WO2000007580A3 - Pharmaceutical compositions against autoimmune diseases - Google Patents

Pharmaceutical compositions against autoimmune diseases Download PDF

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Publication number
WO2000007580A3
WO2000007580A3 PCT/HU1999/000054 HU9900054W WO0007580A3 WO 2000007580 A3 WO2000007580 A3 WO 2000007580A3 HU 9900054 W HU9900054 W HU 9900054W WO 0007580 A3 WO0007580 A3 WO 0007580A3
Authority
WO
WIPO (PCT)
Prior art keywords
autoimmune diseases
pharmaceutical compositions
against autoimmune
compositions against
formula
Prior art date
Application number
PCT/HU1999/000054
Other languages
French (fr)
Other versions
WO2000007580A2 (en
Inventor
Balazs Suemegi
Original Assignee
Gene Kutato Kft N
Balazs Suemegi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9801772A external-priority patent/HU9801772D0/en
Priority claimed from HU9902398A external-priority patent/HUP9902398A3/en
Application filed by Gene Kutato Kft N, Balazs Suemegi filed Critical Gene Kutato Kft N
Priority to AU52967/99A priority Critical patent/AU5296799A/en
Publication of WO2000007580A2 publication Critical patent/WO2000007580A2/en
Publication of WO2000007580A3 publication Critical patent/WO2000007580A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

The invention refers to the use of hydroximic acid derivatives of formula (I), wherein R?1, R2, R3¿, R, X, Y, A and B are as defined in the description, for the preparation of a pharmaceutical composition against autoimmune diseases.
PCT/HU1999/000054 1998-08-03 1999-08-02 Pharmaceutical compositions against autoimmune diseases WO2000007580A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52967/99A AU5296799A (en) 1998-08-03 1999-08-02 Pharmaceutical compositions against autoimmune diseases

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HUP9801772 1998-08-03
HU9801772A HU9801772D0 (en) 1998-08-03 1998-08-03 Pharmaceutical composition
HU9902398A HUP9902398A3 (en) 1999-07-19 1999-07-19 Use of hydroxamic acid derivatives for preparation of medicaments against autoimmun illnesses
HUP9902398 1999-07-19

Publications (2)

Publication Number Publication Date
WO2000007580A2 WO2000007580A2 (en) 2000-02-17
WO2000007580A3 true WO2000007580A3 (en) 2000-05-18

Family

ID=89998777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1999/000054 WO2000007580A2 (en) 1998-08-03 1999-08-02 Pharmaceutical compositions against autoimmune diseases

Country Status (2)

Country Link
AU (1) AU5296799A (en)
WO (1) WO2000007580A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2452558C (en) 2001-07-17 2009-12-22 N-Gene Research Laboratories Inc. A synergistic pharmaceutical combination for the prevention or treatment of diabetes
US7763601B2 (en) 2006-11-02 2010-07-27 N-Gene Research Laboratories, Inc. Prevention and treatment of obesity
HUP1100445A2 (en) 2011-08-17 2013-02-28 Pharma Gene Sa Pharmaceutical composition
HUP1100444A2 (en) 2011-08-17 2013-02-28 Pharma Gene Sa Pharmaceutical composition
HUP1800298A1 (en) 2018-08-30 2020-05-28 N Gene Res Laboratories Inc Combination of beta blocker and hydroximic acid derivative with reduced side effects

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2362845A1 (en) * 1976-08-27 1978-03-24 Chinoin Gyogyszer Es Vegyeszet NEW O- (3-AMINO-2-HYDROXY-PROPYL) -AMIDOXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1990004584A1 (en) * 1988-10-20 1990-05-03 Biorex Kutató Fejleszto^' Kft. Novel o-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same
WO1997013504A1 (en) * 1995-09-29 1997-04-17 Medgene Limited Pharmaceutical compositions containing hydroximic acid derivatives
WO1997016439A1 (en) * 1995-11-02 1997-05-09 Biorex Kutató és Fejlesztó Rt. Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
DE19756236A1 (en) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Novel piperazinyl-substituted pyridylalkane, alkene and alkyarboxylic acid amides
DE19818044A1 (en) * 1998-04-22 1999-10-28 Klinge Co Chem Pharm Fab Reducing side effects or neutralizing action of carcinostatic or immunosuppressive agents, especially pyridine derivatives, using vitamin PP compounds, e.g. nicotinamide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2362845A1 (en) * 1976-08-27 1978-03-24 Chinoin Gyogyszer Es Vegyeszet NEW O- (3-AMINO-2-HYDROXY-PROPYL) -AMIDOXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1990004584A1 (en) * 1988-10-20 1990-05-03 Biorex Kutató Fejleszto^' Kft. Novel o-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same
WO1997013504A1 (en) * 1995-09-29 1997-04-17 Medgene Limited Pharmaceutical compositions containing hydroximic acid derivatives
WO1997016439A1 (en) * 1995-11-02 1997-05-09 Biorex Kutató és Fejlesztó Rt. Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
DE19756236A1 (en) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Novel piperazinyl-substituted pyridylalkane, alkene and alkyarboxylic acid amides
DE19818044A1 (en) * 1998-04-22 1999-10-28 Klinge Co Chem Pharm Fab Reducing side effects or neutralizing action of carcinostatic or immunosuppressive agents, especially pyridine derivatives, using vitamin PP compounds, e.g. nicotinamide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VIGH L ET AL: "Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects.", NATURE MEDICINE, (1997 OCT) 3 (10) 1150-4., XP000876870 *

Also Published As

Publication number Publication date
AU5296799A (en) 2000-02-28
WO2000007580A2 (en) 2000-02-17

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