YU47689B - Postupak za pravljenje 1,4-dihidro-piridinskih derivata - Google Patents

Postupak za pravljenje 1,4-dihidro-piridinskih derivata

Info

Publication number
YU47689B
YU47689B YU46689A YU46689A YU47689B YU 47689 B YU47689 B YU 47689B YU 46689 A YU46689 A YU 46689A YU 46689 A YU46689 A YU 46689A YU 47689 B YU47689 B YU 47689B
Authority
YU
Yugoslavia
Prior art keywords
formula
dihydro
group
iii
correction
Prior art date
Application number
YU46689A
Other languages
English (en)
Other versions
YU46689A (en
Inventor
P. Benko
D. Bozsing
L. Levai
G. Kovanyi
G. Mikite
J. Dinnyes
P. Jompe
E. Poczik
G. Zalavari
E. Furdyga
J. Beck
J. Simonyi
K. Nagy
J. Imre
E. Kiss
E.J. Tajthy
A. Mandi
F. Gorgenyi
Original Assignee
Egis Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU881112A external-priority patent/HU200320B/hu
Priority claimed from HU111188A external-priority patent/HU201912B/hu
Priority claimed from HU405588A external-priority patent/HUT54647A/hu
Application filed by Egis Gyogyszergyar filed Critical Egis Gyogyszergyar
Publication of YU46689A publication Critical patent/YU46689A/xx
Publication of YU47689B publication Critical patent/YU47689B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Postupak za pravljenje dimetil-1,4-dihidro-,2,6-dimetil-4-(2'-nitro-fenil)-piridin-3,5-dikarboksilata I: naznačen time, što obuhvata reakciju jedinjenja opšte formule II: gde n je 1 i R je grupa formule ili n je 3 i R je vodonik, sa metilacetatom formule III: CH3-CO-CH2-COOCH3 (III) i opciono sa amino jedinjenjem opšte formule IV: gde Z je grupa formule CH3-C=CH-COOCH3; p je 0; k je 1; ili Z predstavlja C1-5alkanoiloksi grupu pravog ili račvastog niza ili karbonatni, bikarbonatni ili hidroksi anjon; p je 1; k je 1; ili k je 0 i jedan, p je 0 dok je drugi 1, u inertnom rastvaraču na temperaturi od -10 do 120В°C; ili reakciju 2-nitro-benzaldehida i metilacetoacetata formule III i vodenog amonijum hidroksida u prisustvu inertnog rastvarača u jednoj fazi na temperaturi od 101 do 120В°C, na pritisku 0,2-0,6 MPa. Prijava sadrži još 26 zavisnih zahteva.
YU46689A 1988-03-08 1989-03-06 Postupak za pravljenje 1,4-dihidro-piridinskih derivata YU47689B (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU881112A HU200320B (en) 1988-03-08 1988-03-08 Process for production of derivatives of azometine
HU111188A HU201912B (en) 1988-03-08 1988-03-08 Process for producing dihydropyridine-carboxylic acid esters
HU405588A HUT54647A (en) 1988-08-02 1988-08-02 Process for producing nifedipine

Publications (2)

Publication Number Publication Date
YU46689A YU46689A (en) 1990-12-31
YU47689B true YU47689B (sh) 1996-01-08

Family

ID=27269951

Family Applications (1)

Application Number Title Priority Date Filing Date
YU46689A YU47689B (sh) 1988-03-08 1989-03-06 Postupak za pravljenje 1,4-dihidro-piridinskih derivata

Country Status (22)

