GR1004371B - Συνθεση ταχειας ενεργειας - Google Patents

Συνθεση ταχειας ενεργειας

Info

Publication number
GR1004371B
GR1004371B GR20020100280A GR2002100280A GR1004371B GR 1004371 B GR1004371 B GR 1004371B GR 20020100280 A GR20020100280 A GR 20020100280A GR 2002100280 A GR2002100280 A GR 2002100280A GR 1004371 B GR1004371 B GR 1004371B
Authority
GR
Greece
Prior art keywords
rapid onset
onset formulation
formulation
enterically
rovided
Prior art date
Application number
GR20020100280A
Other languages
English (en)
Other versions
GR20020100280A (el
Inventor
Eric Gervais
Original Assignee
Duchesnay Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42104724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR1004371(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Duchesnay Inc. filed Critical Duchesnay Inc.
Publication of GR20020100280A publication Critical patent/GR20020100280A/el
Publication of GR1004371B publication Critical patent/GR1004371B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seal Device For Vehicle (AREA)
  • Memory System Of A Hierarchy Structure (AREA)
  • Power Steering Mechanism (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Lubricants (AREA)

Abstract

αρέχεται ενταύθα μία νέα εντερικά επικαλυμμένη σύνθεση ταχείας ενεργείας πυριδοξίνης HCI και ηλεκτρικής δοξυλαμίνης περιλαμβάνουσα έναν αποσυνθετικό παράγοντα έτσι ώστε να ικανοποιούνται οι ακόλουθες καμπύλες διαλύσεως μετρούμενες εντός 1000 ml φωσφορικού ρυθμιστικού διαλύματος υπό ph 6,8 και σοτυς 37 βαθμούς Κελσίου εντός μίας συσκευής διαλύσεως τύπου 2 στις 100 σ.α.λ.: (a) τουλάχιστον το περίπου 40 τοις εκατό της ολικής ποσότητος χωριστά της πυριδοξίνης HCI και της ηλεκτρικής δοξυλαμίνης διαλύεται μετά από 30 λεπτά μετρήσεως (b) τουλάχιστον το περίπου 70 τοις εκατό της ολικής ποσότητος χωριστά της πυριδοξίνης HCI και της ηλεκτρικής δοξυλαμίνης διαλύεται μετά από 60 λεπτά μετρήσεως (c) τουλάχιστον το περίπου 80 τοις εκατό της ολικής ποσότητος χωριστά της πυριδοξίνης HCΙ και της ηλεκτρικής δοξυλαμίνης διαλύεται μετά από 90 λεπτά μετρήσεως. (d) τουλάχιστον το περίπου 90 τοις εκατό της ολικής ποσότητος χωριστά της πυριδοξίνης HCI και της ηλεκτρικής δοξυλαμίνης διαλύεται μετά από 120 λεπτά μετρήσεως. Κατά προτίμηση η σύνθεση θα περιέχει έναν πυρήνα επικαλυμμένο με τουλάχιστον μία εντερική επικάλυψη, ο οποίος πυρήνας περιλαμβάνει πυριδοξίνη HCI, ηλεκτρική δοξυλαμίνη και τα ακόλουθα μη δραστικά έκδοχα: μία γόμωση ή συνδετικό, έναν παράγοντα αποσυνθέσεως, ένα λιπαντικό, ένα πυριτικό ρυθμιστή ροής και έναν παράγοντα σταθεροποιήσεως. ΰ
GR20020100280A 2000-12-20 2002-06-12 Συνθεση ταχειας ενεργειας GR1004371B (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA002350195A CA2350195C (en) 2000-12-20 2000-12-20 Rapid onset formulation of pyridoxine hydrochloride and doxylamine succinate
PCT/CA2001/000951 WO2003000263A1 (en) 2000-12-20 2001-06-21 Rapid onset formulation
US09/885,051 US6340695B1 (en) 2000-12-20 2001-06-21 Rapid onset formulation

Publications (2)

Publication Number Publication Date
GR20020100280A GR20020100280A (el) 2003-03-28
GR1004371B true GR1004371B (el) 2003-10-23

Family

ID=42104724

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20020100280A GR1004371B (el) 2000-12-20 2002-06-12 Συνθεση ταχειας ενεργειας

Country Status (35)

