GB1377720A - Hydroxy pyrimidines - Google Patents

Hydroxy pyrimidines

Info

Publication number
GB1377720A
GB1377720A GB5005373A GB5005373A GB1377720A GB 1377720 A GB1377720 A GB 1377720A GB 5005373 A GB5005373 A GB 5005373A GB 5005373 A GB5005373 A GB 5005373A GB 1377720 A GB1377720 A GB 1377720A
Authority
GB
United Kingdom
Prior art keywords
sodium
compound
ethyl
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5005373A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Publication of GB1377720A publication Critical patent/GB1377720A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB5005373A 1971-10-29 1972-02-18 Hydroxy pyrimidines Expired GB1377720A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19400671A 1971-10-29 1971-10-29

Publications (1)

Publication Number Publication Date
GB1377720A true GB1377720A (en) 1974-12-18

Family

ID=22715935

Family Applications (2)

Application Number Title Priority Date Filing Date
GB5005373A Expired GB1377720A (en) 1971-10-29 1972-02-18 Hydroxy pyrimidines
GB774872A Expired GB1377308A (en) 1971-10-29 1972-02-18 Pyrimidones

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB774872A Expired GB1377308A (en) 1971-10-29 1972-02-18 Pyrimidones

Country Status (25)

Country Link
JP (2) JPS5337870B2 (enExample)
AR (2) AR198798A1 (enExample)
AT (2) AT321308B (enExample)
AU (1) AU467600B2 (enExample)
BE (1) BE790125A (enExample)
CA (1) CA980778A (enExample)
CH (2) CH549579A (enExample)
DE (3) DE2248741C3 (enExample)
DK (1) DK131465B (enExample)
EG (1) EG11013A (enExample)
ES (2) ES407730A1 (enExample)
FI (1) FI55503C (enExample)
FR (1) FR2157865B1 (enExample)
GB (2) GB1377720A (enExample)
IE (1) IE37043B1 (enExample)
IL (2) IL40458A (enExample)
LU (1) LU66304A1 (enExample)
NL (1) NL166470C (enExample)
NO (1) NO136574C (enExample)
PH (2) PH10129A (enExample)
PL (2) PL89852B1 (enExample)
SE (2) SE393376B (enExample)
SU (2) SU498908A3 (enExample)
YU (2) YU35125B (enExample)
ZA (1) ZA727362B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151912U (enExample) * 1979-04-17 1980-11-01
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPH0655686B2 (ja) * 1988-08-30 1994-07-27 宇部興産株式会社 ｐ−ブロモフェノキシアセトアルデヒドジアルキルアセタール類の製造方法
KR101452518B1 (ko) 2005-08-22 2014-10-21 멜리어 파마슈티칼스 아이, 인코포레이티드 Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한방법 및 제제
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
WO2011150300A1 (en) 2010-05-28 2011-12-01 Melior Pharmaceuticals I, Inc. Prevention of pancreatic beta cell degeneration
EP3609500B1 (en) 2017-04-10 2024-11-13 Melior Pharmaceuticals I, Inc. Treatment of adipocytes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913462A (en) * 1959-11-17 Eahl h
GB951431A (en) * 1959-03-17 1964-03-04 Wellcome Found Pyrimidine derivatives and the manufacture thereof

Also Published As

Publication number Publication date
DE2248741C3 (de) 1975-06-26
ES436624A1 (es) 1977-02-01
NO136574C (no) 1977-09-28
SU505362A3 (ru) 1976-02-28
AT321308B (de) 1975-03-25
ES407730A1 (es) 1976-01-16
NL7213959A (enExample) 1973-05-02
AR198798A1 (es) 1974-07-24
BE790125A (fr) 1973-04-16
YU255172A (en) 1980-03-15
IE37043L (en) 1973-04-29
FI55503B (fi) 1979-04-30
LU66304A1 (enExample) 1973-05-03
IE37043B1 (en) 1977-04-27
DE2248741B2 (de) 1974-11-14
FI55503C (fi) 1979-08-10
DK131465C (enExample) 1975-12-08
DE2264657C2 (de) 1982-09-16
PL89852B1 (enExample) 1976-12-31
YU99179A (en) 1981-08-31
NO136574B (enExample) 1977-06-20
IL40458A0 (en) 1972-11-28
DE2264374B2 (de) 1980-08-07
YU36295B (en) 1982-06-18
GB1377308A (en) 1974-12-11
PH10129A (en) 1976-09-02
CH549579A (fr) 1974-05-31
SU498908A3 (ru) 1976-01-05
DK131465B (da) 1975-07-21
DE2248741A1 (de) 1973-05-03
IL48790A0 (en) 1976-03-31
AR196263A1 (es) 1973-12-10
NL166470B (nl) 1981-03-16
FR2157865A1 (enExample) 1973-06-08
DE2264374C3 (de) 1981-07-23
PH11594A (en) 1978-03-31
AT320656B (de) 1975-02-25
SE397090B (sv) 1977-10-17
DE2264657A1 (de) 1974-06-20
PL84634B1 (enExample) 1976-04-30
FR2157865B1 (enExample) 1975-10-31
JPS5422995B2 (enExample) 1979-08-10
JPS53116386A (en) 1978-10-11
ZA727362B (en) 1973-11-28
SE393376B (sv) 1977-05-09
JPS4852780A (enExample) 1973-07-24
AU467600B2 (en) 1975-12-04
YU35125B (en) 1980-09-25
SE7505279L (sv) 1975-05-06
IL48790A (en) 1976-05-31
JPS5337870B2 (enExample) 1978-10-12
AU4722872A (en) 1974-04-04
IL40458A (en) 1976-05-31
DE2264374A1 (de) 1973-05-24
EG11013A (en) 1976-11-30
CA980778A (en) 1975-12-30
NL166470C (nl) 1981-08-17
CH555832A (fr) 1974-11-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee