ATE191457T1 - Verfahren zur herstellung von einem bicyclohexanderivat - Google Patents

Verfahren zur herstellung von einem bicyclohexanderivat

Info

Publication number
ATE191457T1
ATE191457T1 AT96304718T AT96304718T ATE191457T1 AT E191457 T1 ATE191457 T1 AT E191457T1 AT 96304718 T AT96304718 T AT 96304718T AT 96304718 T AT96304718 T AT 96304718T AT E191457 T1 ATE191457 T1 AT E191457T1
Authority
AT
Austria
Prior art keywords
producing
bicyclohexane derivative
pharmaceutically acceptable
acceptable salt
salt
Prior art date
Application number
AT96304718T
Other languages
English (en)
Inventor
Roger Lewis Robey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE191457T1 publication Critical patent/ATE191457T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12Saturated polycyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/24Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from hydantoins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/28Unsaturated compounds polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18Saturated compounds containing keto groups
    • C07C62/24Saturated compounds containing keto groups the keto group being part of a ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/18All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96304718T 1995-06-29 1996-06-26 Verfahren zur herstellung von einem bicyclohexanderivat ATE191457T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64295P 1995-06-29 1995-06-29

Publications (1)

Publication Number Publication Date
ATE191457T1 true ATE191457T1 (de) 2000-04-15

Family

ID=21692398

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96304718T ATE191457T1 (de) 1995-06-29 1996-06-26 Verfahren zur herstellung von einem bicyclohexanderivat

Country Status (22)

Country Link
US (1) US5726320A (de)
EP (1) EP0751117B1 (de)
JP (1) JPH11508559A (de)
KR (1) KR19990023022A (de)
CN (1) CN1077878C (de)
AT (1) ATE191457T1 (de)
AU (1) AU700608B2 (de)
BR (1) BR9609337A (de)
CA (1) CA2224235A1 (de)
CZ (1) CZ407197A3 (de)
DE (1) DE69607524T2 (de)
DK (1) DK0751117T3 (de)
EA (1) EA000469B1 (de)
ES (1) ES2144698T3 (de)
GR (1) GR3033658T3 (de)
IL (1) IL118727A (de)
NO (1) NO975921D0 (de)
NZ (1) NZ311544A (de)
PL (1) PL183742B1 (de)
PT (1) PT751117E (de)
SI (1) SI0751117T1 (de)
WO (1) WO1997001526A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
US6124361A (en) * 1997-12-31 2000-09-26 Pfizer Inc Bicyclo[3.1.0]hexanes and related compounds
AU734812B2 (en) * 1998-01-28 2001-06-21 Taisho Pharmaceutical Co., Ltd. Fluorine-containing amino acid derivatives
US6333428B1 (en) * 1998-08-31 2001-12-25 Taisho Pharmaceutical Co., Ltd. 6-fluorobicyclo[3.1.0]hexane derivatives
CH694053A5 (de) * 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja) 1999-04-16 2008-12-10 住友化学株式会社 光学活性2−オキソビシクロ[3.1.0]ヘキサン−6−カルボン酸誘導体の製造方法
WO2002055485A1 (en) * 2001-01-11 2002-07-18 Eli Lilly And Company Prodrugs of excitatory amino acids
HUP0400620A3 (en) * 2001-01-11 2012-09-28 Lilly Co Eli Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds
US7456221B2 (en) * 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2732380A (en) * 1956-01-24 Process for the production of
DE802158C (de) * 1948-11-21 1951-02-05 Paul Heisel Dr Verfahren zur Herstellung von 2-Aminocamphan-2-carbonsaeure
US2560584A (en) * 1949-02-02 1951-07-17 Du Pont N-carboanhydrides
BE507496A (de) * 1950-12-01
US2762708A (en) * 1951-10-23 1956-09-11 Gen Aniline & Film Corp Fungus resistant overcoating for color silver halide emulsion layers
NL257812A (de) * 1959-11-10
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3594413A (en) * 1968-11-20 1971-07-20 American Home Prod Cyclopentene derivatives
US3716553A (en) * 1970-09-04 1973-02-13 American Home Prod 1,3-diazaspiro [4,4]non-7-ene-2,4-dione
US3704312A (en) * 1970-10-30 1972-11-28 American Home Prod Bialicyclic amino acids
US3725423A (en) * 1971-01-14 1973-04-03 Upjohn Co Exo-bicycloalkane carboxamides
US3746495A (en) * 1971-06-01 1973-07-17 American Home Prod Anti-ulcer therapy
US3823177A (en) * 1971-06-25 1974-07-09 Procter & Gamble Insecticidal esters of spiro carboxylic acids
US4315031A (en) * 1977-09-01 1982-02-09 Science Union Et Cie Thiosubstituted amino acids
US4320135A (en) * 1980-05-19 1982-03-16 Sandoz, Inc. Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
DE69017383T2 (de) * 1989-07-04 1995-06-29 Nippon Soda Co Substituierte bicycloheptadionderivate.
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
PL182285B1 (pl) * 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL

Also Published As

Publication number Publication date
US5726320A (en) 1998-03-10
DK0751117T3 (da) 2000-07-10
NO975921L (no) 1997-12-16
CN1077878C (zh) 2002-01-16
EP0751117B1 (de) 2000-04-05
DE69607524T2 (de) 2000-08-10
GR3033658T3 (en) 2000-10-31
PT751117E (pt) 2000-08-31
CZ407197A3 (cs) 1998-03-18
CN1193312A (zh) 1998-09-16
AU6290296A (en) 1997-01-30
IL118727A (en) 2003-01-12
EA199800102A1 (ru) 1998-08-27
DE69607524D1 (de) 2000-05-11
CA2224235A1 (en) 1997-01-16
BR9609337A (pt) 1999-05-11
NO975921D0 (no) 1997-12-16
ES2144698T3 (es) 2000-06-16
WO1997001526A1 (en) 1997-01-16
SI0751117T1 (en) 2000-10-31
NZ311544A (en) 1999-06-29
PL183742B1 (pl) 2002-07-31
EA000469B1 (ru) 1999-08-26
MX9710253A (es) 1998-03-31
KR19990023022A (ko) 1999-03-25
AU700608B2 (en) 1999-01-07
IL118727A0 (en) 1996-10-16
PL324217A1 (en) 1998-05-11
JPH11508559A (ja) 1999-07-27
EP0751117A1 (de) 1997-01-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee