FR2434201A1 - Procede et necessaire de determination et de dosage immunologique d'une substance par creation d'un micro-environnement concentre - Google Patents

Procede et necessaire de determination et de dosage immunologique d'une substance par creation d'un micro-environnement concentre

Info

Publication number
FR2434201A1
FR2434201A1 FR7908533A FR7908533A FR2434201A1 FR 2434201 A1 FR2434201 A1 FR 2434201A1 FR 7908533 A FR7908533 A FR 7908533A FR 7908533 A FR7908533 A FR 7908533A FR 2434201 A1 FR2434201 A1 FR 2434201A1
Authority
FR
France
Prior art keywords
ligand
substance
assay
creating
environment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7908533A
Other languages
English (en)
Other versions
FR2434201B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syva Co
Original Assignee
Syva Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syva Co filed Critical Syva Co
Publication of FR2434201A1 publication Critical patent/FR2434201A1/fr
Application granted granted Critical
Publication of FR2434201B1 publication Critical patent/FR2434201B1/fr
Expired legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/968High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé et des compositions pour l'analyse chimique, dans des conditions ménagees, d'une substance dans un milieu aqueux. On utilise comme réactifs : 1 un conjugué de ligand ou d'anti-ligand avec une entité chimique permettant de changer chimiquement la concentration d'un composé agissant comme médiateur de signal; 2 un précurseur du médiateur de signal; et 3 un conjugué de ligand ou d'anti-ligand et d'un constituant d'un systeme de production de signal (système dont le médiateur fait aussi partie). Le procédé utilise notamment des enzymes. Application : diagnostic d'un état de santé ou étude de processus physiologiques.
FR7908533A 1978-04-05 1979-04-04 Procede et necessaire de determination et de dosage immunologique d'une substance par creation d'un micro-environnement concentre Expired FR2434201B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/893,650 US4233402A (en) 1978-04-05 1978-04-05 Reagents and method employing channeling

Publications (2)

Publication Number Publication Date
FR2434201A1 true FR2434201A1 (fr) 1980-03-21
FR2434201B1 FR2434201B1 (fr) 1985-12-20

Family

ID=25401860

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7908533A Expired FR2434201B1 (fr) 1978-04-05 1979-04-04 Procede et necessaire de determination et de dosage immunologique d'une substance par creation d'un micro-environnement concentre

Country Status (6)

Country Link
US (1) US4233402A (fr)
JP (1) JPS54136896A (fr)
CA (1) CA1110541A (fr)
DE (1) DE2913550A1 (fr)
FR (1) FR2434201B1 (fr)
GB (1) GB2018986B (fr)

Families Citing this family (280)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2747794A1 (de) * 1977-10-25 1979-05-03 Bosch Gmbh Robert Anzeigeeinheit
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4287300A (en) * 1979-07-26 1981-09-01 Syva Company Charge effects in enzyme immunoassays
IT1123573B (it) * 1979-09-10 1986-04-30 Anic Spa Composizione adatta al controllo di tessuti e/o liquidi biiologici e metodo impiegante la stessa
US4446231A (en) * 1979-10-03 1984-05-01 Self Colin H Immunoassay using an amplified cyclic detection system
GB2059421A (en) * 1979-10-03 1981-04-23 Self C H Assay method and reagents therefor
US4391904A (en) * 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
JPS5737261A (en) * 1980-08-15 1982-03-01 Otsuka Pharmaceut Co Ltd Measuring method of physiological active substance
US4404278A (en) * 1980-11-24 1983-09-13 Syva Company Methods and compositions for assaying for the production of 1,4-dihydropyridyl
US4378428A (en) * 1981-03-30 1983-03-29 Baker Instruments Corporation Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays
FR2503870A1 (fr) * 1981-04-10 1982-10-15 Fella Christian Procede de detection de la presence d'antigenes pneumocoque xiv dans un prelevement de cellules humaines, et produits pour mettre en oeuvre ce procede
US4442218A (en) * 1981-05-27 1984-04-10 Corning Glass Works Method of measuring degree of partitioning
JPS585659A (ja) * 1981-06-24 1983-01-13 ハイブリテツク インコ−ポレ−テツド 単クロ−ン性抗体を使用する免疫学的、抑制試験
CA1185177A (fr) * 1981-07-17 1985-04-09 Larry E. Morrison Technique immunochimique basee sur le transfert d'energie non rayonnante
CA1209889A (fr) * 1981-09-18 1986-08-19 Litai Weng Essai homogene sur une surface non poreuse
US4629690A (en) * 1981-09-18 1986-12-16 Syntex (U.S.A.) Inc. Homogeneous enzyme specific binding assay on non-porous surface
US4463090A (en) * 1981-09-30 1984-07-31 Harris Curtis C Cascade amplification enzyme immunoassay
US4562148A (en) * 1981-11-06 1985-12-31 Miles Laboratories, Inc. Analytical element and method for preventing reagent migration
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
EP0091837B1 (fr) * 1982-04-14 1989-07-26 Radiometer Corporate Development Limited Procédés et appareil d'essai microbiologique
