FR2433537A1 - Derives d'hormones steroides antitumoraux et leur procede de preparation - Google Patents

Derives d'hormones steroides antitumoraux et leur procede de preparation

Info

Publication number
FR2433537A1
FR2433537A1 FR7920546A FR7920546A FR2433537A1 FR 2433537 A1 FR2433537 A1 FR 2433537A1 FR 7920546 A FR7920546 A FR 7920546A FR 7920546 A FR7920546 A FR 7920546A FR 2433537 A1 FR2433537 A1 FR 2433537A1
Authority
FR
France
Prior art keywords
preparation
derivatives
steroid hormones
tumor
steroid hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7920546A
Other languages
English (en)
Other versions
FR2433537B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9879778A external-priority patent/JPS5810398B2/ja
Priority claimed from JP9879878A external-priority patent/JPS5810399B2/ja
Priority claimed from JP9879978A external-priority patent/JPS5810395B2/ja
Priority claimed from JP53098796A external-priority patent/JPS5810394B2/ja
Priority claimed from JP10829078A external-priority patent/JPS5810396B2/ja
Priority claimed from JP15217678A external-priority patent/JPS5810400B2/ja
Priority claimed from JP15484278A external-priority patent/JPS5581900A/ja
Priority claimed from JP6649679A external-priority patent/JPS5812279B2/ja
Application filed by Kureha Corp filed Critical Kureha Corp
Publication of FR2433537A1 publication Critical patent/FR2433537A1/fr
Publication of FR2433537B1 publication Critical patent/FR2433537B1/fr
Application granted granted Critical
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dérivés d'hormones stéroïdes et leur procédé de préparation. Procédé pour préparer un dérivé d'hormone stéroïde antitumoral qui attaque sélectivement les cellules tumorales ou cancéreuses, ledit procédé étant caractérisé par le fait que l'on fait réagir le groupe X d'un dérivé d'hormone stéroïde répondant à la formule :
FR7920546A 1978-08-14 1979-08-10 Derives d'hormones steroides antitumoraux et leur procede de preparation Granted FR2433537A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP53098796A JPS5810394B2 (ja) 1978-08-14 1978-08-14 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤
JP9879778A JPS5810398B2 (ja) 1978-08-14 1978-08-14 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤
JP9879978A JPS5810395B2 (ja) 1978-08-14 1978-08-14 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤
JP9879878A JPS5810399B2 (ja) 1978-08-14 1978-08-14 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤
JP10829078A JPS5810396B2 (ja) 1978-09-04 1978-09-04 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤
JP15217678A JPS5810400B2 (ja) 1978-12-08 1978-12-08 新規なエストラジオ−ル誘導体とその製造方法及び抗腫瘍剤
JP15484278A JPS5581900A (en) 1978-12-14 1978-12-14 Preparation of combined steroid hormone derivative- antitumor substance
JP6649679A JPS5812279B2 (ja) 1979-05-29 1979-05-29 新規なエストラジオ−ル結合体とその抗腫瘍剤

Publications (2)

Publication Number Publication Date
FR2433537A1 true FR2433537A1 (fr) 1980-03-14
FR2433537B1 FR2433537B1 (fr) 1982-07-09

Family

ID=27572588

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7920546A Granted FR2433537A1 (fr) 1978-08-14 1979-08-10 Derives d'hormones steroides antitumoraux et leur procede de preparation
FR8101887A Granted FR2476093A1 (fr) 1978-08-14 1981-01-30 Nouveaux composes 3-hydroxy ou 3-acyloxy 1,3,5(10)-estratriene-17b-oxycarbonylmethyle et leur application en therapeutique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8101887A Granted FR2476093A1 (fr) 1978-08-14 1981-01-30 Nouveaux composes 3-hydroxy ou 3-acyloxy 1,3,5(10)-estratriene-17b-oxycarbonylmethyle et leur application en therapeutique

Country Status (8)

