GR890100669A - Μέ?οδος παρασκευής νέων αλογονιδίων 0-(3-αμινο-2-υδροξυπροπυλ)-υδροξιμικού οξέος. - Google Patents
Μέ?οδος παρασκευής νέων αλογονιδίων 0-(3-αμινο-2-υδροξυπροπυλ)-υδροξιμικού οξέος.Info
- Publication number
- GR890100669A GR890100669A GR890100669A GR890100669A GR890100669A GR 890100669 A GR890100669 A GR 890100669A GR 890100669 A GR890100669 A GR 890100669A GR 890100669 A GR890100669 A GR 890100669A GR 890100669 A GR890100669 A GR 890100669A
- Authority
- GR
- Greece
- Prior art keywords
- novel
- acid halides
- hydroxypropyl
- amino
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
Δίδονται μια μέθοδος δια την παρασκευήν νέων αλογονιδίων υδροξιμικού οξέος και φαρμακευτικαί συνθέσεις αι οποίαι περιέχουν τις ανωτέρω νέες ενώσεις ως δραστικόν συστατικόν προς χρήσιν δια την θεραπείαν της διαβητικής αγγεοπάθειας. (χημικές ενώσεις) ω
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU885405A HU207988B (en) | 1988-10-20 | 1988-10-20 | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
Publications (2)
Publication Number | Publication Date |
---|---|
GR890100669A true GR890100669A (el) | 1990-11-29 |
GR1002253B GR1002253B (en) | 1996-04-23 |
Family
ID=10970243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR890100669A GR1002253B (en) | 1988-10-20 | 1989-10-19 | Novel 0-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same |
Country Status (20)
Country | Link |
---|---|
US (3) | US5147879A (el) |
EP (1) | EP0417210B1 (el) |
JP (1) | JPH0819078B2 (el) |
KR (1) | KR0154117B1 (el) |
AU (1) | AU620460B2 (el) |
CA (1) | CA2000830C (el) |
DE (1) | DE68913737T2 (el) |
DK (1) | DK175584B1 (el) |
ES (1) | ES2020030A6 (el) |
FI (1) | FI93214C (el) |
GR (1) | GR1002253B (el) |
HU (1) | HU207988B (el) |
IE (1) | IE65113B1 (el) |
IL (1) | IL92000A (el) |
NO (1) | NO178148C (el) |
PL (1) | PL164547B1 (el) |
PT (1) | PT92041B (el) |
RU (1) | RU2093508C1 (el) |
UA (1) | UA34412C2 (el) |
WO (1) | WO1990004584A1 (el) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100372312B1 (ko) * | 1994-05-06 | 2003-05-09 | 바이오렉스 쿠타토 에스 페레즈토 알티 | 신규의히드록시믹산유도체,그를포함한약제학적조성물및그의제조방법 |
US5665756A (en) * | 1994-08-03 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders |
HU9502843D0 (en) * | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
US6884424B2 (en) | 1995-12-22 | 2005-04-26 | N-Gene Research Laboratories Inc. | Method for treating the pathological lesions of the skin that develop by ultraviolet radiation of the sunlight |
HUT78138A (hu) | 1995-12-22 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt | Hidroximsavszármazékot tartalmazó készítmény a növénytermesztés elősegítésére és alkalmazása |
HUT78139A (hu) * | 1995-12-22 | 2000-11-28 | BIOREX Kutató és Fejlesztő Rt. | Készítmény, különösen a bőr öregedési folyamatainak mérséklésére |
US6458371B1 (en) | 1995-12-22 | 2002-10-01 | Medgene, Limited | Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin |
AU745987B2 (en) * | 1995-12-22 | 2002-04-11 | N-Gene Research Laboratories Inc. | A cosmetic composition and a method for reducing the ageing processes of skin |
DE19607960A1 (de) * | 1996-03-01 | 1997-09-04 | Hoechst Schering Agrevo Gmbh | Verfahren zur Herstellung von Ketonoximether durch Boronsäurekupplung |
GB9613339D0 (en) * | 1996-06-26 | 1996-08-28 | Kritzinger Ann C | Limp bookbinding assembly technique for two books in one pass |
UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
HU220971B1 (hu) * | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
HU9701081D0 (en) | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
WO2000007580A2 (en) * | 1998-08-03 | 2000-02-17 | N-Gene Kutató Kft. | Pharmaceutical compositions against autoimmune diseases |
HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
US6933104B1 (en) | 1999-04-23 | 2005-08-23 | Shiva Biomedical, Llc | Diagnosis and treatment of human kidney diseases |
HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
ATE386523T1 (de) * | 2001-07-17 | 2008-03-15 | N Gene Res Lab Inc | Synergistische pharmazeutische zusammensetzungen zur behandlung bzw. prophylaxe von diabetes |
HUP0105205A2 (hu) * | 2001-11-29 | 2003-08-28 | BIOREX Kutató és Fejlesztő Rt. | Metformint és egy hidroxilaminszármazékot tartalmazó, gyógyászati készítmény |
