GR3022660T3 - Method of producing eicosapentaenoic acid or an ester derivative thereof - Google Patents

Method of producing eicosapentaenoic acid or an ester derivative thereof

Info

Publication number
GR3022660T3
GR3022660T3 GR970400347T GR970400347T GR3022660T3 GR 3022660 T3 GR3022660 T3 GR 3022660T3 GR 970400347 T GR970400347 T GR 970400347T GR 970400347 T GR970400347 T GR 970400347T GR 3022660 T3 GR3022660 T3 GR 3022660T3
Authority
GR
Greece
Prior art keywords
ester derivative
eicosapentaenoic acid
producing eicosapentaenoic
present
producing
Prior art date
Application number
GR970400347T
Other languages
Greek (el)
Inventor
Kazuhiko Hata
Hideo Noda
Masahiro Makuta
Original Assignee
Nippon Suisan Kaisha Ltd
Kansai Chem Eng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2145618A external-priority patent/JP3005638B2/en
Priority claimed from JP2145617A external-priority patent/JP3040136B2/en
Application filed by Nippon Suisan Kaisha Ltd, Kansai Chem Eng filed Critical Nippon Suisan Kaisha Ltd
Publication of GR3022660T3 publication Critical patent/GR3022660T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation

Abstract

The present invention provides a method for producing eicosapentaenoic acid and the ester derivative thereof with a concentration as high as 80% or more, using a unique continuous distillation process under and a reduced pressure. The present invention also a method above-mentioned, using a continuous distillation process and urea adduct process by a specific apparatus construction.
GR970400347T 1990-06-04 1997-02-26 Method of producing eicosapentaenoic acid or an ester derivative thereof GR3022660T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2145618A JP3005638B2 (en) 1990-06-04 1990-06-04 Method for producing high concentration eicosapentaenoic acid or ester thereof
JP2145617A JP3040136B2 (en) 1990-06-04 1990-06-04 Method for producing eicosapentaenoic acid or ester thereof

Publications (1)

Publication Number Publication Date
GR3022660T3 true GR3022660T3 (en) 1997-05-31

Family

ID=26476703

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970400347T GR3022660T3 (en) 1990-06-04 1997-02-26 Method of producing eicosapentaenoic acid or an ester derivative thereof

Country Status (11)

Country Link
EP (1) EP0460917B1 (en)
JP (1) JPH11236591A (en)
KR (1) KR100208701B1 (en)
AT (1) ATE147062T1 (en)
AU (1) AU641016B2 (en)
CA (1) CA2043615C (en)
DE (1) DE69123880T2 (en)
DK (1) DK0460917T3 (en)
ES (1) ES2095909T3 (en)
GR (1) GR3022660T3 (en)
NO (1) NO177699C (en)

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JP3400466B2 (en) * 1991-10-28 2003-04-28 日本水産株式会社 Method for producing high-purity eicosapentaenoic acid or ester thereof
NO322213B1 (en) * 1998-01-30 2006-08-28 Ube Industries A process for purifying heat-degradable aromatic hydroxyl compounds by distillation wherein the heat-degradable aromatic hydroxyl compounds are in a multicomponent liquid mixture.
NZ332331A (en) * 1998-10-15 2000-03-27 Craig Nazzer Continuous process for removing solids from miscible liquid mixture; lower boiling point liquid(s) removed by flashing or boiling
GB9901809D0 (en) * 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
JP4558870B2 (en) 1999-11-08 2010-10-06 株式会社日本触媒 Tower-type processing method and apparatus
FR2833006A1 (en) * 2001-11-30 2003-06-06 Cognis France Sa PROCESS FOR THE PREPARATION OF METHYL ESTER OF INDUSTRIAL OLEIC ACID
JP5924834B2 (en) 2008-09-02 2016-05-25 アマリン ファーマシューティカルズ アイルランド リミテッド Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and method of using this pharmaceutical composition
SG173612A1 (en) 2009-02-10 2011-09-29 Amarin Pharma Inc Use of eicosapentaenoic acid ethyl ester for treating hypertriglyceridemia
CN102458109B (en) 2009-04-29 2015-02-11 阿马里纳制药公司 Stable pharmaceutical composition and methods of using same
RU2624506C2 (en) 2009-04-29 2017-07-04 АМАРИН КОРПОРЕЙШН ПиЭлСи Pharmaceutical compositions containing epa and cardiovascular agents and their application methods
PT2443246T (en) 2009-06-15 2018-03-14 Amarin Pharmaceuticals Ie Ltd Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
BR122019016628B8 (en) 2009-09-23 2021-07-27 Amarin Corp Plc use of a composition comprising an atorvastatin hydroxy derivative or pharmaceutically acceptable salt thereof and an oil comprising ethyl eicosapentaenoate or ethyl docosahexaenoate for the manufacture of a medicament for the treatment of a cardiovascular disease
NZ744990A (en) 2010-11-29 2019-10-25 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
CN102417447B (en) * 2011-10-31 2014-04-30 广西亿康药业股份有限公司 Production method of undecylenic acid
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2775837A4 (en) 2011-11-07 2015-10-28 Amarin Pharmaceuticals Ie Ltd Methods of treating hypertriglyceridemia
JP6307442B2 (en) 2012-01-06 2018-04-04 アマリン ファーマシューティカルス アイルランド リミテッド Compositions and methods for reducing the level of high sensitivity (HS-CRP) in a subject
KR102453616B1 (en) 2012-05-14 2022-10-11 닛폰 스이산 가부시키가이샤 Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same
CN102776067A (en) * 2012-05-31 2012-11-14 源华能源科技（福建）有限公司 Process for purifying crude fatty acidmethyl ester through molecular distillation
KR20150036252A (en) 2012-06-29 2015-04-07 애머린 파마슈티칼스 아일랜드 리미티드 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
US20150265566A1 (en) 2012-11-06 2015-09-24 Amarin Pharmaceuticals Ireland Limited Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103570590B (en) * 2013-10-30 2016-04-06 临沂远博化工有限公司 A kind of equipment producing methyl-sulfate
CA2930897C (en) 2013-12-04 2022-08-16 Nippon Suisan Kaisha, Ltd. Dihomo-.gamma.-linolenic acid-containing microbial oil and dihomo-.gamma.-linolenic acid-containing microbial biomass
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
US9918953B2 (en) 2014-09-17 2018-03-20 Nippon Suisan Kaisha, Ltd. Composition containing eicosapentaenoic acid alkyl ester, and method for producing same
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10966951B2 (en) 2017-05-19 2021-04-06 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
SG11202102872QA (en) 2018-09-24 2021-04-29 Amarin Pharmaceuticals Ie Ltd Methods of reducing the risk of cardiovascular events in a subject

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DE2055892C3 (en) * 1970-11-13 1979-08-16 Basf Ag, 6700 Ludwigshafen Process for purifying butanediol
DE2220922C2 (en) * 1972-04-28 1985-06-20 Feld & Hahn Gmbh, 5413 Bendorf Method and device for the separation of fatty acids by distillation
JPS57149400A (en) * 1981-03-12 1982-09-14 Kureha Chemical Ind Co Ltd Manufacture of high purity long chain highly unsaturated fatty acid ester
US4377526A (en) * 1981-05-15 1983-03-22 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid and its esters
JPS588037A (en) * 1981-07-03 1983-01-18 Nippon Suisan Kaisha Ltd Preparation of eicosapentaenoic acid or its ester
DE3226116A1 (en) * 1981-07-16 1983-02-03 VEB Chemieanlagenbaukombinat Leipzig-Grimma, DDR 7240 Grimma Process and apparatus for the continuous rectification of mixtures containing a plurality and a multiplicity of substances
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
JPH02268133A (en) * 1989-04-10 1990-11-01 Nippon Suisan Kaisha Ltd Production of eicosapentaenoic acid or ester thereof

Also Published As

Publication number Publication date
NO177699B (en) 1995-07-31
DK0460917T3 (en) 1997-01-20
EP0460917B1 (en) 1997-01-02
DE69123880T2 (en) 1997-07-03
KR920000690A (en) 1992-01-29
NO177699C (en) 1995-11-08
EP0460917A3 (en) 1993-07-07
JPH11236591A (en) 1999-08-31
CA2043615A1 (en) 1991-12-05
NO912144D0 (en) 1991-06-04
DE69123880D1 (en) 1997-02-13
CA2043615C (en) 2001-08-14
EP0460917A2 (en) 1991-12-11
ES2095909T3 (en) 1997-03-01
KR100208701B1 (en) 1999-07-15
AU7818691A (en) 1991-12-05
AU641016B2 (en) 1993-09-09
ATE147062T1 (en) 1997-01-15
NO912144L (en) 1991-12-05

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