GB761618A - Steroid hormone compositions - Google Patents

Steroid hormone compositions

Info

Publication number
GB761618A
GB761618A GB22095/54A GB2209554A GB761618A GB 761618 A GB761618 A GB 761618A GB 22095/54 A GB22095/54 A GB 22095/54A GB 2209554 A GB2209554 A GB 2209554A GB 761618 A GB761618 A GB 761618A
Authority
GB
United Kingdom
Prior art keywords
hormones
nicotinamide
solubilized
hydrocortisone
nicotinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22095/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB761618A publication Critical patent/GB761618A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Steroid hormones are solubilized by a pyridine derivative of formula <FORM:0761618/VI/1> where R is an alkoxy, amino or substituted amino radical. Specified derivatives include methyl nicotinate, ethyl nicotinate, methyl isonicotinate, nicotinamide, N, N-diethyl nicotinamide, isonicotnic acid hydrazide and pyrizinamide. Adrenal hormones (cortisone, hydrocortisone, corticosterone, desoxycorticosterone and dehydrocorticosterone), estrogenic hormones (a -estradiol), corpus luteum hormone (progesterone) and androgenic hormones (testosterone), alone or mixed, may be solubilized. The composition gives a solution on addition of water or a medicinally acceptable oil. Benzyl alcohol may also be present. The solutions formed may be used for oral, topical, intramuscular, intravenous, opthalmic, nasal or irrigational administration. An example describes the preparation of an aqueous solution of hydrocortisone alcohol and nicotinamide.
GB22095/54A 1953-08-12 1954-07-28 Steroid hormone compositions Expired GB761618A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US761618XA 1953-08-12 1953-08-12

Publications (1)

Publication Number Publication Date
GB761618A true GB761618A (en) 1956-11-14

Family

ID=22130318

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22095/54A Expired GB761618A (en) 1953-08-12 1954-07-28 Steroid hormone compositions

Country Status (1)

Country Link
GB (1) GB761618A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1674399A1 (en) * 2004-12-22 2006-06-28 Mattern, Udo Use of a container made of a plastic material containing an inorganic additive
US8609043B2 (en) 2004-12-28 2013-12-17 M & P Patent Aktiengesellschaft Use of a container of an inorganic additive containing plastic material
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US10111888B2 (en) 2011-05-13 2018-10-30 Acerus Biopharma Inc. Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US10668084B2 (en) 2011-05-13 2020-06-02 Acerus Biopharma Inc. Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US11090312B2 (en) 2013-03-15 2021-08-17 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testerosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1674399A1 (en) * 2004-12-22 2006-06-28 Mattern, Udo Use of a container made of a plastic material containing an inorganic additive
WO2006066645A2 (en) * 2004-12-22 2006-06-29 M & P Patent Aktiengesellschaft Use of a container made of a plastic material containing an inorganic additive
WO2006066645A3 (en) * 2004-12-22 2006-08-17 Mattern Udo Use of a container made of a plastic material containing an inorganic additive
JP2008523931A (en) * 2004-12-22 2008-07-10 エム アンド ペー パテント アクツィエンゲゼルシャフト Use of plastic material containers containing inorganic additives
HRP20070151B1 (en) * 2004-12-22 2014-06-06 M & P Patent Aktiengesellschaft, C/O Fundationanstalt Use of a container of an inorganic additive containing plastic material
NO338427B1 (en) * 2004-12-22 2016-08-15 M & P Patent Ag Use of a container of an inorganic additive-containing plastic material
US8609043B2 (en) 2004-12-28 2013-12-17 M & P Patent Aktiengesellschaft Use of a container of an inorganic additive containing plastic material
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US10111888B2 (en) 2011-05-13 2018-10-30 Acerus Biopharma Inc. Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US10668084B2 (en) 2011-05-13 2020-06-02 Acerus Biopharma Inc. Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US11090312B2 (en) 2013-03-15 2021-08-17 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testerosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event

Similar Documents

Publication Publication Date Title
Potter et al. Novel steroidal inhibitors of human cytochrome P45017. alpha.-Hydroxylase-C17, 20-lyase): potential agents for the treatment of prostatic cancer
GB761618A (en) Steroid hormone compositions
Clinton et al. Communications. Steroidal [2, 3-d] isoxazoles
Dube et al. Estradiol and progesterone receptors in dog prostate cytosol
Kraus GLYCYRRHETINIC ACID—A TRITERPENE WITH ANTI‐OESTROGENIC AND ANTI‐INFLAMMATORY ACTIVITY
Hannah et al. Substituted pyrazolo corticoids as topical antiinflammatory agents
GB931222A (en) Steroid compounds
GB1409239A (en) Process for the preparation of 3alpha-hydroxy-5alpha-steroids
IE34308B1 (en) 11beta,13beta dialkylgona-1,3,5(10)-trien-3-ol 3-cycloalkyl ethers
US3026317A (en) [3, 2-c]-pyrimidine derivatives of androstane compounds
JPS51149258A (en) A process for preparing steroid derivatives
GB754609A (en) Adrenal hormone compositions
GB555445A (en) Hormone preparations
GB1152180A (en) delta&lt;8(14)&gt;-Steroids
GB1037891A (en) Process for the manufacture of 19-nor-steroids
GB765509A (en) Improvements in or relating to steroids and the preparation thereof
IE43985L (en) D-homosteroids
GB884544A (en) 6-methyl steroid compounds
GB924588A (en) Improvements in or relating to a - nor - steroid derivatives
JPS5589299A (en) Novel estradiol derivative, its preparation, and antitumor agent
GB750941A (en) Steroids
DE2611535A1 (en) 6ALPHA-HYDROXY-8ALPHA-OESTRADIOLS
GB1061236A (en) Pharmaceutical compositions comprising anti-inflammatory steroids and anti-viral nucleosides
GB752826A (en) Improvements relating to the preparation of í¸ pregnene-17ª , 21-diol-3,11,20-trione-, 20-di-alkylene ketals
FR2438055A1 (en) Nor:steroid fertility control agents - of oestrane, androstane and gonane and the corresponding di:homo-steroid(s)