ES2012687A6 - Procedimiento de preparacion de derivados 1,4-dihidro-piridinas. - Google Patents
Procedimiento de preparacion de derivados 1,4-dihidro-piridinas.Info
- Publication number
- ES2012687A6 ES2012687A6 ES8900848A ES8900848A ES2012687A6 ES 2012687 A6 ES2012687 A6 ES 2012687A6 ES 8900848 A ES8900848 A ES 8900848A ES 8900848 A ES8900848 A ES 8900848A ES 2012687 A6 ES2012687 A6 ES 2012687A6
- Authority
- ES
- Spain
- Prior art keywords
- nitrophenyl
- dihydro
- preparation
- pyridine derivatives
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS 1,4-DIHIDRO-PIRIDINAS. LA INVENCION SE RELACIONA CON UN PROCEDIMIENTO DE PREPARACION DE DIMETIL-1,4-DIHIDRO-2,6-DIMETIL-4-(2''-NITROFENIL)-PIRIDINA-3,5-DICARBOXILATO DE FORMULA I, QUE COMPRENDE: A) LA REACCION DE UN COMPUESTO DE FORMULA GENERAL II (EN LA QUE N ES 1 O 3; SI N ES 1, ENTONCES R REPRESENTA UN GRUPO DE FORMULA (A) O (B) Y SI N ES 3, ENTONCES R REPRESENTA HIDROGENO) CON ACETOACETATO METILICO DE FORMULA III Y OPTATIVAMENTE CON UN COMPUESTO AMINO DE FORMULA GENERAL IV (EN LA QUE Z ES UN GRUPO DE FORMULA (C); K ES 1 Y AMBOS SIMBOLOS P SON 0; Z REPRESENTA UN GRUPO ALCANOILOXILO DE CADENA LINEAL O RAMIFICADA O UN ANION CARBONATO, HIDROCARBONATO O HIDROXILO, K ES 1 Y AMBOS SIMBOLOS P SON 1; K ES 0, UNO DE AMBOS SIMBOLOS P ES 0 Y EL OTRO ES 1) EN UN DISOLVENTE INERTE; O B) LA REACCION DE 2-NITRO-BENZALDEHIDO Y ACETOACETATO METILICO DE FORMULA III E HIDROXIDO AMONICO ACUOSO EN PRESENCIA DE UN DISOLVENTE INERTE EN UNA OPERACION, A UNA TEMPERATURA DE 101-120GC, BAJO UNA PRESION DE 2,0 A 6,0 BARES. EL DIMETIL-1,4-DIHIDRO-2,6-DIMETIL-4-(2''-NITRO-FENIL)-PIRIDINA-3,5-DICARBOXILATO DE FORMULA I ES UN CONOCIDO ANTAGONISTA DEL CALCIO, UTIL EN EL TRATAMIENTO DE LA HIPERTENSION.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU881112A HU200320B (en) | 1988-03-08 | 1988-03-08 | Process for production of derivatives of azometine |
HU111188A HU201912B (en) | 1988-03-08 | 1988-03-08 | Process for producing dihydropyridine-carboxylic acid esters |
HU405588A HUT54647A (en) | 1988-08-02 | 1988-08-02 | Process for producing nifedipine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2012687A6 true ES2012687A6 (es) | 1990-04-01 |
Family
ID=27269951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8900848A Expired - Lifetime ES2012687A6 (es) | 1988-03-08 | 1989-03-08 | Procedimiento de preparacion de derivados 1,4-dihidro-piridinas. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5126457A (es) |
JP (1) | JPH01316358A (es) |
KR (1) | KR0131338B1 (es) |
AT (1) | AT395586B (es) |
AU (1) | AU615521B2 (es) |
BE (1) | BE1003199A5 (es) |
CA (1) | CA1340193C (es) |
CH (1) | CH677490A5 (es) |
CY (1) | CY1760A (es) |
CZ (1) | CZ285313B6 (es) |
DE (1) | DE3907508A1 (es) |
DK (1) | DK113189A (es) |
ES (1) | ES2012687A6 (es) |
FI (1) | FI92056C (es) |
FR (1) | FR2628421B1 (es) |
GB (2) | GB2216521B (es) |
GR (1) | GR1002248B (es) |
IL (1) | IL89536A0 (es) |
NL (1) | NL8900569A (es) |
PL (1) | PL159098B1 (es) |
SE (1) | SE469659B (es) |
YU (1) | YU47689B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
AU640019B2 (en) * | 1990-05-22 | 1993-08-12 | Unichema Chemie Bv | Lubricants |
DE19727350C1 (de) * | 1997-06-27 | 1999-01-21 | Bayer Ag | Verfahren zur Herstellung von Nifedipin |
LV12200B (lv) * | 1997-07-03 | 1999-04-20 | Gunārs DUBURS | Antidiabētisks līdzeklis |
