FR2497807A1 - Nouveaux derives steroides substitues en 11b, leur proc ede de preparation et leur application comme medicament - Google Patents

Nouveaux derives steroides substitues en 11b, leur proc ede de preparation et leur application comme medicament Download PDF

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Publication number
FR2497807A1
FR2497807A1 FR8100272A FR8100272A FR2497807A1 FR 2497807 A1 FR2497807 A1 FR 2497807A1 FR 8100272 A FR8100272 A FR 8100272A FR 8100272 A FR8100272 A FR 8100272A FR 2497807 A1 FR2497807 A1 FR 2497807A1
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FR
France
Prior art keywords
radical
formula
carbon atoms
group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8100272A
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English (en)
French (fr)
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FR2497807B1 (US07754267-20100713-C00017.png
Inventor
Jean Georges Teutsch
Germain Costerousse
Daniel Philibert
Roger Deraedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ZA8231A priority Critical patent/ZA8231B/xx
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8100272A priority patent/FR2497807A1/fr
Priority to HU813808A priority patent/HU185158B/hu
Priority to FI820042A priority patent/FI77872C/fi
Priority to JP57000638A priority patent/JPS57168000A/ja
Priority to EP83201391A priority patent/EP0110434B1/fr
Priority to ES508588A priority patent/ES8305786A1/es
Priority to DE8383201391T priority patent/DE3273985D1/de
Priority to DK004082A priority patent/DK166680B1/da
Priority to EP82400025A priority patent/EP0057115B1/fr
Priority to US06/338,077 priority patent/US4386085A/en
Priority to PT74263A priority patent/PT74263A/pt
Priority to AU79296/82A priority patent/AU550334B2/en
Priority to DE1999175073 priority patent/DE19975073I2/de
Priority to DE8282400025T priority patent/DE3262580D1/de
Priority to AT83201391T priority patent/ATE23167T1/de
Priority to AT82400025T priority patent/ATE12239T1/de
Priority to SU823378150A priority patent/SU1447289A3/ru
Priority to CA000393808A priority patent/CA1193246A/fr
Priority to IE44/82A priority patent/IE52595B1/en
Priority to IL6568082A priority patent/IL65680A/xx
Priority to US06/386,967 priority patent/US4447424A/en
Priority to KR8202614A priority patent/KR870001936B1/ko
Publication of FR2497807A1 publication Critical patent/FR2497807A1/fr
Priority to ES517764A priority patent/ES517764A0/es
Application granted granted Critical
Publication of FR2497807B1 publication Critical patent/FR2497807B1/fr
Priority to US06/614,440 priority patent/US4519946A/en
Priority to CA000468274A priority patent/CA1199907A/fr
Priority to US06/693,682 priority patent/US4634695A/en
Priority to AU51236/85A priority patent/AU579211B2/en
Priority to US06/810,316 priority patent/US4978657A/en
Priority to SG459/87A priority patent/SG45987G/en
Priority to FR8718376A priority patent/FR2625505B2/fr
Priority to JP1066488A priority patent/JPH01279897A/ja
Priority to US07/421,526 priority patent/US5043332A/en
Priority to GEAP19931370A priority patent/GEP19960479B/en
Priority to LTRP982A priority patent/LT2618B/xx
Priority to BG098505A priority patent/BG60768B2/bg
Priority to MD94-0265A priority patent/MD207C2/ro
Priority to NL300001C priority patent/NL300001I2/nl
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8100272A 1981-01-09 1981-01-09 Nouveaux derives steroides substitues en 11b, leur proc ede de preparation et leur application comme medicament Granted FR2497807A1 (fr)

Priority Applications (38)

Application Number Priority Date Filing Date Title
ZA8231A ZA8231B (en) 1981-01-09 1981-01-05 New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR8100272A FR2497807A1 (fr) 1981-01-09 1981-01-09 Nouveaux derives steroides substitues en 11b, leur proc ede de preparation et leur application comme medicament
HU813808A HU185158B (en) 1981-01-09 1981-12-17 Process for the preparation of beta-substituted steroide derivatives
JP57000638A JPS57168000A (en) 1981-01-09 1982-01-07 Novel 11 beta position substituted steroid derivatives, manufacture, intermediates, use thereof and composition
FI820042A FI77872C (fi) 1981-01-09 1982-01-07 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara i 11 -staellning substituerade steroidderivat.
DE8282400025T DE3262580D1 (en) 1981-01-09 1982-01-08 Steroid derivatives substituted in the 11-beta position, process for their preparation, their utilization as medicaments and compositions containing them
DE8383201391T DE3273985D1 (en) 1981-01-09 1982-01-08 Steroid intermediates substituted at position 11, and process for their preparation
DK004082A DK166680B1 (da) 1981-01-09 1982-01-08 Analogifremgangsmaade til fremstilling af 11beta-substituerede 4-umaettede steroider samt forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden
EP82400025A EP0057115B1 (fr) 1981-01-09 1982-01-08 Nouveaux dérivés stéroides substitués en 11beta, procédé de préparation, leur application comme médicament et les compositions les renfermant
US06/338,077 US4386085A (en) 1981-01-09 1982-01-08 Novel steroids
PT74263A PT74263A (fr) 1981-01-09 1982-01-08 Procede de preparation de nouveaux derives steroides substitues en 11-beta
AU79296/82A AU550334B2 (en) 1981-01-09 1982-01-08 1.-nor steroid derivatives substituted at 11beta position
DE1999175073 DE19975073I2 (de) 1981-01-09 1982-01-08 In Stellung 11-beta substituierte Steroidderivate,Verfahren zu ihrer Herstellung, ihre Anwendung als Arzneimittel und Zusammensetzungen, die sie enthalten.
ES508588A ES8305786A1 (es) 1981-01-09 1982-01-08 "procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b".
AT83201391T ATE23167T1 (de) 1981-01-09 1982-01-08 In stellung 11 substituierte steroidzwischenprodukte und verfahren zu ihrer herstellung.
AT82400025T ATE12239T1 (de) 1981-01-09 1982-01-08 In stellung 11-beta substituierte steroidderivate, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und zusammensetzungen, die sie enthalten.
SU823378150A SU1447289A3 (ru) 1981-01-09 1982-01-08 Способ получени производных стероидов
CA000393808A CA1193246A (fr) 1981-01-09 1982-01-08 PROCEDE DE PREPARATION DE NOUVEAUX DERIVES STEROIDES SUBSTITUES EN 11 .beta.
EP83201391A EP0110434B1 (fr) 1981-01-09 1982-01-08 Nouveaux produits intermédiaires stéroides substitués en 11-beta et procédé de préparation de ces produits
IE44/82A IE52595B1 (en) 1981-01-09 1982-01-11 New steroid derivatives substituted at position 11beta,process and intermediates for preparing them,their use as medicaments and the compositions containing them
IL6568082A IL65680A (en) 1981-01-09 1982-05-04 11beta substituted steroids,process for preparing them,medicaments and compositions containing them
US06/386,967 US4447424A (en) 1981-01-09 1982-06-10 Steroid derivatives
KR8202614A KR870001936B1 (ko) 1981-01-09 1982-06-11 새로운 스테로이드 유도 체의 제조방법
ES517764A ES517764A0 (es) 1981-01-09 1982-11-29 Procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b.
US06/614,440 US4519946A (en) 1981-01-09 1984-05-25 Steroids
CA000468274A CA1199907A (fr) 1981-01-09 1984-11-20 PROCEDE POUR LA PREPARATION DE DERIVES DE STEROIDES HYDROXYLES EN 5.alpha., ET LES DERIVES AINSI OBTENUS
US06/693,682 US4634695A (en) 1981-01-09 1985-01-22 Steroid derivatives
AU51236/85A AU579211B2 (en) 1981-01-09 1985-12-12 Intermediate steroid products substituted at position 11 ` and processes for preparing them
US06/810,316 US4978657A (en) 1981-01-09 1985-12-17 Novel 11β-substituted-19-nor-steroids
SG459/87A SG45987G (en) 1981-01-09 1987-05-21 Steroid derivatives substituted in the 11-beta position, process for their preparation, their utilization as medicaments and compositions containing them
FR8718376A FR2625505B2 (fr) 1981-01-09 1987-12-30 Nouveaux derives steroides substitues en 11beta leur procede de preparation et leur application comme medicaments et les compositions pharmaceutiques les renfermant
JP1066488A JPH01279897A (ja) 1981-01-09 1989-03-20 新規な１１β位置換ステロイド誘導体の製造中間体
US07/421,526 US5043332A (en) 1981-01-09 1989-10-13 Novel 11β-substituted -19-nor-steriods
GEAP19931370A GEP19960479B (en) 1981-01-09 1993-07-31 Method of producing derivatives of steroids
LTRP982A LT2618B (lt) 1981-01-09 1993-09-16 Steroidu dariniu gavimo budas
BG098505A BG60768B2 (bg) 1981-01-09 1994-02-22 Производни на заместени стероиди в 11 бета,метод за получаването им,приложението им като лекарствени средства и състави,които ги съдържат
MD94-0265A MD207C2 (ro) 1981-01-09 1994-08-08 Procedeu de obţinere a derivaţilor steroizilor
NL300001C NL300001I2 (nl) 1981-01-09 2000-02-01 Nieuw, op de 11beta-plaats gesubstitueerde steroidederivaten, werkwijze voor de bereiding, hun toepassing als geneesmiddel en preparaten waarin ze zijn verwerkt.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8100272A FR2497807A1 (fr) 1981-01-09 1981-01-09 Nouveaux derives steroides substitues en 11b, leur proc ede de preparation et leur application comme medicament

