GB2176702B - Novel formulation. - Google Patents

Novel formulation.

Info

Publication number
GB2176702B
GB2176702B GB8612780A GB8612780A GB2176702B GB 2176702 B GB2176702 B GB 2176702B GB 8612780 A GB8612780 A GB 8612780A GB 8612780 A GB8612780 A GB 8612780A GB 2176702 B GB2176702 B GB 2176702B
Authority
GB
United Kingdom
Prior art keywords
novel formulation
formulation
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8612780A
Other languages
English (en)
Other versions
GB2176702A (en
GB8612780D0 (en
Inventor
Michael Denis Johnston
Henry Berger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB8612780D0 publication Critical patent/GB8612780D0/en
Publication of GB2176702A publication Critical patent/GB2176702A/en
Application granted granted Critical
Publication of GB2176702B publication Critical patent/GB2176702B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GB8612780A 1985-05-28 1986-05-27 Novel formulation. Expired GB2176702B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (3)

Publication Number Publication Date
GB8612780D0 GB8612780D0 (en) 1986-07-02
GB2176702A GB2176702A (en) 1987-01-07
GB2176702B true GB2176702B (en) 1989-07-05

Family

ID=26289290

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8612780A Expired GB2176702B (en) 1985-05-28 1986-05-27 Novel formulation.

Country Status (22)

Country Link
US (2) US4929444A (enExample)
JP (1) JPH0759517B2 (enExample)
AU (1) AU567236B2 (enExample)
BE (1) BE904830A (enExample)
CA (1) CA1300008C (enExample)
CH (1) CH665356A5 (enExample)
DE (1) DE3617752A1 (enExample)
DK (1) DK163173C (enExample)
ES (2) ES8800601A1 (enExample)
FI (1) FI85335C (enExample)
FR (1) FR2583984B1 (enExample)
GB (1) GB2176702B (enExample)
GR (1) GR861366B (enExample)
HU (1) HU195733B (enExample)
IL (1) IL78938A (enExample)
IT (1) IT1191926B (enExample)
LU (1) LU86444A1 (enExample)
NL (1) NL8601355A (enExample)
NO (1) NO171345C (enExample)
NZ (1) NZ216307A (enExample)
PT (1) PT82646B (enExample)
SE (1) SE462016B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI85334C (fi) * 1985-05-28 1992-04-10 Wellcome Found Foerfarande foer framstaellning av en vattenbaserad, vaevnadsplasminogenaktivator (t-pa) innehaollande, koncentrerad parenterad loesning.
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
IE59895B1 (en) * 1986-05-12 1994-04-20 Wellcome Found Medicaments containing tissue plasminogen activator
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (en) * 1991-01-14 1992-07-23 Duke University LAMININ SEQUENCE AS tPA ACTIVATOR
DE69333127T2 (de) * 1992-06-03 2004-05-06 Genentech, Inc., South San Francisco Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
AU710612B2 (en) * 1995-12-13 1999-09-23 Abbvie Inc. Endothelial cell proliferation inhibitor and method of use
BR9611174A (pt) * 1995-10-23 1999-09-14 Childrens Medical Center Proteína de endostatina isolada, e composições terapêuticas antiangiogénicas formadas com a mesma.
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DE69719265T2 (de) * 1996-09-06 2003-12-04 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Kumamoto Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält
CN1553811A (zh) * 2001-09-07 2004-12-08 ӡ�����Ƽ��ɷ����޹�˾ 人组织尿激酶类型纤溶酶原激活物制剂
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
JP2007525963A (ja) * 2003-06-20 2007-09-13 イルミナ インコーポレイテッド 全ゲノム増幅および遺伝型決定のための方法および組成物
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
EP1879599B1 (en) * 2005-04-20 2013-10-16 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492959A (en) * 1973-12-03 1977-11-23 Fabre Sa Pierre Process for obtaining a plasminogen activator
EP0113319A2 (en) * 1982-12-30 1984-07-11 Elaine Lynette Dr. Wilson Cell lines and their use for the production of proteins
EP0123304A2 (en) * 1983-04-21 1984-10-31 Asahi Kasei Kogyo Kabushiki Kaisha A method for stabilizing tissue plasminogen activator and a stable aqueous solution or powder containing the same
EP0156169A1 (en) * 1984-02-29 1985-10-02 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
EP0211592A2 (en) * 1985-07-29 1987-02-25 Smithkline Beecham Corporation Pharmaceutical dosage unit

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
CH660742A5 (de) * 1982-10-29 1987-06-15 Mitsui Toatsu Chemicals Plasminogen-aktivator, verfahren zu seiner herstellung und diesen enthaltendes thrombolytisches agens.
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492959A (en) * 1973-12-03 1977-11-23 Fabre Sa Pierre Process for obtaining a plasminogen activator
EP0113319A2 (en) * 1982-12-30 1984-07-11 Elaine Lynette Dr. Wilson Cell lines and their use for the production of proteins
EP0123304A2 (en) * 1983-04-21 1984-10-31 Asahi Kasei Kogyo Kabushiki Kaisha A method for stabilizing tissue plasminogen activator and a stable aqueous solution or powder containing the same
EP0156169A1 (en) * 1984-02-29 1985-10-02 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
EP0211592A2 (en) * 1985-07-29 1987-02-25 Smithkline Beecham Corporation Pharmaceutical dosage unit

Also Published As

Publication number Publication date
IT1191926B (it) 1988-03-31
DK246786D0 (da) 1986-05-27
FR2583984B1 (fr) 1989-06-02
BE904830A (fr) 1986-11-27
GB2176702A (en) 1987-01-07
AU5796486A (en) 1986-12-04
DK246786A (da) 1986-11-29
SE462016B (sv) 1990-04-30
US4929444A (en) 1990-05-29
FI862227A0 (fi) 1986-05-27
ES8802439A1 (es) 1988-06-01
FI85335C (fi) 1992-04-10
DE3617752C2 (enExample) 1988-06-30
US4968617A (en) 1990-11-06
HUT41638A (en) 1987-05-28
ES557374A0 (es) 1988-06-01
HU195733B (en) 1988-07-28
CH665356A5 (de) 1988-05-13
DK163173B (da) 1992-02-03
FR2583984A1 (fr) 1987-01-02
DK163173C (da) 1992-06-22
IT8648065A0 (it) 1986-05-27
IL78938A (en) 1993-02-21
JPH0759517B2 (ja) 1995-06-28
LU86444A1 (fr) 1986-12-05
NO171345B (no) 1992-11-23
PT82646A (en) 1986-06-01
ES8800601A1 (es) 1987-11-16
PT82646B (pt) 1989-01-30
CA1300008C (en) 1992-05-05
IL78938A0 (en) 1986-09-30
JPH06183995A (ja) 1994-07-05
FI85335B (fi) 1991-12-31
DE3617752A1 (de) 1986-12-04
AU567236B2 (en) 1987-11-12
FI862227L (fi) 1986-11-29
GR861366B (en) 1986-09-29
NO171345C (no) 1993-03-03
SE8602405L (sv) 1986-11-29
SE8602405D0 (sv) 1986-05-27
NO862096L (no) 1986-12-01
NL8601355A (nl) 1986-12-16
ES555353A0 (es) 1987-11-16
GB8612780D0 (en) 1986-07-02
NZ216307A (en) 1989-10-27

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950527