HUP9900353A3 (en) * | 1999-02-15 | 2002-01-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids |
CN103204814A (zh) * | 2010-09-02 | 2013-07-17 | 常州市第四制药厂有限公司 | 硝苯地平的制备及其杂质分离方法与应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863920A (en) * | 1956-07-26 | 1958-12-09 | Gen Aniline & Film Corp | Process of preparing hydrobenzamide |
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2210667A1 (de) * | 1972-03-06 | 1973-09-20 | Bayer Ag | Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS4936682A (es) * | 1972-08-16 | 1974-04-05 | ||
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
DE2335466A1 (de) * | 1973-07-12 | 1975-01-30 | Bayer Ag | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DD120019A1 (es) * | 1975-04-11 | 1976-05-20 | ||
US4012032A (en) * | 1975-11-28 | 1977-03-15 | International Business Machines Corporation | Document reproduction having output means with plural outputs operable in a plurality of modes |
DE2639257A1 (de) * | 1976-09-01 | 1978-03-02 | Bayer Ag | Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
ES537914A0 (es) * | 1984-11-23 | 1985-11-01 | Coma Julia Concepcio | Procedimiento de obtencion del dimetil ester del acido 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridindicarboxilico |
EP0191724A3 (de) * | 1985-01-15 | 1986-12-03 | Sandoz Ag | 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
DE3501855A1 (de) * | 1985-01-22 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
PL141347B1 (en) * | 1985-10-10 | 1987-07-31 | Inst Przemyslu Farmaceutic | Method of obtaining chromatographically pure 4-/2-nitrophenyl/-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine |
-
1989
- 1989-02-28 GR GR890100133A patent/GR1002248B/el unknown
- 1989-03-03 CH CH799/89A patent/CH677490A5/de not_active IP Right Cessation
- 1989-03-06 YU YU46689A patent/YU47689B/sh unknown
- 1989-03-08 DK DK113189A patent/DK113189A/da unknown
- 1989-03-08 ES ES8900848A patent/ES2012687A6/es not_active Expired - Lifetime
- 1989-03-08 DE DE3907508A patent/DE3907508A1/de not_active Withdrawn
- 1989-03-08 US US07/321,293 patent/US5126457A/en not_active Expired - Fee Related
- 1989-03-08 CA CA000593128A patent/CA1340193C/en not_active Expired - Fee Related
- 1989-03-08 IL IL89536A patent/IL89536A0/xx not_active IP Right Cessation
- 1989-03-08 FR FR8903043A patent/FR2628421B1/fr not_active Expired - Fee Related
- 1989-03-08 CZ CS891454A patent/CZ285313B6/cs unknown
- 1989-03-08 SE SE8900813A patent/SE469659B/sv not_active IP Right Cessation
- 1989-03-08 PL PL1989278134A patent/PL159098B1/pl unknown
- 1989-03-08 GB GB8905270A patent/GB2216521B/en not_active Expired - Lifetime
- 1989-03-08 AT AT0052589A patent/AT395586B/de not_active IP Right Cessation
- 1989-03-08 BE BE8900247A patent/BE1003199A5/fr not_active IP Right Cessation
- 1989-03-08 JP JP1053968A patent/JPH01316358A/ja active Pending
- 1989-03-08 KR KR1019890002844A patent/KR0131338B1/ko not_active IP Right Cessation
- 1989-03-08 AU AU31129/89A patent/AU615521B2/en not_active Ceased
- 1989-03-08 FI FI891111A patent/FI92056C/fi not_active IP Right Cessation
- 1989-03-08 NL NL8900569A patent/NL8900569A/nl not_active Application Discontinuation
-
1991
- 1991-04-24 GB GB9108770A patent/GB2243608B/en not_active Expired - Lifetime
-
1994
- 1994-07-15 CY CY176094A patent/CY1760A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000301 |