Country Link
US (1) US5126457A (sh)
JP (1) JPH01316358A (sh)
KR (1) KR0131338B1 (sh)
AT (1) AT395586B (sh)
AU (1) AU615521B2 (sh)
BE (1) BE1003199A5 (sh)
CA (1) CA1340193C (sh)
CH (1) CH677490A5 (sh)
CY (1) CY1760A (sh)
CZ (1) CZ285313B6 (sh)
DE (1) DE3907508A1 (sh)
DK (1) DK113189A (sh)
ES (1) ES2012687A6 (sh)
FI (1) FI92056C (sh)
FR (1) FR2628421B1 (sh)
GB (2) GB2216521B (sh)
GR (1) GR1002248B (sh)
IL (1) IL89536A0 (sh)
NL (1) NL8900569A (sh)
PL (1) PL159098B1 (sh)
SE (1) SE469659B (sh)
YU (1) YU47689B (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
AU640019B2 (en) * 1990-05-22 1993-08-12 Unichema Chemie Bv Lubricants
DE19727350C1 (de) * 1997-06-27 1999-01-21 Bayer Ag Verfahren zur Herstellung von Nifedipin
LV12200B (lv) * 1997-07-03 1999-04-20 Gunārs DUBURS Antidiabētisks līdzeklis
HUP9900353A3 (en) * 1999-02-15 2002-01-28 Egis Gyogyszergyar Nyilvanosan Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids
CN103204814A (zh) * 2010-09-02 2013-07-17 常州市第四制药厂有限公司 硝苯地平的制备及其杂质分离方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863920A (en) * 1956-07-26 1958-12-09 Gen Aniline & Film Corp Process of preparing hydrobenzamide
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2210667A1 (de) * 1972-03-06 1973-09-20 Bayer Ag Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS4936682A (sh) * 1972-08-16 1974-04-05
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DD120019A1 (sh) * 1975-04-11 1976-05-20
US4012032A (en) * 1975-11-28 1977-03-15 International Business Machines Corporation Document reproduction having output means with plural outputs operable in a plurality of modes
DE2639257A1 (de) * 1976-09-01 1978-03-02 Bayer Ag Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
ES8600745A1 (es) * 1984-11-23 1985-11-01 Coma Julia Concepcio Procedimiento de obtencion del dimetil ester del acido 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridindicarboxilico
EP0191724A3 (de) * 1985-01-15 1986-12-03 Sandoz Ag 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE3501855A1 (de) * 1985-01-22 1986-07-24 Bayer Ag, 5090 Leverkusen 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
PL141347B1 (en) * 1985-10-10 1987-07-31 Inst Przemyslu Farmaceutic Method of obtaining chromatographically pure 4-/2-nitrophenyl/-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine

Also Published As

Publication number Publication date
IL89536A0 (en) 1989-09-10
GB8905270D0 (en) 1989-04-19
GR890100133A (el) 1990-01-19
BE1003199A5 (fr) 1992-01-14
GB9108770D0 (en) 1991-06-12
GB2243608B (en) 1992-02-12
PL159098B1 (en) 1992-11-30
FR2628421B1 (fr) 1994-09-23
AU615521B2 (en) 1991-10-03
US5126457A (en) 1992-06-30
SE469659B (sv) 1993-08-16
FR2628421A1 (fr) 1989-09-15
KR890014477A (ko) 1989-10-23
DK113189A (da) 1989-09-09
JPH01316358A (ja) 1989-12-21
CA1340193C (en) 1998-12-15
FI891111A0 (fi) 1989-03-08
FI891111A (fi) 1989-09-09
FI92056C (fi) 1994-09-26
DE3907508A1 (de) 1989-09-21
ATA52589A (de) 1992-06-15
GB2216521B (en) 1992-02-26
YU46689A (en) 1990-12-31
GR1002248B (en) 1996-04-23
FI92056B (fi) 1994-06-15
CH677490A5 (sh) 1991-05-31
ES2012687A6 (es) 1990-04-01
AU3112989A (en) 1989-09-14
KR0131338B1 (ko) 1998-04-17
GB2216521A (en) 1989-10-11
GB2243608A (en) 1991-11-06
CY1760A (en) 1994-07-15
AT395586B (de) 1993-01-25
CZ145489A3 (cs) 1999-04-14
DK113189D0 (da) 1989-03-08
CZ285313B6 (cs) 1999-07-14
SE8900813L (sv) 1989-09-09
SE8900813D0 (sv) 1989-03-08
NL8900569A (nl) 1989-10-02

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