ES8305786A1 - "procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b". - Google Patents

"procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b".

Info

Publication number
ES8305786A1
ES8305786A1 ES508588A ES508588A ES8305786A1 ES 8305786 A1 ES8305786 A1 ES 8305786A1 ES 508588 A ES508588 A ES 508588A ES 508588 A ES508588 A ES 508588A ES 8305786 A1 ES8305786 A1 ES 8305786A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
preparation
medicaments
utilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508588A
Other languages
English (en)
Other versions
ES508588A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES508588A0 publication Critical patent/ES508588A0/es
Publication of ES8305786A1 publication Critical patent/ES8305786A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS ESTEROIDES SUSTITUIDOS EN 11~J, DE FORMULA GENERAL (I), EN LA QUE R REPRESENTA UN RADICAL ORGANICO CON 1 A 18 ATOMOS DE CARBONO; R REPRESENTA UN RADICAL HIDROCARBURADO CON 1 A 8 ATOMOS DE CARBONO; X REPRESENTA EL RESTO DE UN ANILLO PENTAGONAL O EXAGONAL SUSTITUIDO; EL GRUPO C=A EN POSICION 3 REPRESENTA UN GRUPO OXO; Y B Y C FORMAN JUNTOS UN DOBLE ENLACE, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER UN COMPUESTO DE FORMULA (II), EN LA QUE K REPRESENTA UN GRUPO CETONICO BLOQUEADO EN FORMA DE CETAL, DE DIOCETAL O DE METILOXIMA; Y R , R Y X TIENEN LOS SIGNIFICADOS YA INDICADOS, A LA ACCION DE UN AGENTE DE DESHIDRATACION, SUSCEPTIBLE DE LIBERAR LA FUNCION CETONA. DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANTIGLUCOCORTICOIDE.
ES508588A 1981-01-09 1982-01-08 "procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b". Expired ES8305786A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8100272A FR2497807A1 (fr) 1981-01-09 1981-01-09 Nouveaux derives steroides substitues en 11b, leur proc ede de preparation et leur application comme medicament

Publications (2)

Publication Number Publication Date
ES508588A0 ES508588A0 (es) 1983-04-16
ES8305786A1 true ES8305786A1 (es) 1983-04-16

Family

ID=9253984

Family Applications (2)

Application Number Title Priority Date Filing Date
ES508588A Expired ES8305786A1 (es) 1981-01-09 1982-01-08 "procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b".
ES517764A Expired ES8401498A1 (es) 1981-01-09 1982-11-29 Procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES517764A Expired ES8401498A1 (es) 1981-01-09 1982-11-29 Procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b.

Country Status (22)