US4663278A (en) * 1982-04-30 1987-05-05 Syva Company Agglutination dependent enzyme channeling immunoassay
US4435504A (en) * 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US4614712A (en) * 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
US4687735A (en) * 1983-03-14 1987-08-18 Syntex (U.S.A.) Inc. Enzymatic poly-reactant channeling binding assay
US4536479A (en) * 1983-03-22 1985-08-20 E. I. Du Pont De Nemours And Company Use of anti-idiotype antibodies in immunoassays
US4550075A (en) * 1983-06-22 1985-10-29 Kallestad Laboratories, Inc. Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
USRE34405E (en) * 1983-08-01 1993-10-12 Abbott Laboratories Determination of analytes in particle-containing medium
JPS6071958A (ja) * 1983-09-28 1985-04-23 Akio Tsuji 酵素免疫測定法
ZA849594B (en) * 1983-12-12 1985-08-28 Miles Lab Nucleic acid hybridization assay employing antibodies to intercalation complexes
EP0152254A3 (fr) * 1984-02-06 1986-08-06 E.I. Du Pont De Nemours And Company Immunoessai à base d'un support chromogénique utilisant des composants complémentaires marqués
US4645828A (en) 1984-03-23 1987-02-24 Oncogen Platelet related growth regulator
JPH0617909B2 (ja) * 1984-04-23 1994-03-09 ボストン バイオメディカル リサーチ インスティテュート,インコーポレイテッド 双特異性抗体決定子
AU560779B2 (en) * 1985-01-24 1987-04-16 Quidel Assay for drugs of abuse
IE64785B1 (en) 1985-04-08 1995-09-06 Genetic Systems Corp Expression of immunologically reactive viral proteins
CA1259374A (fr) * 1985-11-19 1989-09-12 Arnold L. Newman Capteur capacitif pour les analyses et les mesures chimiques
JPH0799369B2 (ja) * 1985-11-25 1995-10-25 日本ケミカルリサーチ株式会社 上皮細胞増殖因子の酵素免疫測定法
US5190864A (en) * 1986-04-15 1993-03-02 Northeastern University Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
US4937188A (en) * 1986-04-15 1990-06-26 Northeastern University Enzyme activity amplification method for increasing assay sensitivity
US4777128A (en) * 1986-05-27 1988-10-11 Ethigen Corporation Fluorescence immunoassay involving energy transfer between two fluorophores
US4888276A (en) * 1986-06-26 1989-12-19 Minnesota Mining And Manufacturing Company Method and composition for the diagnosis of Lyme disease
US4835099A (en) * 1986-11-20 1989-05-30 Becton, Dickinson And Company Signal enhancement in immunoassay by modulation of enzymatic catalysis
US5494793A (en) * 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
US5346670A (en) * 1986-12-24 1994-09-13 British Technology Group U.S.A. Inc. Phthalocyanine and tetrabenztriazaporphyrin reagents
US5082627A (en) * 1987-05-01 1992-01-21 Biotronic Systems Corporation Three dimensional binding site array for interfering with an electrical field
EP0310361A3 (fr) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Conjugat tridenté et méthode de sa mise en oeuvre
US4859612A (en) * 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
US5256372A (en) * 1987-11-06 1993-10-26 Idexx Corporation Dipstick test device including a removable filter assembly
US5202267A (en) * 1988-04-04 1993-04-13 Hygeia Sciences, Inc. Sol capture immunoassay kit and procedure
US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
US5137804A (en) * 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
US5334513A (en) * 1988-05-17 1994-08-02 Syntex (U.S.A.) Inc. Method for immunochromatographic analysis
US5039607A (en) * 1988-05-17 1991-08-13 Syntex (U.S.A.) Inc. Method for immunochromatographic analysis
US5939272A (en) * 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5028535A (en) * 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5196306A (en) * 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
US5532138A (en) * 1990-04-26 1996-07-02 Behringwerke Ag Method and kits for determining peroxidatively active catalysts
WO1992005282A1 (fr) * 1990-09-14 1992-04-02 Biosite Diagnostics, Inc. Anticorps contre des complexes de recepteurs de ligand et des ligands ainsi que leur utilite dans des dosages ligands-recepteurs
US5143852A (en) * 1990-09-14 1992-09-01 Biosite Diagnostics, Inc. Antibodies to ligand analogues and their utility in ligand-receptor assays
DE4103167A1 (de) * 1991-02-02 1992-08-06 Boehringer Mannheim Gmbh Diphenylmethanderivate, verfahren zu deren herstellung und ihre verwendung zur verdraengung von jodthyroninen von diesen bindenden proteinen
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5998220A (en) * 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US5877028A (en) * 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
CA2074752A1 (fr) 1991-07-29 1993-01-30 Tadakazu Yamauchi Procede et instrument de dosage par fixation d'une substance specifique
EP0806482A3 (fr) * 1992-03-17 1998-01-28 Unitika Ltd. Méthode pour l'analyse enzymatique et réactif pour cette méthode
US5332662A (en) * 1992-07-31 1994-07-26 Syntex (U.S.A.) Inc. Methods for determining peroxidatively active substances
