US4879236A
(en)
*
|
1984-05-16 |
1989-11-07 |
The Texas A&M University System |
Method for producing a recombinant baculovirus expression vector
|
JPS619288A
(ja)
*
|
1984-06-21 |
1986-01-16 |
Dai Ichi Seiyaku Co Ltd |
ペプチド類の製法
|
IL80529A0
(en)
*
|
1985-11-14 |
1987-02-27 |
Daiichi Seiyaku Co |
Method of producing peptides
|
EP0228036A3
(en)
*
|
1985-12-18 |
1988-09-07 |
Microgenesys, Inc. |
Method for producing selected polypeptides in virally infected insect cells and polypeptides isolated therefrom
|
US6150328A
(en)
|
1986-07-01 |
2000-11-21 |
Genetics Institute, Inc. |
BMP products
|
IL83003A
(en)
|
1986-07-01 |
1995-07-31 |
Genetics Inst |
Osteoinductive factors
|
GR871029B
(en)
|
1986-07-14 |
1987-11-02 |
Genetics Inst |
Novel osteoinductive factors
|
EP0260090A3
(en)
*
|
1986-09-08 |
1988-07-27 |
David H.L. Bishop |
Expression of hepatitis b viral antigens from recombinant baculovirus vectors
|
ES2008204A6
(es)
*
|
1986-09-09 |
1989-07-16 |
Genetics Inst |
Metodos para producir cuerpos de inclusion polihedrica de composicion mezclada (pib),para coinfectar insectos huespedes y para producir proteinas heterologas en insectos.
|
US5071748A
(en)
*
|
1986-09-09 |
1991-12-10 |
Genetics Institute, Inc. |
Mixed baculovirus compositions and uses thereof
|
US5041379A
(en)
*
|
1987-03-16 |
1991-08-20 |
American Biogenetic Science, Inc. |
Heliothis expression systems
|
US5024947A
(en)
*
|
1987-07-24 |
1991-06-18 |
Cetus Corporation |
Serum free media for the growth on insect cells and expression of products thereby
|
US5443964A
(en)
*
|
1987-08-10 |
1995-08-22 |
Duke University |
Poxvirus insertion/expression vector
|
US5578468A
(en)
*
|
1987-08-10 |
1996-11-26 |
Duke University |
Site-specific RNA cleavage
|
GB8810808D0
(en)
*
|
1988-05-06 |
1988-06-08 |
Wellcome Found |
Vectors
|
JP2511494B2
(ja)
*
|
1988-05-12 |
1996-06-26 |
善治 松浦 |
日本脳炎ウイルス表面抗原蛋白質の製造法
|
JPH0221955A
(ja)
*
|
1988-07-07 |
1990-01-24 |
Nippon Steel Corp |
流体噴射ノズル
|
SE8802939D0
(sv)
*
|
1988-08-19 |
1988-08-19 |
Kabigen Ab |
A method for the production and isolation of a fusion protein in eukaryotic cells
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
WO1990005783A1
(en)
*
|
1988-11-18 |
1990-05-31 |
Cetus Corporation |
Insect signal peptide mediated secretion of recombinant proteins
|
US5244805A
(en)
*
|
1989-05-17 |
1993-09-14 |
University Of Georgia Research Foundation, Inc. |
Baculovirus expression vectors
|
AU674500B2
(en)
|
1991-11-04 |
1997-01-02 |
Genetics Institute, Llc |
Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
|
CA2161808C
(en)
|
1993-05-12 |
2008-08-05 |
Anthony J. Celeste |
Bmp-11 compositions
|
US6291206B1
(en)
|
1993-09-17 |
2001-09-18 |
Genetics Institute, Inc. |
BMP receptor proteins
|
US6027919A
(en)
|
1993-12-07 |
2000-02-22 |
Genetics Institute, Inc. |
BMP-12 and BMP-13 proteins and DNA encoding them
|
DE69434651T2
(de)
|
1993-12-07 |
2007-03-08 |
Genetics Institute, Inc., Cambridge |
Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
