GR1001619B - Παράγωγα ινδόλης. - Google Patents

Παράγωγα ινδόλης.

Info

Publication number
GR1001619B
GR1001619B GR930100154A GR930100154A GR1001619B GR 1001619 B GR1001619 B GR 1001619B GR 930100154 A GR930100154 A GR 930100154A GR 930100154 A GR930100154 A GR 930100154A GR 1001619 B GR1001619 B GR 1001619B
Authority
GR
Greece
Prior art keywords
indole derivatives
indole
derivatives
compound
formula
Prior art date
Application number
GR930100154A
Other languages
Greek (el)
English (en)
Inventor
Alfredo Cugola
Giovanni Gaviraghi
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of GR1001619B publication Critical patent/GR1001619B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
GR930100154A 1992-04-16 1993-04-15 Παράγωγα ινδόλης. GR1001619B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
GR1001619B true GR1001619B (el) 1994-07-29

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
GR930100154A GR1001619B (el) 1992-04-16 1993-04-15 Παράγωγα ινδόλης.

Country Status (41)

Country Link
US (4) US5374648A (en:Method)
EP (1) EP0568136A1 (en:Method)
JP (2) JPH0649027A (en:Method)
KR (1) KR100264114B1 (en:Method)
CN (1) CN1042331C (en:Method)
AP (1) AP480A (en:Method)
AT (1) AT403917B (en:Method)
AU (1) AU666927B2 (en:Method)
BE (1) BE1006343A5 (en:Method)
BG (1) BG62136B1 (en:Method)
BR (1) BR1100323A (en:Method)
CA (3) CA2094076A1 (en:Method)
CH (1) CH685630A5 (en:Method)
CY (1) CY2038B1 (en:Method)
CZ (1) CZ285799B6 (en:Method)
DK (1) DK169890B1 (en:Method)
ES (1) ES2105924B1 (en:Method)
FI (1) FI106198B (en:Method)
FR (1) FR2690919B1 (en:Method)
GB (2) GB9208492D0 (en:Method)
GE (1) GEP19991704B (en:Method)
GR (1) GR1001619B (en:Method)
HK (1) HK95797A (en:Method)
HU (2) HU217964B (en:Method)
IL (1) IL105412A (en:Method)
IS (1) IS3994A (en:Method)
IT (1) IT1265325B1 (en:Method)
LU (1) LU88248A1 (en:Method)
MX (1) MX9302195A (en:Method)
MY (1) MY112232A (en:Method)
NO (1) NO301879B1 (en:Method)
NZ (1) NZ247413A (en:Method)
OA (1) OA10103A (en:Method)
PL (1) PL176451B1 (en:Method)
RO (1) RO113242B1 (en:Method)
RU (1) RU2129544C1 (en:Method)
SE (1) SE504336C2 (en:Method)
SK (1) SK281941B6 (en:Method)
TW (1) TW224457B (en:Method)
WO (1) WO1993021153A1 (en:Method)
ZA (1) ZA932642B (en:Method)

Families Citing this family (44)