DK0653066T3 (da) * 1992-07-31 1998-09-23 Dade Behring Marburg Gmbh Fotoaktiverbare kemiluminescerende matricer
US5354692A (en) * 1992-09-08 1994-10-11 Pacific Biotech, Inc. Analyte detection device including a hydrophobic barrier for improved fluid flow
US6953573B1 (en) 1993-03-17 2005-10-11 University Of Washington Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated
US5801005A (en) * 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US5869445A (en) * 1993-03-17 1999-02-09 University Of Washington Methods for eliciting or enhancing reactivity to HER-2/neu protein
AU679008B2 (en) * 1993-05-06 1997-06-19 Chiron Diagnostics Corporation Mixed luminescent conjugate test assays
JP3498960B2 (ja) * 1993-09-03 2004-02-23 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 蛍光酸素チャンネリングイムノアッセイ
US7635597B2 (en) 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
US6942862B2 (en) * 1996-04-01 2005-09-13 University Of Washington Methods and compositions to generate immunity in humans against self tumor antigens by immunization with homologous foreign proteins
DE69736382T2 (de) * 1996-05-01 2007-08-09 Dade Behring Marburg Gmbh Chemilumineszente zusammensetungen und ihre verwendung zum nachweis von wasserstoffperoxid
US5968839A (en) * 1996-05-13 1999-10-19 Metrika, Inc. Method and device producing a predetermined distribution of detectable change in assays
EP0918845A4 (fr) 1996-07-08 2000-08-30 Burstein Lab Inc Procede et dispositif a element de signal clivable
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
US6331275B1 (en) 1996-07-08 2001-12-18 Burstein Technologies, Inc. Spatially addressable, cleavable reflective signal elements, assay device and method
EP0880704B1 (fr) * 1996-07-18 2003-09-24 Dade Behring Marburg GmbH Reactif pour le dosage de l'acide mycophenolique
CA2231775A1 (fr) 1996-07-18 1998-01-29 Behringwerke Aktiengesellschaft Reactifs pour dosage de ligands
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
GB9622524D0 (en) 1996-10-29 1997-01-08 London Biotechnology Ltd Enzyme labels for assays
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
US6153442A (en) * 1998-05-20 2000-11-28 Dade Behring Inc. Reagents and methods for specific binding assays
JP2002521666A (ja) * 1998-07-21 2002-07-16 バースタイン テクノロジーズ,インコーポレイティド 光ディスクをベースとするアッセイ装置および方法
WO2000005579A1 (fr) 1998-07-22 2000-02-03 Syntron Bioresearch, Inc. Dispositif permettant de deceler differents composants
AU6206800A (en) 1999-07-06 2001-01-22 Surromed, Inc. Bridged fluorescent dyes, their preparation and their use in assays
WO2001039722A2 (fr) 1999-11-30 2001-06-07 Mayo Foundation For Medical Education And Research Nouvelle molecule immunoregulatrice b7-h1,
AU2001283507A1 (en) 2000-07-27 2002-02-13 Mayo Foundation For Medical Education And Research B7-h3 and b7-h4, novel immunoregulatory molecules
AU2002219979A1 (en) * 2000-12-01 2002-06-11 Burstein Technologies, Inc. Apparatus and methods for separating components of particulate suspension
EP1493014A2 (fr) 2001-04-11 2005-01-05 Burstein Technologies, Inc. Dosages a parametres multiples mettant en oeuvre des disques d'analyse, et procedes s'y rapportant
WO2003027723A2 (fr) * 2001-07-24 2003-04-03 Burstein Technologies, Inc. Procede et dispositif de fabrication d'un disque biologique optique equipe d'un circuit fluidique, forme a partir de deux disques colles l'un contre l'autre
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
AU2002335715A1 (en) * 2001-09-07 2003-03-24 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
EP1448992A4 (fr) * 2001-11-20 2005-11-02 Burstein Technologies Inc Biodisques optiques et circuits fluidiques utilises pour l'analyse de cellules et methodes correspondantes
US6696254B2 (en) 2001-11-21 2004-02-24 Kimberly-Clark Worldwide, Inc. Detection and identification of enteric bacteria
US7875435B2 (en) * 2001-12-12 2011-01-25 Proteome Systems Ltd Diagnostic testing process
WO2003057904A1 (fr) * 2001-12-28 2003-07-17 Arkray, Inc. Procede de colorimetrie et reactif destine a etre utilise dans ce procede
ES2322990T3 (es) * 2001-12-28 2009-07-03 Arkray, Inc. Metodo colorimetro y reactivo que se utiliza para el mismo.
WO2003065355A2 (fr) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Elements de securite biologique pour disque d'analyse optique et systeme de disques les contenant
US20040241381A1 (en) * 2002-01-31 2004-12-02 Chen Yihfar Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs
US20050221048A1 (en) * 2002-01-31 2005-10-06 James Rodney Norton Manufacturing processes for making optical analysis discs including successive patterning operations and optical discs thereby manufactured
WO2003064996A2 (fr) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Distributeur a securite biologique et ensemble a disque d'analyse optique
DK2508596T3 (en) 2002-02-21 2015-10-19 Inst Virology MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use.
