GR850787B - - Google Patents

Info

Publication number
GR850787B
GR850787B GR850787A GR850100787A GR850787B GR 850787 B GR850787 B GR 850787B GR 850787 A GR850787 A GR 850787A GR 850100787 A GR850100787 A GR 850100787A GR 850787 B GR850787 B GR 850787B
Authority
GR
Greece
Prior art keywords
derivative
benzyl
condensing
addition salt
acid addition
Prior art date
Application number
GR850787A
Other languages
Greek (el)
English (en)
Inventor
Hiroshi Ohtaka
Toshiro Kanazawa
Keizo Ito
Goro Tsukamoto
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Publication of GR850787B publication Critical patent/GR850787B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GR850787A 1984-03-30 1985-03-28 GR850787B (member.php)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59064464A JPS60222472A (ja) 1984-03-30 1984-03-30 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Publications (1)

Publication Number Publication Date
GR850787B true GR850787B (member.php) 1985-11-25

Family

ID=13258978

Family Applications (1)

Application Number Title Priority Date Filing Date
GR850787A GR850787B (member.php) 1984-03-30 1985-03-28

Country Status (10)

Country Link
US (1) US4663325A (member.php)
EP (1) EP0159566B1 (member.php)
JP (1) JPS60222472A (member.php)
AT (1) ATE31411T1 (member.php)
CA (1) CA1248110A (member.php)
DE (1) DE3561199D1 (member.php)
ES (3) ES8702393A1 (member.php)
FI (1) FI79101C (member.php)
GR (1) GR850787B (member.php)
NO (1) NO163185C (member.php)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPS62277370A (ja) * 1986-02-04 1987-12-02 Terumo Corp ジエン誘導体およびこれを含有する血管拡張剤
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
FI953748A7 (fi) * 1993-12-08 1995-08-07 Alcon Lab Inc Yhdisteitä, joilla on sekä voimakas kalsium antagonisti- että antioksi danttiaktiivisuus sekä niiden käyttö solua suojaavina aineina
CN1149086C (zh) 1998-01-29 2004-05-12 阿克苏诺贝尔公司 改善视神经乳头循环的药物
RU2204556C2 (ru) * 2001-06-18 2003-05-20 Федеральное государственное унитарное предприятие "Новокузнецкий научно-исследовательский химико-фармацевтический институт" Способ получения 1-(парахлорбензгидрил)-4-(2-оксиэтил)пиперазина
EP1545519B1 (en) 2002-08-19 2011-03-23 Pfizer Inc. Combination therapy for hyperproliferative diseases
US7403561B2 (en) 2003-04-04 2008-07-22 Avid Technology, Inc. Fixed bit rate, intraframe compression and decompression of video
US7433519B2 (en) 2003-04-04 2008-10-07 Avid Technology, Inc. Bitstream format for compressed image data
US20050159403A1 (en) * 2003-04-22 2005-07-21 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
US20060135506A1 (en) * 2003-04-22 2006-06-22 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
KR20110117731A (ko) * 2003-05-30 2011-10-27 랜박시 래보러터리스 리미티드 치환된 피롤 유도체와 ｈｍｇ―ｃｏ 억제제로서의 이의 용도
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
WO2006099244A1 (en) * 2005-03-11 2006-09-21 Hong Kong Nitric Oxide Limited Combination therapy for endothelial dysfunction, angina and diabetes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
JP2009513660A (ja) * 2005-10-26 2009-04-02 旭化成ファーマ株式会社 肺動脈性高血圧の治療用併用療法におけるファスジル
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
AU2006313430B2 (en) * 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CL2007000667A1 (es) * 2006-03-14 2008-03-14 Ranbaxi Lab Ltd Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e
TW200811101A (en) * 2006-07-14 2008-03-01 Ranbaxy Lab Ltd Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
EP2094643B1 (en) 2006-12-01 2012-02-29 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
JP5313125B2 (ja) 2007-02-28 2013-10-09 旭化成ファーマ株式会社 スルホンアミド誘導体
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN102936233B (zh) * 2012-11-16 2016-01-20 葛长乐 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型
KR101695582B1 (ko) 2013-04-17 2017-01-13 화이자 인코포레이티드 심혈관 질환을 치료하기 위한 n-피페리딘-3-일벤즈아미드 유도체
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2017069343A1 (ko) * 2015-10-20 2017-04-27 한국표준과학연구원 위치조절이 용이한 전자현미경용 전자총 및 이를 포함하는 전자현미경
CN109666008A (zh) * 2018-12-31 2019-04-23 辰欣药业股份有限公司 一种盐酸洛美利嗪的合成方法
CN119060040A (zh) 2019-01-18 2024-12-03 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB705979A (en) * 1951-03-22 1954-03-24 Henri Morren 1.4-aralkyl piperazines and process for the preparation thereof
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR1303080A (fr) * 1961-07-25 1962-09-07 Science Union Et Compagnie Soc Pipérazines disubstituées
NL7306771A (member.php) * 1972-06-02 1973-12-04
DE2900810A1 (de) * 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent

Also Published As

Publication number Publication date
JPH0313232B2 (member.php) 1991-02-22
ES8801237A1 (es) 1988-01-01
FI851217A0 (fi) 1985-03-26
FI851217L (fi) 1985-10-01
US4663325A (en) 1987-05-05
EP0159566B1 (en) 1987-12-16
CA1248110A (en) 1989-01-03
ATE31411T1 (de) 1988-01-15
EP0159566A1 (en) 1985-10-30
JPS60222472A (ja) 1985-11-07
NO163185C (no) 1990-04-18
DE3561199D1 (en) 1988-01-28
FI79101B (fi) 1989-07-31
ES556980A0 (es) 1988-01-01
ES541728A0 (es) 1987-01-01
ES556981A0 (es) 1988-01-01
FI79101C (fi) 1989-11-10
NO851298L (no) 1985-10-01
ES8801236A1 (es) 1988-01-01
ES8702393A1 (es) 1987-01-01

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