HK1009807A1 - Intermediates and process for preparing olanzapine - Google Patents

Intermediates and process for preparing olanzapine

Info

Publication number
HK1009807A1
HK1009807A1 HK98110796A HK98110796A HK1009807A1 HK 1009807 A1 HK1009807 A1 HK 1009807A1 HK 98110796 A HK98110796 A HK 98110796A HK 98110796 A HK98110796 A HK 98110796A HK 1009807 A1 HK1009807 A1 HK 1009807A1
Authority
HK
Hong Kong
Prior art keywords
intermediates
preparing olanzapine
olanzapine
preparing
Prior art date
Application number
HK98110796A
Other languages
English (en)
Inventor
Charles Arthur Bunnell
Samuel Dean Larsen
John Richard Nichols
Susan Marie Reutzel
Gregory Alan Stephenson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1009807(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1009807A1 publication Critical patent/HK1009807A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK98110796A 1996-09-23 1998-09-21 Intermediates and process for preparing olanzapine HK1009807A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23

Publications (1)

Publication Number Publication Date
HK1009807A1 true HK1009807A1 (en) 1999-06-11

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98110796A HK1009807A1 (en) 1996-09-23 1998-09-21 Intermediates and process for preparing olanzapine

Country Status (36)

Country Link
US (1) US6020487A (da)
EP (1) EP0831098B1 (da)
JP (2) JP2001500877A (da)
KR (1) KR100560015B1 (da)
CN (1) CN1122036C (da)
AR (1) AR013838A1 (da)
AT (1) ATE209208T1 (da)
AU (1) AU719441B2 (da)
BR (1) BR9712100A (da)
CA (1) CA2265712C (da)
CO (1) CO4910140A1 (da)
CZ (1) CZ299248B6 (da)
DE (1) DE69708428T2 (da)
DK (1) DK0831098T3 (da)
EA (1) EA001642B1 (da)
EG (1) EG23861A (da)
ES (1) ES2166051T3 (da)
HK (1) HK1009807A1 (da)
HU (1) HU226484B1 (da)
ID (1) ID27275A (da)
IL (1) IL128962A (da)
IN (1) IN187156B (da)
MY (1) MY125565A (da)
NO (1) NO323980B1 (da)
NZ (1) NZ334448A (da)
PE (1) PE110398A1 (da)
PL (3) PL196069B1 (da)
PT (1) PT831098E (da)
RS (1) RS49598B (da)
SI (1) SI0831098T1 (da)
SV (1) SV1997000081A (da)
TR (1) TR199900640T2 (da)
TW (1) TW470746B (da)
UA (1) UA59371C2 (da)
WO (1) WO1998012199A1 (da)
ZA (1) ZA978515B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004507548A (ja) * 2000-08-31 2004-03-11 ドクター・レディーズ・ラボラトリーズ・リミテッド オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法
US6740753B2 (en) * 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
AU2002340328A1 (en) * 2001-10-29 2003-05-12 Janet I. Cord Olanzapine dihydrate-ii a process for its preparation and use thereof
CH695862A5 (fr) 2001-12-24 2006-09-29 Sun Pharmaceutical Ind Ltd Forme cristalline I de la methyl-4-(4-methyl-1-piperazinyl) 10H-thieno [2,3-b] [1,5] benzodiazepine.
WO2003091260A1 (en) * 2002-04-23 2003-11-06 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
ATE500258T1 (de) 2002-05-31 2011-03-15 Sandoz Ag Verfahren zur herstellung von olanzapin form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
EP1575962A1 (en) 2002-12-24 2005-09-21 Teva Pharmaceutical Industries Limited Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
CA2546200A1 (en) * 2003-11-18 2005-06-02 3M Innovative Properties Company Olanzapine containing transdermal drug delivery compositions
EP1611139B1 (en) * 2003-12-22 2008-06-04 Teva Pharmaceutical Industries Ltd. Methods of preparing olanzapine
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
US20070072845A1 (en) * 2004-02-19 2007-03-29 Davuluri Rammohan Rao Process for the preparation of olanzapine form 1 useful as antipsychotic drug
US20080009481A1 (en) * 2004-07-14 2008-01-10 Shasun Chemicals And Drugs Limited Process For Making Form I Of Olanzapine
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
ES2303462B1 (es) * 2004-09-06 2009-06-05 Shasun Chemicals And Drugs Limited Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura.
JP5324098B2 (ja) * 2004-11-16 2013-10-23 アルケルメス ファーマ アイルランド リミテッド 注射可能なナノ粒子のオランザピン製剤
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
DE69329887T2 (de) * 1992-05-29 2001-05-23 Eli Lilly And Co., Ltd. Thienobenzodiazepinderivate zur Behandlung von Störungen des Zentralnervensystems
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
ID21924A (id) * 1996-09-23 1999-08-12 Lilly Co Eli Olanzapin dihidrat d

Also Published As

Publication number Publication date
NO323980B1 (no) 2007-07-30
JP2009242407A (ja) 2009-10-22
ZA978515B (en) 1999-03-23
WO1998012199A1 (en) 1998-03-26
TR199900640T2 (xx) 1999-06-21
CZ99099A3 (cs) 1999-11-17
SV1997000081A (es) 1999-01-14
DE69708428D1 (de) 2002-01-03
CZ299248B6 (cs) 2008-05-28
NO991382L (no) 1999-03-22
CA2265712A1 (en) 1998-03-26
ID27275A (id) 2001-03-22
PL332482A1 (en) 1999-09-13
MY125565A (en) 2006-08-30
EP0831098A2 (en) 1998-03-25
EP0831098A3 (en) 1998-04-29
PL196068B1 (pl) 2007-12-31
EA001642B1 (ru) 2001-06-25
UA59371C2 (uk) 2003-09-15
KR100560015B1 (ko) 2006-03-15
ES2166051T3 (es) 2002-04-01
CN1234802A (zh) 1999-11-10
DK0831098T3 (da) 2002-05-21
PL196069B1 (pl) 2007-12-31
DE69708428T2 (de) 2002-07-04
HUP0000066A3 (en) 2000-11-28
US6020487A (en) 2000-02-01
KR20000048520A (ko) 2000-07-25
AU719441B2 (en) 2000-05-11
CA2265712C (en) 2006-10-31
IL128962A (en) 2003-01-12
NO991382D0 (no) 1999-03-22
TW470746B (en) 2002-01-01
PL194565B1 (pl) 2007-06-29
SI0831098T1 (en) 2002-04-30
IN187156B (da) 2002-02-16
ATE209208T1 (de) 2001-12-15
IL128962A0 (en) 2000-02-17
RS49598B (sr) 2007-06-04
CN1122036C (zh) 2003-09-24
HUP0000066A2 (hu) 2000-06-28
PE110398A1 (es) 1999-01-14
CO4910140A1 (es) 2000-04-24
JP2001500877A (ja) 2001-01-23
AR013838A1 (es) 2001-01-31
AU4484197A (en) 1998-04-14
EG23861A (en) 2007-11-18
EP0831098B1 (en) 2001-11-21
NZ334448A (en) 2000-08-25
HU226484B1 (en) 2009-03-02
BR9712100A (pt) 1999-08-31
EA199900326A1 (ru) 1999-08-26
YU15599A (sh) 2001-12-26
PT831098E (pt) 2002-04-29

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20050922