FR2140616A1 - - Google Patents

Info

Publication number
FR2140616A1
FR2140616A1 FR7220803A FR7220803A FR2140616A1 FR 2140616 A1 FR2140616 A1 FR 2140616A1 FR 7220803 A FR7220803 A FR 7220803A FR 7220803 A FR7220803 A FR 7220803A FR 2140616 A1 FR2140616 A1 FR 2140616A1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7220803A
Other versions
FR2140616B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2140616A1 publication Critical patent/FR2140616A1/fr
Application granted granted Critical
Publication of FR2140616B1 publication Critical patent/FR2140616B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/31—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation of cyclic compounds with ring-splitting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
FR7220803A 1971-06-09 1972-06-09 Expired FR2140616B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1960471A GB1364672A (en) 1971-06-09 1971-06-09 Penicillins

Publications (2)

Publication Number Publication Date
FR2140616A1 true FR2140616A1 (fr) 1973-01-19
FR2140616B1 FR2140616B1 (fr) 1976-08-20

Family

ID=10132139

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7220804A Expired FR2140617B1 (fr) 1971-06-09 1972-06-09
FR7220803A Expired FR2140616B1 (fr) 1971-06-09 1972-06-09
FR7605942A Granted FR2299857A1 (fr) 1971-06-09 1976-03-03 Esters de penicillines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7220804A Expired FR2140617B1 (fr) 1971-06-09 1972-06-09

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7605942A Granted FR2299857A1 (fr) 1971-06-09 1976-03-03 Esters de penicillines

Country Status (33)

Country Link
US (7) US3860579A (fr)
JP (8) JPS602310B1 (fr)
AR (2) AR192944A1 (fr)
AT (4) AT320155B (fr)
AU (2) AU476038B2 (fr)
BE (2) BE784698A (fr)
CA (3) CA1126260A (fr)
CH (4) CH605986A5 (fr)
CS (1) CS198111B2 (fr)
CY (1) CY861A (fr)
DD (1) DD99802A5 (fr)
DE (2) DE2228012C3 (fr)
DK (1) DK140597B (fr)
ES (4) ES403667A1 (fr)
FI (1) FI58642C (fr)
FR (3) FR2140617B1 (fr)
GB (1) GB1364672A (fr)
HK (1) HK71676A (fr)
HU (1) HU166360B (fr)
IE (3) IE37757B1 (fr)
IL (3) IL39771A (fr)
IS (1) IS923B6 (fr)
KE (2) KE2632A (fr)
MY (2) MY7600196A (fr)
NL (2) NL178006C (fr)
NO (1) NO144169C (fr)
OA (1) OA04101A (fr)
PL (2) PL96668B1 (fr)
SE (7) SE432102B (fr)
SU (2) SU507244A3 (fr)
YU (2) YU36029B (fr)
ZA (2) ZA723799B (fr)
ZM (1) ZM9172A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2198745A1 (fr) * 1972-09-08 1974-04-05 Beecham Group Ltd
FR2474033A1 (fr) * 1980-01-11 1981-07-24 Squibb & Sons Inc Esters phtalidyliques du produit d'addition acetonique de l'epicilline, a action antibacterienne