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GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
FI955604A0 (fi) * 1993-05-27 1995-11-21 Merrell Pharma Inc 3-(indol-3-yyli)propenoiinihappojohdannaiset NMDA-antagonisteina
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (en:Method) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
US6030968A (en) * 1996-09-17 2000-02-29 The Regents Of The University Of California Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
ATE309215T1 (de) * 1996-09-30 2005-11-15 Aventis Pharma Inc Nmda (n-methyl-d-aspartate) antagonists
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
IL138466A (en) * 1998-03-26 2005-11-20 Fujisawa Pharmaceutical Co Sustained release formulations containing macrolide compounds
SK1292003A3 (en) * 2000-07-31 2003-08-05 Dainippon Pharmaceutical Co Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient
WO2003039540A2 (en) * 2001-11-09 2003-05-15 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
EP1463714A4 (en) * 2001-12-10 2005-10-19 Amgen Inc VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
JP2006526612A (ja) * 2003-06-05 2006-11-24 ファイザー・プロダクツ・インク ベータ−ラクタマーゼ阻害剤・プロドラッグ
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
DK1689721T3 (da) * 2003-11-26 2010-09-20 Pfizer Prod Inc Aminopyrazolderivater som GSK-3-ihibitorer
CZ2006427A3 (cs) * 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
US20080293726A1 (en) 2005-07-06 2008-11-27 Sepracor Inc. Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
BRPI0706365A2 (pt) * 2006-01-06 2011-03-22 Sepracor Inc Cicloalquilaminas como inibidores da recaptação de monoamina
CN101426372A (zh) * 2006-01-06 2009-05-06 塞普拉柯公司 基于四氢萘酮的单胺再摄取抑制剂
CN103588659A (zh) 2006-03-31 2014-02-19 赛诺维信制药公司 手性酰胺和胺的制备
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
BRPI0806604A2 (pt) * 2007-01-18 2011-09-06 Sepracor Inc inibidores de d-aminoácido oxidase
BRPI0811639A2 (pt) 2007-05-31 2014-09-30 Sepracor Inc Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
US20090247644A1 (en) * 2008-03-28 2009-10-01 Forest Laboratories Holdings Limited Memantine formulations
WO2010017418A1 (en) * 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2010104093A1 (ja) 2009-03-10 2010-09-16 参天製薬株式会社 ４，６－ジクロロ－１ｈ－インドール－２－カルボン酸誘導体又はその塩を有効成分として含有する視神経障害の予防又は治療剤
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
IL248567B (en) 2014-04-30 2022-08-01 Univ Nat Taiwan Use of known compounds as d-amino acid oxidase inhibitors
AU2017326359B2 (en) 2016-09-14 2021-02-04 National Chiao Tung University Novel substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors
CA3067162A1 (en) 2017-06-12 2018-12-20 Glytech Llc. Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
DE69118539T2 (de) * 1990-07-16 1996-09-19 Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio Exzitatorische Aminosäureantagonisten
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
CN1042331C (zh) 1999-03-03
ZA932642B (en) 1994-01-10
CN1085212A (zh) 1994-04-13
IL105412A0 (en) 1993-08-18
ES2105924A1 (es) 1997-10-16
MX9302195A (es) 1994-03-31
GB9307808D0 (en) 1993-06-02
JPH0649027A (ja) 1994-02-22
US5374648A (en) 1994-12-20
HU217964B (hu) 2000-05-28
BE1006343A5 (fr) 1994-07-26
AU666927B2 (en) 1996-02-29
FI106198B (fi) 2000-12-15
GB2266091A (en) 1993-10-20
IL105412A (en) 1998-02-22
AP9300524A0 (en) 1993-04-30
GB2266091B (en) 1995-08-09
ITRM930236A1 (it) 1994-10-15
FR2690919B1 (fr) 1995-05-05
RO113242B1 (ro) 1998-05-29
DK169890B1 (da) 1995-03-27
IT1265325B1 (it) 1996-10-31
NO943913D0 (no) 1994-10-14
SK281941B6 (sk) 2001-09-11
SK124194A3 (en) 1995-05-10
JPH07505407A (ja) 1995-06-15
CH685630A5 (fr) 1995-08-31
LU88248A1 (fr) 1994-03-01
US5373018A (en) 1994-12-13
AP480A (en) 1996-03-22
SE9301241L (sv) 1993-10-17
AU3692393A (en) 1993-10-21
TW224457B (en:Method) 1994-06-01
HU211826A9 (en) 1995-12-28
FR2690919A1 (fr) 1993-11-12
FI944800L (fi) 1994-10-12
BG99111A (bg) 1995-05-31
AT403917B (de) 1998-06-25
PL176451B1 (pl) 1999-05-31
MY112232A (en) 2001-05-31
CZ285799B6 (cs) 1999-11-17
DK43193D0 (da) 1993-04-15
IS3994A (is) 1993-10-17
GB9208492D0 (en) 1992-06-03
CY2038B1 (en) 1998-04-30
CZ254394A3 (en) 1995-07-12
EP0568136A1 (en) 1993-11-03
HK95797A (en) 1997-08-08
ITRM930236A0 (it) 1993-04-15
ATA75293A (de) 1997-11-15
NO301879B1 (no) 1997-12-22
SE504336C2 (sv) 1997-01-13
RU2129544C1 (ru) 1999-04-27
FI944800A0 (fi) 1994-10-12
HU9402975D0 (en) 1995-02-28
BR1100323A (pt) 2000-06-27
US5510367A (en) 1996-04-23
CA2094076A1 (en) 1993-10-17
CA2094075A1 (en) 1993-10-17
NO943913L (no) 1994-12-14
OA10103A (en) 1996-12-18
DK43193A (da) 1993-10-17
NZ247413A (en) 1995-12-21
GEP19991704B (en) 1999-08-05
HUT70526A (en) 1995-10-30
RU94045915A (ru) 1996-09-10
US5374649A (en) 1994-12-20
ES2105924B1 (es) 1998-07-01
WO1993021153A1 (en) 1993-10-28
SE9301241D0 (sv) 1993-04-15
KR100264114B1 (ko) 2000-11-01
CA2094073A1 (en) 1993-10-17
BG62136B1 (bg) 1999-03-31

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