FR2550533B1 - Procede pour la fabrication de derives de type penem - Google Patents

Procede pour la fabrication de derives de type penem

Info

Publication number
FR2550533B1
FR2550533B1 FR8412466A FR8412466A FR2550533B1 FR 2550533 B1 FR2550533 B1 FR 2550533B1 FR 8412466 A FR8412466 A FR 8412466A FR 8412466 A FR8412466 A FR 8412466A FR 2550533 B1 FR2550533 B1 FR 2550533B1
Authority
FR
France
Prior art keywords
penem
manufacture
type derivatives
derivatives
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8412466A
Other languages
English (en)
Other versions
FR2550533A1 (fr
Inventor
Carlo Battistini
Maurizio Foglio
Giovanni Franceschi
Cosimo Scarafile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2550533A1 publication Critical patent/FR2550533A1/fr
Application granted granted Critical
Publication of FR2550533B1 publication Critical patent/FR2550533B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/06—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8412466A 1983-08-11 1984-08-07 Procede pour la fabrication de derives de type penem Expired FR2550533B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838321677A GB8321677D0 (en) 1983-08-11 1983-08-11 Preparation of penems

Publications (2)

Publication Number Publication Date
FR2550533A1 FR2550533A1 (fr) 1985-02-15
FR2550533B1 true FR2550533B1 (fr) 1987-01-30

Family

ID=10547172

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8412466A Expired FR2550533B1 (fr) 1983-08-11 1984-08-07 Procede pour la fabrication de derives de type penem

Country Status (20)

Country Link
US (1) US4631150A (fr)
JP (1) JPS6058988A (fr)
KR (1) KR910002098B1 (fr)
AT (1) AT383808B (fr)
BE (1) BE900316A (fr)
CA (1) CA1279640C (fr)
CH (1) CH663024A5 (fr)
DE (1) DE3429102A1 (fr)
DK (1) DK167926B1 (fr)
ES (1) ES8600306A1 (fr)
FI (1) FI83521C (fr)
FR (1) FR2550533B1 (fr)
GB (2) GB8321677D0 (fr)
GR (1) GR80102B (fr)
HU (1) HU192415B (fr)
IL (1) IL72612A (fr)
IT (1) IT1209578B (fr)
NL (1) NL8402478A (fr)
PT (1) PT79065B (fr)
SE (1) SE463514B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416651D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
US5215997A (en) * 1985-09-11 1993-06-01 Ciba-Geigy Corporation Synthesis of beta-lactam compounds
DE3688960D1 (de) * 1985-09-11 1993-10-07 Ciba Geigy Synthese von Beta-Lactamverbindungen.
EP0232966B1 (fr) * 1986-01-17 1997-10-08 Beecham Group Plc Procédé de préparation de dérivés de pénème et intermédiaires pour cette préparation
EP0233155A1 (fr) * 1986-02-14 1987-08-19 Ciba-Geigy Ag Dérivés d'amino-acyloxyméthyle
US5215891A (en) * 1986-10-15 1993-06-01 Farmitalia Carlo Erba Process for preparing penems
EP0279781A3 (fr) * 1987-02-17 1989-07-26 Ciba-Geigy Ag Procédé pour la préparation de 4-acétoxy-3-hydroxyéthyl-azétidinone
US5312914A (en) * 1987-02-17 1994-05-17 Ciba-Geigy Corp Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
US5364768A (en) * 1987-07-07 1994-11-15 Farmitalia Carlo Erba S.R.L. Process for the preparation of penems
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
US5191075A (en) * 1988-10-19 1993-03-02 Pfizer Inc Process for the preparation of penems
US4992543A (en) * 1988-10-19 1991-02-12 Pfizer Inc. Penem derivatives
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
CA2001203C (fr) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Dithiocarbamoyl quinolones antimicrobiens
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
EP0997466A1 (fr) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Lactam-quinolones antimicrobiennes
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5198544A (en) * 1989-04-29 1993-03-30 Hoechst Aktiengesellschaft Process for the preparation of penem compounds
EP0399228A1 (fr) * 1989-04-29 1990-11-28 Hoechst Aktiengesellschaft Procédé de préparation de dérivés de pénème
JPH05506033A (ja) * 1990-04-18 1993-09-02 ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド 抗微生物性キノロニルラクタム類
US5399679A (en) * 1992-06-16 1995-03-21 Farmitalia Carlo Erba S.R.L. (1'R,3S,4R)4-acylthio azetidinones
EP0597401A3 (fr) * 1992-11-11 1995-07-26 Takeda Chemical Industries Ltd Préparation de pénèmes.
IT1286558B1 (it) * 1996-02-27 1998-07-15 Menarini Farma Ind Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
CN100417654C (zh) * 2004-01-09 2008-09-10 中国医学科学院医药生物技术研究所 2-苯羧酸酯青霉烯类化合物及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500457A (en) * 1977-05-09 1985-02-19 Ciba-Geigy Corporation Process for preparing thia-aza compounds with a beta-lactam ring
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (fr) * 1978-02-02 1986-01-08 Ciba-Geigy Ag Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation
EP0013067A1 (fr) * 1978-12-22 1980-07-09 Beecham Group Plc Agents antibactériens à cycle bêta-lactame bicyclique, leur utilisation dans des compositions pharmaceutiques, procédés pour leur préparation et intermédiaires à utiliser dans de tels procédés
AT368506B (de) * 1979-02-24 1982-10-25 Erba Farmitalia Verfahren zur herstellung von neuen penemcarbonsaeuren und deren salzen
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4395418A (en) * 1980-06-06 1983-07-26 Sankyo Company Limited Penem-3-carboxylic acid derivatives
GB2079744A (en) * 1980-07-04 1982-01-27 Erba Farmitalia 6-Alkyl-2-functionalized penems
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
US4411906A (en) * 1981-11-25 1983-10-25 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
NL8204720A (nl) * 1981-12-11 1983-07-01 Erba Farmitalia Werkwijze voor het bereiden van optisch actieve penemverbindingen.
US4443373A (en) * 1982-03-30 1984-04-17 Schering Corporation Process for the production of antibiotic penems
US4584133A (en) * 1983-11-07 1986-04-22 Schering Corporation Process for the production of penems