WO2003089659A1 (fr) * 2002-04-16 2003-10-30 The Regents Of The University Of California Methodes de pronostic d'un hypernephrome et selection de traitement a l'aide d'une anhydrase ix carbonique
WO2004045364A2 (fr) * 2002-05-15 2004-06-03 Mayo Foundation For Medical Education And Research Procedes de detection d'une neoplasie ovarienne
EP1506318A2 (fr) * 2002-05-20 2005-02-16 Regents of the University of California Procedes et compositions de regulation et de manipulation de la steroidogenese
ATE414539T1 (de) * 2002-05-21 2008-12-15 Mayo Foundation Verfahren und materialien zur behandlung und diagnose von mit kallikrein-6 zusammenhängenden entzündlichen zuständen
US20050221349A1 (en) * 2002-05-30 2005-10-06 Stuart Wilson Methods of detecting target molecules and molecular interactions
US20050032126A1 (en) * 2003-03-03 2005-02-10 Coombs James H. Methods and apparatus for use in detection and quantitation of various cell types and use of optical bio-disc for performing same
WO2004095034A1 (fr) * 2003-04-23 2004-11-04 Nagaoka & Co., Ltd. Bio-disques optiques comprenant des circuits fluidiques spiraux pour la realisation de dosages
US7390464B2 (en) * 2003-06-19 2008-06-24 Burstein Technologies, Inc. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
EP1656203A2 (fr) * 2003-06-19 2006-05-17 Nagaoka & Co., Ltd. Circuits fluidiques pour preparation d'echantillons comprenant des disques biologiques et procedes correspondants
ES2354881T3 (es) 2003-06-20 2011-03-18 Mayo Foundation For Medical Education And Research Isoformas de péptido natriurético cerebral.
US20070166721A1 (en) * 2003-06-27 2007-07-19 Phan Brigitte C Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays
AU2004257645A1 (en) * 2003-07-07 2005-01-27 David H. Wagner Methods for predicting development of auto-immune diseases and treatment of same
JP2007500351A (ja) * 2003-07-25 2007-01-11 長岡実業株式会社 バイオディスクを有するサンプル調製用流体回路及びそれに関連した方法
DE602004028643D1 (de) 2003-11-04 2010-09-23 Novartis Vaccines & Diagnostic Verfahren zur behandlung von soliden tumoren mit expression des cd40-zelloberflächen-antigens
ZA200604419B (en) 2003-11-04 2008-06-25 Novartis Vaccines & Diagnostic Antagonist anti-CD40 monoclonal antibodies and methods for their use
ES2346978T3 (es) 2003-11-04 2010-10-22 Novartis Vaccines And Diagnostics, Inc. Uso de anticuerpos monoclonantes anti-cd40 antagonistas para el tratamiento del mieloma multiple.
SI1682177T1 (sl) 2003-11-04 2010-12-31 Novartis Vaccines & Diagnostic Uporaba antagonističnih anti-CD40 protiteles za zdravljenje kronične limfocitne levkemije
JP3615752B1 (ja) 2003-11-18 2005-02-02 淳 高橋 細径樹脂捩じりブラシ
US7022492B2 (en) 2003-12-15 2006-04-04 Dade Behring Inc. Ecstasy haptens and immunogens
US6991911B2 (en) 2003-12-15 2006-01-31 Dade Behring Inc. Assay for entactogens
US7150995B2 (en) 2004-01-16 2006-12-19 Metrika, Inc. Methods and systems for point of care bodily fluid analysis
PL1810026T3 (pl) 2004-10-06 2018-08-31 Mayo Foundation For Medical Education And Research B7-H1 i PD-1 w leczeniu raka nerkowokomórkowego
EP1809765A2 (fr) * 2004-11-04 2007-07-25 Roche Diagnostics GmbH Classification de la leucemie myeloblastique aigue
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
WO2006086670A2 (fr) * 2005-02-09 2006-08-17 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University Procede destine a determiner l'activite oxydoreductrice et composes de criblage bases sur l'activite oxydoreductrice
US8017401B2 (en) * 2005-01-28 2011-09-13 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University Method for determining redox activity and screening compounds based on redox activity
US8323977B2 (en) 2005-01-28 2012-12-04 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University Method for determining redox activity and screening compounds based on redox activity
US20060188997A1 (en) * 2005-01-28 2006-08-24 Portland State University Detection of superoxide ions
US20060182722A1 (en) * 2005-02-11 2006-08-17 Hering Bernhard J Methods and materials for isolating isogenic islet cells
CA2597271A1 (fr) * 2005-02-16 2006-08-24 Dana-Farber Cancer Institute Methodes de detection du cancer de l'ovaire
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
WO2006125021A2 (fr) * 2005-05-16 2006-11-23 Dana Farber Cancer Institute, Inc. Methodes de detection du cancer
WO2006125117A2 (fr) 2005-05-18 2006-11-23 Novartis Ag Procedes de diagnostic et de traitement de maladies ayant une composante auto-immune et/ou inflammatoire
LT2397156T (lt) 2005-06-08 2017-02-27 Dana-Farber Cancer Institute, Inc. Būdai ir kompozicijos, skirti nuolatinių infekcijų ir vėžio gydymui inhibuojant užprogramuotos ląstelės mirties-1 (pd-1) kelią
