GR3022660T3 - Method of producing eicosapentaenoic acid or an ester derivative thereof - Google Patents

Method of producing eicosapentaenoic acid or an ester derivative thereof

Info

Publication number
GR3022660T3
GR3022660T3 GR970400347T GR970400347T GR3022660T3 GR 3022660 T3 GR3022660 T3 GR 3022660T3 GR 970400347 T GR970400347 T GR 970400347T GR 970400347 T GR970400347 T GR 970400347T GR 3022660 T3 GR3022660 T3 GR 3022660T3
Authority
GR
Greece
Prior art keywords
ester derivative
eicosapentaenoic acid
producing eicosapentaenoic
present
producing
Prior art date
Application number
GR970400347T
Other languages
English (en)
Inventor
Kazuhiko Hata
Hideo Noda
Masahiro Makuta
Original Assignee
Nippon Suisan Kaisha Ltd
Kansai Chem Eng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2145618A external-priority patent/JP3005638B2/ja
Priority claimed from JP2145617A external-priority patent/JP3040136B2/ja
Application filed by Nippon Suisan Kaisha Ltd, Kansai Chem Eng filed Critical Nippon Suisan Kaisha Ltd
Publication of GR3022660T3 publication Critical patent/GR3022660T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GR970400347T 1990-06-04 1997-02-26 Method of producing eicosapentaenoic acid or an ester derivative thereof GR3022660T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2145618A JP3005638B2 (ja) 1990-06-04 1990-06-04 高濃度エイコサペンタエン酸またはそのエステルの製造方法
JP2145617A JP3040136B2 (ja) 1990-06-04 1990-06-04 エイコサペンタエン酸またはそのエステルの製造方法

Publications (1)

Publication Number Publication Date
GR3022660T3 true GR3022660T3 (en) 1997-05-31

Family

ID=26476703

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970400347T GR3022660T3 (en) 1990-06-04 1997-02-26 Method of producing eicosapentaenoic acid or an ester derivative thereof

Country Status (11)

Country Link
EP (1) EP0460917B1 (el)
JP (1) JPH11236591A (el)
KR (1) KR100208701B1 (el)
AT (1) ATE147062T1 (el)
AU (1) AU641016B2 (el)
CA (1) CA2043615C (el)
DE (1) DE69123880T2 (el)
DK (1) DK0460917T3 (el)
ES (1) ES2095909T3 (el)
GR (1) GR3022660T3 (el)
NO (1) NO177699C (el)

