NO912144D0 - Fremgangsmaate og apparat for fremstilling av eicosapentaensyre eller dens esterderivat. - Google Patents

Fremgangsmaate og apparat for fremstilling av eicosapentaensyre eller dens esterderivat.

Info

Publication number
NO912144D0
NO912144D0 NO912144A NO912144A NO912144D0 NO 912144 D0 NO912144 D0 NO 912144D0 NO 912144 A NO912144 A NO 912144A NO 912144 A NO912144 A NO 912144A NO 912144 D0 NO912144 D0 NO 912144D0
Authority
NO
Norway
Prior art keywords
derivative
esteric
preparing
acid
eicosapentaic
Prior art date
Application number
NO912144A
Other languages
English (en)
Other versions
NO912144L (no
NO177699B (no
NO177699C (no
Inventor
Kazuhiko Hata
Hideo Noda
Masahiro Makuta
Original Assignee
Nippon Suisan Kaisha Ltd
Kansai Chem Eng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2145618A external-priority patent/JP3005638B2/ja
Priority claimed from JP2145617A external-priority patent/JP3040136B2/ja
Application filed by Nippon Suisan Kaisha Ltd, Kansai Chem Eng filed Critical Nippon Suisan Kaisha Ltd
Publication of NO912144D0 publication Critical patent/NO912144D0/no
Publication of NO912144L publication Critical patent/NO912144L/no
Publication of NO177699B publication Critical patent/NO177699B/no
Publication of NO177699C publication Critical patent/NO177699C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO912144A 1990-06-04 1991-06-04 Fremgangsmåte og apparat for fremstilling av eicosapentaensyre eller dens esterderivat NO177699C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2145618A JP3005638B2 (ja) 1990-06-04 1990-06-04 高濃度エイコサペンタエン酸またはそのエステルの製造方法
JP2145617A JP3040136B2 (ja) 1990-06-04 1990-06-04 エイコサペンタエン酸またはそのエステルの製造方法

Publications (4)

Publication Number Publication Date
NO912144D0 true NO912144D0 (no) 1991-06-04
NO912144L NO912144L (no) 1991-12-05
NO177699B NO177699B (no) 1995-07-31
NO177699C NO177699C (no) 1995-11-08

Family

ID=26476703

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912144A NO177699C (no) 1990-06-04 1991-06-04 Fremgangsmåte og apparat for fremstilling av eicosapentaensyre eller dens esterderivat

Country Status (11)

Country Link
EP (1) EP0460917B1 (no)
JP (1) JPH11236591A (no)
KR (1) KR100208701B1 (no)
AT (1) ATE147062T1 (no)
AU (1) AU641016B2 (no)
CA (1) CA2043615C (no)
DE (1) DE69123880T2 (no)
DK (1) DK0460917T3 (no)
ES (1) ES2095909T3 (no)
GR (1) GR3022660T3 (no)
NO (1) NO177699C (no)

