GB2217320B - Dideoxydidehydrocarbocyclic nucleosides - Google Patents

Dideoxydidehydrocarbocyclic nucleosides

Info

Publication number
GB2217320B
GB2217320B GB8901187A GB8901187A GB2217320B GB 2217320 B GB2217320 B GB 2217320B GB 8901187 A GB8901187 A GB 8901187A GB 8901187 A GB8901187 A GB 8901187A GB 2217320 B GB2217320 B GB 2217320B
Authority
GB
United Kingdom
Prior art keywords
dideoxydidehydrocarbocyclic
nucleosides
dideoxydidehydrocarbocyclic nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8901187A
Other languages
English (en)
Other versions
GB8901187D0 (en
GB2217320A (en
Inventor
Robert Vince
Mei Hua
Peter Leslie Myers
Richard Storer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/146,252 external-priority patent/US4916224A/en
Priority claimed from GB888821011A external-priority patent/GB8821011D0/en
Priority claimed from US07/278,652 external-priority patent/US4931559A/en
Application filed by University of Minnesota filed Critical University of Minnesota
Publication of GB8901187D0 publication Critical patent/GB8901187D0/en
Publication of GB2217320A publication Critical patent/GB2217320A/en
Priority to GB9110987A priority Critical patent/GB2243609B/en
Application granted granted Critical
Publication of GB2217320B publication Critical patent/GB2217320B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
GB8901187A 1988-01-20 1989-01-19 Dideoxydidehydrocarbocyclic nucleosides Expired - Lifetime GB2217320B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9110987A GB2243609B (en) 1988-01-20 1991-05-21 Dideoxydidehydrocarbocyclic pyrimidines

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/146,252 US4916224A (en) 1988-01-20 1988-01-20 Dideoxycarbocyclic nucleosides
GB888821011A GB8821011D0 (en) 1988-09-07 1988-09-07 Chemical compounds
US07/278,652 US4931559A (en) 1988-01-20 1988-12-05 Optically-active isomers of dideoxycarbocyclic nucleosides

Publications (3)

Publication Number Publication Date
GB8901187D0 GB8901187D0 (en) 1989-03-15
GB2217320A GB2217320A (en) 1989-10-25
GB2217320B true GB2217320B (en) 1992-04-08

Family

ID=27264063

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8901187A Expired - Lifetime GB2217320B (en) 1988-01-20 1989-01-19 Dideoxydidehydrocarbocyclic nucleosides

Country Status (29)

Country Link
JP (1) JP2793825B2 (fi)
KR (1) KR0127137B1 (fi)
AT (1) AT397801B (fi)
AU (2) AU626278B2 (fi)
BE (1) BE1003815A4 (fi)
CA (1) CA1339896C (fi)
CH (1) CH679152A5 (fi)
DE (1) DE3901502C2 (fi)
DK (1) DK175131B1 (fi)
ES (1) ES2010091A6 (fi)
FI (1) FI93546C (fi)
FR (1) FR2626002B1 (fi)
GB (1) GB2217320B (fi)
GR (1) GR890100033A (fi)
HU (1) HU203755B (fi)
IE (1) IE62275B1 (fi)
IL (1) IL88999A (fi)
IT (1) IT1229531B (fi)
LU (1) LU87437A1 (fi)
MY (1) MY103801A (fi)
NL (1) NL8900122A (fi)
NO (1) NO169123C (fi)
NZ (1) NZ227663A (fi)
OA (1) OA09031A (fi)
PL (1) PL163814B1 (fi)
PT (1) PT89482B (fi)
RU (1) RU2114846C1 (fi)
SE (1) SE505213C2 (fi)
YU (1) YU47791B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215339B (it) * 1987-01-14 1990-02-08 Co Pharma Corp Srl Procedimento per la preparazione di 9-(idrossialchil)-ipoxantine
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
ES2136061T3 (es) * 1989-06-27 1999-11-16 Wellcome Found Nucleosidos terapeuticos.
GB8916480D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916478D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916479D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916477D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5144034A (en) * 1990-04-06 1992-09-01 Glaxo Inc. Process for the synthesis of cyclopentene derivatives of purines
US5241069A (en) * 1990-04-06 1993-08-31 Glaxo Inc. Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives
US5057630A (en) * 1990-04-06 1991-10-15 Glaxo Inc. Synthesis of cyclopentene derivatives
US5126452A (en) * 1990-04-06 1992-06-30 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
CN1137274A (zh) * 1993-11-12 1996-12-04 默里尔药物公司 用作免疫抑制剂的6-氧代-核苷
GB9721780D0 (en) 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
KR100606625B1 (ko) 1998-10-30 2006-07-28 론자 아게 4-[(2',5'-디아미노-6'-할로피리미딘-4'-일)아미노]-시클로펜트-2-에닐메탄올의 제조 방법
HU227559B1 (en) * 1998-10-30 2011-08-29 Lonza Ag Method for producing 4-[(2',5'-diamino-6'-halopyrimidine-4'-yl)amino]-cyclopent-2-enylmethanols
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB9903091D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
AR039540A1 (es) 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
TW202019942A (zh) 2018-07-27 2020-06-01 日商富士軟片股份有限公司 環戊烯嘌呤衍生物或其鹽
JP2023519882A (ja) 2020-03-27 2023-05-15 ソム、イノベーション、バイオテック、ソシエダッド、アノニマ シヌクレイノパチーの治療に有用な化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349242A2 (en) * 1988-06-27 1990-01-03 The Wellcome Foundation Limited Therapeutic nucleosides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
JPS62177234A (ja) * 1986-01-30 1987-08-04 Mitsubishi Heavy Ind Ltd 遠心紡糸によるカ−ボン繊維の製造装置
IN164556B (fi) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349242A2 (en) * 1988-06-27 1990-01-03 The Wellcome Foundation Limited Therapeutic nucleosides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Biochem, Biophys, Res. Commun, 156(2), 1046-53(Vince and others) *
Chemical Abstracts 110(7): 50717z. *

