BE1003199A5 - Procede de preparation des derives de 1,4-dihydropyridine et a de nouveaux intermediaires utiles pour cette preparation. - Google Patents
Procede de preparation des derives de 1,4-dihydropyridine et a de nouveaux intermediaires utiles pour cette preparation. Download PDFInfo
- Publication number
- BE1003199A5 BE1003199A5 BE8900247A BE8900247A BE1003199A5 BE 1003199 A5 BE1003199 A5 BE 1003199A5 BE 8900247 A BE8900247 A BE 8900247A BE 8900247 A BE8900247 A BE 8900247A BE 1003199 A5 BE1003199 A5 BE 1003199A5
- Authority
- BE
- Belgium
- Prior art keywords
- preparation
- intermediates useful
- new intermediates
- dihydropyridine derivatives
- dihydropyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
L'invention est relative à un procédé pour la préparation du 1,4-dihydro-2,6-diméthyl-4-(2'-nitrophényl)-pyridine-3,5-dicarboxylate de diméthyle de formule.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU881112A HU200320B (en) | 1988-03-08 | 1988-03-08 | Process for production of derivatives of azometine |
HU111188A HU201912B (en) | 1988-03-08 | 1988-03-08 | Process for producing dihydropyridine-carboxylic acid esters |
HU405588A HUT54647A (en) | 1988-08-02 | 1988-08-02 | Process for producing nifedipine |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1003199A5 true BE1003199A5 (fr) | 1992-01-14 |
Family
ID=27269951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8900247A BE1003199A5 (fr) | 1988-03-08 | 1989-03-08 | Procede de preparation des derives de 1,4-dihydropyridine et a de nouveaux intermediaires utiles pour cette preparation. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5126457A (fr) |
JP (1) | JPH01316358A (fr) |
KR (1) | KR0131338B1 (fr) |
AT (1) | AT395586B (fr) |
AU (1) | AU615521B2 (fr) |
BE (1) | BE1003199A5 (fr) |
CA (1) | CA1340193C (fr) |
CH (1) | CH677490A5 (fr) |
CY (1) | CY1760A (fr) |
CZ (1) | CZ285313B6 (fr) |
DE (1) | DE3907508A1 (fr) |
DK (1) | DK113189A (fr) |
ES (1) | ES2012687A6 (fr) |
FI (1) | FI92056C (fr) |
FR (1) | FR2628421B1 (fr) |
GB (2) | GB2216521B (fr) |
GR (1) | GR1002248B (fr) |
IL (1) | IL89536A0 (fr) |
NL (1) | NL8900569A (fr) |
PL (1) | PL159098B1 (fr) |
SE (1) | SE469659B (fr) |
YU (1) | YU47689B (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
AU640019B2 (en) * | 1990-05-22 | 1993-08-12 | Unichema Chemie Bv | Lubricants |
DE19727350C1 (de) * | 1997-06-27 | 1999-01-21 | Bayer Ag | Verfahren zur Herstellung von Nifedipin |
LV12200B (lv) * | 1997-07-03 | 1999-04-20 | Gunārs DUBURS | Antidiabētisks līdzeklis |
HUP9900353A3 (en) * | 1999-02-15 | 2002-01-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids |
CN103204814A (zh) * | 2010-09-02 | 2013-07-17 | 常州市第四制药厂有限公司 | 硝苯地平的制备及其杂质分离方法与应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863920A (en) * | 1956-07-26 | 1958-12-09 | Gen Aniline & Film Corp | Process of preparing hydrobenzamide |
DE1670827A1 (de) * | 1967-03-20 | 1971-03-11 | Bayer Ag | Neue Arzneimittel auf der Grundlage von 4-Aryl-1,4-dihydropyridinderivaten |
JPS4936682A (fr) * | 1972-08-16 | 1974-04-05 | ||
ES8600745A1 (es) * | 1984-11-23 | 1985-11-01 | Coma Julia Concepcio | Procedimiento de obtencion del dimetil ester del acido 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridindicarboxilico |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2210667A1 (de) * | 1972-03-06 | 1973-09-20 | Bayer Ag | Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
DE2335466A1 (de) * | 1973-07-12 | 1975-01-30 | Bayer Ag | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DD120019A1 (fr) * | 1975-04-11 | 1976-05-20 | ||
US4012032A (en) * | 1975-11-28 | 1977-03-15 | International Business Machines Corporation | Document reproduction having output means with plural outputs operable in a plurality of modes |
DE2639257A1 (de) * | 1976-09-01 | 1978-03-02 | Bayer Ag | Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
EP0191724A3 (fr) * | 1985-01-15 | 1986-12-03 | Sandoz Ag | 1,4-Dihydropyridines, leur procédé de préparation et les compositions pharmaceutiques les contenant |
DE3501855A1 (de) * | 1985-01-22 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
PL141347B1 (en) * | 1985-10-10 | 1987-07-31 | Inst Przemyslu Farmaceutic | Method of obtaining chromatographically pure 4-/2-nitrophenyl/-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine |
-
1989
- 1989-02-28 GR GR890100133A patent/GR1002248B/el unknown
- 1989-03-03 CH CH799/89A patent/CH677490A5/de not_active IP Right Cessation
- 1989-03-06 YU YU46689A patent/YU47689B/sh unknown
- 1989-03-08 DK DK113189A patent/DK113189A/da unknown
- 1989-03-08 ES ES8900848A patent/ES2012687A6/es not_active Expired - Lifetime
- 1989-03-08 DE DE3907508A patent/DE3907508A1/de not_active Withdrawn
- 1989-03-08 US US07/321,293 patent/US5126457A/en not_active Expired - Fee Related
- 1989-03-08 CA CA000593128A patent/CA1340193C/fr not_active Expired - Fee Related
- 1989-03-08 IL IL89536A patent/IL89536A0/xx not_active IP Right Cessation
- 1989-03-08 FR FR8903043A patent/FR2628421B1/fr not_active Expired - Fee Related
- 1989-03-08 CZ CS891454A patent/CZ285313B6/cs unknown
- 1989-03-08 SE SE8900813A patent/SE469659B/sv not_active IP Right Cessation
- 1989-03-08 PL PL1989278134A patent/PL159098B1/pl unknown
- 1989-03-08 GB GB8905270A patent/GB2216521B/en not_active Expired - Lifetime
- 1989-03-08 AT AT0052589A patent/AT395586B/de not_active IP Right Cessation
- 1989-03-08 BE BE8900247A patent/BE1003199A5/fr not_active IP Right Cessation
- 1989-03-08 JP JP1053968A patent/JPH01316358A/ja active Pending
- 1989-03-08 KR KR1019890002844A patent/KR0131338B1/ko not_active IP Right Cessation
- 1989-03-08 AU AU31129/89A patent/AU615521B2/en not_active Ceased
- 1989-03-08 FI FI891111A patent/FI92056C/fi not_active IP Right Cessation
- 1989-03-08 NL NL8900569A patent/NL8900569A/nl not_active Application Discontinuation
-
1991
- 1991-04-24 GB GB9108770A patent/GB2243608B/en not_active Expired - Lifetime
-
1994
- 1994-07-15 CY CY176094A patent/CY1760A/xx unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863920A (en) * | 1956-07-26 | 1958-12-09 | Gen Aniline & Film Corp | Process of preparing hydrobenzamide |
DE1670827A1 (de) * | 1967-03-20 | 1971-03-11 | Bayer Ag | Neue Arzneimittel auf der Grundlage von 4-Aryl-1,4-dihydropyridinderivaten |
JPS4936682A (fr) * | 1972-08-16 | 1974-04-05 | ||
ES8600745A1 (es) * | 1984-11-23 | 1985-11-01 | Coma Julia Concepcio | Procedimiento de obtencion del dimetil ester del acido 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridindicarboxilico |
Non-Patent Citations (4)
