FR2919188B1 - Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps - Google Patents

Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps

Info

Publication number
FR2919188B1
FR2919188B1 FR0705536A FR0705536A FR2919188B1 FR 2919188 B1 FR2919188 B1 FR 2919188B1 FR 0705536 A FR0705536 A FR 0705536A FR 0705536 A FR0705536 A FR 0705536A FR 2919188 B1 FR2919188 B1 FR 2919188B1
Authority
FR
France
Prior art keywords
bmps
complexes
family
amphiphilic polymer
osteogenic protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0705536A
Other languages
English (en)
French (fr)
Other versions
FR2919188A1 (fr
Inventor
Gerard Soula
Olivier Soula
Remi Soula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PROTEINS AND PEPTIDES MANAGEMENT
Original Assignee
PROTEINS AND PEPTIDES MANAGEMENT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0705536A priority Critical patent/FR2919188B1/fr
Application filed by PROTEINS AND PEPTIDES MANAGEMENT filed Critical PROTEINS AND PEPTIDES MANAGEMENT
Priority to CA2694600A priority patent/CA2694600A1/fr
Priority to EP08786481A priority patent/EP2178565A1/fr
Priority to AU2008281848A priority patent/AU2008281848A1/en
Priority to US12/219,679 priority patent/US8389661B2/en
Priority to BRPI0813025A priority patent/BRPI0813025A2/pt
Priority to JP2010518637A priority patent/JP2010534708A/ja
Priority to RU2010107203/15A priority patent/RU2010107203A/ru
Priority to PCT/EP2008/059832 priority patent/WO2009016131A1/fr
Priority to MX2010001104A priority patent/MX2010001104A/es
Priority to KR1020107004494A priority patent/KR20100051695A/ko
Priority to CN200880107383A priority patent/CN101835493A/zh
Publication of FR2919188A1 publication Critical patent/FR2919188A1/fr
Priority to ZA201001163A priority patent/ZA201001163B/xx
Application granted granted Critical
Publication of FR2919188B1 publication Critical patent/FR2919188B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
    • C08B11/12—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals, e.g. carboxymethylcellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
FR0705536A 2007-07-27 2007-07-27 Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps Expired - Fee Related FR2919188B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR0705536A FR2919188B1 (fr) 2007-07-27 2007-07-27 Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
KR1020107004494A KR20100051695A (ko) 2007-07-27 2008-07-25 양쪽 친매성 폴리머와 ｂｍｐ 패밀리의 골형성 단백질의 복합체
AU2008281848A AU2008281848A1 (en) 2007-07-27 2008-07-25 Complexes between an amphiphilic polymer and an osteogenic protein of the BMPs family
US12/219,679 US8389661B2 (en) 2007-07-27 2008-07-25 Complexes between an amphiphilic polymer and an osteogenic protein belonging to the family of BMPs
BRPI0813025A BRPI0813025A2 (pt) 2007-07-27 2008-07-25 "complexos entre um polímero anfifílico e uma proteína osteogênica da família das bmps"
JP2010518637A JP2010534708A (ja) 2007-07-27 2008-07-25 両親媒性ポリマーとｂｍｐファミリーに属する骨形成タンパク質との複合体
CA2694600A CA2694600A1 (fr) 2007-07-27 2008-07-25 Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
PCT/EP2008/059832 WO2009016131A1 (fr) 2007-07-27 2008-07-25 COMPLEXES ENTRE UN POLYMÈRE AMPHIPHILE ET UNE PROTÉINE OSTÉOGÉNIQUE APPARTENANT À LA FAMILLE DES BMPs
MX2010001104A MX2010001104A (es) 2007-07-27 2008-07-25 Complejos entre un polimero anfif?lico y una prote?na osteog?nica que pertenece a la familia de proteinas morfogen?ticas ?seas (bmp).
EP08786481A EP2178565A1 (fr) 2007-07-27 2008-07-25 COMPLEXES ENTRE UN POLYMÈRE AMPHIPHILE ET UNE PROTÉINE OSTÉOGÉNIQUE APPARTENANT À LA FAMILLE DES BMPs
CN200880107383A CN101835493A (zh) 2007-07-27 2008-07-25 两亲性聚合物和属于bmp家族的成骨蛋白之间的复合物
RU2010107203/15A RU2010107203A (ru) 2007-07-27 2008-07-25 Комплексы между амфифильным полимером и остеогенным белком, принадлежащим к семейству вмр
ZA201001163A ZA201001163B (en) 2007-07-27 2010-02-17 Complexes between an amphiphilic polymer and an osteogenic protein of the BMPS family

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705536A FR2919188B1 (fr) 2007-07-27 2007-07-27 Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps

Publications (2)

Publication Number Publication Date
FR2919188A1 FR2919188A1 (fr) 2009-01-30
FR2919188B1 true FR2919188B1 (fr) 2010-02-26

