FR2016455A1 - - Google Patents

Info

Publication number
FR2016455A1
FR2016455A1 FR6929284A FR6929284A FR2016455A1 FR 2016455 A1 FR2016455 A1 FR 2016455A1 FR 6929284 A FR6929284 A FR 6929284A FR 6929284 A FR6929284 A FR 6929284A FR 2016455 A1 FR2016455 A1 FR 2016455A1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6929284A
Other versions
FR2016455B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2016455A1 publication Critical patent/FR2016455A1/fr
Application granted granted Critical
Publication of FR2016455B1 publication Critical patent/FR2016455B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
FR6929284A 1968-08-27 1969-08-27 Expired FR2016455B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76759468A 1968-08-27 1968-08-27

Publications (2)

Publication Number Publication Date
FR2016455A1 true FR2016455A1 (fr) 1970-05-08
FR2016455B1 FR2016455B1 (fr) 1974-02-01

Family

ID=25079964

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6929284A Expired FR2016455B1 (fr) 1968-08-27 1969-08-27

Country Status (18)

Country Link
US (1) US3591584A (fr)
JP (2) JPS50677B1 (fr)
AT (2) AT298503B (fr)
BE (1) BE737962A (fr)
BR (1) BR6911817D0 (fr)
CH (1) CH520705A (fr)
DE (2) DE1943265C3 (fr)
DK (1) DK145297C (fr)
ES (1) ES370861A1 (fr)
FI (1) FI51189C (fr)
FR (1) FR2016455B1 (fr)
GB (1) GB1257180A (fr)
IL (1) IL32836A (fr)
MY (1) MY7300310A (fr)
NL (1) NL157013B (fr)
NO (1) NO129746B (fr)
PH (1) PH10029A (fr)
SE (2) SE373854B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2128371A1 (fr) * 1971-03-01 1972-10-20 Warner Lambert Co
FR2183008A1 (fr) * 1972-04-28 1973-12-14 Warner Lambert Co
FR2401167A1 (fr) * 1977-08-22 1979-03-23 Hoffmann La Roche Derives de thienothiazine utiles comme medicaments
FR2485532A1 (fr) * 1980-06-27 1981-12-31 Mitsui Toatsu Chemicals Derives de benzothiazine, leur procede de preparation et composition therapeutique les contenant