US7695975B2 (en) 2005-06-23 2010-04-13 Siemens Healthcare Diagnostics Inc. Detection of adulterated samples
US20070037174A1 (en) * 2005-08-12 2007-02-15 Rampal Jang B Chemiluminescent generated fluorescent labeling
US8119358B2 (en) 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
BRPI0617332A2 (pt) * 2005-10-11 2011-07-26 Tethys Bioscience Inc marcadores asoociados ao diabetes e mÉtodos de uso dos mesmos
AU2006313611B2 (en) * 2005-11-12 2013-01-31 Platform Diagnostics Limited Agglutination assay
US9121853B2 (en) * 2006-03-20 2015-09-01 Mayo Foundation For Medical Education And Research B7-H4 expression on tumor vasculature
MEP39508A (en) 2006-04-21 2011-02-10 Novartis Ag Antagonist anti-cd40 antibody pharmaceutical compositions
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7799534B2 (en) * 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
CA2659082A1 (fr) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Marqueurs associes a des evenements arterio-vasculaires et procedes d'utilisation de ces marqueurs
BRPI0716416A2 (pt) 2006-08-08 2016-10-11 Mayo Foundation polipeptídeo substancialmente puro entre 37 e 47 besíduos de aminoácido de comprimento, ácido nucléico isolado, vetor: célula hospedeira e composição farmacêutica
US7951776B2 (en) 2006-09-01 2011-05-31 American Type Culture Collection Methods for treatment of type 1 diabetes
US20080300170A1 (en) * 2006-09-01 2008-12-04 Cohava Gelber Compositions and methods for diagnosis and treatment for type 2 diabetes
US20090203602A1 (en) * 2006-09-01 2009-08-13 Cohava Gelber Compositions and methods for diagnosis and treatment of type 2 diabetes
US20100267052A1 (en) * 2006-09-01 2010-10-21 American Type Culture Collection Compositions and methods for diagnosis and treatment of type 2 diabetes
EP2059524A4 (fr) 2006-09-08 2009-11-25 Mayo Foundation Polypeptides aquaretiques et natriuretiques depourvus d'activite vasodilatatoire
WO2011008990A1 (fr) 2009-07-15 2011-01-20 Prometheus Laboratories Inc. Sélection de médicaments pour la thérapie d’un cancer gastrique au moyen de réseaux à base d’anticorps
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
GB0700133D0 (en) 2007-01-04 2007-02-14 Humabs Llc Human cytomegalovirus neutralising antibodies and use thereof
EP2121750A2 (fr) * 2007-01-16 2009-11-25 Wyeth Traitement, détection et surveillance de l'inflammation au moyen de trem-1
EP2147315B1 (fr) 2007-04-18 2013-06-26 Tethys Bioscience, Inc. Biomarqueurs associés au diabète et leurs procédés d'utilisation
AU2008300338A1 (en) * 2007-06-04 2009-03-26 Diagnoplex Biomarker combinations for colorectal cancer
KR101553723B1 (ko) * 2007-07-13 2015-09-16 네스텍 소시에테아노님 항체­기반 어레이를 사용한 폐 암 치료를 위한 약물 선별법
AU2008279379B2 (en) 2007-07-20 2016-03-24 Mayo Foundation For Medical Education And Research Natriuretic polypeptides
US7790401B2 (en) 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
WO2009036448A2 (fr) * 2007-09-15 2009-03-19 Mayo Foundation For Medical Education And Research Agonistes des récepteurs peptidiques natriurétiques de type c
US20100240070A1 (en) * 2007-11-07 2010-09-23 Beckman Coulter, Inc. Nonseparation Assay Methods Using Peroxide Generating Enzymes
US7910378B2 (en) 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
ES2398618T3 (es) * 2008-02-25 2013-03-20 Nestec S.A. Selección de fármacos para terapia del cáncer de mama utilizando matrices de anticuerpos
EP2307886A2 (fr) * 2008-06-26 2011-04-13 Dana-Farber Cancer Institute Inc. Signatures et déterminants associés à des métastases, et leurs procédés d'utilisation
EP2307447B1 (fr) 2008-07-02 2016-03-09 Mayo Foundation For Medical Education And Research Polypeptides natriurétiques dotés de profils pharmacologiques uniques
US20120009581A1 (en) 2008-07-08 2012-01-12 Bankaitis-Davis Danute M Gene Expression Profiling for Predicting the Survivability of Prostate Cancer Subjects
NZ591055A (en) 2008-07-16 2012-08-31 Inst Research In Biomedicine Human cytomegalovirus neutralising antibodies and use thereof
SG10201706350PA (en) 2008-07-16 2017-09-28 Inst For Res In Biomedicine Human cytomegalovirus neutralizing antibodies and use thereof
US8329647B2 (en) 2008-07-17 2012-12-11 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Method of treating a subject according to biomarkers for insulin resistance
EP2338051B1 (fr) 2008-07-17 2013-11-20 IKFE Institut für klinische Forschung und Entwicklung GmbH Biomarqueurs pour cardiodiabète