Title |
---|
CHEMICAL ABSTRACTS, vol. 105, 1986, page 717, résumé no. 190966b, Columbus, Ohio, US; & ES-A1-8600745 (COMA JULIA, CONCEPCION) 01-02-1986 * |
CHEMICAL ABSTRACTS, vol. 55, colonne 22333, résumé a, Columbus, Ohio, US; S.V. SVETOZARSKII et al.: "Reaction of benzaldehyde with ammonia", & ZHUR. OBSHSCHEI KHIM. 31, 1717-19(1961) * |
CHEMICAL ABSTRACTS, vol. 81, 1974, page 408, résumé no. 135965m, Columbus, Ohio, US; & JP-A-49 036 682 (SANKYO CO., LTD) 05-04-1974 * |
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS I, vol. 10, 1975, pages 926-929; T. CHENNAT et al.: "A new synthesis of 1,4-dihydropyridines" * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU88666I2 (fr) | 2,6-Diméthyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylique acide,3-méthyl ester 5-ethylester à activité hypotensive son procédé de préparation et compositions pharmaceutiques le contenant | |
ES8600273A1 (es) | Un procedimiento para producir 2,6-dimetil-4-(3nitrofenil)-1,4-dihidropiridin 3,5-dicarboxilato de 1, bencil-3-piperidilo y metilo y su hidrocloruro. | |
MX9708662A (es) | Un procedimiento para la preparacion de clorhidrato de lercanidipino. | |
BE1003199A5 (fr) | Procede de preparation des derives de 1,4-dihydropyridine et a de nouveaux intermediaires utiles pour cette preparation. | |
DK0531845T3 (da) | Farmaceutiske præparater med en speciel krystalmodifikation af 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarboxylsyre-isopropyl-(2-methoxyethyl)-ester | |
CA1176255A (fr) | Derives de dihydro-1,4-pyridine et methode de preparation | |
EP0207674A3 (en) | 1,4-dihydropyridine derivatives, their preparation and their pharmaceutical use | |
ES8707185A1 (es) | Proceso para producir derivados de 1,4-dihidro-piridina-3,5,dicarboxilato. | |
ATE126190T1 (de) | 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5- | |
DK169185A (da) | Dihydropyridin-3,5-dicarboxylsyreesterderivater, fremgangsmaade tilfremstilling heraf og farmaceutiske praeparater indeholdende disse | |
PT83599A (en) | Process for preparing 1,4-dihydropyridine derivatives | |
DK32789A (da) | Derivat af antibiotikum a 42867 | |
YU66687A (en) | Process for obtaining hydrochloride of 2(n-benzyl-n-m-ethylamino)-ethyl-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridin-dicarboxilate | |
IL94502A0 (en) | Preparation of methyl,1,2-dihydroxypropan-3-yl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate | |
YU188386A (en) | Process for obtaining asymmetric diesthers of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarboxylic acid | |
DE3788738D1 (de) | Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel. | |
KR910015573A (ko) | 신규의 1, 4- 디히드로피리딘 유도체와, 그 제조방법 및 혈류에 영향을 주기 위한 그 사용 | |
RU1828464C (ru) | Способ получени диметилового эфира 1,4-дигидро-2,6-диметил-4-/2 @ -нитрофенил/-пиридин-3,5-дикарбоновой кислоты | |
IT8420614A1 (it) | "processo per la preparazione di esteri asimmetrici dell'acido 2,6-dimetil-4-(3'-nitrofenil)-1,4-diidro-3,5-piridindicarbossilico" | |
HRP950452B1 (en) | Process for the preparation of benzosulphonate salts 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)1,4-dihydro-6-methylpyridine -3,5-dicarboxylate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: EGIS GYOGYSZERGYAR Effective date: 19980331 |