|
WO1995017515A1
(en)
*
|
1993-12-23 |
1995-06-29 |
University Technologies International Inc. |
Methods of expressing proteins in insect cells and methods of killing insects
|
US5629167A
(en)
|
1994-04-19 |
1997-05-13 |
Biocine S.P.A. |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
|
US6544523B1
(en)
|
1996-11-13 |
2003-04-08 |
Chiron Corporation |
Mutant forms of Fas ligand and uses thereof
|
US6165748A
(en)
|
1997-07-11 |
2000-12-26 |
Genetics Institute, Inc. |
Frazzled nucleotide sequences and expression products
|
US6030619A
(en)
|
1997-08-27 |
2000-02-29 |
Chiron Corporation |
Molecular mimetics of meningococcal B epitopes
|
CN1263854C
(zh)
|
1997-11-06 |
2006-07-12 |
启龙股份公司 |
奈瑟球菌抗原
|
PT1047784E
(pt)
|
1998-01-14 |
2009-12-21 |
Novartis Vaccines & Diagnostic |
Antigénios de neisseria meningitidis
|
GB9808932D0
(en)
|
1998-04-27 |
1998-06-24 |
Chiron Spa |
Polyepitope carrier protein
|
US7576176B1
(en)
|
1998-05-01 |
2009-08-18 |
Novartis Vaccines And Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
WO2000022130A2
(en)
|
1998-10-15 |
2000-04-20 |
Chiron Corporation |
Metastatic breast and colon cancer regulated genes
|
ATE519840T1
(de)
|
1998-12-16 |
2011-08-15 |
Novartis Vaccines & Diagnostic |
Menschliche cyclin-abhängige kinase (hpnqalre)
|
US6727224B1
(en)
|
1999-02-01 |
2004-04-27 |
Genetics Institute, Llc. |
Methods and compositions for healing and repair of articular cartilage
|
EP2278007B1
(en)
|
1999-04-30 |
2014-04-16 |
Novartis Vaccines and Diagnostics S.r.l. |
Conserved neisserial antigens
|
GB9911683D0
(en)
|
1999-05-19 |
1999-07-21 |
Chiron Spa |
Antigenic peptides
|
GB9916529D0
(en)
|
1999-07-14 |
1999-09-15 |
Chiron Spa |
Antigenic peptides
|
AU783767B2
(en)
|
1999-10-14 |
2005-12-01 |
Takara Bio Usa, Inc. |
Anthozoa derived chromophores/fluorophores and methods for using the same
|
US7189392B1
(en)
|
1999-10-15 |
2007-03-13 |
Genetics Institute, Llc |
Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
|
EP2275554B1
(en)
|
1999-10-29 |
2015-03-25 |
Novartis Vaccines and Diagnostics S.r.l. |
Neisserial antigenic peptides
|
US7605246B2
(en)
|
2000-01-10 |
2009-10-20 |
Novartis Vaccines And Diagnostics, Inc. |
Genes differentially expressed in breast cancer
|
PT1897555E
(pt)
|
2000-01-17 |
2014-10-10 |
Novartis Vaccines & Diagnostic |
Vacina omv suplementada contra meningococos
|
US6689599B1
(en)
|
2000-10-20 |
2004-02-10 |
Genetics Institute, Llc |
Aggrecanase molecules
|
AU2002214127B2
(en)
|
2000-10-27 |
2007-06-07 |
J. Craig Venter Institute, Inc. |
Nucleic acids and proteins from streptococcus groups A and B
|
TWI329129B
(en)
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
GB0107661D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Staphylococcus aureus
|
GB0107658D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Streptococcus pneumoniae
|
WO2002081641A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene scc-112 and diagnostic and therapeutic uses thereof
|
