GT200900328A - Derivados de bencimidazol - Google Patents

Derivados de bencimidazol

Info

Publication number
GT200900328A
GT200900328A GT200900328A GT200900328A GT200900328A GT 200900328 A GT200900328 A GT 200900328A GT 200900328 A GT200900328 A GT 200900328A GT 200900328 A GT200900328 A GT 200900328A GT 200900328 A GT200900328 A GT 200900328A
Authority
GT
Guatemala
Prior art keywords
derivatives
benzimidazol
mammals
compounds
treatment
Prior art date
Application number
GT200900328A
Other languages
English (en)
Spanish (es)
Inventor
Chistopher Scott Jones
Qifang Li
Michael John Munchhof
Susan La Greca
Lawrence Alan Reiter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200900328A publication Critical patent/GT200900328A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GT200900328A 2007-06-29 2009-12-21 Derivados de bencimidazol GT200900328A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94728707P 2007-06-29 2007-06-29
US4164508P 2008-04-02 2008-04-02

Publications (1)

Publication Number Publication Date
GT200900328A true GT200900328A (es) 2011-08-29

Family

ID=40161351

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200900328A GT200900328A (es) 2007-06-29 2009-12-21 Derivados de bencimidazol

Country Status (46)

Country Link
US (2) US8148401B2 (el)
EP (1) EP2170860B9 (el)
JP (2) JP4567099B2 (el)
KR (1) KR101143246B1 (el)
CN (1) CN101687841B (el)
AP (1) AP2377A (el)
AR (1) AR067346A1 (el)
AU (1) AU2008272641B2 (el)
BR (1) BRPI0813412B8 (el)
CA (1) CA2690953C (el)
CL (1) CL2008001922A1 (el)
CO (1) CO6160232A2 (el)
CR (1) CR11150A (el)
CU (1) CU23847B1 (el)
CY (2) CY1118650T1 (el)
DK (1) DK2170860T5 (el)
DO (1) DOP2009000278A (el)
EA (1) EA016888B1 (el)
EC (1) ECSP099803A (el)
ES (1) ES2609258T3 (el)
FR (1) FR20C1038I2 (el)
GE (1) GEP20125702B (el)
GT (1) GT200900328A (el)
HK (1) HK1139658A1 (el)
HN (1) HN2008000974A (el)
HR (1) HRP20161562T2 (el)
HU (2) HUE030052T4 (el)
IL (1) IL202420A (el)
LT (2) LT2170860T (el)
MA (1) MA31466B1 (el)
ME (1) ME00962B (el)
MY (1) MY148636A (el)
NI (1) NI200900219A (el)
NL (1) NL301057I2 (el)
NO (1) NO2020027I1 (el)
NZ (1) NZ581889A (el)
PA (1) PA8785401A1 (el)
PE (2) PE20090772A1 (el)
PL (1) PL2170860T3 (el)
PT (1) PT2170860T (el)
RS (1) RS55395B9 (el)
SI (1) SI2170860T1 (el)
TN (1) TN2009000544A1 (el)
TW (1) TWI371451B (el)
UY (1) UY31164A1 (el)
WO (1) WO2009004427A2 (el)

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HUE030052T4 (en) 2007-06-29 2017-06-28 Pfizer Benzimidazole derivatives
CA2735593C (en) 2008-09-03 2017-08-15 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
CN102803246A (zh) * 2009-06-11 2012-11-28 锡耶纳生物技术股份公司 Hedgehog途径拮抗剂及其治疗应用
JP5599802B2 (ja) 2009-08-26 2014-10-01 武田薬品工業株式会社 縮合複素環誘導体およびその用途
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
WO2012052948A1 (en) 2010-10-20 2012-04-26 Pfizer Inc. Pyridine- 2- derivatives as smoothened receptor modulators
JP5452459B2 (ja) 2010-12-16 2014-03-26 株式会社Ｎｔｔドコモ ホーム基地局及びハンドオーバ方法
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
EP3524324A1 (en) 2011-02-28 2019-08-14 BioMarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
EP2684167B1 (en) 2011-03-08 2020-09-09 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
FR2980477B1 (fr) 2011-09-23 2013-10-18 Centre Nat Rech Scient Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications
AU2012314943B9 (en) 2011-09-26 2017-06-08 Merck Patent Gmbh Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist
WO2013192423A2 (en) 2012-06-20 2013-12-27 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
EP2922544B1 (en) 2012-11-21 2018-08-01 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
KR20150132345A (ko) 2013-03-15 2015-11-25 바이오마린 파머수티컬 인크. Hdac 저해제
WO2014170350A1 (en) * 2013-04-17 2014-10-23 Albert Ludwigs Universität Freiburg Compounds for use as bromodomain inhibitors
WO2015017788A1 (en) 2013-08-01 2015-02-05 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
GB2519344A (en) * 2013-10-18 2015-04-22 Redx Pharma Ltd Compounds
EP3063302B1 (en) 2013-10-30 2019-12-04 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
ES2923593T3 (es) * 2015-04-24 2022-09-28 Pfizer Proceso de preparación de una forma cristalina de 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-il)-1-metilpiperidin-4-il)-3-(4-cianofenil)urea maleato; una forma cristalina del complejo 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-il)-1-metilpiperidin-4-il)-3-(4-cianofenil)urea imidazol (1:1)
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
JP2020164722A (ja) * 2019-03-29 2020-10-08 デクセリアルズ株式会社 接着剤組成物
EP4097093B8 (en) 2020-01-28 2024-02-28 Assia Chemical Industries LTD Processes for the preparation of glasdegib and salt thereof and solid state forms of glasdegib maleate and process for preparation thereof
CN113248475B (zh) * 2020-02-11 2023-03-17 中国科学院上海药物研究所 一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途
WO2021191278A1 (en) 2020-03-26 2021-09-30 Lek Pharmaceuticals D.D. Dimaleate form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
CA3184767A1 (en) 2020-06-26 2021-12-30 Raqualia Pharma Inc. Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent
WO2023002362A1 (en) 2021-07-22 2023-01-26 Pfizer Inc. Treatment of hematological malignancy

