GR890100133A - Μεθοδος παρασκευης παραγωγων 1,4 διυδροπυριδινης. - Google Patents

Μεθοδος παρασκευης παραγωγων 1,4 διυδροπυριδινης.

Info

Publication number
GR890100133A
GR890100133A GR890100133A GR890100133A GR890100133A GR 890100133 A GR890100133 A GR 890100133A GR 890100133 A GR890100133 A GR 890100133A GR 890100133 A GR890100133 A GR 890100133A GR 890100133 A GR890100133 A GR 890100133A
Authority
GR
Greece
Prior art keywords
dihydropyridine derivatives
derivatives preparation
preparation
dimethyl
dihydropyridine
Prior art date
Application number
GR890100133A
Other languages
English (en)
Other versions
GR1002248B (en
Inventor
Ivan Dr Beck
Pal Dr Benko
Daniel Bozsing
Eva Furdyga
Frigyes Dr Gorgenyi
Janos Imre
Erzsebet Kiss
Gyorgyi Kovanyi
Laszlo Levai
Attila Mandi
Gyula Dinnyes Ilona Mikite
Kalman Dr Nagy
Eva Poczik
Istvan Simonyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU881112A external-priority patent/HU200320B/hu
Priority claimed from HU111188A external-priority patent/HU201912B/hu
Priority claimed from HU405588A external-priority patent/HUT54647A/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of GR890100133A publication Critical patent/GR890100133A/el
Publication of GR1002248B publication Critical patent/GR1002248B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μια μέθοδο για την παρασκευή διμεθυλ - 1, 4-διϋδρο - 2, 6-διμεθυλ-4-(2' - νιτρο - φαινυλ ) πυριδινο - 3,5 - δικαρβοξυλικού του τύπου Ι,ω
GR890100133A 1988-03-08 1989-02-28 1,4-dihydropyridine derivatives preparation method GR1002248B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU881112A HU200320B (en) 1988-03-08 1988-03-08 Process for production of derivatives of azometine
HU111188A HU201912B (en) 1988-03-08 1988-03-08 Process for producing dihydropyridine-carboxylic acid esters
HU405588A HUT54647A (en) 1988-08-02 1988-08-02 Process for producing nifedipine

Publications (2)

Publication Number Publication Date
GR890100133A true GR890100133A (el) 1990-01-19
GR1002248B GR1002248B (en) 1996-04-23

Family

ID=27269951

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100133A GR1002248B (en) 1988-03-08 1989-02-28 1,4-dihydropyridine derivatives preparation method

Country Status (22)

Country Link
US (1) US5126457A (el)
JP (1) JPH01316358A (el)
KR (1) KR0131338B1 (el)
AT (1) AT395586B (el)
AU (1) AU615521B2 (el)
BE (1) BE1003199A5 (el)
CA (1) CA1340193C (el)
CH (1) CH677490A5 (el)
CY (1) CY1760A (el)
CZ (1) CZ285313B6 (el)
DE (1) DE3907508A1 (el)
DK (1) DK113189A (el)
ES (1) ES2012687A6 (el)
FI (1) FI92056C (el)
FR (1) FR2628421B1 (el)
GB (2) GB2216521B (el)
GR (1) GR1002248B (el)
IL (1) IL89536A0 (el)
NL (1) NL8900569A (el)
PL (1) PL159098B1 (el)
SE (1) SE469659B (el)
YU (1) YU47689B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
AU640019B2 (en) * 1990-05-22 1993-08-12 Unichema Chemie Bv Lubricants
DE19727350C1 (de) * 1997-06-27 1999-01-21 Bayer Ag Verfahren zur Herstellung von Nifedipin
LV12200B (lv) * 1997-07-03 1999-04-20 Gunārs DUBURS Antidiabētisks līdzeklis
HUP9900353A3 (en) * 1999-02-15 2002-01-28 Egis Gyogyszergyar Nyilvanosan Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids
CN103204814A (zh) * 2010-09-02 2013-07-17 常州市第四制药厂有限公司 硝苯地平的制备及其杂质分离方法与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863920A (en) * 1956-07-26 1958-12-09 Gen Aniline & Film Corp Process of preparing hydrobenzamide
DE1670827A1 (de) * 1967-03-20 1971-03-11 Bayer Ag Neue Arzneimittel auf der Grundlage von 4-Aryl-1,4-dihydropyridinderivaten
JPS4936682A (el) * 1972-08-16 1974-04-05
ES8600745A1 (es) * 1984-11-23 1985-11-01 Coma Julia Concepcio Procedimiento de obtencion del dimetil ester del acido 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridindicarboxilico

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210667A1 (de) * 1972-03-06 1973-09-20 Bayer Ag Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DD120019A1 (el) * 1975-04-11 1976-05-20
US4012032A (en) * 1975-11-28 1977-03-15 International Business Machines Corporation Document reproduction having output means with plural outputs operable in a plurality of modes
DE2639257A1 (de) * 1976-09-01 1978-03-02 Bayer Ag Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0191724A3 (de) * 1985-01-15 1986-12-03 Sandoz Ag 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE3501855A1 (de) * 1985-01-22 1986-07-24 Bayer Ag, 5090 Leverkusen 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
PL141347B1 (en) * 1985-10-10 1987-07-31 Inst Przemyslu Farmaceutic Method of obtaining chromatographically pure 4-/2-nitrophenyl/-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863920A (en) * 1956-07-26 1958-12-09 Gen Aniline & Film Corp Process of preparing hydrobenzamide
DE1670827A1 (de) * 1967-03-20 1971-03-11 Bayer Ag Neue Arzneimittel auf der Grundlage von 4-Aryl-1,4-dihydropyridinderivaten
JPS4936682A (el) * 1972-08-16 1974-04-05
ES8600745A1 (es) * 1984-11-23 1985-11-01 Coma Julia Concepcio Procedimiento de obtencion del dimetil ester del acido 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridindicarboxilico

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 105, 1986, page 717, abstract no. 190966b, Columbus, Ohio, US; & ES-A1-8600745 (C. COMA JULIA) 01-02-1986 *
CHEMICAL ABSTRACTS, vol. 55, 1961, abstract no. 22333a, Columbus, Ohio, US; S.V. SVETOZARSKII et al.: "Reaction of benzaldehyde with ammonia", & ZHUR. OBSHCHEI KHIM. 31, 1717-19(1961) *
CHEMICAL ABSTRACTS, vol. 81, 1974, page 408, abstract no. 135965m, Columbus, Ohio, US; & JP-A-49 036 682 (SANKYO CO., LTD) 05-04-1974 *
CLAIMS SEARCHED: ALL *
J. CHEM. SOC., PERKIN TRANS. I, 1975, pages 926-929; T. CHENNAT et al.: "A new synthesis of 1,4-dihydropyridines" *

Also Published As

Publication number Publication date
GB2216521A (en) 1989-10-11
JPH01316358A (ja) 1989-12-21
CA1340193C (en) 1998-12-15
CH677490A5 (el) 1991-05-31
KR0131338B1 (ko) 1998-04-17
GB2216521B (en) 1992-02-26
BE1003199A5 (fr) 1992-01-14
FR2628421A1 (fr) 1989-09-15
CY1760A (en) 1994-07-15
CZ145489A3 (cs) 1999-04-14
GB8905270D0 (en) 1989-04-19
PL159098B1 (en) 1992-11-30
FI92056B (fi) 1994-06-15
SE8900813L (sv) 1989-09-09
FI891111A (fi) 1989-09-09
GB2243608B (en) 1992-02-12
GR1002248B (en) 1996-04-23
CZ285313B6 (cs) 1999-07-14
SE469659B (sv) 1993-08-16
KR890014477A (ko) 1989-10-23
FR2628421B1 (fr) 1994-09-23
YU47689B (sh) 1996-01-08
NL8900569A (nl) 1989-10-02
DK113189D0 (da) 1989-03-08
US5126457A (en) 1992-06-30
AU615521B2 (en) 1991-10-03
ES2012687A6 (es) 1990-04-01
YU46689A (en) 1990-12-31
ATA52589A (de) 1992-06-15
GB2243608A (en) 1991-11-06
AU3112989A (en) 1989-09-14
SE8900813D0 (sv) 1989-03-08
AT395586B (de) 1993-01-25
FI92056C (fi) 1994-09-26
DE3907508A1 (de) 1989-09-21
FI891111A0 (fi) 1989-03-08
IL89536A0 (en) 1989-09-10
GB9108770D0 (en) 1991-06-12
DK113189A (da) 1989-09-09

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