ES2298438T3 (es) * | 2001-12-21 | 2008-05-16 | Rhodia Inc. | Composiciones estables combinadas de tensioactivos cationicos y anionicos. |
AU2003202104B8 (en) * | 2002-01-11 | 2008-10-02 | Cytrx Corporation | Carboxamidine derivatives and their use in the treatment of vascular diseases |
HUP0303584A3 (en) * | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
DE10351448A1 (de) * | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
US20080227813A1 (en) * | 2006-09-26 | 2008-09-18 | Jack Raymond Barber | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
US7763601B2 (en) * | 2006-11-02 | 2010-07-27 | N-Gene Research Laboratories, Inc. | Prevention and treatment of obesity |
BRPI0919867A2 (pt) | 2008-11-18 | 2015-12-15 | Santen Pharmaceutical Co Ltd | agente terapeutico ou profilatico para uma doenca degenerativa coriorretiniana, e metodo profilatico ou terapeutico para uma doenca degenerativa coriorrentiniana |
HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
KR101995300B1 (ko) | 2018-03-30 | 2019-10-17 | 주식회사 아세아텍 | 다목적 관리기용 작업기 탈부착장치 |
HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
CN112174853B (zh) * | 2020-11-03 | 2023-07-25 | 湖南经世新材料有限责任公司 | 一种氨解法制备(z)-n-羟基苯脒的方法 |
US20230416224A1 (en) | 2020-11-19 | 2023-12-28 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
WO2023053008A1 (en) * | 2021-09-28 | 2023-04-06 | Kempharm Denmark A/S | Oximes and their use in treatment of gba-related diseases |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2362845A1 (fr) * | 1976-08-27 | 1978-03-24 | Chinoin Gyogyszer Es Vegyeszet | Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant |
US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670497C3 (de) * | 1967-06-06 | 1973-12-20 | Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt, Budapest | Isochinohnderivate und Verfahren zu deren Herstellung |
US4308399A (en) * | 1977-08-30 | 1981-12-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
EP0369944A1 (de) * | 1988-11-18 | 1990-05-23 | Ciba-Geigy Ag | Substituierte Oxadiaminobutane |
FR2639942B1 (fr) * | 1988-12-02 | 1991-03-29 | Sanofi Sa | Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant |
HUT54347A (en) * | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
-
1988
- 1988-10-20 HU HU885405A patent/HU207988B/hu unknown
-
1989
- 1989-10-16 IL IL9200089A patent/IL92000A/en not_active IP Right Cessation
- 1989-10-17 CA CA002000830A patent/CA2000830C/en not_active Expired - Lifetime
- 1989-10-19 GR GR890100669A patent/GR1002253B/el not_active IP Right Cessation
- 1989-10-19 AU AU44186/89A patent/AU620460B2/en not_active Expired
- 1989-10-19 KR KR1019900701346A patent/KR0154117B1/ko not_active IP Right Cessation
- 1989-10-19 UA UA4830570A patent/UA34412C2/uk unknown
- 1989-10-19 PL PL89281898A patent/PL164547B1/pl unknown
- 1989-10-19 RU SU894830570A patent/RU2093508C1/ru active
- 1989-10-19 IE IE336489A patent/IE65113B1/en not_active IP Right Cessation
- 1989-10-19 DE DE68913737T patent/DE68913737T2/de not_active Expired - Lifetime
- 1989-10-19 JP JP1510821A patent/JPH0819078B2/ja not_active Expired - Fee Related
- 1989-10-19 EP EP89911590A patent/EP0417210B1/en not_active Expired - Lifetime
- 1989-10-19 PT PT92041A patent/PT92041B/pt not_active IP Right Cessation
- 1989-10-19 US US07/499,318 patent/US5147879A/en not_active Expired - Lifetime
- 1989-10-19 WO PCT/HU1989/000048 patent/WO1990004584A1/en active IP Right Grant
- 1989-10-20 ES ES8903542A patent/ES2020030A6/es not_active Expired - Fee Related
-
1990
- 1990-06-18 NO NO902703A patent/NO178148C/no unknown
- 1990-06-19 DK DK199001497A patent/DK175584B1/da not_active IP Right Cessation
- 1990-06-19 FI FI903075A patent/FI93214C/fi active IP Right Grant
-
1992
- 1992-07-01 US US07/906,402 patent/US5296606A/en not_active Expired - Lifetime
-
1993
- 1993-06-07 US US08/072,765 patent/US5328906A/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2362845A1 (fr) * | 1976-08-27 | 1978-03-24 | Chinoin Gyogyszer Es Vegyeszet | Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant |
US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
Non-Patent Citations (1)
Title |
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CLAIMS SEARCHED: ALL * |
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MA | Right expired |