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JP3400466B2 (ja) * 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
NO322213B1 (no) 1998-01-30 2006-08-28 Ube Industries Fremgangsmåte for rensing av varmenedbrytbare aromatiske hydroksylforbindelser ved destillasjon hvor de varmenedbrytbare aromatiske hydroksylforbindelsene befinner seg i en flerkomponentholdig væskeblanding.
NZ332331A (en) * 1998-10-15 2000-03-27 Craig Nazzer Continuous process for removing solids from miscible liquid mixture; lower boiling point liquid(s) removed by flashing or boiling
GB9901809D0 (en) 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
JP4558870B2 (ja) 1999-11-08 2010-10-06 株式会社日本触媒 塔式処理方法および装置
FR2833006A1 (fr) * 2001-11-30 2003-06-06 Cognis France Sa Procede de preparation d'ester methylique d'acide oleique industriel
ES2862336T3 (es) 2008-09-02 2021-10-07 Amarin Pharmaceuticals Ie Ltd Composición farmacéutica que comprende ácido eicosapentaenoico y ácido nicotínico y métodos de uso de la misma
LT3037089T (lt) 2009-02-10 2020-01-10 Amarin Pharmaceuticals Ireland Limited Eikozapentaeno rūgšties etilo esteris skirtas hipertriglicidemijai gydydti
CN102458109B (zh) 2009-04-29 2015-02-11 阿马里纳制药公司 稳定的药物组合物和使用其的方法
CN106822080A (zh) 2009-04-29 2017-06-13 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
SG10201708950XA (en) 2009-06-15 2017-12-28 Ian Osterloh Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
AU2010298222B2 (en) 2009-09-23 2017-01-05 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
WO2012074930A2 (en) 2010-11-29 2012-06-07 Amarin Pharma, Inc. Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
CN102417447B (zh) * 2011-10-31 2014-04-30 广西亿康药业股份有限公司 十一烯酸的生产方法
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US20130131170A1 (en) 2011-11-07 2013-05-23 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2800469B1 (en) 2012-01-06 2021-08-25 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
KR102229106B1 (ko) 2012-05-14 2021-03-18 닛폰 스이산 가부시키가이샤 환경 오염 물질을 저감시킨 고도 불포화 지방산 또는 고도 불포화 지방산 에틸에스테르 및 그 제조 방법
CN102776067A (zh) * 2012-05-31 2012-11-14 源华能源科技（福建）有限公司 一种分子蒸馏提纯粗脂肪酸甲酯工艺
JP2015522029A (ja) 2012-06-29 2015-08-03 アマリン ファーマシューティカルス アイルランド リミテッド スタチン療法中の患者における心血管系イベントの危険性を減少させる方法
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103570590B (zh) * 2013-10-30 2016-04-06 临沂远博化工有限公司 一种生产硫酸二甲酯的设备
SG11201604500YA (en) 2013-12-04 2016-07-28 Nippon Suisan Kaisha Ltd Microbial oil, method for manufacturing microbial oil, concentrated microbial oil, and method for manufacturing concentrated microbial oil
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
DE202015009883U1 (de) 2014-09-17 2021-01-15 Mochida Pharmaceutical Co. Ltd. Eicosapentaensäurealkylester enthaltende Zusammensetzung
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
WO2018213663A1 (en) 2017-05-19 2018-11-22 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
CN112218630A (zh) 2018-09-24 2021-01-12 阿马里纳药物爱尔兰有限公司 降低受试者的心血管事件的风险的方法
WO2022225896A1 (en) 2021-04-21 2022-10-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2055892C3 (de) * 1970-11-13 1979-08-16 Basf Ag, 6700 Ludwigshafen Verfahren zur Reinigung von Butandiol
DE2220922C2 (de) * 1972-04-28 1985-06-20 Feld & Hahn Gmbh, 5413 Bendorf Verfahren und Vorrichtung zur Abtrennung von Fettsäuren durch Destillation
JPS57149400A (en) * 1981-03-12 1982-09-14 Kureha Chemical Ind Co Ltd Manufacture of high purity long chain highly unsaturated fatty acid ester
US4377526A (en) * 1981-05-15 1983-03-22 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid and its esters
JPS588037A (ja) * 1981-07-03 1983-01-18 Nippon Suisan Kaisha Ltd エイコサペンタエン酸またはそのエステルの製法
DE3226116A1 (de) * 1981-07-16 1983-02-03 VEB Chemieanlagenbaukombinat Leipzig-Grimma, DDR 7240 Grimma Verfahren und vorrichtung zur kontinuierlichen rektifikation von mehr- und vielstoffgemischen
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
JPH02268133A (ja) * 1989-04-10 1990-11-01 Nippon Suisan Kaisha Ltd エイコサペンタエン酸またはそのエステルの製造法

Also Published As

Publication number Publication date
DE69123880D1 (de) 1997-02-13
DE69123880T2 (de) 1997-07-03
NO912144L (no) 1991-12-05
AU641016B2 (en) 1993-09-09
NO177699B (no) 1995-07-31
KR100208701B1 (ko) 1999-07-15
DK0460917T3 (da) 1997-01-20
EP0460917B1 (en) 1997-01-02
ES2095909T3 (es) 1997-03-01
CA2043615A1 (en) 1991-12-05
KR920000690A (ko) 1992-01-29
AU7818691A (en) 1991-12-05
NO177699C (no) 1995-11-08
JPH11236591A (ja) 1999-08-31
GR3022660T3 (en) 1997-05-31
EP0460917A2 (en) 1991-12-11
ATE147062T1 (de) 1997-01-15
EP0460917A3 (en) 1993-07-07
CA2043615C (en) 2001-08-14

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