GB972976A - Novel trifluoromethyl-benzophenones and the preparation thereof - Google Patents

Novel trifluoromethyl-benzophenones and the preparation thereof

Info

Publication number
GB972976A
GB972976A GB20071/63A GB2007163A GB972976A GB 972976 A GB972976 A GB 972976A GB 20071/63 A GB20071/63 A GB 20071/63A GB 2007163 A GB2007163 A GB 2007163A GB 972976 A GB972976 A GB 972976A
Authority
GB
United Kingdom
Prior art keywords
preparation
chloro
trifluoromethyl
benzophenones
novel trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20071/63A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB972976A publication Critical patent/GB972976A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GB20071/63A 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof Expired GB972976A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
GB972976A true GB972976A (en) 1964-10-21

Family

ID=27485190

Family Applications (13)

Application Number Title Priority Date Filing Date
GB20071/63A Expired GB972976A (en) 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof
GB42403/60A Expired GB972965A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB40978/62A Expired GB972972A (en) 1959-12-10 1960-12-09 Novel 2-amino-benzophenones and the preparation thereof
GB42405/60A Expired GB972967A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42404/60A Expired GB972966A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42399/60A Expired GB972961A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42400/60A Expired GB972962A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42402/60A Expired GB972964A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB40979/62A Expired GB972973A (en) 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof
GB42408/60A Expired GB972968A (en) 1959-12-10 1960-12-09 Benzodiazepine derivatives
GB42401/60A Expired GB972963A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB1168/61A Expired GB972969A (en) 1959-12-10 1961-01-11 Benzodiazepine derivatives and a process for the manufacture of same
GB29834/62A Expired GB972970A (en) 1959-12-10 1961-01-11 Novel quinazoline 3-oxides and a process for the manufacture thereof

Family Applications After (12)

Application Number Title Priority Date Filing Date
GB42403/60A Expired GB972965A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB40978/62A Expired GB972972A (en) 1959-12-10 1960-12-09 Novel 2-amino-benzophenones and the preparation thereof
GB42405/60A Expired GB972967A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42404/60A Expired GB972966A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42399/60A Expired GB972961A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42400/60A Expired GB972962A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42402/60A Expired GB972964A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB40979/62A Expired GB972973A (en) 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof
GB42408/60A Expired GB972968A (en) 1959-12-10 1960-12-09 Benzodiazepine derivatives
GB42401/60A Expired GB972963A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB1168/61A Expired GB972969A (en) 1959-12-10 1961-01-11 Benzodiazepine derivatives and a process for the manufacture of same
GB29834/62A Expired GB972970A (en) 1959-12-10 1961-01-11 Novel quinazoline 3-oxides and a process for the manufacture thereof

Country Status (11)

Country Link
BE (4) BE598012A (cg-RX-API-DMAC7.html)
BR (1) BR6024755D0 (cg-RX-API-DMAC7.html)
CH (9) CH408045A (cg-RX-API-DMAC7.html)
CY (1) CY324A (cg-RX-API-DMAC7.html)
DE (5) DE1288609B (cg-RX-API-DMAC7.html)
ES (2) ES263123A1 (cg-RX-API-DMAC7.html)
GB (13) GB972976A (cg-RX-API-DMAC7.html)
MY (1) MY6500178A (cg-RX-API-DMAC7.html)
NL (2) NL6412250A (cg-RX-API-DMAC7.html)
OA (7) OA00817A (cg-RX-API-DMAC7.html)
SE (2) SE310887B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1295563B (de) * 1963-05-29 1969-05-22 American Home Prod Verfahren zur Herstellung von 5-Phenyl-7-chlor-1, 2-dihydro-3H-1, 4-benzodiazepinon-(2)-4-oxyd
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
JP2005503356A (ja) * 2001-06-07 2005-02-03 ニューロ３デー 環状ヌクレオチドホスホジエステラーゼ阻害剤、その製造および使用
AU2003248549B2 (en) * 2002-05-24 2010-04-08 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
GB972966A (en) 1964-10-21
GB972965A (en) 1964-10-21
DE1445908A1 (de) 1969-04-17
CH408045A (de) 1966-02-28
OA00817A (fr) 1967-11-15
DE1290143B (de) 1969-03-06
ES263124A1 (es) 1961-06-01
GB972973A (en) 1964-10-21
CH418341A (de) 1966-08-15
GB972967A (en) 1964-10-21
GB972964A (en) 1964-10-21
GB972961A (en) 1964-10-21
DE1288609B (de) 1969-02-06
CY324A (en) 1965-11-03
OA02384A (fr) 1970-05-05
NL6412251A (cg-RX-API-DMAC7.html) 1966-01-25
BE598015A (fr) 1961-06-09
BR6024755D0 (pt) 1973-05-24
CH414652A (de) 1966-06-15
GB972970A (en) 1964-10-21
DE1288610B (de) 1969-02-06
CH418342A (de) 1966-08-15
CH408940A (de) 1966-03-15
CH396016A (de) 1965-07-31
GB972969A (en) 1964-10-21
MY6500178A (en) 1965-12-31
CH408029A (de) 1966-02-28
ES263123A1 (es) 1961-06-01
GB972962A (en) 1964-10-21
NL6412250A (cg-RX-API-DMAC7.html) 1966-01-25
CH414653A (de) 1966-06-15
GB972963A (en) 1964-10-21
GB972972A (en) 1964-10-21
OA02385A (fr) 1970-05-05
BE598013A (fr) 1961-06-09
OA00816A (fr) 1967-11-15
BE598008A (fr) 1961-06-09
DE1445073A1 (de) 1968-10-31
OA00953A (fr) 1968-03-22
GB972968A (en) 1964-10-21
SE318283B (cg-RX-API-DMAC7.html) 1969-12-08
BE598012A (fr) 1961-06-09
OA00959A (fr) 1968-03-22
OA00958A (fr) 1968-03-22
CH411910A (de) 1966-04-30
SE310887B (cg-RX-API-DMAC7.html) 1969-05-19

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