Country Link
US (1) US6340695B1 (el)
EP (1) EP1397133B1 (el)
JP (1) JP4242763B2 (el)
KR (1) KR100527985B1 (el)
CN (1) CN1229112C (el)
AT (1) ATE307582T1 (el)
AU (1) AU2001272243B2 (el)
BE (1) BE1014929A4 (el)
BR (1) BR0107371A (el)
CA (1) CA2350195C (el)
DE (2) DE10196426T1 (el)
DK (2) DK1397133T3 (el)
EG (1) EG24483A (el)
ES (1) ES2251494T3 (el)
FI (1) FI117961B (el)
FR (1) FR2826277B1 (el)
GB (1) GB2383751C (el)
GR (1) GR1004371B (el)
HK (1) HK1052654A1 (el)
HU (1) HU227003B1 (el)
IL (1) IL150349A0 (el)
IS (1) IS2225B (el)
IT (1) ITTO20020524A1 (el)
LU (1) LU90934B1 (el)
MC (1) MC200059A1 (el)
MX (1) MXPA02006037A (el)
MY (1) MY132786A (el)
NL (1) NL1020895C2 (el)
NO (1) NO332190B1 (el)
PL (1) PL204507B1 (el)
SE (1) SE526307C2 (el)
TR (1) TR200201685T1 (el)
UA (1) UA74807C2 (el)
UY (1) UY27352A1 (el)
WO (1) WO2003000263A1 (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2350195C (en) * 2000-12-20 2003-06-10 Duchesnay Inc. Rapid onset formulation of pyridoxine hydrochloride and doxylamine succinate
US8257746B2 (en) 2001-04-10 2012-09-04 Pernix Therapeutics, Llc Tannate compositions, methods of making and methods of use
US8012506B2 (en) * 2001-04-10 2011-09-06 Pernix Therapeutics, Llc Tannate compositions, methods of making and methods of use
ES2229876B1 (es) * 2001-06-26 2006-03-01 Duchesnay Inc. Formulacion de accion rapida.
CA2392486A1 (en) * 2002-07-05 2002-12-08 Duchesnay Inc. Pharmaceutical dosage form bearing pregnancy-friendly indicia
CA2406592C (en) * 2002-10-04 2003-09-30 Duchesnay Inc. Method of preparing pharmaceutical dosage forms containing multiple active ingredients
JP2004231520A (ja) * 2003-01-28 2004-08-19 Nichiko Pharmaceutical Co Ltd 保存安定性及び溶出速度に優れた医薬組成物
US20050004181A1 (en) * 2003-07-03 2005-01-06 Duchesnay Inc. Use of anti-emetic for pre and post operative care
NZ555693A (en) * 2004-12-27 2010-10-29 Eisai R&D Man Co Ltd Matrix type sustained-release preparation containing donepezil
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
WO2006118265A1 (ja) * 2005-04-28 2006-11-09 Eisai R & D Management Co., Ltd. 抗痴呆薬を含有する組成物
US20070277530A1 (en) * 2006-05-31 2007-12-06 Constantin Alexandru Dinu Inlet flow conditioner for gas turbine engine fuel nozzle
CN102108059B (zh) * 2010-09-03 2012-05-09 合肥工业大学 一种琥珀酸多西拉敏的合成方法
US8950188B2 (en) 2011-09-09 2015-02-10 General Electric Company Turning guide for combustion fuel nozzle in gas turbine and method to turn fuel flow entering combustion chamber
MX355912B (es) * 2012-02-22 2018-05-04 Duchesnay Inc Formulación de doxilamina y piridoxina y/o sus metabolitos o sales.
WO2013123569A1 (en) * 2012-02-22 2013-08-29 Duchesnay Inc. Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof
DK2851075T3 (da) 2012-05-14 2022-01-31 Shionogi & Co Præparat, der indeholder 6,7-umættet -7-carbamoylmorphinanderivat
US9452181B2 (en) 2013-07-22 2016-09-27 Duchesnay Inc. Composition for the management of nausea and vomiting
BR112016001474A2 (pt) * 2013-07-22 2020-04-14 Duchesnay Inc Composição para o controle de náusea e vômito
CN103432126A (zh) * 2013-08-05 2013-12-11 北京阜康仁生物制药科技有限公司 一种治疗孕吐的药物组合物
TWI595874B (zh) 2014-08-29 2017-08-21 達契斯奈股份有限公司 多西拉敏及吡哆醇及／或其代謝產物或鹽之多模式釋放調配物
WO2016029290A1 (en) * 2014-08-29 2016-03-03 Duchesnay Inc. Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof
CA2995431A1 (en) 2015-08-17 2017-02-23 Aequus Pharmaceuticals Inc. Transdermal delivery of doxylamine succinate and pyridoxine hydrochloride
CN105510512B (zh) * 2016-01-25 2018-06-29 南京济群医药科技股份有限公司 一种琥珀酸多西拉敏有关物质的rt-hplc检测方法
ES2847648T3 (es) * 2018-09-27 2021-08-03 Inibsa Ginecologia S A Procedimiento para la preparación de una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina
CN114099450A (zh) * 2020-08-31 2022-03-01 长春海悦药业股份有限公司 一种比拉斯汀片及其制备方法
AU2021225255B1 (en) * 2021-09-03 2022-06-16 Patel, Mihir MR Compositions, kits, and methods to provide synergistic and/or additive effects from comprised ingredients for the prevention, treatment and management of nausea and vomiting.

