NO943688L - Fremgangsmåte for fremstilling av 4-pyridyl- og 4-piperidinylimidazoler som er nyttige som mellomprodukter for syntese av histaminreseptorantagonister - Google Patents
Fremgangsmåte for fremstilling av 4-pyridyl- og 4-piperidinylimidazoler som er nyttige som mellomprodukter for syntese av histaminreseptorantagonisterInfo
- Publication number
- NO943688L NO943688L NO943688A NO943688A NO943688L NO 943688 L NO943688 L NO 943688L NO 943688 A NO943688 A NO 943688A NO 943688 A NO943688 A NO 943688A NO 943688 L NO943688 L NO 943688L
- Authority
- NO
- Norway
- Prior art keywords
- receptor antagonists
- preparation
- intermediates
- useful
- piperidinylimidazoles
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 229940122236 Histamine receptor antagonist Drugs 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- BSTAWYYHYJYBIZ-UHFFFAOYSA-N 1-(1h-imidazol-5-yl)piperidine Chemical class C1CCCCN1C1=CNC=N1 BSTAWYYHYJYBIZ-UHFFFAOYSA-N 0.000 title 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229940115480 Histamine H3 receptor antagonist Drugs 0.000 abstract 1
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 1
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Ny fremgangsmåte for fremstilling av sterktvirkende histaminreseptorantagonister av formelen: R4¿N N-Z (D spesielt histamin H3-reseptorantagonlster. Det er også beskrevet en ny fremgangsmåte for fremstilling av mellomprodukter (II) *_ ¿¿ (II) og (III) R1 X NH (ni) som er nyttige i fremstillingen av histaminreseptor- antagonister, spesielt H3-reseptorantagonister.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/862,658 US5380858A (en) | 1992-04-01 | 1992-04-01 | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists |
PCT/US1993/003105 WO1993020062A1 (en) | 1992-04-01 | 1993-03-31 | Process for the preparation of 4-pyridyl- and 4-piperidinylimidazoles useful as intermediates for the synthesis of histamine receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
NO943688D0 NO943688D0 (no) | 1994-10-03 |
NO943688L true NO943688L (no) | 1994-11-25 |
Family
ID=25338980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO943688A NO943688L (no) | 1992-04-01 | 1994-10-03 | Fremgangsmåte for fremstilling av 4-pyridyl- og 4-piperidinylimidazoler som er nyttige som mellomprodukter for syntese av histaminreseptorantagonister |
Country Status (13)
Country | Link |
---|---|
US (2) | US5380858A (no) |
EP (1) | EP0633883A1 (no) |
JP (1) | JPH07509220A (no) |
KR (1) | KR950700899A (no) |
AU (1) | AU3944693A (no) |
BR (1) | BR9306191A (no) |
CA (1) | CA2133460A1 (no) |
FI (1) | FI944606A (no) |
HU (1) | HU9402826D0 (no) |
NO (1) | NO943688L (no) |
RU (1) | RU94045838A (no) |
SK (1) | SK118894A3 (no) |
WO (1) | WO1993020062A1 (no) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5817823A (en) * | 1997-04-17 | 1998-10-06 | Sepracor Inc. | Method for synthesizing 2-substituted imidazoles |
US6887870B1 (en) * | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
EP1707203A1 (en) | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
EP1717233A1 (en) * | 2005-04-29 | 2006-11-02 | Bioprojet | Histamine H3-receptor ligands and their therapeutic application |
EP1717235A3 (en) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
FR2671083B1 (fr) * | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
FR2674855B1 (fr) * | 1991-04-03 | 1994-01-14 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique. |
-
1992
- 1992-04-01 US US07/862,658 patent/US5380858A/en not_active Expired - Fee Related
-
1993
- 1993-03-31 EP EP93908725A patent/EP0633883A1/en not_active Withdrawn
- 1993-03-31 JP JP5517716A patent/JPH07509220A/ja active Pending
- 1993-03-31 BR BR9306191A patent/BR9306191A/pt not_active Application Discontinuation
- 1993-03-31 AU AU39446/93A patent/AU3944693A/en not_active Abandoned
- 1993-03-31 WO PCT/US1993/003105 patent/WO1993020062A1/en not_active Application Discontinuation
- 1993-03-31 CA CA002133460A patent/CA2133460A1/en not_active Abandoned
- 1993-03-31 RU RU94045838/04A patent/RU94045838A/ru unknown
- 1993-03-31 SK SK1188-94A patent/SK118894A3/sk unknown
- 1993-03-31 HU HU9402826A patent/HU9402826D0/hu unknown
-
1994
- 1994-06-02 US US08/252,810 patent/US5663350A/en not_active Expired - Fee Related
- 1994-09-30 KR KR1019940703409A patent/KR950700899A/ko not_active Application Discontinuation
- 1994-10-03 FI FI944606A patent/FI944606A/fi not_active Application Discontinuation
- 1994-10-03 NO NO943688A patent/NO943688L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HU9402826D0 (en) | 1994-12-28 |
FI944606A (fi) | 1994-11-30 |
US5380858A (en) | 1995-01-10 |
SK118894A3 (en) | 1995-07-11 |
FI944606A0 (fi) | 1994-10-03 |
BR9306191A (pt) | 1998-06-30 |
KR950700899A (ko) | 1995-02-20 |
JPH07509220A (ja) | 1995-10-12 |
AU3944693A (en) | 1993-11-08 |
WO1993020062A1 (en) | 1993-10-14 |
CA2133460A1 (en) | 1993-10-14 |
EP0633883A1 (en) | 1995-01-18 |
US5663350A (en) | 1997-09-02 |
RU94045838A (ru) | 1996-08-10 |
NO943688D0 (no) | 1994-10-03 |
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