AU2002303261A1
(en)
|
2001-04-06 |
2002-10-21 |
Georgetown University |
Gene brcc2 and diagnostic and therapeutic uses thereof
|
AU2002258728A1
(en)
|
2001-04-06 |
2002-10-21 |
Georgetown University |
Gene brcc-3 and diagnostic and therapeutic uses thereof
|
DK1399023T3
(da)
|
2001-06-01 |
2008-08-18 |
Wyeth Corp |
Sammensætninger til systemisk indgivelse af sekvenser, der koder for knoglemorfogenese-proteiner
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
AU2002319703A1
(en)
|
2001-07-27 |
2003-02-17 |
Wyeth |
Aggrecanase molecules
|
NZ562929A
(en)
|
2001-12-12 |
2009-07-31 |
Novartis Vaccines & Diagnostic |
Immunisation against chlamydia trachomatis
|
EP1456223B1
(en)
|
2001-12-19 |
2009-08-12 |
The University Of Chicago |
Rapidly maturing fluorescent proteins and methods for using the same
|
SG158739A1
(en)
|
2002-01-31 |
2010-02-26 |
Wyeth Corp |
Aggrecanase molecules
|
WO2003066822A2
(en)
|
2002-02-05 |
2003-08-14 |
Wyeth |
Truncated aggrecanase molecules
|
US7244565B2
(en)
|
2002-04-10 |
2007-07-17 |
Georgetown University |
Gene shinc-3 and diagnostic and therapeutic uses thereof
|
US7138512B2
(en)
|
2002-04-10 |
2006-11-21 |
Georgetown University |
Gene SHINC-2 and diagnostic and therapeutic uses thereof
|
CA2485703A1
(en)
|
2002-05-24 |
2003-12-04 |
Fred W. Wagner |
Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
|
AU2003239865A1
(en)
|
2002-05-24 |
2003-12-12 |
Restoragen Inc. |
Method for universal enzymatic production of bioactive peptides
|
ATE466875T1
(de)
|
2002-11-15 |
2010-05-15 |
Novartis Vaccines & Diagnostic |
Unerwartete oberflächenproteine in neisseria meningitidis
|
GB0308198D0
(en)
|
2003-04-09 |
2003-05-14 |
Chiron Srl |
ADP-ribosylating bacterial toxin
|
SI1675608T1
(sl)
|
2003-09-12 |
2007-08-31 |
Wyeth Corp |
Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov
|
SI1704234T1
(sl)
|
2003-11-21 |
2012-08-31 |
Nps Pharma Inc |
Proizvodnja glukagonu podobnih peptidov 2 in analogov
|
MXPA06008507A
(es)
|
2004-02-02 |
2008-02-13 |
Ambrx Inc |
Cuatro polipeptidos en haz helicoidal humanos modificados y sus usos.
|
CA2561696C
(en)
|
2004-03-29 |
2013-09-03 |
Galpharma Co., Ltd. |
Novel modified galectin 9 proteins and use thereof
|
US7250298B2
(en)
|
2004-04-07 |
2007-07-31 |
The University Of Chicago |
Monomeric red fluorescent proteins
|
NZ582684A
(en)
|
2004-06-18 |
2011-05-27 |
Ambrx Inc |
Use of an antibody or binding fragment thereof comprising a non naturally encoded amino acid coupled to a linker
|
WO2009100255A2
(en)
|
2008-02-08 |
2009-08-13 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
EP1771573A4
(en)
|
2004-07-21 |
2009-02-18 |
Ambrx Inc |
BIOSYNTHETIC POLYPEPTIDES OBTAINED FROM NON-NATURALLY CITED AMINO ACIDS
|
US7332571B2
(en)
|
2004-12-22 |
2008-02-19 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
CN103690936A
(zh)
|
2004-12-22 |
2014-04-02 |
Ambrx公司 |
经修饰的人类生长激素
|
PT1865940E
(pt)
|
2005-03-21 |
2013-04-08 |
Virobay Inc |
Compostos alfa-cetoamida como inibidores de proteases de cisteína