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FR2085641A1 (en) * 1970-04-20 1971-12-31 Investigations Sci Pharm Noramidopyrine doxylamine succinate compsn - antiinflammatories analgesics and antipyretics
US4642231A (en) * 1983-07-20 1987-02-10 Warner-Lambert Company Magnesium trisilicate suitable for preparation of medicament adsorbates of antihistamines
DE69216642T2 (de) * 1992-01-13 1997-05-07 Pfizer Verfahren zur herstellung von tabletten mit hoher festigkeit
CA2139896C (en) * 1995-01-10 2000-03-28 Don B. Mcdonah Use of antinauseant agent for terminally ill humans
US6013280A (en) * 1997-10-07 2000-01-11 Fuisz Technologies Ltd. Immediate release dosage forms containing microspheres
AU7581800A (en) * 1999-09-14 2001-04-17 Smithkline Beecham Corporation Process for making aqueous coated beadlets
CA2350195C (en) * 2000-12-20 2003-06-10 Duchesnay Inc. Rapid onset formulation of pyridoxine hydrochloride and doxylamine succinate

Also Published As

Publication number Publication date
IS2225B (is) 2007-04-15
MY132786A (en) 2007-10-31
HUP0301950A2 (hu) 2003-11-28
KR100527985B1 (ko) 2005-11-09
AU2001272243B2 (en) 2004-02-05
SE0202061D0 (sv) 2002-07-03
CN1229112C (zh) 2005-11-30
DE60114475D1 (de) 2005-12-01
NO332190B1 (no) 2012-07-23
HUP0301950A3 (en) 2005-06-28
DE10196426T1 (de) 2003-08-21
NO20022982L (no) 2002-10-09
UA74807C2 (en) 2006-02-15
DK200200947A (da) 2003-01-03
FR2826277B1 (fr) 2004-07-02
WO2003000263A1 (en) 2003-01-03
EG24483A (en) 2009-08-09
BR0107371A (pt) 2003-06-10
EP1397133A1 (en) 2004-03-17
GR20020100280A (el) 2003-03-28
MXPA02006037A (es) 2005-05-12
ATE307582T1 (de) 2005-11-15
MC200059A1 (fr) 2003-01-30
GB2383751C (en) 2008-08-05
KR20030023612A (ko) 2003-03-19
CA2350195C (en) 2003-06-10
IS6412A (is) 2002-12-22
DK176018B1 (da) 2005-12-05
NL1020895A1 (nl) 2002-12-30
SE526307C2 (sv) 2005-08-16
TR200201685T1 (tr) 2003-06-23
EP1397133B1 (en) 2005-10-26
LU90934B1 (fr) 2002-12-23
BE1014929A4 (fr) 2004-06-01
HU227003B1 (en) 2010-04-28
CA2350195A1 (en) 2001-08-11
IL150349A0 (en) 2003-12-23
FI117961B (fi) 2007-05-15
GB2383751B (en) 2005-02-09
ITTO20020524A0 (it) 2002-06-18
HK1052654A1 (en) 2003-09-26
FI20021708A (fi) 2002-12-22
GB2383751A (en) 2003-07-09
NL1020895C2 (nl) 2003-03-13
FI20021708A0 (fi) 2002-09-25
FR2826277A1 (fr) 2002-12-27
SE0202061L (sv) 2003-01-28
JP4242763B2 (ja) 2009-03-25
CN1447694A (zh) 2003-10-08
ITTO20020524A1 (it) 2003-12-18
DE60114475T2 (de) 2006-07-13
PL362763A1 (en) 2004-11-02
NO20022982D0 (no) 2002-06-20
PL204507B1 (pl) 2010-01-29
UY27352A1 (es) 2002-09-30
GB0213990D0 (en) 2002-07-31
ES2251494T3 (es) 2006-05-01
JP2004521146A (ja) 2004-07-15
DK1397133T3 (da) 2006-02-27
IE20020488A1 (en) 2003-04-30
US6340695B1 (en) 2002-01-22

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