JPS5581900A - Preparation of combined steroid hormone derivative- antitumor substance - Google Patents
Preparation of combined steroid hormone derivative- antitumor substanceInfo
- Publication number
- JPS5581900A JPS5581900A JP15484278A JP15484278A JPS5581900A JP S5581900 A JPS5581900 A JP S5581900A JP 15484278 A JP15484278 A JP 15484278A JP 15484278 A JP15484278 A JP 15484278A JP S5581900 A JPS5581900 A JP S5581900A
- Authority
- JP
- Japan
- Prior art keywords
- antitumor substance
- steroid hormone
- preparation
- antitumor
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:A compound comprising a steroid derivative having a cyclopentanone phenanthrene hydrocarbon skeleton, e.g. gonane, estrane, or androstane, combined with an antitumor substance. EXAMPL:3-Hydroxy-1,3,5( 10 )-estratriene-17β-[methyl-2-[N'-( 2-chloroethyl )-α- N'-nitrosoureido]-2-deoxy-D-glucuronoyl-oxy]acetate.
USE: Antitumor agents.
PROCESS: A steroid hormone derivative of the formula (ST is steroid residue; R' is 1W4C alkylene group; X is halogen, anino group, etc.), e.g. 3-hydroxy-1,3,5(10) -estratrienl-17β-monobromoacetate, is reacted with an antitumor substance, e.g. silver salt of methyl-N-benzyloxycarbonyl-α-D-glucosamine uronate, in a solvent, at room temperature, and then hydrogenated to give the desired substance.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15484278A JPS5581900A (en) | 1978-12-14 | 1978-12-14 | Preparation of combined steroid hormone derivative- antitumor substance |
US06/062,819 US4260736A (en) | 1978-08-14 | 1979-08-01 | Steroid hormone-antitumor derivatives |
DE2932606A DE2932606C2 (en) | 1978-08-14 | 1979-08-10 | Estradiol antitumor derivatives |
FR7920546A FR2433537A1 (en) | 1978-08-14 | 1979-08-10 | DERIVATIVES OF ANTI-TUMOR STEROID HORMONES AND THEIR PREPARATION METHOD |
CH740179A CH642976A5 (en) | 1978-08-14 | 1979-08-13 | METHOD FOR PRODUCING STEROIDHORMONE ANTITUM OR DERIVATIVES. |
IT25084/79A IT1196399B (en) | 1978-08-14 | 1979-08-13 | STEROID HORMONE-BASED ANTI-TUMOR DERIVATIVES |
CA000333653A CA1120922A (en) | 1978-08-14 | 1979-08-13 | Steroid hormone antitumor derivatives |
NL7906178A NL190747C (en) | 1978-08-14 | 1979-08-14 | A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method. |
GB7928321A GB2028336B (en) | 1978-08-14 | 1979-08-14 | Steroid hormone-antitumour drug conjugates |
US06/212,117 US4360663A (en) | 1978-08-14 | 1980-12-02 | Steroid hormone-antitumor derivatives |
FR8101887A FR2476093A1 (en) | 1978-08-14 | 1981-01-30 | NOVEL 3-HYDROXY OR 3-ACYLOXY 1,3,5 (10) -ESTRATRIENE-17B-OXYCARBONYLMETHYL COMPOUNDS AND THEIR THERAPEUTIC APPLICATION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15484278A JPS5581900A (en) | 1978-12-14 | 1978-12-14 | Preparation of combined steroid hormone derivative- antitumor substance |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5581900A true JPS5581900A (en) | 1980-06-20 |
JPS629119B2 JPS629119B2 (en) | 1987-02-26 |
Family
ID=15593075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15484278A Granted JPS5581900A (en) | 1978-08-14 | 1978-12-14 | Preparation of combined steroid hormone derivative- antitumor substance |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5581900A (en) |
-
1978
- 1978-12-14 JP JP15484278A patent/JPS5581900A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS629119B2 (en) | 1987-02-26 |
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