FR22C1047I1 - Derives de benzimidazole-proline - Google Patents
Derives de benzimidazole-prolineInfo
- Publication number
- FR22C1047I1 FR22C1047I1 FR22C1047C FR22C1047C FR22C1047I1 FR 22C1047 I1 FR22C1047 I1 FR 22C1047I1 FR 22C1047 C FR22C1047 C FR 22C1047C FR 22C1047 C FR22C1047 C FR 22C1047C FR 22C1047 I1 FR22C1047 I1 FR 22C1047I1
- Authority
- FR
- France
- Prior art keywords
- benzimidazole
- proline derivatives
- proline
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170748 | 2012-06-04 | ||
| EP13158520 | 2013-03-11 | ||
| PCT/IB2013/054567 WO2013182972A1 (fr) | 2012-06-04 | 2013-06-03 | Dérivés de benzimidazole-proline |
| EP13744805.6A EP2855453B1 (fr) | 2012-06-04 | 2013-06-03 | Dérivés de benzimidazole-proline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR22C1047I1 true FR22C1047I1 (fr) | 2022-10-14 |
| FR22C1047I2 FR22C1047I2 (fr) | 2023-08-18 |
Family
ID=48914370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR22C1047C Active FR22C1047I2 (fr) | 2012-06-04 | 2022-09-13 | Derives de benzimidazole-proline |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US9732075B2 (fr) |
| EP (1) | EP2855453B1 (fr) |
| JP (1) | JP5814491B2 (fr) |
| KR (3) | KR101689093B1 (fr) |
| CN (1) | CN104334544B (fr) |
| AR (1) | AR091257A1 (fr) |
| AU (1) | AU2013273222B2 (fr) |
| BR (1) | BR112014030173B1 (fr) |
| CA (1) | CA2873341C (fr) |
| CL (1) | CL2014003294A1 (fr) |
| CY (1) | CY1118735T1 (fr) |
| DK (1) | DK2855453T3 (fr) |
| EA (2) | EA028046B1 (fr) |
| ES (1) | ES2617863T3 (fr) |
| FR (1) | FR22C1047I2 (fr) |
| HK (1) | HK1208449A1 (fr) |
| HR (1) | HRP20170351T1 (fr) |
| HU (2) | HUE031753T2 (fr) |
| IL (1) | IL236024A (fr) |
| LT (2) | LT2855453T (fr) |
| MX (1) | MX354102B (fr) |
| MY (1) | MY169986A (fr) |
| NL (1) | NL301197I2 (fr) |
| NO (1) | NO2022044I1 (fr) |
| NZ (1) | NZ703448A (fr) |
| PH (1) | PH12014502540A1 (fr) |
| PL (1) | PL2855453T3 (fr) |
| PT (1) | PT2855453T (fr) |
| SG (2) | SG11201408004SA (fr) |
| SI (1) | SI2855453T1 (fr) |
| TW (2) | TWI570120B (fr) |
| WO (1) | WO2013182972A1 (fr) |
| ZA (1) | ZA201409422B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807000C (fr) | 2010-08-24 | 2018-12-04 | Actelion Pharmaceuticals Ltd | Derives de proline sulfonamide comme antagonistes des recepteurs de l'orexine |
| EP2855453B1 (fr) | 2012-06-04 | 2016-12-07 | Actelion Pharmaceuticals Ltd. | Dérivés de benzimidazole-proline |
| CN104703980B (zh) | 2012-10-10 | 2017-09-22 | 埃科特莱茵药品有限公司 | 属于[邻双(杂)芳基]‑[2‑(间双(杂)芳基)吡咯烷‑1‑基]甲酮衍生物的食欲素受体拮抗剂 |
| KR20150130413A (ko) | 2013-03-12 | 2015-11-23 | 액테리온 파마슈티칼 리미티드 | 오렉신 수용체 길항제로서의 아제티딘 아미드 유도체 |
| SG11201600504TA (en) | 2013-07-22 | 2016-02-26 | Actelion Pharmaceuticals Ltd | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
| PT3077389T (pt) | 2013-12-03 | 2017-12-15 | Idorsia Pharmaceuticals Ltd | Forma cristalina de (s)-(2-(6-cloro-7-metil-1hbenzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metoxi-2-(2h-1,2,3-triazol-2-il)fenil)metanona e a sua utilização como como antagonistas do receptor de orexina |
| UA119151C2 (uk) * | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| LT3077391T (lt) * | 2013-12-04 | 2018-10-25 | Idorsia Pharmaceuticals Ltd | Benzimidazolo prolino darinių panaudojimas |
| KR20160124188A (ko) * | 2014-02-20 | 2016-10-26 | 다케다 파머수티컬 컴패니 리미티드 | 오렉신 수용체 길항제로서의 치환된 시클로펜탄, 테트라히드로푸란 및 피롤리딘 |
| TW201613864A (en) * | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| ES2709985T3 (es) * | 2015-01-15 | 2019-04-22 | Idorsia Pharmaceuticals Ltd | Derivados de hidroxialquil-piperazina como moduladores del receptor CXCR3 |
| AU2016295693B2 (en) | 2015-07-17 | 2020-05-21 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
| TWI734702B (zh) | 2015-10-01 | 2021-08-01 | 美商百歐克斯製藥公司 | 人類血漿激肽釋放酶抑制劑 |
| AU2016360245B2 (en) | 2015-11-23 | 2020-07-09 | Sunshine Lake Pharma Co., Ltd. | Octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof |
| CN110612291B (zh) | 2017-05-03 | 2024-02-13 | 爱杜西亚药品有限公司 | 2-([1,2,3]三唑-2-基)-苯甲酸衍生物的制备 |
| WO2019002344A1 (fr) | 2017-06-29 | 2019-01-03 | Lonza Guangzhou Nansha Ltd. | Procédé de préparation d'alpha-méthyl-l-proline |
| WO2020007964A1 (fr) | 2018-07-05 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | Dérivés de 2-(2-azabicyclo [3.1.0] hexan-1-yl)-1h-benzimidazole |
| WO2020007977A1 (fr) | 2018-07-06 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | Dérivés de 7-trifluorométhyl-[1,4]diazépane |
| CN108997308A (zh) * | 2018-07-09 | 2018-12-14 | 西藏大学 | 一种苯并咪唑类衍生物及其制备方法和应用 |
| WO2020099511A1 (fr) | 2018-11-14 | 2020-05-22 | Idorsia Pharmaceuticals Ltd | Dérivés de benzimidazole-2-méthyl-morpholine |
| EP4138822A1 (fr) | 2020-04-19 | 2023-03-01 | Idorsia Pharmaceuticals Ltd | Utilisation médicale de daridorexant |
| WO2022166768A1 (fr) * | 2021-02-02 | 2022-08-11 | 南京明德新药研发有限公司 | Composé tétrahydropyrrolocyclique et son application |
| WO2023160004A1 (fr) * | 2022-02-25 | 2023-08-31 | 南京知和医药科技有限公司 | Composé à cycle fusionné ayant une activité analgésique, son procédé de préparation et son utilisation |
| TW202400149A (zh) | 2022-05-13 | 2024-01-01 | 瑞士商愛杜西亞製藥有限公司 | 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物 |
| CN117736193A (zh) * | 2023-12-19 | 2024-03-22 | 南京知和医药科技有限公司 | 一种氘代稠环化合物及其制备方法与用途 |
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