998B/fi not_active IP Right Cessation
-
1995
- 1995-05-09 US US08/437,682 patent/US5565447A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00696P patent/HU211243A9/hu unknown
-
1996
- 1996-10-10 BR BR1100061-9A patent/BR1100061A/pt active IP Right Grant
-
1998
- 1998-12-02 HK HK98112654A patent/HK1011680A1/xx not_active IP Right Cessation
-
1999
- 1999-04-07 GR GR990401006T patent/GR3029915T3/el unknown
-
2001
- 2001-04-11 LU LU90758C patent/LU90758I2/fr unknown
- 2001-08-21 NL NL300053C patent/NL300053I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG48708A1 (en) | Indol derivatives for the treatment of migraine | |
| UA27238C2 (uk) | Індолінові похідні, а також їх фармацевтично прийнятні солі, що є антагоністами вазопресинових v1-рецепторів, спосіб їх одержання, проміжні продукти і фармацевтична композиція | |
| HUP0100615A2 (hu) | Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére | |
| AU671933B2 (en) | The administration of monoamine acridine in cholinergic neuronal deficit states | |
| ES8801789A1 (es) | Un procedimiento para la preparacion de derivados de indol | |
| IE811831L (en) | Indoles. | |
| RU94020400A (ru) | Производные индола, способ их получения, фармацевтическая композиция, способ лечения головной боли | |
| DE69332945D1 (de) | Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung | |
| AP9801321A0 (en) | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives. | |
| TW336232B (en) | Indol-3-yl propenoic acid derivatives for antagonizing NMDA(N-methyl-D-aspartate) and pharmaceutical compositions thereof | |
| ES2056025A1 (es) | Nuevos derivados de indol. | |
| ES2084560A1 (es) | Procedimiento de preparacion de derivados el indol | |
| EP0782988A4 (fr) | Derives d'indole | |
| ES2063700A1 (es) | Agente activo sobre el sistema nervioso central, proceso para su preparacion y composiciones farmaceuticas que lo contengan. | |
| TW349092B (en) | Substituted indole derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PE | Patent expired |
Effective date: 20130718 |