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1377661A (en) * 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
GB1364672A (en) * 1971-06-09 1974-08-29 Beecham Group Ltd Penicillins
US4092476A (en) * 1974-02-21 1978-05-30 Beecham Group Limited Phthalidyl esters of 7-[(α amino, 2 substituted acetamido)-3-(heterocyclic-thio methyl)]cephalosporins
US4115646A (en) * 1975-02-22 1978-09-19 Beecham Group Limited Process for preparing 7-aminocephalosporanic acid derivatives
GB1565656A (en) * 1975-12-13 1980-04-23 Beecham Group Ltd Preparation of substituted penicillin acid esters
NZ189945A (en) * 1978-04-01 1981-04-24 Beecham Group Ltd Ampicillin phthalidyl ester naphthalene 2-sulphonate also pharmaceutical compositions
US4206218A (en) * 1978-08-31 1980-06-03 E. R. Squibb & Sons, Inc. Phthalidyl esters of the acetone adduct of epicillin
EP0014651B1 (fr) * 1979-02-05 1982-08-04 Sanofi S.A. 2-Méthoxyphénoxyacétate de talampicilline, procédé pour sa préparation et médicaments le renfermant
US4340539A (en) * 1980-01-21 1982-07-20 Bristol-Myers Company Derivatives of 6-bromo penicillanic acid
IT1130969B (it) * 1980-03-14 1986-06-18 Dob Far Spa Esteri della cefapirina,loro sali e procedimento per il loro ottenimento
CA1212105A (fr) 1980-04-30 1986-09-30 Shoji Ikeda Esters d'ampiciline, et leur production
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
GB2157284B (en) * 1984-04-11 1987-11-04 Leo Pharm Prod Ltd 6-b-halopenicillanic acid salts
IT1180207B (it) * 1984-07-30 1987-09-23 Istituto Biochimico Italiano Procedimento per la preparazione, con resa e purezza elevate, di antibiotici beta-lattamici
US4675210A (en) * 1984-10-10 1987-06-23 Hercules Incorporated Maleic modified butene copolymers for adhering polypropylene
JPH01148353A (ja) * 1987-12-02 1989-06-09 Sadami Ujima 遠心脱水機
US5695473A (en) * 1994-07-27 1997-12-09 Sims Deltec, Inc. Occlusion detection system for an infusion pump
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1404324B2 (fr) * 2001-06-11 2011-04-06 XenoPort, Inc. Promedicaments d'analogues de gaba, compositions et utilisations desdits promedicaments
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en) * 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP2354120A1 (fr) 2003-08-20 2011-08-10 XenoPort, Inc. Synthèse de promédicaments a base de carbamate d'acyloxyalkyle et leurs intermédiaires
KR20110097942A (ko) * 2003-08-20 2011-08-31 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
BRPI0517227B8 (pt) * 2004-11-04 2021-05-25 Xenoport Inc comprimido oral de liberação prolongada do ácido 1-{[alfa-isobutanoiloxietoxi)carbonil]amino metil}-1-cicloexano acético, e, uso do comprimido
AU2006262386B2 (en) 2005-06-20 2012-02-02 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
WO2011028234A1 (fr) * 2009-09-04 2011-03-10 Xenoport, Inc. Utilisations de promédicaments acyloxyalkyl carbamates de l'acide tranexamique
US20110184060A1 (en) * 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
US3652546A (en) * 1965-07-22 1972-03-28 Bristol Myers Co Esters of 6-aminopenicillanic acid
GB1175590A (en) * 1967-08-09 1969-12-23 Beecham Group Ltd Therapeutic Compositions
US3697507A (en) * 1968-09-26 1972-10-10 Leo Pharm Prod Ltd Esters of {60 -aminobenzylpenicillin
FR2020209A1 (en) * 1968-10-09 1970-07-10 Sarath Antibiotic acylxymethyl 7-(alpha-amino-alpha-phenyl- - acetamido)-3-methyl-delta-3-cephem-4-carboxylates
GB1234426A (fr) * 1968-10-23 1971-06-03
IE34019B1 (en) * 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
BE754141A (fr) * 1969-08-04 1971-02-01 Pfizer Esters d'alpha-carboxyarylmethyl penicillines
BE758782A (fr) * 1969-11-11 1971-05-10 Leo Pharm Prod Ltd Nouveaux derives d'acide 6-amidino penicillanique leur procede de preparation et leurs applications comme antibiotiques
US3726861A (en) * 1971-06-03 1973-04-10 American Home Prod Ureido derivatives of 6-aminopenicillanic acid saccharimide
GB1377661A (en) * 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
GB1364672A (en) * 1971-06-09 1974-08-29 Beecham Group Ltd Penicillins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2198745A1 (fr) * 1972-09-08 1974-04-05 Beecham Group Ltd
FR2474033A1 (fr) * 1980-01-11 1981-07-24 Squibb & Sons Inc Esters phtalidyliques du produit d'addition acetonique de l'epicilline, a action antibacterienne

