JPS5581900A - Preparation of combined steroid hormone derivative- antitumor substance - Google Patents

Preparation of combined steroid hormone derivative- antitumor substance

Info

Publication number
JPS5581900A
JPS5581900A JP15484278A JP15484278A JPS5581900A JP S5581900 A JPS5581900 A JP S5581900A JP 15484278 A JP15484278 A JP 15484278A JP 15484278 A JP15484278 A JP 15484278A JP S5581900 A JPS5581900 A JP S5581900A
Authority
JP
Japan
Prior art keywords
antitumor substance
steroid hormone
preparation
antitumor
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15484278A
Other languages
Japanese (ja)
Other versions
JPS629119B2 (en
Inventor
Yoshiro Asano
Fumio Tamura
Hiromitsu Tanaka
Satoshi Enomoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP15484278A priority Critical patent/JPS5581900A/en
Priority to US06/062,819 priority patent/US4260736A/en
Priority to DE2932606A priority patent/DE2932606C2/en
Priority to FR7920546A priority patent/FR2433537A1/en
Priority to IT25084/79A priority patent/IT1196399B/en
Priority to CH740179A priority patent/CH642976A5/en
Priority to CA000333653A priority patent/CA1120922A/en
Priority to NL7906178A priority patent/NL190747C/en
Priority to GB7928321A priority patent/GB2028336B/en
Publication of JPS5581900A publication Critical patent/JPS5581900A/en
Priority to US06/212,117 priority patent/US4360663A/en
Priority to FR8101887A priority patent/FR2476093A1/en
Publication of JPS629119B2 publication Critical patent/JPS629119B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:A compound comprising a steroid derivative having a cyclopentanone phenanthrene hydrocarbon skeleton, e.g. gonane, estrane, or androstane, combined with an antitumor substance. EXAMPL:3-Hydroxy-1,3,5( 10 )-estratriene-17β-[methyl-2-[N'-( 2-chloroethyl )-α- N'-nitrosoureido]-2-deoxy-D-glucuronoyl-oxy]acetate.
USE: Antitumor agents.
PROCESS: A steroid hormone derivative of the formula (ST is steroid residue; R' is 1W4C alkylene group; X is halogen, anino group, etc.), e.g. 3-hydroxy-1,3,5(10) -estratrienl-17β-monobromoacetate, is reacted with an antitumor substance, e.g. silver salt of methyl-N-benzyloxycarbonyl-α-D-glucosamine uronate, in a solvent, at room temperature, and then hydrogenated to give the desired substance.
COPYRIGHT: (C)1980,JPO&Japio
JP15484278A 1978-08-14 1978-12-14 Preparation of combined steroid hormone derivative- antitumor substance Granted JPS5581900A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP15484278A JPS5581900A (en) 1978-12-14 1978-12-14 Preparation of combined steroid hormone derivative- antitumor substance
US06/062,819 US4260736A (en) 1978-08-14 1979-08-01 Steroid hormone-antitumor derivatives
DE2932606A DE2932606C2 (en) 1978-08-14 1979-08-10 Estradiol antitumor derivatives
FR7920546A FR2433537A1 (en) 1978-08-14 1979-08-10 DERIVATIVES OF ANTI-TUMOR STEROID HORMONES AND THEIR PREPARATION METHOD
CH740179A CH642976A5 (en) 1978-08-14 1979-08-13 METHOD FOR PRODUCING STEROIDHORMONE ANTITUM OR DERIVATIVES.
IT25084/79A IT1196399B (en) 1978-08-14 1979-08-13 STEROID HORMONE-BASED ANTI-TUMOR DERIVATIVES
CA000333653A CA1120922A (en) 1978-08-14 1979-08-13 Steroid hormone antitumor derivatives
NL7906178A NL190747C (en) 1978-08-14 1979-08-14 A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method.
GB7928321A GB2028336B (en) 1978-08-14 1979-08-14 Steroid hormone-antitumour drug conjugates
US06/212,117 US4360663A (en) 1978-08-14 1980-12-02 Steroid hormone-antitumor derivatives
FR8101887A FR2476093A1 (en) 1978-08-14 1981-01-30 NOVEL 3-HYDROXY OR 3-ACYLOXY 1,3,5 (10) -ESTRATRIENE-17B-OXYCARBONYLMETHYL COMPOUNDS AND THEIR THERAPEUTIC APPLICATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15484278A JPS5581900A (en) 1978-12-14 1978-12-14 Preparation of combined steroid hormone derivative- antitumor substance

Publications (2)

Publication Number Publication Date
JPS5581900A true JPS5581900A (en) 1980-06-20
JPS629119B2 JPS629119B2 (en) 1987-02-26

Family

ID=15593075

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15484278A Granted JPS5581900A (en) 1978-08-14 1978-12-14 Preparation of combined steroid hormone derivative- antitumor substance

Country Status (1)

Country Link
JP (1) JPS5581900A (en)

Also Published As

Publication number Publication date
JPS629119B2 (en) 1987-02-26

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