Also Published As

Publication number Publication date
DK382084A (da) 1985-02-12
JPS6058988A (ja) 1985-04-05
IT1209578B (it) 1989-08-30
GB8420236D0 (en) 1984-09-12
IT8422234A0 (it) 1984-08-06
ES534892A0 (es) 1985-09-16
HUT34984A (en) 1985-05-28
PT79065A (en) 1984-09-01
GB2144743B (en) 1987-01-28
HU192415B (en) 1987-06-29
JPH037675B2 (fr) 1991-02-04
IL72612A0 (en) 1984-11-30
GB2144743A (en) 1985-03-13
KR910002098B1 (ko) 1991-04-03
GR80102B (en) 1984-12-14
FI83521C (fi) 1991-07-25
FI843111A (fi) 1985-02-12
AT383808B (de) 1987-08-25
SE8404004D0 (sv) 1984-08-07
US4631150A (en) 1986-12-23
FR2550533A1 (fr) 1985-02-15
DK167926B1 (da) 1994-01-03
SE463514B (sv) 1990-12-03
SE8404004L (sv) 1985-02-12
FI843111A0 (fi) 1984-08-08
NL8402478A (nl) 1985-03-01
IL72612A (en) 1988-06-30
ES8600306A1 (es) 1985-09-16
FI83521B (fi) 1991-04-15
DE3429102A1 (de) 1985-02-28
CH663024A5 (de) 1987-11-13
DK382084D0 (da) 1984-08-08
CA1279640C (fr) 1991-01-29
PT79065B (en) 1986-11-14
KR850001757A (ko) 1985-04-01
GB8321677D0 (en) 1983-09-14
ATA255884A (de) 1987-01-15
BE900316A (fr) 1985-02-08

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse
RC Opposition against decision of lapse
DA Annulment of decision of lapse
ST Notification of lapse