GEP19960641B - Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives - Google Patents

Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives

Info

Publication number
GEP19960641B
GEP19960641B GEAP19931653A GEAP1993001653A GEP19960641B GE P19960641 B GEP19960641 B GE P19960641B GE AP19931653 A GEAP19931653 A GE AP19931653A GE AP1993001653 A GEAP1993001653 A GE AP1993001653A GE P19960641 B GEP19960641 B GE P19960641B
Authority
GE
Georgia
Prior art keywords
carbon atoms
groups
group
denotes
tetrazin
Prior art date
Application number
GEAP19931653A
Other languages
English (en)
Inventor
Kenneth Robert Harr Wooldridge
Robert Stone
Edward Lunt
Original Assignee
Cancer Resarch Campaign Tech Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Resarch Campaign Tech Limited filed Critical Cancer Resarch Campaign Tech Limited
Publication of GEP19960641B publication Critical patent/GEP19960641B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GEAP19931653A 1981-08-24 1993-11-16 Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives GEP19960641B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24

Publications (1)

Publication Number Publication Date
GEP19960641B true GEP19960641B (en) 1996-11-15

Family

ID=10524141

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19931653A GEP19960641B (en) 1981-08-24 1993-11-16 Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives

Country Status (29)

Country Link
JP (1) JPS5843975A (cs)
KR (1) KR890000094B1 (cs)
AT (1) AT380256B (cs)
AU (1) AU571430B2 (cs)
BE (1) BE894175A (cs)
CA (1) CA1197247A (cs)
CH (1) CH655114A5 (cs)
DE (2) DE3231255A1 (cs)
DK (1) DK161147C (cs)
ES (1) ES8400438A1 (cs)
FI (1) FI73434C (cs)
FR (1) FR2511679A1 (cs)
GB (1) GB2104522B (cs)
GE (1) GEP19960641B (cs)
GR (1) GR76863B (cs)
HU (1) HU186107B (cs)
IE (1) IE53408B1 (cs)
IL (1) IL66606A (cs)
IT (1) IT1152505B (cs)
LT (1) LT2436B (cs)
LU (1) LU84347A1 (cs)
LV (2) LV5511A3 (cs)
NL (2) NL192739C (cs)
NZ (1) NZ201668A (cs)
OA (1) OA07174A (cs)
SE (1) SE448543B (cs)
SU (1) SU1447284A3 (cs)
UA (1) UA5971A1 (cs)
ZA (1) ZA826120B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
FR2531958B1 (fr) * 1982-08-17 1986-10-31 May & Baker Ltd Nouveaux derive
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
EP0866709B1 (en) * 1995-09-25 2007-01-10 Sanofi-Aventis U.S. LLC 1,2,4-benzotriazine oxides formulations
US7615632B2 (en) 2003-12-30 2009-11-10 Chemagis Ltd. Crystalline forms of temozolomide
BRPI0606455A (pt) 2005-01-21 2008-03-11 Astex Therapeutics Ltd compostos farmacêuticos
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
CA2703489A1 (en) 2007-10-23 2009-04-30 Banyu Pharmaceutical Co., Ltd. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
AU2009318790A1 (en) * 2008-11-24 2011-06-23 Reliance Life Sciences Pvt. Ltd. Process for the preparation of tetrazine derivatives
WO2010101734A1 (en) 2009-03-06 2010-09-10 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
PL2445915T3 (pl) 2009-06-23 2016-10-31 Związki 3-podstawionego-8-podstawionego-3H imidazo[5,1-d][1,2,3,5 tetrazyn]-4-onu i ich zastosowanie
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ
WO2013055985A1 (en) 2011-10-12 2013-04-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
KR20230042756A (ko) 2016-03-15 2023-03-29 오리존 지노믹스 에스.에이. 고형 종양의 치료에 사용하기 위한 lsd1 억제제의 조합물
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Also Published As

Publication number Publication date
BE894175A (fr) 1983-02-23
NL192739C (nl) 1998-01-06
ES515176A0 (es) 1983-11-01
IL66606A (en) 1987-07-31
DK161147B (da) 1991-06-03
FI73434B (fi) 1987-06-30
FR2511679B1 (cs) 1985-02-01
IT8222938A0 (it) 1982-08-23
NL990010I2 (nl) 1999-09-01
ZA826120B (en) 1983-07-27
ATA319182A (de) 1985-09-15
SE448543B (sv) 1987-03-02
IT1152505B (it) 1987-01-07
NZ201668A (en) 1985-08-16
FI822921L (fi) 1983-02-25
IT8222938A1 (it) 1984-02-23
AT380256B (de) 1986-05-12
AU8749382A (en) 1983-03-03
OA07174A (fr) 1984-04-30
FI73434C (fi) 1987-10-09
NL990010I1 (nl) 1999-07-01
SE8204817D0 (sv) 1982-08-23
SE8204817L (sv) 1983-02-25
DK377882A (da) 1983-02-25
LT2436B (lt) 1994-02-15
IE822026L (en) 1983-02-24
GB2104522A (en) 1983-03-09
DE3231255C2 (cs) 1992-02-27
IL66606A0 (en) 1982-12-31
FR2511679A1 (fr) 1983-02-25
IE53408B1 (en) 1988-11-09
UA5971A1 (uk) 1994-12-29
KR840001175A (ko) 1984-03-28
JPS5843975A (ja) 1983-03-14
KR890000094B1 (ko) 1989-03-07
ES8400438A1 (es) 1983-11-01
GR76863B (cs) 1984-09-04
DE3231255A1 (de) 1983-03-03
GB2104522B (en) 1985-06-12
LU84347A1 (fr) 1983-06-07
DK161147C (da) 1991-11-18
NL192739B (nl) 1997-09-01
NL8203286A (nl) 1983-03-16
CA1197247A (fr) 1985-11-26
CH655114A5 (fr) 1986-03-27
DE19975037I2 (de) 2001-06-13
FI822921A0 (fi) 1982-08-23
HU186107B (en) 1985-06-28
LV5511A3 (lv) 1994-03-10
SU1447284A3 (ru) 1988-12-23
AU571430B2 (en) 1988-04-21
LV5621A3 (lv) 1994-05-10
JPH045029B2 (cs) 1992-01-30

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