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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US3692780A (en) * 1970-10-14 1972-09-19 Warner Lambert Pharmaceutical 4-substituted-2-alkyl-3-phenyl-2h-1,2-benzothiazine-1,1-dioxides and processes for their production
US3862319A (en) * 1971-02-09 1975-01-21 Pfizer Benzothiazine dioxides as anti-thromobotic agents
DK153148C (da) * 1971-03-01 1988-10-31 Warner Lambert Co Analogifremgangsmaade til fremstilling af 4-hydroxy-3-(3-isoxazolcarbamyl)-2h-1,2-benzothiazin-1,1-d ioxider eller alkalimetal-, jordalkalimetal- eller aminsalte deraf
US3853862A (en) * 1973-04-23 1974-12-10 Pfizer Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
US3927002A (en) * 1973-04-23 1975-12-16 Pfizer N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives
SE411208B (sv) * 1973-06-15 1979-12-10 Merck & Co Inc Forfarande for framstellning av merkaptoalkylpyridiner med en etenylsubstituent
US3891637A (en) * 1974-10-01 1975-06-24 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
DE2539112C2 (de) * 1975-09-03 1983-12-15 Dr. Karl Thomae Gmbh, 7950 Biberach 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SE421792B (sv) * 1976-01-12 1982-02-01 Pfizer Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid
MC1135A1 (fr) * 1976-02-23 1977-11-18 Hoffmann La Roche Derives de thiazine
US4100347A (en) 1976-06-10 1978-07-11 Pfizer Inc. 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
JPS5342370U (fr) * 1976-09-16 1978-04-12
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4213980A (en) * 1978-01-30 1980-07-22 Ciba-Geigy Corporation Azathianaphthalenes
US4246263A (en) 1979-10-15 1981-01-20 Pfizer Inc. Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
JPS5714589A (en) * 1980-06-27 1982-01-25 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation and drug composition
JPS57140785A (en) * 1981-02-24 1982-08-31 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation, and pharmaceutical composition containing the same
US4289879A (en) * 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
US4434164A (en) 1981-06-01 1984-02-28 Pfizer Inc. Crystalline benzothiazine dioxide salts
US4474955A (en) * 1981-06-17 1984-10-02 Vincenzo Iannella Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester
GT198276334A (es) * 1981-08-03 1984-01-10 Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina.
IN159273B (fr) * 1981-10-05 1987-04-25 Pfizer
CA1197244A (fr) * 1982-04-16 1985-11-26 Medichem, S.A. Methode de preparation de 4-hydroxy-2-methyl- 2h-1,2-benzothiazine-3-carboxamide-1,1-dioxydes
SU1306476A3 (ru) * 1982-06-17 1987-04-23 Пфайзер,Инк (Фирма) Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида
ATE31309T1 (de) * 1982-07-07 1987-12-15 Siegfried Ag Verfahren zur herstellung von 4-hydroxy-2-methyln-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid 1,1- dioxid.
JPS5913714A (ja) * 1982-07-13 1984-01-24 Taito Pfizer Kk 外用消炎鎮痛剤
US4483982A (en) * 1982-09-02 1984-11-20 Pfizer Inc. Processes for preparing piroxicam and intermediates leading thereto
DE3237473A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel
IT1153293B (it) * 1982-10-22 1987-01-14 Francia Famaceutici S R L Derivati del 4-idrossi-2-metil-2h-1, 2-benzotiazina-3-carbossamide 1, 1-biossido e procedimento per la loro preparazione
JPS59193879A (ja) * 1983-03-31 1984-11-02 Fujisawa Pharmaceut Co Ltd トロポン誘導体
JPS59179683U (ja) * 1983-05-19 1984-11-30 寺田毛織株式会社 貼り合わせふとん
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
DE3437232A1 (de) * 1984-10-10 1986-04-17 Mack Chem Pharm Stabilisierte injektionsloesungen von piroxicam
US4582831A (en) * 1984-11-16 1986-04-15 Pfizer Inc. Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
CH663899A5 (fr) * 1985-03-20 1988-01-29 Nestle Sa Procede pour la preparation d'une composition a base d'un principe actif de faible hydrosolubilite finement divise.
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4761424A (en) * 1985-10-01 1988-08-02 Warner-Lambert Company Enolamides, pharmaceutical compositions and methods for treating inflammation
US4829062A (en) * 1986-05-16 1989-05-09 Pfizer Inc. Benzothiazine dioxide derivatives
ATE66477T1 (de) * 1986-08-29 1991-09-15 Pfizer 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren.
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
WO1988009793A1 (fr) * 1987-06-10 1988-12-15 Pfizer Inc. DIHYDRO-3,4-ALKYL-2-OXO-3-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXYDES
US5081118A (en) * 1987-10-26 1992-01-14 Pfizer Inc. Benzothiazine dioxide derivatives
JPH0629271B2 (ja) * 1988-03-09 1994-04-20 株式会社日本ハイポックス ベンゾチアジン―１，１―ジオキシド誘導体及びそれを含有する医薬組成物
HU200926B (en) * 1988-10-28 1990-09-28 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules
JPH0717589B2 (ja) * 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規１，３―ジカルボニル化合物およびその組成物
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
DE4141218A1 (de) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
JP2964195B2 (ja) * 1992-04-28 1999-10-18 エスエス製薬株式会社 ピロキシカム錠及びその製造法
US5362758A (en) * 1992-09-18 1994-11-08 Pfizer Inc. Ophthalmic piroxicam solution
US5420124A (en) * 1994-01-12 1995-05-30 Kim; Young S. Stable, painless piroxicam potassium injectable composition
US5436241A (en) * 1994-01-14 1995-07-25 Bristol-Myers Squibb Company Topical anti-inflammatory compositions containing piroxicam
US5741798A (en) * 1996-06-03 1998-04-21 Boehringer Ingelheim Pharmaceuticals, Inc. 2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as antiinflammatory agents
US5952328A (en) * 1997-11-12 1999-09-14 Cephalon, Inc. Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
WO2000025776A1 (fr) 1998-10-30 2000-05-11 Nitromed, Inc. Composes anti-inflammatoires non steroidiens nitroses et nitrosyles, compositions et procedes d'utilisation
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
ITMI20020773A1 (it) * 2002-04-11 2003-10-13 Nicox Sa Farmaci per il trattamento dell'artrite
EP1653952A4 (fr) * 2003-08-06 2007-04-04 Pfizer Prod Inc Composes d'oxazole destines au traitement de troubles neurodegenerescents
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
US20050222227A1 (en) * 2004-04-01 2005-10-06 Pfizer Inc Oxazole-amine compounds for the treatment of neurodegenerative disorders
WO2007103540A2 (fr) 2006-03-08 2007-09-13 Pharmena North America Inc. Polytherapie presentant des inhibiteurs cox non selectifs en vue de prevenir des lesions gastriques liees a cox
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments
CN101665472B (zh) * 2009-06-15 2011-08-24 威海迪素制药有限公司 2-甲基-3，4-二氢-4-氧代-2h-1，2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法
ITUB20152229A1 (it) * 2015-07-16 2017-01-16 Edmond Pharma Srl Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302858B (fr) * 1962-09-21 1972-05-04

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2128371A1 (fr) * 1971-03-01 1972-10-20 Warner Lambert Co
FR2183008A1 (fr) * 1972-04-28 1973-12-14 Warner Lambert Co
FR2401167A1 (fr) * 1977-08-22 1979-03-23 Hoffmann La Roche Derives de thienothiazine utiles comme medicaments
FR2485532A1 (fr) * 1980-06-27 1981-12-31 Mitsui Toatsu Chemicals Derives de benzothiazine, leur procede de preparation et composition therapeutique les contenant

Also Published As

Publication number Publication date
SE402459B (sv) 1978-07-03
FI51189B (fr) 1976-08-02
SE373854B (fr) 1975-02-17
IL32836A0 (en) 1969-11-12
BE737962A (fr) 1970-02-26
DK145297C (da) 1983-03-14
DE1943265C3 (de) 1982-02-04
DK145297B (da) 1982-10-25
MY7300310A (en) 1973-12-31
IL32836A (en) 1972-08-30
JPS50677B1 (fr) 1975-01-10
DE1967325C2 (de) 1982-03-18
BR6911817D0 (pt) 1973-02-13
AT298503B (de) 1972-05-10
US3591584A (en) 1971-07-06
DE1967325B2 (de) 1981-08-13
AT294113B (de) 1971-11-10
FR2016455B1 (fr) 1974-02-01
DE1943265B2 (de) 1981-05-14
NL6912981A (fr) 1970-03-03
NL157013B (nl) 1978-06-15
NO129746B (fr) 1974-05-20
JPS5142114B1 (fr) 1976-11-13
PH10029A (en) 1976-07-13
CH520705A (fr) 1972-03-31
ES370861A1 (es) 1971-07-01
FI51189C (fi) 1976-11-10
GB1257180A (fr) 1971-12-15
DE1943265A1 (de) 1970-08-13

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Legal Events

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CD Change of name or company name
CL Concession to grant licences
CL Concession to grant licences