FR2340932A1 - Derives de proline et composes apparentes, utiles pour reduire la tension sanguine - Google Patents

Derives de proline et composes apparentes, utiles pour reduire la tension sanguine

Info

Publication number
FR2340932A1
FR2340932A1 FR7704122A FR7704122A FR2340932A1 FR 2340932 A1 FR2340932 A1 FR 2340932A1 FR 7704122 A FR7704122 A FR 7704122A FR 7704122 A FR7704122 A FR 7704122A FR 2340932 A1 FR2340932 A1 FR 2340932A1
Authority
FR
France
Prior art keywords
compounds useful
related compounds
reducing blood
proline derivatives
blood tension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7704122A
Other languages
English (en)
French (fr)
Other versions
FR2340932B1 (enrdf_load_stackoverflow
Inventor
Miguel Angel Ondetti
David Wayne Cushman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/657,792 external-priority patent/US4046889A/en
Priority claimed from US05/751,851 external-priority patent/US4105776A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2340932A1 publication Critical patent/FR2340932A1/fr
Application granted granted Critical
Publication of FR2340932B1 publication Critical patent/FR2340932B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7704122A 1976-02-13 1977-02-14 Derives de proline et composes apparentes, utiles pour reduire la tension sanguine Granted FR2340932A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/657,792 US4046889A (en) 1976-02-13 1976-02-13 Azetidine-2-carboxylic acid derivatives
US69843276A 1976-06-21 1976-06-21
US05/751,851 US4105776A (en) 1976-06-21 1976-12-22 Proline derivatives and related compounds

Publications (2)

Publication Number Publication Date
FR2340932A1 true FR2340932A1 (fr) 1977-09-09
FR2340932B1 FR2340932B1 (enrdf_load_stackoverflow) 1981-02-06

Family

ID=27417986

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7704122A Granted FR2340932A1 (fr) 1976-02-13 1977-02-14 Derives de proline et composes apparentes, utiles pour reduire la tension sanguine

Country Status (31)