Family

ID=38990010

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0705536A Expired - Fee Related FR2919188B1 (fr) 2007-07-27 2007-07-27 Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps

Country Status (13)

Country Link
US (1) US8389661B2 (enExample)
EP (1) EP2178565A1 (enExample)
JP (1) JP2010534708A (enExample)
KR (1) KR20100051695A (enExample)
CN (1) CN101835493A (enExample)
AU (1) AU2008281848A1 (enExample)
BR (1) BRPI0813025A2 (enExample)
CA (1) CA2694600A1 (enExample)
FR (1) FR2919188B1 (enExample)
MX (1) MX2010001104A (enExample)
RU (1) RU2010107203A (enExample)
WO (1) WO2009016131A1 (enExample)
ZA (1) ZA201001163B (enExample)

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AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
CN101801405A (zh) 2007-08-07 2010-08-11 先进科技及再生医学有限责任公司 包含于酸性水溶液中的gdf-5的蛋白质配方
JP5599778B2 (ja) 2008-04-14 2014-10-01 デピュイ・シンセス・プロダクツ・エルエルシー 液体緩衝ｇｄｆ−５製剤
US20090291114A1 (en) * 2008-04-14 2009-11-26 Adocia Osteogenic composition comprising a growth factor/amphiphilic polymer complex, a soluble cation salt and an organic support
EP2288371A1 (fr) * 2008-04-14 2011-03-02 Adocia Composition osteogenique comprenant un facteur de croissance un sel soluble de cation et un support organique
FR2934999B1 (fr) * 2008-08-13 2011-07-29 Adocia Polysaccharides fonctionnalises par des derives du tryptophane
BRPI0913684A2 (pt) * 2008-09-26 2015-10-20 Adocia complexo composto por um polissacarídeo substituído por um triptofano ou um derivado de triptofano a partir de uma proteína ligadora à heparina, composição farmacêutica e seus usos
FR2948573B1 (fr) * 2009-07-31 2011-11-18 Adocia Nouvelle forme d'administration de complexes de proteines osteogeniques
US8529933B2 (en) 2009-07-27 2013-09-10 Warsaw Orthopedic, Inc. Biphasic calcium phosphate cement for drug delivery
JP2011030455A (ja) * 2009-07-30 2011-02-17 Uha Mikakuto Co Ltd トリプトファン−ヒアルロン酸食品素材及びトリプトファン高含有ペプチド−ヒアルロン酸食品素材並びにそれらの製造方法
FR2952375A1 (fr) * 2009-11-10 2011-05-13 Adocia Polysaccharides comportant des groupes fonctionnels carboxyles substitues par esterification par un derive d'alcool hydrophobe
FR2956116A1 (fr) * 2010-02-09 2011-08-12 Adocia Complexes polysaccharide/bmp-7 solubles a ph physiologique
WO2011097342A1 (en) * 2010-02-04 2011-08-11 University Of Utah Research Foundation Hydrophobically-modified hyaluronan and methods of making and using thereof
WO2011098962A2 (fr) * 2010-02-09 2011-08-18 Adocia Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent
FR2958647B1 (fr) 2010-04-08 2013-08-23 Adocia Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent.
AU2011284657B2 (en) * 2010-07-30 2013-11-14 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
CN101942101A (zh) * 2010-09-02 2011-01-12 四川大学 含疏水烷基侧链的两亲性聚电解质接枝物制备方法
JP2012082180A (ja) * 2010-10-14 2012-04-26 Nagoya Univ 骨再生用自己組織化ペプチドハイドロゲル
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US9198971B2 (en) 2012-01-09 2015-12-01 Adocia Injectable solution at pH 7 comprising at least one basal insulin the pI of which is between 5.8 and 8.5 and a substituted co-polyamino acid
US9815912B2 (en) * 2012-03-19 2017-11-14 University Of Massachusetts Hydrophilic modification of water insoluble polysaccharide as surface-active agents
US20150314003A2 (en) 2012-08-09 2015-11-05 Adocia Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
EP2919804B1 (fr) 2012-11-13 2018-01-31 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
EA201590937A1 (ru) * 2012-11-13 2016-04-29 Адосиа Замещенные анионные соединения, имеющие скелет, образованный из небольшого числа сахаридных звеньев
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FR2919188A1 (fr) 2009-01-30
US20090048412A1 (en) 2009-02-19
MX2010001104A (es) 2010-04-01
KR20100051695A (ko) 2010-05-17
WO2009016131A1 (fr) 2009-02-05
US8389661B2 (en) 2013-03-05
EP2178565A1 (fr) 2010-04-28
RU2010107203A (ru) 2011-09-10
JP2010534708A (ja) 2010-11-11
BRPI0813025A2 (pt) 2017-08-08
CN101835493A (zh) 2010-09-15
ZA201001163B (en) 2010-10-27
CA2694600A1 (fr) 2009-02-05
AU2008281848A1 (en) 2009-02-05

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