GB2073193A - Inhibitors of Cholesterol Biosynthesis, their Preparation and Use - Google Patents

Inhibitors of Cholesterol Biosynthesis, their Preparation and Use Download PDF

Info

Publication number
GB2073193A
GB2073193A GB8110075A GB8110075A GB2073193A GB 2073193 A GB2073193 A GB 2073193A GB 8110075 A GB8110075 A GB 8110075A GB 8110075 A GB8110075 A GB 8110075A GB 2073193 A GB2073193 A GB 2073193A
Authority
GB
United Kingdom
Prior art keywords
group
compounds
straight
branched chain
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8110075A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2073193(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of GB2073193A publication Critical patent/GB2073193A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB8110075A 1980-03-31 1981-03-31 Inhibitors of Cholesterol Biosynthesis, their Preparation and Use Withdrawn GB2073193A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (ja) 1980-03-31 1980-03-31 Ｍｂ−５３０ａ誘導体

Publications (1)

Publication Number Publication Date
GB2073193A true GB2073193A (en) 1981-10-14

Family

ID=12604367

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8110075A Withdrawn GB2073193A (en) 1980-03-31 1981-03-31 Inhibitors of Cholesterol Biosynthesis, their Preparation and Use

Country Status (15)

Country Link
JP (1) JPH0692381B2 (enrdf_load_html_response)
AT (1) ATA150781A (enrdf_load_html_response)
AU (1) AU6893281A (enrdf_load_html_response)
BE (1) BE888214A (enrdf_load_html_response)
CH (1) CH646966A5 (enrdf_load_html_response)
DE (2) DE3112566A1 (enrdf_load_html_response)
DK (3) DK151273C (enrdf_load_html_response)
FI (1) FI810991L (enrdf_load_html_response)
FR (1) FR2479222A1 (enrdf_load_html_response)
GB (1) GB2073193A (enrdf_load_html_response)
IE (1) IE52367B1 (enrdf_load_html_response)
IT (1) IT1144325B (enrdf_load_html_response)
MX (1) MX9203567A (enrdf_load_html_response)
NL (1) NL8101592A (enrdf_load_html_response)
SE (1) SE461590B (enrdf_load_html_response)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113881A1 (en) * 1982-12-22 1984-07-25 Merck & Co. Inc. Antihypercholesterolemic compounds
EP0215665A3 (en) * 1985-09-13 1988-10-05 Sankyo Company Limited Hydroxy-ml-236b derivatives, their preparation and use
EP0314435A2 (en) 1987-10-27 1989-05-03 Sankyo Company Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition, processes for their preparation and compositions containing them
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101820099B1 (ko) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 저항 발열체, 이를 채용한 가열 부재, 및 정착 장치
CN111788196A (zh) * 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (enrdf_load_html_response) * 1974-06-07 1981-03-18
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113881A1 (en) * 1982-12-22 1984-07-25 Merck & Co. Inc. Antihypercholesterolemic compounds
EP0215665A3 (en) * 1985-09-13 1988-10-05 Sankyo Company Limited Hydroxy-ml-236b derivatives, their preparation and use
US5403860A (en) * 1987-10-27 1995-04-04 Sankyo Company, Limited Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
EP0314435A2 (en) 1987-10-27 1989-05-03 Sankyo Company Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition, processes for their preparation and compositions containing them
US5658942A (en) * 1987-10-27 1997-08-19 Sankyo Company, Limited Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
WO2010049900A1 (fr) * 2008-10-29 2010-05-06 Centre National De La Recherche Scientifique Nanoparticules de statine
US8748414B2 (en) 2008-10-29 2014-06-10 Patrick Couvreur Statin nanoparticles

Also Published As

Publication number Publication date
DK145481A (da) 1981-10-01
JPH0692381B2 (ja) 1994-11-16
IE52367B1 (en) 1987-09-30
IE810698L (en) 1981-09-30
DE3112566A1 (de) 1982-03-11
FR2479222A1 (fr) 1981-10-02
JPS56138181A (en) 1981-10-28
MX9203567A (es) 1992-09-01
IT8167438A0 (it) 1981-03-30
DK32290A (da) 1990-02-07
DE3112566C2 (enrdf_load_html_response) 1990-04-05
SE461590B (sv) 1990-03-05
IT1144325B (it) 1986-10-29
AU6893281A (en) 1981-10-08
DK151273C (da) 1988-07-04
DK32190D0 (da) 1990-02-07
ATA150781A (de) 1983-03-15
DK167805B1 (da) 1993-12-20
BE888214A (fr) 1981-09-30
DE3153666C2 (de) 1993-11-11
DK32190A (da) 1990-02-07
FI810991A7 (fi) 1981-10-01
CH646966A5 (de) 1984-12-28
NL8101592A (nl) 1981-10-16
FI810991L (fi) 1981-10-01
FR2479222B1 (enrdf_load_html_response) 1983-08-26
DK32290D0 (da) 1990-02-07
DK151273B (da) 1987-11-16
SE8102047L (sv) 1981-10-01

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)