Country Link
JP (1) JPS604815B2 (enrdf_load_stackoverflow)
AR (4) AR222445A1 (enrdf_load_stackoverflow)
AT (1) AT365569B (enrdf_load_stackoverflow)
AU (1) AU509899B2 (enrdf_load_stackoverflow)
BG (3) BG37074A3 (enrdf_load_stackoverflow)
CA (1) CA1101864A (enrdf_load_stackoverflow)
CH (3) CH622503A5 (enrdf_load_stackoverflow)
DD (1) DD129442B3 (enrdf_load_stackoverflow)
DE (2) DE2759862C2 (enrdf_load_stackoverflow)
DK (1) DK157487C (enrdf_load_stackoverflow)
ES (5) ES455803A1 (enrdf_load_stackoverflow)
FI (1) FI66596C (enrdf_load_stackoverflow)
FR (1) FR2340932A1 (enrdf_load_stackoverflow)
GB (1) GB1576161A (enrdf_load_stackoverflow)
GR (1) GR69811B (enrdf_load_stackoverflow)
HK (1) HK20281A (enrdf_load_stackoverflow)
HU (1) HU181965B (enrdf_load_stackoverflow)
IE (1) IE44707B1 (enrdf_load_stackoverflow)
IL (1) IL51297A (enrdf_load_stackoverflow)
IT (1) IT1062293B (enrdf_load_stackoverflow)
KE (1) KE3136A (enrdf_load_stackoverflow)
MY (2) MY8200075A (enrdf_load_stackoverflow)
NL (1) NL168509C (enrdf_load_stackoverflow)
NO (1) NO146985C (enrdf_load_stackoverflow)
NZ (1) NZ183130A (enrdf_load_stackoverflow)
PH (1) PH12970A (enrdf_load_stackoverflow)
PL (1) PL118161B1 (enrdf_load_stackoverflow)
RO (1) RO69941A (enrdf_load_stackoverflow)
SE (2) SE423812B (enrdf_load_stackoverflow)
SU (1) SU747422A3 (enrdf_load_stackoverflow)
YU (1) YU40664B (enrdf_load_stackoverflow)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372817A1 (fr) * 1976-12-03 1978-06-30 Squibb & Sons Inc Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
FR2377374A1 (fr) * 1977-01-17 1978-08-11 Squibb & Sons Inc Derives acyles d'amino-acides et leur utilisation comme medicaments
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
FR2413089A1 (fr) * 1977-12-27 1979-07-27 Squibb & Sons Inc Composition de traitement de l'hypertension
FR2417500A1 (fr) * 1978-02-15 1979-09-14 Squibb & Sons Inc Derives d'amino-acides cycliques dehydrogenes et leur utilisation therapeutique
FR2417499A1 (fr) * 1978-02-21 1979-09-14 Squibb & Sons Inc Mercaptoacylamino-acides halogenes et leur utilisation therapeutique
FR2422651A1 (fr) * 1978-04-14 1979-11-09 Squibb & Sons Inc Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde a usage therapeutique
FR2432019A1 (fr) * 1978-07-27 1980-02-22 Squibb & Sons Inc Thiopropanoylamino-acides et leur utilisation therapeutique
FR2443460A1 (fr) * 1978-12-08 1980-07-04 Squibb & Sons Inc Derives mercaptoacyles d'acides 4,5-dihydro-1h-pyrrole-2-carboxyliques et d'acides 1,4,5,6-tetrahydropyridine-2-carboxyliques, utiles comme agents hypotenseurs
FR2445324A1 (fr) * 1978-12-30 1980-07-25 Santen Pharmaceutical Co Ltd Nouveaux derives disulfures contenant un cycle pyrrolidine ou thiazolidine utiles comme antihypertenseurs et pour prevenir et traiter les complications du diabete et procedes pour leur preparation
FR2446281A1 (fr) * 1979-01-15 1980-08-08 Squibb & Sons Inc Carbamates de mercaptoacyl hydroxy prolines, a action antihypertensive
FR2450824A1 (fr) * 1979-03-08 1980-10-03 Squibb & Sons Inc Nouveaux derives d'acides 1-(o-mercaptoacyl)-5-pyrazolidinone-3-carboxyliques, utiles notamment comme agents hypotenseurs
FR2468589A1 (fr) * 1979-05-18 1981-05-08 Squibb & Sons Inc Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive
FR2471975A1 (fr) * 1979-12-13 1981-06-26 Kanegafuchi Chemical Ind Procede pour la preparation de n-mercaptoalcanoylaminoacides optiquement actifs
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them
FR2473517A1 (fr) * 1979-12-10 1981-07-17 Squibb & Sons Inc Derives d'acide carbothioique de mercaptoacyl amino acides a action anti-hypertensive et leur procede de preparation
FR2478632A1 (fr) * 1980-03-21 1981-09-25 Squibb & Sons Inc Derives mercaptoacyles de la proline et de l'acide pipecolique a fonction cetonique, a action anti-hypertensive
FR2567881A1 (fr) * 1984-07-23 1986-01-24 Boryung Pharm Procede pour la production d'un derive de pyrrolidine
FR2574792A1 (fr) * 1984-12-19 1986-06-20 Boryung Pharm Procede pour la preparation de derives de pyrrolidine
FR2577222A1 (fr) * 1985-02-11 1986-08-14 Boryung Pharm Procede pour la preparation de l'acide 1-(3-mercapto-25-methylpropionyl)-pyrrolidine-(25)-carboxylique
EP0427435A1 (en) * 1989-11-06 1991-05-15 E.R. Squibb & Sons, Inc. Process for direct isolation of captopril
WO1994004129A3 (de) * 1992-08-26 1994-05-26 Beiersdorf Ag Kosmetische und dermatologische lichtschutzformulierungen mit einem gehalt an thiolen und/oder thiolderivaten
WO1994004128A3 (de) * 1992-08-26 1994-07-07 Beiersdorf Ag Verwendung von radikalfängern als immunmodulierende agentien in kosmetischen und dermatologischen zubereitungen