Publications (2)

Publication Number Publication Date
FR2497807A1 true FR2497807A1 (fr) 1982-07-16
FR2497807B1 FR2497807B1 (US07754267-20100713-C00017.png) 1983-07-29

Family

ID=9253984

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8100272A Granted FR2497807A1 (fr) 1981-01-09 1981-01-09 Nouveaux derives steroides substitues en 11b, leur proc ede de preparation et leur application comme medicament

Country Status (22)

Country Link
US (4) US4386085A (US07754267-20100713-C00017.png)
EP (1) EP0057115B1 (US07754267-20100713-C00017.png)
JP (2) JPS57168000A (US07754267-20100713-C00017.png)
KR (1) KR870001936B1 (US07754267-20100713-C00017.png)
AU (2) AU550334B2 (US07754267-20100713-C00017.png)
BG (1) BG60768B2 (US07754267-20100713-C00017.png)
CA (1) CA1193246A (US07754267-20100713-C00017.png)
DE (2) DE3262580D1 (US07754267-20100713-C00017.png)
DK (1) DK166680B1 (US07754267-20100713-C00017.png)
ES (2) ES8305786A1 (US07754267-20100713-C00017.png)
FI (1) FI77872C (US07754267-20100713-C00017.png)
FR (1) FR2497807A1 (US07754267-20100713-C00017.png)
GE (1) GEP19960479B (US07754267-20100713-C00017.png)
HU (1) HU185158B (US07754267-20100713-C00017.png)
IE (1) IE52595B1 (US07754267-20100713-C00017.png)
LT (1) LT2618B (US07754267-20100713-C00017.png)
MD (1) MD207C2 (US07754267-20100713-C00017.png)
NL (1) NL300001I2 (US07754267-20100713-C00017.png)
PT (1) PT74263A (US07754267-20100713-C00017.png)
SG (1) SG45987G (US07754267-20100713-C00017.png)
SU (1) SU1447289A3 (US07754267-20100713-C00017.png)
ZA (1) ZA8231B (US07754267-20100713-C00017.png)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3231828A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 17(alpha)-alkinyl-3,3-alkylendioxy-5(alpha),10(alpha)-epoxy-9(11)-estren-17(beta)-ol-derivate, verfahren zu deren herstellung und deren verwendung zur weiterverarbeitung
FR2549067A1 (fr) * 1983-06-14 1985-01-18 Roussel Uclaf Derives estradieniques radioactifs marques au tritium, leur procede de preparation et leur application pour l'etude et le dosage radio-immunologique de steroides dans les fluides biologiques
FR2582654A1 (fr) * 1985-05-31 1986-12-05 Erba Farmitalia Steroides 11b-substitues utiles notamment dans le traitement des tumeurs hormono-dependantes et procede pour la fabrication