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JP3400466B2 (ja) * 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
NO322213B1 (no) 1998-01-30 2006-08-28 Ube Industries Fremgangsmåte for rensing av varmenedbrytbare aromatiske hydroksylforbindelser ved destillasjon hvor de varmenedbrytbare aromatiske hydroksylforbindelsene befinner seg i en flerkomponentholdig væskeblanding.
NZ332331A (en) * 1998-10-15 2000-03-27 Craig Nazzer Continuous process for removing solids from miscible liquid mixture; lower boiling point liquid(s) removed by flashing or boiling
GB9901809D0 (en) 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
JP4558870B2 (ja) 1999-11-08 2010-10-06 株式会社日本触媒 塔式処理方法および装置
FR2833006A1 (fr) * 2001-11-30 2003-06-06 Cognis France Sa Procede de preparation d'ester methylique d'acide oleique industriel
EP3578177A1 (en) 2008-09-02 2019-12-11 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
KR20140007973A (ko) 2009-02-10 2014-01-20 아마린 파마, 인크. 고중성지방혈증 치료 방법
NZ624963A (en) 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
BRPI1011876B1 (pt) 2009-04-29 2020-03-31 Amarin Pharma, Inc. Composições farmacêuticas estáveis compreendendo etilácido eicosapentaenoico (etil-epa) e uso das mesmas para tratar ou prevenir uma doença relacionada ao cardiovascular
CN102625847A (zh) 2009-06-15 2012-08-01 阿马里纳制药公司 在相伴他汀类疗法的对象中降低甘油三酯、没有增加ldl-c水平的组合物和方法
AU2010298222B2 (en) 2009-09-23 2017-01-05 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
AU2011336856A1 (en) 2010-11-29 2013-07-04 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
CN102417447B (zh) * 2011-10-31 2014-04-30 广西亿康药业股份有限公司 十一烯酸的生产方法
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US20130131170A1 (en) 2011-11-07 2013-05-23 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
ES2891473T3 (es) 2012-01-06 2022-01-28 Amarin Pharmaceuticals Ie Ltd Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto
DK2851361T3 (da) 2012-05-14 2022-01-03 Nippon Suisan Kaisha Ltd Højumættet fedtsyre eller højumættet fedtsyreethylester med reduceret indhold af miljøforurenende stoffer, og fremgangsmåde til fremstilling deraf
CN102776067A (zh) * 2012-05-31 2012-11-14 源华能源科技（福建）有限公司 一种分子蒸馏提纯粗脂肪酸甲酯工艺
SG10201913645RA (en) 2012-06-29 2020-03-30 Amarin Pharmaceuticals Ie Ltd Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103570590B (zh) * 2013-10-30 2016-04-06 临沂远博化工有限公司 一种生产硫酸二甲酯的设备
JP6824038B2 (ja) 2013-12-04 2021-02-03 日本水産株式会社 ジホモ−γ−リノレン酸含有微生物油及びジホモ−γ−リノレン酸含有微生物菌体
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
CN106795452A (zh) 2014-09-17 2017-05-31 日本水产株式会社 含有二十碳五烯酸烷基酯的组合物及其制造方法
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10966951B2 (en) 2017-05-19 2021-04-06 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
MA51765A (fr) 2018-09-24 2020-12-16 Amarin Pharmaceuticals Ie Ltd Procédés de réduction du risque d'événements cardiovasculaires chez un sujet
US11986452B2 (en) 2021-04-21 2024-05-21 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2055892C3 (de) * 1970-11-13 1979-08-16 Basf Ag, 6700 Ludwigshafen Verfahren zur Reinigung von Butandiol
DE2220922C2 (de) * 1972-04-28 1985-06-20 Feld & Hahn Gmbh, 5413 Bendorf Verfahren und Vorrichtung zur Abtrennung von Fettsäuren durch Destillation
JPS57149400A (en) * 1981-03-12 1982-09-14 Kureha Chemical Ind Co Ltd Manufacture of high purity long chain highly unsaturated fatty acid ester
JPS588037A (ja) * 1981-07-03 1983-01-18 Nippon Suisan Kaisha Ltd エイコサペンタエン酸またはそのエステルの製法
US4377526A (en) * 1981-05-15 1983-03-22 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid and its esters
DE3226116A1 (de) * 1981-07-16 1983-02-03 VEB Chemieanlagenbaukombinat Leipzig-Grimma, DDR 7240 Grimma Verfahren und vorrichtung zur kontinuierlichen rektifikation von mehr- und vielstoffgemischen
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
JPH02268133A (ja) * 1989-04-10 1990-11-01 Nippon Suisan Kaisha Ltd エイコサペンタエン酸またはそのエステルの製造法

Also Published As

Publication number Publication date
EP0460917A3 (en) 1993-07-07
NO177699B (no) 1995-07-31
CA2043615A1 (en) 1991-12-05
EP0460917A2 (en) 1991-12-11
NO912144D0 (no) 1991-06-04
ATE147062T1 (de) 1997-01-15
EP0460917B1 (en) 1997-01-02
DK0460917T3 (da) 1997-01-20
JPH11236591A (ja) 1999-08-31
KR920000690A (ko) 1992-01-29
CA2043615C (en) 2001-08-14
KR100208701B1 (ko) 1999-07-15
AU641016B2 (en) 1993-09-09
DE69123880D1 (de) 1997-02-13
AU7818691A (en) 1991-12-05
DE69123880T2 (de) 1997-07-03
NO912144L (no) 1991-12-05
NO177699C (no) 1995-11-08
ES2095909T3 (es) 1997-03-01

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