US9340603B2 (en) * 2008-07-25 2016-05-17 Institute For Research In Biomedicine Neutralizing anti-influenza A virus antibodies and uses thereof
US8871207B2 (en) 2008-07-25 2014-10-28 Humabs, LLC Neutralizing anti-influenza A virus antibodies and uses thereof
US8642550B2 (en) 2008-10-24 2014-02-04 Mayo Foundation For Medical Education And Research Chimeric natriuretic peptides without hypotensive inducing capability
AU2009323767A1 (en) 2008-12-04 2011-07-21 IKFE Instituit fur klinische Forschung und Entwicklung GmbH Biomarkers for atherosclerosis
US20100183633A1 (en) * 2008-12-04 2010-07-22 University Of Massachusetts Interleukin 6 and tumor necrosis factor alpha as biomarkers of jnk inhibition
US20110118134A1 (en) 2008-12-11 2011-05-19 Ikfe Gmbh Biomarkers for insulin sensitizer drug response
US8455438B2 (en) 2008-12-29 2013-06-04 Mayo Foundation For Medical Education And Research Natriuretic polypeptides for reducing or preventing restenosis
EP2382467A1 (fr) 2008-12-30 2011-11-02 IKFE GmbH Biomarqueurs de l'activité des tissus adipeux
US8455263B2 (en) 2008-12-30 2013-06-04 Jin Po Lee Quantitative analyte assay device and method
US20100210541A1 (en) 2009-01-07 2010-08-19 Andreas Pfuetzner Biomarkers for Appetite Regulation
WO2010091206A1 (fr) 2009-02-04 2010-08-12 Massachusetts Institute Of Technology Compositions et utilisations pour régler la croissance de cellules cancéreuses
US20120108514A1 (en) 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
WO2011026132A2 (fr) 2009-08-31 2011-03-03 1/3Acamplimmune, Inc. Méthodes et compositions permettant d'inhiber les rejets de greffe
CA2777800C (fr) 2009-10-15 2019-11-12 Crescendo Bioscience Biomarqueurs et procedes de mesure et de surveillance de l'activite d'une maladie inflammatoire
US9740819B2 (en) 2009-10-29 2017-08-22 True Health Ip Llc Method for determining risk of diabetes
US9217747B2 (en) 2009-10-29 2015-12-22 Health Diagnostic Laboratory, Inc. Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes
WO2011058367A2 (fr) 2009-11-13 2011-05-19 Astrazeneca Ab Test de diagnostic pour prédire la sensibilité à un traitement par un inhibiteur de poly(adp-ribose) polymérase
WO2011063198A2 (fr) 2009-11-20 2011-05-26 St. Jude Children's Research Hospital Procédés et compositions de modulation de l'activité du complexe du récepteur de l'interleukine 35
CN103119444B (zh) 2010-04-21 2016-10-26 米密德诊断学有限公司 区分细菌与病毒感染的标记物和决定因素以及其使用方法
US8329424B2 (en) 2010-06-25 2012-12-11 Siemens Healthcare Diagnostics Reduction in false results in assay measurements
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US10088490B2 (en) 2010-08-20 2018-10-02 Siemens Healthcare Diagnostics Inc. Assay for analytes using multiple receptors
WO2012054870A2 (fr) 2010-10-21 2012-04-26 Vertex Pharmaceuticals Incorporated Biomarqueurs pour des patients infectés par le vhc
WO2012075111A1 (fr) 2010-11-30 2012-06-07 Novartis Ag Utilisation d'anticorps anti-cd40 en thérapie combinée contre des cancers associés aux cellules b
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
SI2734545T1 (sl) 2011-07-18 2019-06-28 Institute For Research In Biomedicine Protitelesa, ki nevtralizirajo virus influence A in njihova uporaba
ES2671238T3 (es) 2011-08-12 2018-06-05 Siemens Healthcare Diagnostics Inc. Detección de esteroides sexuales
JP2014525439A (ja) 2011-08-30 2014-09-29 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ ナトリウム利尿ポリペプチド
KR101851425B1 (ko) 2011-09-02 2018-04-23 네스텍 소시에테아노님 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링
WO2013071066A1 (fr) 2011-11-11 2013-05-16 The Broad Institute, Inc. Signatures associées à la sensibilité vis-à-vis d'une thérapie de cancer
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
US8771964B2 (en) 2012-02-02 2014-07-08 Siemens Healthcare Diagnostics Inc. Compositions and methods for detection of methadone metabolite
IN2014MN01780A (fr) 2012-02-09 2015-07-03 Memed Diagnostics Ltd
EA030319B1 (ru) 2012-03-20 2018-07-31 Хумабс Биомед Са Антитела, нейтрализующие rsv, mpv и pvm, и их применения
EP2847589A1 (fr) 2012-05-09 2015-03-18 Advanced Animal Diagnostics, Inc. Détection rapide d'analytes dans des échantillons liquides
JP6377054B2 (ja) 2012-05-11 2018-08-22 リセット セラピューティークス, インコーポレイテッド クリプトクロム調節薬としてのカルバゾール含有スルホンアミド
US20150140679A1 (en) 2012-06-27 2015-05-21 Siemens Healthcare Diagnostics Inc. Compositions and methods for liquid mixing assessment
WO2014015217A1 (fr) 2012-07-19 2014-01-23 Vertex Pharmaceuticals Incorporated Biomarqueurs pour patients infectés par le hcv
EP2885423B1 (fr) 2012-08-15 2017-09-27 The Procter and Gamble Company Systèmes pour identifier et évaluer des agents actifs sur la peau efficaces pour traiter une gamme de troubles cutanés