Country Link
US (4) US4386085A (es)
EP (1) EP0057115B1 (es)
JP (2) JPS57168000A (es)
KR (1) KR870001936B1 (es)
AU (2) AU550334B2 (es)
BG (1) BG60768B2 (es)
CA (1) CA1193246A (es)
DE (2) DE19975073I2 (es)
DK (1) DK166680B1 (es)
ES (2) ES8305786A1 (es)
FI (1) FI77872C (es)
FR (1) FR2497807A1 (es)
GE (1) GEP19960479B (es)
HU (1) HU185158B (es)
IE (1) IE52595B1 (es)
LT (1) LT2618B (es)
MD (1) MD207C2 (es)
NL (1) NL300001I2 (es)
PT (1) PT74263A (es)
SG (1) SG45987G (es)
SU (1) SU1447289A3 (es)
ZA (1) ZA8231B (es)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978657A (en) * 1981-01-09 1990-12-18 Roussel Uclaf Novel 11β-substituted-19-nor-steroids
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2528434B1 (fr) 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
DE3231827A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3231828A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 17(alpha)-alkinyl-3,3-alkylendioxy-5(alpha),10(alpha)-epoxy-9(11)-estren-17(beta)-ol-derivate, verfahren zu deren herstellung und deren verwendung zur weiterverarbeitung
DE3306121A1 (de) * 1983-02-18 1984-09-06 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-spirolaktone in der steroidreihe, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische praeparate
DE3461090D1 (en) * 1983-02-18 1986-12-04 Schering Ag 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
IL68222A (en) * 1983-03-24 1987-02-27 Yeda Res & Dev Contraceptive compositions comprising a progesterone antagonist and a blocker of progesterone activity
DE3320580A1 (de) * 1983-06-03 1984-12-06 Schering AG, 1000 Berlin und 4709 Bergkamen D-homo-4,9,16-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2549067B1 (fr) * 1983-06-14 1985-12-27 Roussel Uclaf Derives estradieniques radioactifs marques au tritium, leur procede de preparation et leur application pour l'etude et le dosage radio-immunologique de steroides dans les fluides biologiques
FR2548192B1 (fr) * 1983-06-20 1985-11-22 Roussel Uclaf Derives estradieniques radioactifs marques a l'iode, leur procede de preparation et leur application aux dosages radioimmunologiques
NO162241C (no) * 1983-06-14 1989-11-29 Roussel Uclaf Nye, radioaktive estradienderivater merket med jod125, fremgangsmaate ved deres fremstilling og deres anvendelse vedradioimmunologisk undersoekelse og mengdebestemmelse av steroider i biologiske vaesker.
DE3446661A1 (de) * 1984-12-18 1986-06-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 13(alpha)-alkyl-17(beta)-(3-acyloxypropyl)-gonane
ES533260A0 (es) * 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos
IT1212835B (it) * 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
DE3337450A1 (de) * 1983-10-12 1985-04-25 Schering AG, 1000 Berlin und 4709 Bergkamen Prostaglandine und antigestagene fuer den schwangerschaftsabbruch
AU572589B2 (en) 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2566779B2 (fr) * 1984-06-29 1987-03-06 Roussel Uclaf Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments
US5116830A (en) * 1984-08-17 1992-05-26 Sri International Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses
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FR2573657B1 (fr) * 1984-11-29 1989-05-12 Roussel Uclaf Produit comprenant une substance antiprogestomimetique et une substance uterotonique
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FR2598421B1 (fr) * 1986-05-06 1988-08-19 Roussel Uclaf Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
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DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
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DE3917274A1 (de) * 1989-05-24 1990-11-29 Schering Ag 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
US5276023A (en) * 1989-08-08 1994-01-04 Roussel Uclaf 19-nor-steroid esters
FR2651435A1 (fr) * 1989-09-07 1991-03-08 Roussel Uclaf Nouvelle utilisation de composes anti-progestomimetiques.
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
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PT74263A (fr) 1982-02-01
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IE52595B1 (en) 1987-12-23
KR870001936B1 (ko) 1987-10-22
JPH0466879B2 (es) 1992-10-26
JPH0234958B2 (es) 1990-08-07
US4447424A (en) 1984-05-08
DE19975073I1 (de) 2000-03-09
EP0057115B1 (fr) 1985-03-20
GEP19960479B (en) 1996-07-22
FR2497807B1 (es) 1983-07-29
US4634695A (en) 1987-01-06
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ZA8231B (en) 1982-11-24
EP0057115A2 (fr) 1982-08-04
SU1447289A3 (ru) 1988-12-23
MD207B1 (ro) 1995-05-31
DK4082A (da) 1982-07-10
ES517764A0 (es) 1983-12-01
ES8401498A1 (es) 1983-12-01
FI820042L (fi) 1982-07-10
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CA1193246A (fr) 1985-09-10
FR2497807A1 (fr) 1982-07-16
EP0057115A3 (en) 1982-09-29
AU550334B2 (en) 1986-03-20
MD207C2 (ro) 1995-12-31
US4386085A (en) 1983-05-31
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US4519946A (en) 1985-05-28
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