Also Published As

Publication number Publication date
IL39772A0 (en) 1972-08-30
JPS5253888A (en) 1977-04-30
SE7600562L (sv) 1976-01-20
IE37757L (en) 1972-12-09
DE2228012C3 (de) 1980-01-17
CA1131620A (fr) 1982-09-14
AR193581A1 (es) 1973-04-30
DD99802A5 (fr) 1973-08-20
KE2631A (en) 1976-06-11
AR192944A1 (es) 1973-03-21
IS2078A7 (is) 1972-12-10
IE37757B1 (en) 1977-10-12
HU166360B (fr) 1975-03-28
KE2632A (en) 1976-06-11
US3939180A (en) 1976-02-17
ZM9172A1 (en) 1973-01-22
JPS5253889A (en) 1977-04-30
USRE29650E (en) 1978-05-30
IE37758B1 (en) 1977-10-12
CH605986A5 (fr) 1978-10-13
NO144169B (no) 1981-03-30
SE433939B (sv) 1984-06-25
JPS5235678B1 (fr) 1977-09-10
DE2228255C2 (de) 1983-12-08
FR2140617B1 (fr) 1976-07-02
MY7600195A (en) 1976-12-31
AU463395B2 (en) 1975-07-24
SE7809237L (sv) 1978-09-01
AU4331372A (en) 1973-12-13
YU36377B (en) 1983-06-30
IL39771A0 (en) 1972-08-30
AT318147B (de) 1974-09-25
PL96668B1 (pl) 1978-01-31
AT318806B (de) 1974-11-25
AU4331472A (en) 1973-12-13
HK71676A (en) 1976-11-26
ZA723800B (en) 1973-03-28
NL7207626A (fr) 1972-12-12
ES403672A1 (es) 1975-07-01
OA04101A (fr) 1979-11-15
ES403667A1 (es) 1976-01-01
JPS5253887A (en) 1977-04-30
SU507244A3 (ru) 1976-03-15
ES431087A1 (es) 1976-11-01
IS923B6 (is) 1976-03-30
AT317427B (de) 1974-08-26
CH577514A5 (fr) 1976-07-15
NL178006B (nl) 1985-08-01
SU578887A3 (ru) 1977-10-30
JPS5253886A (en) 1977-04-30
CH587265A5 (fr) 1977-04-29
US3919196A (en) 1975-11-11
CA1126260A (fr) 1982-06-22
JPS6021593B2 (ja) 1985-05-28
DK140597C (fr) 1980-02-25
YU36029B (en) 1981-11-13
MY7600196A (en) 1976-12-31
DE2228255A1 (de) 1972-12-28
DE2228012A1 (de) 1972-12-28
NL7207820A (fr) 1972-12-12
BE784699A (fr) 1972-12-11
ZA723799B (en) 1973-03-28
FI58642C (fi) 1981-03-10
IL47578A (en) 1975-12-31
JPS5659779A (en) 1981-05-23
YU186679A (en) 1981-11-13
IE36461L (en) 1972-12-09
AT320155B (de) 1975-01-27
JPS5659780A (en) 1981-05-23
FI58642B (fi) 1980-11-28
CH587267A5 (fr) 1977-04-29
FR2299857B1 (fr) 1978-11-17
FR2140617A1 (fr) 1973-01-19
US4036829A (en) 1977-07-19
GB1364672A (en) 1974-08-29
AU476038B2 (en) 1976-09-09
JPS6021594B2 (ja) 1985-05-28
FR2140616B1 (fr) 1976-08-20
DK140597B (da) 1979-10-08
SE7809236L (sv) 1978-09-01
IL39771A (en) 1975-12-31
SE430605B (sv) 1983-11-28
CA1126258A (fr) 1982-06-22
JPS602310B1 (fr) 1985-01-21
US3963702A (en) 1976-06-15
ES431086A1 (es) 1976-11-01
CS198111B2 (en) 1980-05-30
IE36461B1 (en) 1976-11-10
US3860579A (en) 1975-01-14
BE784698A (fr) 1972-12-11
SE7600561L (sv) 1976-01-20
SE430606B (sv) 1983-11-28
PL87735B1 (en) 1976-07-31
SE433938B (sv) 1984-06-25
SE7809241L (sv) 1978-09-01
US3963704A (en) 1976-06-15
NO144169C (no) 1981-07-08
CY861A (en) 1976-12-17
DE2228012B2 (de) 1979-05-23
SE390415B (sv) 1976-12-20
IL39772A (en) 1977-03-31
NL178006C (nl) 1986-01-02
FR2299857A1 (fr) 1976-09-03
YU153772A (en) 1981-04-30
SE432102B (sv) 1984-03-19

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Legal Events

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ST Notification of lapse