US10288626B2 (en) 2012-09-14 2019-05-14 University Of Kentucky Research Foundation Secreted tumor-associated cytochrome as a blood-based biomarker for cancer
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
US9121859B2 (en) 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
US9448232B2 (en) 2013-01-24 2016-09-20 Mayo Foundation For Medical Education And Research Methods and materials for detecting C9ORF72 hexanucleotide repeat expansion positive frontotemporal lobar degeneration or C9ORF72 hexanucleotide repeat expansion positive amyotrophic lateral sclerosis
US9302005B2 (en) 2013-03-14 2016-04-05 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
US20140308751A1 (en) 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
EP3004372A1 (fr) * 2013-06-04 2016-04-13 Roche Diagnostics GmbH Nouveaux composés utiles pour fret et procédés associés
ES2714708T3 (es) 2013-10-01 2019-05-29 Mayo Found Medical Education & Res Procedimientos para el tratamiento de cáncer en pacientes con niveles elevados de Bim
DK3052192T3 (da) 2013-10-02 2020-09-28 Medimmune Llc Neutraliserende anti-influenza a-antistoffer og anvendelser deraf
KR20160058960A (ko) 2013-10-04 2016-05-25 압토스 바이오사이언시스 인코포레이티드 암을 치료하기 위한 조성물과 방법
WO2015061260A1 (fr) 2013-10-24 2015-04-30 Siemens Healthcare Diagnostics Inc. Dosages pour analytes macromoléculaires
JP6559135B2 (ja) 2013-12-13 2019-08-14 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. 非凝集検定における前処理剤
WO2015095426A1 (fr) 2013-12-18 2015-06-25 Siemens Healthcare Diagnostics Inc. Détection d'une maladie endothéliale
SG10201808565QA (en) 2014-03-31 2018-11-29 Debiopharm Int Sa Fgfr fusions
CA2943821A1 (fr) 2014-04-02 2015-10-08 Crescendo Bioscience Biomarqueurs et procedes de mesure et de surveillance de l'activite de l'arthrite idiopathique juvenile
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
US9176113B1 (en) 2014-04-11 2015-11-03 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
US10302653B2 (en) 2014-05-22 2019-05-28 Mayo Foundation For Medical Education And Research Distinguishing antagonistic and agonistic anti B7-H1 antibodies
EP3155439A4 (fr) 2014-06-10 2018-03-14 Crescendo Bioscience Biomarqueurs et procédés de mesure et de surveillance de l'activité d'une maladie de spondylarthrite axiale
WO2015200186A1 (fr) 2014-06-27 2015-12-30 Siemens Healthcare Diagnostics Inc. Partenaires de liaison spécifiques à des épimères de la vitamine d dans des dosages de vitamine d
EP3172239A4 (fr) 2014-06-27 2017-06-21 Siemens Healthcare Diagnostics Inc. Partenaires de liaison spécifiques des épimères de la vitamine d
CN113563462B (zh) 2014-07-15 2024-08-13 免疫医疗有限责任公司 中和抗乙型流感抗体及其用途
EP3171896A4 (fr) 2014-07-23 2018-03-21 Mayo Foundation for Medical Education and Research Ciblage d'adn-pkcs et de b7-h1 pour traiter le cancer
CN111624346A (zh) 2014-08-14 2020-09-04 米密德诊断学有限公司 用于预测及/或决定预后的套组
WO2016055950A1 (fr) 2014-10-08 2016-04-14 Novartis Ag Combinaison d'anticorps de neutralistion du cytomégalovirus humain
WO2016075546A2 (fr) 2014-11-14 2016-05-19 Antonio Lanzavecchia Anticorps qui neutralisent le virus ebola et leurs utilisations
DK3220947T3 (da) 2014-11-18 2020-11-30 Humabs Biomed S A Antistoffer som potent neutraliserer rabiesvirus og øvrige lyssavirusser og anvendelser deraf
HUE056407T2 (hu) 2015-06-01 2022-02-28 Medimmune Llc Neutralizáló influenzaellenes kötõmolekulák és alkalmazásaik
WO2016207402A1 (fr) 2015-06-26 2016-12-29 Institute For Research In Biomedicine Protéines comprenant un fragment lair-1 muté et leurs utilisations
WO2017058999A2 (fr) 2015-09-29 2017-04-06 Crescendo Bioscience Biomarqueurs et méthodes d'évaluation de la réponse à l'arrêt d'une thérapie contre les maladies inflammatoires
EP3356832A4 (fr) 2015-09-29 2019-06-19 Sasso, Eric Biomarqueurs et procédés d'évaluation de l'activité de la maladie arthrite psoriasique
WO2017059878A1 (fr) 2015-10-07 2017-04-13 Humabs Biomed Sa Anticorps neutralisant puissamment le virus de l'hépatite b et utilisations de ces derniers
US10875923B2 (en) 2015-10-30 2020-12-29 Mayo Foundation For Medical Education And Research Antibodies to B7-H1
SG11201805001UA (en) 2016-01-13 2018-07-30 Medimmune Llc Method of treating influenza a
CA3021343C (fr) 2016-04-20 2024-05-28 Crescendo Bioscience Biomarqueurs et procedes d'evaluation de la reponse a un traitement de maladie inflammatoire
EP4184167A1 (fr) 2016-07-10 2023-05-24 MeMed Diagnostics Ltd. Diagnostic précoce d'infections
EP4141448A1 (fr) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Signatures protéiques permettant de faire la distinction entre des infections bactériennes et virales
