NO975921L - Fremstilling av bicykloheksanderivater - Google Patents

Fremstilling av bicykloheksanderivater

Info

Publication number
NO975921L
NO975921L NO975921A NO975921A NO975921L NO 975921 L NO975921 L NO 975921L NO 975921 A NO975921 A NO 975921A NO 975921 A NO975921 A NO 975921A NO 975921 L NO975921 L NO 975921L
Authority
NO
Norway
Prior art keywords
preparation
pharmaceutically acceptable
acceptable salt
bicyclohexane
derivatives
Prior art date
Application number
NO975921A
Other languages
English (en)
Other versions
NO975921D0 (no
Inventor
Roger Lewis Robey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO975921D0 publication Critical patent/NO975921D0/no
Publication of NO975921L publication Critical patent/NO975921L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/24—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from hydantoins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/24—Saturated compounds containing keto groups the keto group being part of a ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det er beskrevet en fremgangsmåte for fremstilling av (+)-2-aminobicyklo[3.1.0]-heksan-2-6-dikarboksylsyre, eller et farmasøytisk akseptabelt salt derav, som innbefatter hydrolysering av (-)-2-spiro-5'-hydantoinbicyklo[3.1.0]heksan-6-karboksylsyre eller et salt derav, og eventuelt dannelse av et farmsøytisk akseptabelt salt. Det er også beskrevet nye mellomprodukter som er nyttige i prosessen.
NO975921A 1995-06-29 1997-12-16 Fremstilling av bicykloheksanderivater NO975921L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64295P 1995-06-29 1995-06-29
PCT/US1996/010847 WO1997001526A1 (en) 1995-06-29 1996-06-25 Preparation of bicyclohexane derivative

Publications (2)

Publication Number Publication Date
NO975921D0 NO975921D0 (no) 1997-12-16
NO975921L true NO975921L (no) 1997-12-16

Family

ID=21692398

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975921A NO975921L (no) 1995-06-29 1997-12-16 Fremstilling av bicykloheksanderivater

Country Status (22)

Country Link
US (1) US5726320A (no)
EP (1) EP0751117B1 (no)
JP (1) JPH11508559A (no)
KR (1) KR19990023022A (no)
CN (1) CN1077878C (no)
AT (1) ATE191457T1 (no)
AU (1) AU700608B2 (no)
BR (1) BR9609337A (no)
CA (1) CA2224235A1 (no)
CZ (1) CZ407197A3 (no)
DE (1) DE69607524T2 (no)
DK (1) DK0751117T3 (no)
EA (1) EA000469B1 (no)
ES (1) ES2144698T3 (no)
GR (1) GR3033658T3 (no)
IL (1) IL118727A (no)
NO (1) NO975921L (no)
NZ (1) NZ311544A (no)
PL (1) PL183742B1 (no)
PT (1) PT751117E (no)
SI (1) SI0751117T1 (no)
WO (1) WO1997001526A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
US6124361A (en) * 1997-12-31 2000-09-26 Pfizer Inc Bicyclo[3.1.0]hexanes and related compounds
US6316498B1 (en) * 1998-01-28 2001-11-13 Taisho Pharmaceutical Co., Ltd. Fluorine-containing amino acid derivatives
ATE269293T1 (de) * 1998-08-31 2004-07-15 Taisho Pharmaceutical Co Ltd 6-fluoro(3.1.0)hexan-derivate
CH694053A5 (de) * 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja) 1999-04-16 2008-12-10 住友化学株式会社 光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
EP1351925A1 (en) * 2001-01-11 2003-10-15 Eli Lilly And Company Prodrugs of excitatory amino acids
HUP0400620A3 (en) * 2001-01-11 2012-09-28 Lilly Co Eli Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds
US7456221B2 (en) * 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2732380A (en) * 1956-01-24 Process for the production of
DE802158C (de) * 1948-11-21 1951-02-05 Paul Heisel Dr Verfahren zur Herstellung von 2-Aminocamphan-2-carbonsaeure
US2560584A (en) * 1949-02-02 1951-07-17 Du Pont N-carboanhydrides
BE507496A (no) * 1950-12-01
US2762708A (en) * 1951-10-23 1956-09-11 Gen Aniline & Film Corp Fungus resistant overcoating for color silver halide emulsion layers
NL257812A (no) * 1959-11-10
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3594413A (en) * 1968-11-20 1971-07-20 American Home Prod Cyclopentene derivatives
US3716553A (en) * 1970-09-04 1973-02-13 American Home Prod 1,3-diazaspiro [4,4]non-7-ene-2,4-dione
US3704312A (en) * 1970-10-30 1972-11-28 American Home Prod Bialicyclic amino acids
US3725423A (en) * 1971-01-14 1973-04-03 Upjohn Co Exo-bicycloalkane carboxamides
US3746495A (en) * 1971-06-01 1973-07-17 American Home Prod Anti-ulcer therapy
US3823177A (en) * 1971-06-25 1974-07-09 Procter & Gamble Insecticidal esters of spiro carboxylic acids
US4315031A (en) * 1977-09-01 1982-02-09 Science Union Et Cie Thiosubstituted amino acids
US4320135A (en) * 1980-05-19 1982-03-16 Sandoz, Inc. Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions
DK0432275T3 (da) * 1989-07-04 1995-07-31 Nippon Soda Co Substituerede bicykloheptandionderivater
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
PL182285B1 (pl) * 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL

Also Published As

Publication number Publication date
NO975921D0 (no) 1997-12-16
US5726320A (en) 1998-03-10
MX9710253A (es) 1998-03-31
IL118727A0 (en) 1996-10-16
BR9609337A (pt) 1999-05-11
PL324217A1 (en) 1998-05-11
NZ311544A (en) 1999-06-29
DE69607524D1 (de) 2000-05-11
PT751117E (pt) 2000-08-31
KR19990023022A (ko) 1999-03-25
GR3033658T3 (en) 2000-10-31
PL183742B1 (pl) 2002-07-31
EA000469B1 (ru) 1999-08-26
JPH11508559A (ja) 1999-07-27
EA199800102A1 (ru) 1998-08-27
CN1077878C (zh) 2002-01-16
DE69607524T2 (de) 2000-08-10
CN1193312A (zh) 1998-09-16
CZ407197A3 (cs) 1998-03-18
AU700608B2 (en) 1999-01-07
WO1997001526A1 (en) 1997-01-16
IL118727A (en) 2003-01-12
ATE191457T1 (de) 2000-04-15
DK0751117T3 (da) 2000-07-10
SI0751117T1 (en) 2000-10-31
EP0751117B1 (en) 2000-04-05
AU6290296A (en) 1997-01-30
ES2144698T3 (es) 2000-06-16
CA2224235A1 (en) 1997-01-16
EP0751117A1 (en) 1997-01-02

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Legal Events

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