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NZ530580A (en) 2001-07-27 2007-02-23 Curis Inc Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE60207894T2 (de) * 2001-12-04 2006-07-20 Actelion Pharmaceuticals Ltd. 4-(piperidyl- und pyrrolidyl-alkyl-ureido)-chinoline als urotensin ii rezeptor antagonisten
TW200304820A (en) 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
WO2004035549A1 (en) 2002-10-17 2004-04-29 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
WO2005042495A1 (en) 2003-10-21 2005-05-12 Imclone Systems Incorporated (benzimidazol-2-yl)-phenyl-phenyl-urea compounds and methods for inhibiting heparanase activity
CN1902181A (zh) 2003-10-28 2007-01-24 沃泰克斯药物股份有限公司 可用作离子通道调控剂的苯并咪唑
CA2587489C (en) 2004-11-03 2013-12-31 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE102005012875B4 (de) 2005-03-19 2006-11-16 Sanofi-Aventis Deutschland Gmbh Verwendung von Amino substituierten 8-N-Benzimidazolen
WO2006124780A2 (en) * 2005-05-12 2006-11-23 Kalypsys, Inc. Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
WO2008064830A1 (en) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Bicyclic and heterobicyclic derivatives, processes for preparing them and their pharmaceutical uses
JP2010513263A (ja) 2006-12-15 2010-04-30 ファイザー・プロダクツ・インク ベンズイミダゾール誘導体
HUE030052T4 (en) 2007-06-29 2017-06-28 Pfizer Benzimidazole derivatives
WO2009154739A2 (en) 2008-06-17 2009-12-23 Duke University Smoothened receptor modulators
CA2733533C (en) 2008-08-25 2013-12-17 Irm Llc Hedgehog pathway modulators

Also Published As

Publication number Publication date
RS55395B9 (sr) 2020-01-31
CY2020028I2 (el) 2020-11-25
PE20121010A1 (es) 2012-08-06
CR11150A (es) 2010-02-08
TWI371451B (en) 2012-09-01
IL202420A (en) 2014-05-28
HRP20161562T1 (hr) 2016-12-30
TW200911792A (en) 2009-03-16
BRPI0813412B8 (pt) 2021-05-25
AU2008272641A1 (en) 2009-01-08
WO2009004427A3 (en) 2009-06-04
AR067346A1 (es) 2009-10-07
HRP20161562T2 (hr) 2017-04-21
CU23847B1 (es) 2012-10-15
HK1139658A1 (en) 2010-09-24
US20090005416A1 (en) 2009-01-01
DK2170860T3 (en) 2017-01-09
LT2170860T (lt) 2017-01-10
TN2009000544A1 (fr) 2011-03-31
SI2170860T1 (sl) 2017-01-31
US20120157495A1 (en) 2012-06-21
AP2009005089A0 (en) 2009-12-31
UY31164A1 (es) 2009-01-30
FR20C1038I1 (el) 2020-10-02
EA200971104A1 (ru) 2010-06-30
EP2170860A2 (en) 2010-04-07
BRPI0813412A2 (pt) 2014-12-30
NL301057I2 (nl) 2020-09-10
DK2170860T5 (en) 2017-03-20
EP2170860B9 (en) 2017-02-22
CA2690953A1 (en) 2009-01-08
ME00962B (me) 2012-06-20
WO2009004427A2 (en) 2009-01-08
RS55395B1 (sr) 2017-04-28
MA31466B1 (fr) 2010-06-01
HUE030052T4 (en) 2017-06-28
CY2020028I1 (el) 2020-11-25
KR101143246B1 (ko) 2012-05-18
LTPA2020528I1 (lt) 2020-09-25
PT2170860T (pt) 2017-01-04
KR20100028120A (ko) 2010-03-11
LTC2170860I2 (lt) 2022-03-10
CA2690953C (en) 2012-10-02
HN2008000974A (es) 2011-01-24
CN101687841B (zh) 2013-07-10
CO6160232A2 (es) 2010-05-20
AU2008272641B2 (en) 2013-08-29
EA016888B1 (ru) 2012-08-30
CY1118650T1 (el) 2017-07-12
GEP20125702B (en) 2012-12-10
US8148401B2 (en) 2012-04-03
FR20C1038I2 (fr) 2021-08-13
EP2170860B1 (en) 2016-11-02
MY148636A (en) 2013-05-15
HUE030052T2 (hu) 2017-04-28
NZ581889A (en) 2011-05-27
NL301057I1 (nl) 2020-07-22
NI200900219A (es) 2010-03-11
PE20090772A1 (es) 2009-06-24
HUS2000031I1 (hu) 2020-09-28
NO2020027I1 (no) 2020-08-11
DOP2009000278A (es) 2009-12-31
BRPI0813412B1 (pt) 2020-01-21
JP4567099B2 (ja) 2010-10-20
PA8785401A1 (es) 2009-01-23
ECSP099803A (es) 2010-01-29
IL202420A0 (en) 2010-06-30
AP2377A (en) 2012-03-07
US8431597B2 (en) 2013-04-30
JP2010280693A (ja) 2010-12-16
CN101687841A (zh) 2010-03-31
JP2010531869A (ja) 2010-09-30
PL2170860T3 (pl) 2017-05-31
CU20090225A7 (es) 2012-02-15
CL2008001922A1 (es) 2009-01-02
ES2609258T3 (es) 2017-04-19

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