WO2018010789A1 (fr) 2016-07-13 2018-01-18 Humabs Biomed Sa Nouveaux anticorps se liant spécifiquement aux épitopes du virus zika et leurs utilisations
EP4033248B1 (fr) 2016-08-10 2024-04-10 MeMed Diagnostics Ltd. Système et procédé d'analyse de mx1 et crp dans le sang
CN118085055A (zh) 2017-04-19 2024-05-28 生物医学研究所 作为疫苗及新疟疾疫苗和抗体结合靶标的疟原虫子孢子npdp肽
US10696899B2 (en) 2017-05-09 2020-06-30 International Business Machines Corporation Light emitting shell in multi-compartment microcapsules
US10900908B2 (en) * 2017-05-24 2021-01-26 International Business Machines Corporation Chemiluminescence for tamper event detection
US10357921B2 (en) 2017-05-24 2019-07-23 International Business Machines Corporation Light generating microcapsules for photo-curing
US10392452B2 (en) 2017-06-23 2019-08-27 International Business Machines Corporation Light generating microcapsules for self-healing polymer applications
WO2019042555A1 (fr) 2017-08-31 2019-03-07 Humabs Biomed Sa Anticorps multispécifiques se liant spécifiquement aux épitopes du virus zika et leurs utilisations
WO2019055609A1 (fr) 2017-09-14 2019-03-21 University Of Alabama At Birmingham Biomarqueurs et méthodes d'évaluation de risque d'infarctus du myocarde et d'infection grave chez des patients atteints de polyarthrite rhumatoïde
US20210361767A1 (en) 2018-02-14 2021-11-25 Mayo Foundation For Medical Education And Research Rescuing cancer patients from resistance to treatment with inhibitors of pd-1/pd-l1 interactions
CA3118682A1 (fr) 2018-11-04 2020-05-07 Figene, Llc Methodes et compositions pour le traitement du diabete de type 1 utilisant des fibroblastes en tant que faciliteurs de la prise de greffe d'ilots
PL3898668T3 (pl) 2018-12-19 2024-04-02 Humabs Biomed Sa Przeciwciała, które neutralizują wirusa zapalenia wątroby typu B i ich zastosowania
EP4021578A1 (fr) 2019-08-29 2022-07-06 VIR Biotechnology, Inc. Compositions d'anticorps et méthodes pour traiter une infection par le virus de l'hépatite b
CN118465272A (zh) 2019-12-04 2024-08-09 珠海泰诺麦博制药股份有限公司 抗人巨细胞病毒抗体及其用途
US20230242621A1 (en) 2020-06-24 2023-08-03 Vir Biotechnology, Inc. Engineered hepatitis b virus neutralizing antibodies and uses thereof
EP4284428A1 (fr) 2021-01-26 2023-12-06 VIR Biotechnology, Inc. Compositions et méthodes pour traiter une infection par le virus de l'hépatite b
EP4305058A2 (fr) 2021-03-10 2024-01-17 Mabylon AG Anticorps dirigés contre la tdp-43 et méthodes d'utilisation de ceux-ci
GB2613386A (en) 2021-12-02 2023-06-07 Apis Assay Tech Limited Diagnostic test
GB202203588D0 (en) 2022-03-15 2022-04-27 Argonaut Therapeutics Ltd Cancer diagnostic

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2121723A1 (fr) * 1971-01-11 1972-08-25 Synvar Ass
US3839153A (en) * 1970-12-28 1974-10-01 Akzona Inc Process for the detection and determination of specific binding proteins and their corresponding bindable substances
FR2257259A1 (fr) * 1973-08-30 1975-08-08 Gen Electric
FR2332533A1 (fr) * 1975-04-28 1977-06-17 Miles Lab Composition et procede de fixation specifique pour la detection d'un ligand dans un milieu liquide
GB1502563A (en) * 1975-01-27 1978-03-01 Kabi Ab Diagnostic devices for immuno-chemical quantification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852157A (en) * 1971-05-14 1974-12-03 Syva Corp Compounds for enzyme amplification assay
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4181650A (en) * 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4080264A (en) * 1976-03-01 1978-03-21 Massachusetts Institute Of Technology Immunoassay by light scattering spectroscopy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839153A (en) * 1970-12-28 1974-10-01 Akzona Inc Process for the detection and determination of specific binding proteins and their corresponding bindable substances
FR2121723A1 (fr) * 1971-01-11 1972-08-25 Synvar Ass
FR2257259A1 (fr) * 1973-08-30 1975-08-08 Gen Electric
GB1502563A (en) * 1975-01-27 1978-03-01 Kabi Ab Diagnostic devices for immuno-chemical quantification
FR2332533A1 (fr) * 1975-04-28 1977-06-17 Miles Lab Composition et procede de fixation specifique pour la detection d'un ligand dans un milieu liquide

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CA1110541A (fr) 1981-10-13
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US4233402A (en) 1980-11-11
GB2018986A (en) 1979-10-24
FR2434201B1 (fr) 1985-12-20
GB2018986B (en) 1982-12-22
JPS6337348B2 (fr) 1988-07-25
DE2913550A1 (de) 1979-10-18

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