|
AU2006247591B2
(en)
|
2005-05-12 |
2011-12-15 |
Zymogenetics, Inc. |
Compositions and methods for modulating immune responses
|
WO2007053732A2
(en)
|
2005-11-01 |
2007-05-10 |
Mayo Foundation For Medical Education And Research |
Promoter polymorphisms of the blys gene and use in diagnostic methods
|
WO2007059312A2
(en)
|
2005-11-16 |
2007-05-24 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
WO2008020335A2
(en)
|
2006-06-09 |
2008-02-21 |
Novartis Ag |
Immunogenic compositions for streptococcus agalactiae
|
EP2615108B1
(en)
|
2006-09-08 |
2016-10-26 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and thier uses
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
ES2385114T3
(es)
|
2007-03-30 |
2012-07-18 |
Ambrx, Inc. |
Polipéptidos de FGF-21 modificados y sus usos
|
CN102099055A
(zh)
|
2007-10-04 |
2011-06-15 |
津莫吉尼蒂克斯公司 |
B7家族成员zB7H6及相关的组合物和方法
|
US8679749B2
(en)
|
2007-11-01 |
2014-03-25 |
The University Of Chicago |
Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
|
US8946148B2
(en)
|
2007-11-20 |
2015-02-03 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
US8003325B2
(en)
|
2007-11-30 |
2011-08-23 |
Mayo Foundation For Medical Education And Research |
Polymorphisms of the BLyS gene and use in diagnostic methods
|
UA118536C2
(uk)
|
2008-07-23 |
2019-02-11 |
Амбркс, Інк. |
Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування
|
CA2737026C
(en)
|
2008-09-26 |
2019-12-24 |
Ambrx, Inc. |
Modified animal erythropoietin polypeptides and their uses
|
PT2337846T
(pt)
|
2008-09-26 |
2018-04-05 |
Ambrx Inc |
Vacinas e microrganismos dependentes da replicação de aminoácidos não naturais
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
EP2333074A1
(en)
|
2009-12-14 |
2011-06-15 |
Robert Steinfeld |
Substances and methods for the treatment of lysosmal storage diseases
|
BR112012015461A2
(pt)
|
2009-12-21 |
2017-01-10 |
Ambrx Inc |
polipeptídeos de somatotropina boviina modificados e seus usos
|
NZ600363A
(en)
|
2009-12-21 |
2014-07-25 |
Ambrx Inc |
Modified porcine somatotropin polypeptides and their uses
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
MY162837A
(en)
|
2010-08-17 |
2017-07-31 |
Ambrx Inc |
Modified relaxin polypeptides and their uses
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
US10480010B2
(en)
|
2011-07-27 |
2019-11-19 |
Genethon |
Baculovirus expression systems
|
CN112538501A
(zh)
|
2013-09-12 |
2021-03-23 |
生物马林药物股份有限公司 |
腺相关病毒因子viii载体
|
SI3412302T1
(sl)
|
2014-10-24 |
2021-09-30 |
Bristol-Myers Squibb Company |
Modificirani FGF-21 polipeptidi in njihova uporaba
|
TWI841908B
(zh)
|
2015-09-24 |
2024-05-11 |
美商拜奧馬林製藥公司 |
腺相關病毒因子viii載體、相關病毒粒子及包含其之治療調配物
|
NZ742355A
(en)
|
2015-11-12 |
2025-05-02 |
Res Institute At Nationwide Children’S Hospital |
Methods of treating muscular dystrophy
|
US11584780B2
(en)
|
2016-07-26 |
2023-02-21 |
Biomarin Pharmaceutical Inc. |
Adeno-associated virus capsid proteins
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
