FR2362845A1 - Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2362845A1
FR2362845A1 FR7726070A FR7726070A FR2362845A1 FR 2362845 A1 FR2362845 A1 FR 2362845A1 FR 7726070 A FR7726070 A FR 7726070A FR 7726070 A FR7726070 A FR 7726070A FR 2362845 A1 FR2362845 A1 FR 2362845A1
Authority
FR
France
Prior art keywords
propyl
hydroxy
amino
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7726070A
Other languages
English (en)
French (fr)
Other versions
FR2362845B1 (hu
Inventor
Kalman Takacs
Peter Literati Nagy
Ilona Kiss
Antal Simay
Matyas Szentivanyi
Sandor Virag
Katalin Farago
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of FR2362845A1 publication Critical patent/FR2362845A1/fr
Application granted granted Critical
Publication of FR2362845B1 publication Critical patent/FR2362845B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyrrole Compounds (AREA)
FR7726070A 1976-08-27 1977-08-26 Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant Granted FR2362845A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU76CI1682A HU177578B (en) 1976-08-27 1976-08-27 Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives

Publications (2)

Publication Number Publication Date
FR2362845A1 true FR2362845A1 (fr) 1978-03-24
FR2362845B1 FR2362845B1 (hu) 1981-01-09

Family

ID=10994625

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7726070A Granted FR2362845A1 (fr) 1976-08-27 1977-08-26 Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (23)

Country Link
JP (1) JPS5350131A (hu)
AT (1) AT355554B (hu)
AU (1) AU521432B2 (hu)
BE (1) BE858134A (hu)
CA (1) CA1077506A (hu)
CH (1) CH630344A5 (hu)
CS (1) CS204008B2 (hu)
DD (1) DD132433A5 (hu)
DE (1) DE2738589A1 (hu)
DK (1) DK150196C (hu)
ES (1) ES462346A1 (hu)
FI (1) FI68396C (hu)
FR (1) FR2362845A1 (hu)
GB (1) GB1582029A (hu)
GR (1) GR63623B (hu)
HU (1) HU177578B (hu)
IL (1) IL52804A (hu)
NL (1) NL187478C (hu)
NO (1) NO144793C (hu)
PL (1) PL107628B1 (hu)
SE (1) SE435280B (hu)
SU (1) SU730296A3 (hu)
YU (2) YU202377A (hu)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR890100669A (el) * 1988-10-20 1990-11-29 Biorex Kutato Fejlesztoe Kft Μέ?οδος παρασκευής νέων αλογονιδίων 0-(3-αμινο-2-υδροξυπροπυλ)-υδροξιμικού οξέος.
WO1997016439A1 (en) * 1995-11-02 1997-05-09 Biorex Kutató és Fejlesztó Rt. Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
WO1997023198A1 (en) * 1995-12-22 1997-07-03 Medgene Limited A cosmetic composition and a method for reducing the ageing processes of skin
WO2000007580A2 (en) * 1998-08-03 2000-02-17 N-Gene Kutató Kft. Pharmaceutical compositions against autoimmune diseases

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849522A (en) * 1983-11-03 1989-07-18 Merrell Dow Pharmaceuticals Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
ZA848428B (en) * 1983-11-03 1985-06-26 Merrell Pharma Inc Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones
JPH01169445A (ja) * 1987-12-25 1989-07-04 Fuji Photo Film Co Ltd 焦点距離切換えカメラ
HUT54347A (en) * 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes
IL139470A0 (en) 1998-05-11 2001-11-25 Takeda Chemical Industries Ltd Oxyiminoalkanoic acid derivatives
PL371251A1 (en) 2002-01-11 2005-06-13 Biorex Kutato Es Fejlesztö Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
EP4247792A1 (en) 2020-11-19 2023-09-27 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR890100669A (el) * 1988-10-20 1990-11-29 Biorex Kutato Fejlesztoe Kft Μέ?οδος παρασκευής νέων αλογονιδίων 0-(3-αμινο-2-υδροξυπροπυλ)-υδροξιμικού οξέος.
WO1997016439A1 (en) * 1995-11-02 1997-05-09 Biorex Kutató és Fejlesztó Rt. Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
WO1997023198A1 (en) * 1995-12-22 1997-07-03 Medgene Limited A cosmetic composition and a method for reducing the ageing processes of skin
EP1025838A1 (en) * 1995-12-22 2000-08-09 Medgene Limited A cosmetic composition and a method for reducing the ageing processes of skin
WO2000007580A2 (en) * 1998-08-03 2000-02-17 N-Gene Kutató Kft. Pharmaceutical compositions against autoimmune diseases
WO2000007580A3 (en) * 1998-08-03 2000-05-18 Gene Kutato Kft N Pharmaceutical compositions against autoimmune diseases

Also Published As

Publication number Publication date
CH630344A5 (en) 1982-06-15
FR2362845B1 (hu) 1981-01-09
IL52804A (en) 1981-06-29
FI68396C (fi) 1985-09-10
JPS6216942B2 (hu) 1987-04-15
SE7709482L (sv) 1978-02-28
CS204008B2 (en) 1981-03-31
DE2738589A1 (de) 1978-03-02
NO144793C (no) 1981-11-11
JPS5350131A (en) 1978-05-08
DD132433A5 (de) 1978-09-27
PL107628B1 (pl) 1980-02-29
AU521432B2 (en) 1982-04-01
HU177578B (en) 1981-11-28
FI772551A (fi) 1978-02-28
SU730296A3 (ru) 1980-04-25
YU202377A (en) 1983-12-31
DK150196C (da) 1987-07-06
YU237782A (en) 1983-12-31
FI68396B (fi) 1985-05-31
BE858134A (fr) 1977-12-16
ATA605477A (de) 1979-08-15
NO144793B (no) 1981-08-03
DK150196B (da) 1987-01-05
DK379777A (da) 1978-02-28
ES462346A1 (es) 1978-06-16
GB1582029A (en) 1980-12-31
NL187478C (nl) 1991-10-16
AU2825477A (en) 1979-03-01
AT355554B (de) 1980-03-10
NO772958L (no) 1978-02-28
SE435280B (sv) 1984-09-17
GR63623B (en) 1979-11-27
IL52804A0 (en) 1977-10-31
CA1077506A (en) 1980-05-13
NL7709276A (nl) 1978-03-01

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Legal Events

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ST Notification of lapse