Also Published As

Publication number Publication date
YU47791B (sr) 1996-01-09
AU2867189A (en) 1989-07-20
IL88999A0 (en) 1989-08-15
OA09031A (en) 1991-03-31
IE62275B1 (en) 1995-01-25
PT89482B (pt) 1994-02-28
GB8901187D0 (en) 1989-03-15
NO890253D0 (no) 1989-01-19
NO169123C (no) 1992-05-13
JP2793825B2 (ja) 1998-09-03
ATA10689A (de) 1993-11-15
LU87437A1 (fr) 1989-08-30
AT397801B (de) 1994-07-25
PL163814B1 (en) 1994-05-31
FI93546B (fi) 1995-01-13
DK23489D0 (da) 1989-01-19
NL8900122A (nl) 1989-08-16
PL277261A1 (en) 1989-09-18
NO890253L (no) 1989-07-21
KR890011902A (ko) 1989-08-23
IT1229531B (it) 1991-09-04
IL88999A (en) 1994-12-29
FI93546C (fi) 1995-04-25
CH679152A5 (fi) 1991-12-31
SE8900192L (sv) 1989-07-21
JPH02196788A (ja) 1990-08-03
CA1339896C (en) 1998-06-02
MY103801A (en) 1993-09-30
SE505213C2 (sv) 1997-07-14
BE1003815A4 (fr) 1992-06-23
DE3901502C2 (de) 2002-06-13
AU1018092A (en) 1992-03-12
IT8947546A0 (it) 1989-01-19
KR0127137B1 (ko) 1997-12-29
ES2010091A6 (es) 1989-10-16
HUT48887A (en) 1989-07-28
HU203755B (en) 1991-09-30
GR890100033A (el) 1994-03-31
AU637015B2 (en) 1993-05-13
AU626278B2 (en) 1992-07-30
GB2217320A (en) 1989-10-25
YU12389A (en) 1991-10-31
IE890153L (en) 1989-07-20
NZ227663A (en) 1990-09-26
FI890286A0 (fi) 1989-01-19
FR2626002B1 (fr) 1994-01-28
PT89482A (pt) 1989-10-04
DK23489A (da) 1989-07-21
FI890286A (fi) 1989-07-21
FR2626002A1 (fr) 1989-07-21
DE3901502A1 (de) 1989-07-27
NO169123B (no) 1992-02-03
RU2114846C1 (ru) 1998-07-10
DK175131B1 (da) 2004-06-14
SE8900192D0 (sv) 1989-01-19

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20090118