WO2019067982A2
(en)
|
2017-09-29 |
2019-04-04 |
Massachusetts Eye And Ear Infirmary |
PRODUCTION OF ADENO-ASSOCIATED VIRUSES IN INSECT CELLS
|
KR20250099758A
(ko)
|
2018-01-31 |
2025-07-02 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
2c형 지대근이영양증에 대한 유전자 치료
|
EP3790627A2
(en)
|
2018-05-09 |
2021-03-17 |
BioMarin Pharmaceutical Inc. |
Methods of treating phenylketonuria
|
AR117427A1
(es)
|
2018-05-14 |
2021-08-04 |
Biomarin Pharm Inc |
Expresión estable de vectores de aav en sujetos jóvenes
|
TW202005978A
(zh)
|
2018-05-14 |
2020-02-01 |
美商拜奧馬林製藥公司 |
新穎肝靶向腺相關病毒載體
|
KR20210028162A
(ko)
|
2018-06-29 |
2021-03-11 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
지대근 이영양증 2a형을 치료하기 위한 재조합 아데노 연관 바이러스 생성물 및 방법
|
WO2020176614A1
(en)
|
2019-02-26 |
2020-09-03 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of b-sarcoglycan and the treatment of muscular dystrophy
|
EP3969061A1
(en)
|
2019-05-14 |
2022-03-23 |
BioMarin Pharmaceutical Inc. |
Methods of redosing gene therapy vectors
|
CN120400170A
(zh)
|
2019-08-21 |
2025-08-01 |
全国儿童医院研究所 |
Α-肌聚糖的腺相关病毒载体递送和肌营养不良症的治疗
|
EP4034642A1
(en)
|
2019-09-27 |
2022-08-03 |
BioMarin Pharmaceutical Inc. |
Characterization of gene therapy viral particles using size exclusion chromatography and multi-angle light scattering technologies
|
US20230340078A1
(en)
|
2019-11-14 |
2023-10-26 |
Biomarin Pharmaceutical Inc. |
Treatment of hereditary angioedema with liver-specific gene therapy vectors
|
US20230075854A1
(en)
|
2020-02-10 |
2023-03-09 |
Biomarin Pharmaceutical Inc. |
Virus-free cell cultures
|
WO2021183895A1
(en)
|
2020-03-13 |
2021-09-16 |
Biomarin Pharmaceutical Inc. |
Treatment of fabry disease with aav gene therapy vectors
|
AR122409A1
(es)
|
2020-04-03 |
2022-09-07 |
Biomarin Pharm Inc |
Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas
|
WO2021236908A2
(en)
|
2020-05-20 |
2021-11-25 |
Biomarin Pharmaceutical Inc. |
Use of regulatory proteins for the production of adeno-associated virus
|
AU2021372262B9
(en)
|
2020-11-02 |
2025-05-15 |
Biomarin Pharmaceutical Inc. |
Process for enriching adeno-associated virus
|
EP4408481A2
(en)
|
2021-10-01 |
2024-08-07 |
BioMarin Pharmaceutical Inc. |
Treatment of hereditary angioedema with aav gene therapy vectors and therapeutic formulations
|
JP2023059858A
(ja)
|
2021-10-15 |
2023-04-27 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
自己相補的アデノ随伴ウイルスベクター及び筋ジストロフィーの治療におけるその使用
|
WO2024064863A2
(en)
|
2022-09-22 |
2024-03-28 |
Biomarin Pharmaceutical Inc. |
Treatment of arrhythmogenic cardiomyopathy with aav gene therapy vectors
|
EP4590839A1
(en)
|
2022-09-22 |
2025-07-30 |
Dinaqor AG |
Treatment of cardiomyopathy with aav gene therapy vectors
|
WO2024151568A1
(en)
|
2023-01-09 |
2024-07-18 |
Biomarin Pharmaceutical Inc. |
Epigenetic modifiers improve aav gene therapy durability
|
WO2024238591A2
(en)
|
2023-05-15 |
2024-11-21 |
Biomarin Pharmaceutical Inc. |
Methods of treating anti-aav seropositive hemophilia patients
|