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053651A (en) 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
NZ190995A (en) * 1978-09-05 1982-03-09 American Cyanamid Co Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
NL7809121A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Optisch aktieve derivaten van mercapto-isoboterzuur.
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
GR73585B (enrdf_load_stackoverflow) * 1978-09-11 1984-03-26 Univ Miami
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
JPS5540622A (en) * 1978-09-14 1980-03-22 Santen Pharmaceut Co Ltd Hypotensive agent
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
US4410542A (en) 1978-12-30 1983-10-18 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
JPS5629403U (enrdf_load_stackoverflow) * 1979-08-13 1981-03-20
DE2937779A1 (de) * 1979-09-19 1981-04-09 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
DE3011239A1 (de) * 1980-03-22 1981-10-01 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte alkylthioacylaminosaeuren, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
SE8203245L (sv) * 1981-05-27 1982-11-28 Crc Ricerca Chim Forfarande for enantioselektiv framstellning av n-substituerade prolinderivat
JPH06740B2 (ja) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 光学活性カルボン酸アミドの製造法
HU196369B (en) * 1984-10-18 1988-11-28 Egyt Gyogyszervegyeszeti Gyar New process for producing n-acylized l-prolin derivatives
AT395012B (de) * 1986-06-27 1992-08-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen
JP2863534B2 (ja) * 1988-10-24 1999-03-03 マリオン ラボラトリーズ，インコーポレイティド 医薬組成物
IT1266570B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
GB9704522D0 (en) * 1997-03-05 1997-04-23 Smithkline Beecham Plc Compounds
PT915088E (pt) * 1997-10-31 2003-01-31 Hoffmann La Roche Derivados de d-prolina
IL159983A0 (en) * 2001-08-07 2004-06-20 Sunesis Pharmaceuticals Inc Disulfide and thiosulfonate ligands and libraries comprising these ligands
CN100361971C (zh) * 2005-09-19 2008-01-16 华中师范大学 催化活性可调的双官能团l-脯氨酸衍生物及制备
EP2328619B1 (en) 2008-08-22 2016-12-07 Baxalta GmbH Polymeric benzyl carbonate-derivatives
CN104822266B (zh) 2012-04-27 2017-12-05 陶氏益农公司 杀虫组合物和与其相关的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA946836A (en) * 1970-03-18 1974-05-07 Miguel A. Ondetti Enzyme inhibitor

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372817A1 (fr) * 1976-12-03 1978-06-30 Squibb & Sons Inc Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
FR2377374A1 (fr) * 1977-01-17 1978-08-11 Squibb & Sons Inc Derives acyles d'amino-acides et leur utilisation comme medicaments
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
FR2413089A1 (fr) * 1977-12-27 1979-07-27 Squibb & Sons Inc Composition de traitement de l'hypertension
FR2417500A1 (fr) * 1978-02-15 1979-09-14 Squibb & Sons Inc Derives d'amino-acides cycliques dehydrogenes et leur utilisation therapeutique
FR2417499A1 (fr) * 1978-02-21 1979-09-14 Squibb & Sons Inc Mercaptoacylamino-acides halogenes et leur utilisation therapeutique
FR2422651A1 (fr) * 1978-04-14 1979-11-09 Squibb & Sons Inc Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde a usage therapeutique
FR2432019A1 (fr) * 1978-07-27 1980-02-22 Squibb & Sons Inc Thiopropanoylamino-acides et leur utilisation therapeutique
FR2443460A1 (fr) * 1978-12-08 1980-07-04 Squibb & Sons Inc Derives mercaptoacyles d'acides 4,5-dihydro-1h-pyrrole-2-carboxyliques et d'acides 1,4,5,6-tetrahydropyridine-2-carboxyliques, utiles comme agents hypotenseurs
FR2445324A1 (fr) * 1978-12-30 1980-07-25 Santen Pharmaceutical Co Ltd Nouveaux derives disulfures contenant un cycle pyrrolidine ou thiazolidine utiles comme antihypertenseurs et pour prevenir et traiter les complications du diabete et procedes pour leur preparation
FR2446281A1 (fr) * 1979-01-15 1980-08-08 Squibb & Sons Inc Carbamates de mercaptoacyl hydroxy prolines, a action antihypertensive
FR2450824A1 (fr) * 1979-03-08 1980-10-03 Squibb & Sons Inc Nouveaux derives d'acides 1-(o-mercaptoacyl)-5-pyrazolidinone-3-carboxyliques, utiles notamment comme agents hypotenseurs
FR2468589A1 (fr) * 1979-05-18 1981-05-08 Squibb & Sons Inc Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive
FR2473517A1 (fr) * 1979-12-10 1981-07-17 Squibb & Sons Inc Derives d'acide carbothioique de mercaptoacyl amino acides a action anti-hypertensive et leur procede de preparation
FR2471975A1 (fr) * 1979-12-13 1981-06-26 Kanegafuchi Chemical Ind Procede pour la preparation de n-mercaptoalcanoylaminoacides optiquement actifs
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them
FR2478632A1 (fr) * 1980-03-21 1981-09-25 Squibb & Sons Inc Derives mercaptoacyles de la proline et de l'acide pipecolique a fonction cetonique, a action anti-hypertensive
FR2567881A1 (fr) * 1984-07-23 1986-01-24 Boryung Pharm Procede pour la production d'un derive de pyrrolidine
FR2574792A1 (fr) * 1984-12-19 1986-06-20 Boryung Pharm Procede pour la preparation de derives de pyrrolidine
FR2577222A1 (fr) * 1985-02-11 1986-08-14 Boryung Pharm Procede pour la preparation de l'acide 1-(3-mercapto-25-methylpropionyl)-pyrrolidine-(25)-carboxylique
EP0427435A1 (en) * 1989-11-06 1991-05-15 E.R. Squibb & Sons, Inc. Process for direct isolation of captopril
WO1994004129A3 (de) * 1992-08-26 1994-05-26 Beiersdorf Ag Kosmetische und dermatologische lichtschutzformulierungen mit einem gehalt an thiolen und/oder thiolderivaten
WO1994004128A3 (de) * 1992-08-26 1994-07-07 Beiersdorf Ag Verwendung von radikalfängern als immunmodulierende agentien in kosmetischen und dermatologischen zubereitungen
AU690075B2 (en) * 1992-08-26 1998-04-23 Beiersdorf Aktiengesellschaft Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions

Also Published As

Publication number Publication date
BG37075A3 (bg) 1985-03-15
ATA98977A (de) 1981-06-15
PL195965A1 (pl) 1978-02-27
AU509899B2 (en) 1980-05-29
PH12970A (en) 1979-10-24
AU2134777A (en) 1978-07-20
SE7701561L (sv) 1977-09-23
DD129442B3 (de) 1990-01-10
ES467051A1 (es) 1978-11-01
GR69811B (enrdf_load_stackoverflow) 1982-07-13
DE2703828A1 (de) 1977-08-18
PL118161B1 (en) 1981-09-30
NL168509C (nl) 1982-04-16
AT365569B (de) 1982-01-25
IL51297A (en) 1980-03-31
DD129442A5 (de) 1978-01-18
SE423812B (sv) 1982-06-07
YU33177A (en) 1983-01-21
SE8104660L (sv) 1981-08-03
SU747422A3 (ru) 1980-07-23
DE2703828C2 (de) 1984-06-20
NO146985B (no) 1982-10-04
GB1576161A (en) 1980-10-01
ES467053A1 (es) 1978-11-01
FI770437A7 (enrdf_load_stackoverflow) 1977-08-14
DE2759862C2 (enrdf_load_stackoverflow) 1989-12-07
HU181965B (en) 1983-11-28
ES467052A1 (es) 1978-11-01
RO69941A (ro) 1980-05-15
CH624932A5 (enrdf_load_stackoverflow) 1981-08-31
AR226290A1 (es) 1982-06-30
FI66596B (fi) 1984-07-31
DK157487B (da) 1990-01-15
ES467050A1 (es) 1978-11-01
NO770464L (no) 1977-08-16
ES455803A1 (es) 1978-06-16
IE44707B1 (en) 1982-03-10
IT1062293B (it) 1984-05-23
HK20281A (en) 1981-05-22
MY102705A (en) 1992-09-30
IL51297A0 (en) 1977-03-31
BG37074A3 (bg) 1985-03-15
KE3136A (en) 1981-07-03
FI66596C (fi) 1987-03-18
NL7701457A (nl) 1977-08-16
NZ183130A (en) 1979-08-31
YU40664B (en) 1986-04-30
DK59677A (da) 1977-08-14
FR2340932B1 (enrdf_load_stackoverflow) 1981-02-06
AR222445A1 (es) 1981-05-29
CH624931A5 (enrdf_load_stackoverflow) 1981-08-31
SE426697B (sv) 1983-02-07
CH622503A5 (en) 1981-04-15
JPS604815B2 (ja) 1985-02-06
AR214649A1 (es) 1979-07-13
BG37375A3 (bg) 1985-05-15
CA1101864A (en) 1981-05-26
IE44707L (en) 1977-08-13
NO146985C (no) 1983-01-12
MY8200075A (en) 1982-12-31
DK157487C (da) 1990-06-11
JPS52116457A (en) 1977-09-29
AR222783A1 (es) 1981-06-30

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