Country Link
US (2) US4260736A (fr)
CA (1) CA1120922A (fr)
CH (1) CH642976A5 (fr)
DE (1) DE2932606C2 (fr)
FR (2) FR2433537A1 (fr)
GB (1) GB2028336B (fr)
IT (1) IT1196399B (fr)
NL (1) NL190747C (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3210637A1 (de) * 1982-03-23 1983-09-29 Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg Steroidester von n-(2-halogenethyl)-n-nitroso-carbamoylaminosaeuren und deren peptiden, sowie verfahren zu deren herstellung
EP0105404A1 (fr) * 1982-09-30 1984-04-18 Merck & Co. Inc. Dérivés de stéroides liés à des agents cytotoxiques et procédé de préparation
US4466952A (en) * 1983-01-12 1984-08-21 Indiana University Foundation Compositions and process for the treatment of cancer
JPS617292A (ja) * 1984-06-20 1986-01-13 Japan Atom Energy Res Inst 制癌剤を結合させたエストラサイト系化合物を製造する方法
US4970071A (en) * 1985-01-18 1990-11-13 Mcmichael John Immunotherapeutic methods and compositions employing antigens characteristic of non human malignant neoplasms
DE3511587A1 (de) * 1985-03-27 1986-10-02 Schering AG, Berlin und Bergkamen, 1000 Berlin Glykoester des estradiols und estriols
FR2591599B1 (fr) * 1985-12-17 1988-08-05 Hoechst Lab Nouvelles anthracyclines et medicaments les contenant
DE3769676D1 (de) * 1986-03-14 1991-06-06 Fujisawa Pharmaceutical Co Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung.
AU7580187A (en) * 1986-06-23 1988-01-12 Upjohn Company, The Androstane-type and cortical aminoesters
US4966753A (en) * 1987-08-18 1990-10-30 Molecular Rx, Inc. Immunotherapeutic methods and compositions employing antigens characteristic of malignant neoplasms
US5338837A (en) * 1991-12-13 1994-08-16 The Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making same
US5795870A (en) * 1991-12-13 1998-08-18 Trustees Of Princeton University Compositions and methods for cell transformation
US5693769A (en) * 1991-12-13 1997-12-02 Transcell Technologies, Inc. Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
JP2520074B2 (ja) * 1992-06-11 1996-07-31 呉羽化学工業株式会社 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤
IL108748A0 (en) * 1993-02-23 1994-08-26 Univ Princeton Solution and solid-phase formation of glycosidic linkages
US5639866A (en) * 1993-02-23 1997-06-17 Princeton University Single-step formation of multiple glycosidic linkages
DE4338015A1 (de) * 1993-11-08 1995-05-11 Asta Medica Ag Verwendung von D-glucopyranuronsäuren und deren Derivaten zum Einbau in pharmakologisch wirksame Peptide und deren Salze
JPH07242548A (ja) * 1993-12-29 1995-09-19 Isukura Sangyo Kk 骨吸収抑制・骨形成促進剤
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040175410A1 (en) * 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US20040208910A1 (en) * 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20040115268A1 (en) * 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
JP4827626B2 (ja) * 2006-06-14 2011-11-30 キヤノン株式会社 被制御機器、遠隔制御システムおよび遠隔制御システムの制御方法、プログラム
EP2515864A4 (fr) * 2009-12-23 2013-09-11 Psivida Inc Dispositifs d'administration à libération prolongée
EP3019172B1 (fr) * 2013-07-11 2019-09-25 Evestra, Inc. Composés pour la formation de promédicaments
US11103460B2 (en) 2017-08-07 2021-08-31 Board Of Regents, The University Of Texas System Fabrication methods for nanodelivery systems for long term controlled delivery of active pharmaceutical ingredients
CN111040013A (zh) * 2019-12-21 2020-04-21 长沙霍滋生物科技有限公司 一种类固醇衍生物及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2338951A1 (fr) * 1976-01-22 1977-08-19 Leo Ab Nouveaux esters-17 a d'hydroxy-17 a-progestatifs utiles comme medicaments et leurs procedes de preparation
FR2341594A1 (fr) * 1976-02-19 1977-09-16 Leo Ab Esters d'enols steroidiques, leur preparation et leurs utilisations therapeutiques
GB2015845A (en) * 1978-03-03 1979-09-12 Emi Ltd Improvements in or relating to correlation arrangements

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK290774A (fr) * 1973-06-08 1975-02-03 Schering Ag
GB2010845B (en) * 1977-11-19 1982-02-10 Farmaceutici Italia Doxorubicin derivatives
DE2841074A1 (de) * 1978-09-21 1980-04-03 Basf Ag 4,5-methano-bufadienolid-rhamnoside, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4340158A (en) * 1980-06-13 1982-07-20 Realex Corporation Vent-sealing, down-locked pump dispenser

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2338951A1 (fr) * 1976-01-22 1977-08-19 Leo Ab Nouveaux esters-17 a d'hydroxy-17 a-progestatifs utiles comme medicaments et leurs procedes de preparation
FR2341594A1 (fr) * 1976-02-19 1977-09-16 Leo Ab Esters d'enols steroidiques, leur preparation et leurs utilisations therapeutiques
GB2015845A (en) * 1978-03-03 1979-09-12 Emi Ltd Improvements in or relating to correlation arrangements

Also Published As

Publication number Publication date
NL190747B (nl) 1994-03-01
CH642976A5 (de) 1984-05-15
DE2932606A1 (de) 1980-02-28
FR2476093B1 (fr) 1983-11-25
US4360663A (en) 1982-11-23
DE2932606C2 (de) 1983-03-03
IT1196399B (it) 1988-11-16
NL190747C (nl) 1994-08-01
GB2028336B (en) 1983-05-05
CA1120922A (fr) 1982-03-30
FR2433537B1 (fr) 1982-07-09
IT7925084A0 (it) 1979-08-13
GB2028336A (en) 1980-03-05
NL7906178A (nl) 1980-02-18
US4260736A (en) 1981-04-07
FR2476093A1 (fr) 1981-08-21

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Legal Events

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ST Notification of lapse