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
US4978657A (en) * 1981-01-09 1990-12-18 Roussel Uclaf Novel 11β-substituted-19-nor-steroids
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
DE3231827A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
EP0116974B1 (de) * 1983-02-18 1986-10-29 Schering Aktiengesellschaft 11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE3306121A1 (de) * 1983-02-18 1984-09-06 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-spirolaktone in der steroidreihe, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische praeparate
IL68222A (en) * 1983-03-24 1987-02-27 Yeda Res & Dev Contraceptive compositions comprising a progesterone antagonist and a blocker of progesterone activity
DE3320580A1 (de) * 1983-06-03 1984-12-06 Schering AG, 1000 Berlin und 4709 Bergkamen D-homo-4,9,16-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
NO162241C (no) * 1983-06-14 1989-11-29 Roussel Uclaf Nye, radioaktive estradienderivater merket med jod125, fremgangsmaate ved deres fremstilling og deres anvendelse vedradioimmunologisk undersoekelse og mengdebestemmelse av steroider i biologiske vaesker.
FR2548192B1 (fr) * 1983-06-20 1985-11-22 Roussel Uclaf Derives estradieniques radioactifs marques a l'iode, leur procede de preparation et leur application aux dosages radioimmunologiques
ES533260A0 (es) * 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos
DE3446661A1 (de) * 1984-12-18 1986-06-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 13(alpha)-alkyl-17(beta)-(3-acyloxypropyl)-gonane
IT1212835B (it) * 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
DE3337450A1 (de) * 1983-10-12 1985-04-25 Schering AG, 1000 Berlin und 4709 Bergkamen Prostaglandine und antigestagene fuer den schwangerschaftsabbruch
AU572589B2 (en) 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2566779B2 (fr) * 1984-06-29 1987-03-06 Roussel Uclaf Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments
US5116830A (en) * 1984-08-17 1992-05-26 Sri International Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses
DE3438500C1 (de) * 1984-10-18 1986-05-28 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung 11ß-substituierter Δ↑9↑-19-Norsteroide
FR2573657B1 (fr) * 1984-11-29 1989-05-12 Roussel Uclaf Produit comprenant une substance antiprogestomimetique et une substance uterotonique
DE3504421A1 (de) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
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JPH0466879B2 (US07754267-20100713-C00017.png) 1992-10-26
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DE19975073I1 (de) 2000-03-09
DE3262580D1 (en) 1985-04-25
EP0057115A3 (en) 1982-09-29
ZA8231B (en) 1982-11-24
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HU185158B (en) 1984-12-28
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AU7929682A (en) 1982-07-15
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US4634695A (en) 1987-01-06
LT2618B (lt) 1994-04-25
KR870001936B1 (ko) 1987-10-22
ES8401498A1 (es) 1983-12-01
AU5123685A (en) 1986-04-17
SG45987G (en) 1987-11-13
US4519946A (en) 1985-05-28
NL300001I1 (nl) 2000-04-03
JPH01279897A (ja) 1989-11-10
DE19975073I2 (de) 2004-01-08
ES517764A0 (es) 1983-12-01
US4447424A (en) 1984-05-08
MD207C2 (ro) 1995-12-31

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