NL157013B - Werkwijze voor de bereiding van farmacologisch werkzame benzothiazine-1,1-dioxyde-derivaten en van preparaten die ze bevatten. - Google Patents
Werkwijze voor de bereiding van farmacologisch werkzame benzothiazine-1,1-dioxyde-derivaten en van preparaten die ze bevatten.Info
- Publication number
- NL157013B NL157013B NL6912981.A NL6912981A NL157013B NL 157013 B NL157013 B NL 157013B NL 6912981 A NL6912981 A NL 6912981A NL 157013 B NL157013 B NL 157013B
- Authority
- NL
- Netherlands
- Prior art keywords
- benzothiazine
- preparation
- pharmacologically active
- preparations containing
- dioxide derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76759468A | 1968-08-27 | 1968-08-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
NL6912981A NL6912981A (xx) | 1970-03-03 |
NL157013B true NL157013B (nl) | 1978-06-15 |
Family
ID=25079964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL6912981.A NL157013B (nl) | 1968-08-27 | 1969-08-26 | Werkwijze voor de bereiding van farmacologisch werkzame benzothiazine-1,1-dioxyde-derivaten en van preparaten die ze bevatten. |
Country Status (18)
Country | Link |
---|---|
US (1) | US3591584A (xx) |
JP (2) | JPS50677B1 (xx) |
AT (2) | AT298503B (xx) |
BE (1) | BE737962A (xx) |
BR (1) | BR6911817D0 (xx) |
CH (1) | CH520705A (xx) |
DE (2) | DE1943265C3 (xx) |
DK (1) | DK145297C (xx) |
ES (1) | ES370861A1 (xx) |
FI (1) | FI51189C (xx) |
FR (1) | FR2016455B1 (xx) |
GB (1) | GB1257180A (xx) |
IL (1) | IL32836A (xx) |
MY (1) | MY7300310A (xx) |
NL (1) | NL157013B (xx) |
NO (1) | NO129746B (xx) |
PH (1) | PH10029A (xx) |
SE (2) | SE373854B (xx) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3692780A (en) * | 1970-10-14 | 1972-09-19 | Warner Lambert Pharmaceutical | 4-substituted-2-alkyl-3-phenyl-2h-1,2-benzothiazine-1,1-dioxides and processes for their production |
US3862319A (en) * | 1971-02-09 | 1975-01-21 | Pfizer | Benzothiazine dioxides as anti-thromobotic agents |
US3787324A (en) * | 1971-03-01 | 1974-01-22 | Warner Lambert Co | 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production |
DK153148C (da) * | 1971-03-01 | 1988-10-31 | Warner Lambert Co | Analogifremgangsmaade til fremstilling af 4-hydroxy-3-(3-isoxazolcarbamyl)-2h-1,2-benzothiazin-1,1-d ioxider eller alkalimetal-, jordalkalimetal- eller aminsalte deraf |
US3769292A (en) * | 1972-04-28 | 1973-10-30 | Warner Lambert Co | N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides |
US3927002A (en) * | 1973-04-23 | 1975-12-16 | Pfizer | N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives |
US3853862A (en) * | 1973-04-23 | 1974-12-10 | Pfizer | Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides |
SE411208B (sv) * | 1973-06-15 | 1979-12-10 | Merck & Co Inc | Forfarande for framstellning av merkaptoalkylpyridiner med en etenylsubstituent |
US3891637A (en) * | 1974-10-01 | 1975-06-24 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
DE2539112C2 (de) * | 1975-09-03 | 1983-12-15 | Dr. Karl Thomae Gmbh, 7950 Biberach | 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
SE421792B (sv) * | 1976-01-12 | 1982-02-01 | Pfizer | Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid |
MC1135A1 (fr) * | 1976-02-23 | 1977-11-18 | Hoffmann La Roche | Derives de thiazine |
US4100347A (en) | 1976-06-10 | 1978-07-11 | Pfizer Inc. | 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide |
JPS5342370U (xx) * | 1976-09-16 | 1978-04-12 | ||
LU78009A1 (de) * | 1977-08-22 | 1979-05-23 | Hoffmann La Roche | Verfahren zur herstellung von thiazinderivaten |
DE2756113A1 (de) * | 1977-12-16 | 1979-06-21 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4213980A (en) * | 1978-01-30 | 1980-07-22 | Ciba-Geigy Corporation | Azathianaphthalenes |
US4246263A (en) | 1979-10-15 | 1981-01-20 | Pfizer Inc. | Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions |
JPS57140785A (en) * | 1981-02-24 | 1982-08-31 | Mitsui Toatsu Chem Inc | Benzothiazine derivative, its preparation, and pharmaceutical composition containing the same |
GB2078738B (en) * | 1980-06-27 | 1983-11-30 | Mitsui Toatsu Chemicals | Benzothiazine derivatives |
JPS5714589A (en) * | 1980-06-27 | 1982-01-25 | Mitsui Toatsu Chem Inc | Benzothiazine derivative, its preparation and drug composition |
US4289879A (en) * | 1980-09-29 | 1981-09-15 | Pfizer Inc. | Synthetic method and intermediate for piroxicam |
US4309427A (en) * | 1981-01-15 | 1982-01-05 | Pfizer Inc. | Benzothiazine dioxide derivatives |
US4434164A (en) | 1981-06-01 | 1984-02-28 | Pfizer Inc. | Crystalline benzothiazine dioxide salts |
US4474955A (en) * | 1981-06-17 | 1984-10-02 | Vincenzo Iannella | Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester |
GT198276334A (es) * | 1981-08-03 | 1984-01-10 | Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina. | |
IN159273B (xx) * | 1981-10-05 | 1987-04-25 | Pfizer | |
CA1197244A (en) * | 1982-04-16 | 1985-11-26 | Medichem, S.A. | Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides |
SU1306476A3 (ru) * | 1982-06-17 | 1987-04-23 | Пфайзер,Инк (Фирма) | Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида |
ATE31309T1 (de) * | 1982-07-07 | 1987-12-15 | Siegfried Ag | Verfahren zur herstellung von 4-hydroxy-2-methyln-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid 1,1- dioxid. |
JPS5913714A (ja) * | 1982-07-13 | 1984-01-24 | Taito Pfizer Kk | 外用消炎鎮痛剤 |
US4483982A (en) * | 1982-09-02 | 1984-11-20 | Pfizer Inc. | Processes for preparing piroxicam and intermediates leading thereto |
DE3237473A1 (de) * | 1982-10-09 | 1984-04-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel |
IT1153293B (it) * | 1982-10-22 | 1987-01-14 | Francia Famaceutici S R L | Derivati del 4-idrossi-2-metil-2h-1, 2-benzotiazina-3-carbossamide 1, 1-biossido e procedimento per la loro preparazione |
JPS59193879A (ja) * | 1983-03-31 | 1984-11-02 | Fujisawa Pharmaceut Co Ltd | トロポン誘導体 |
JPS59179683U (ja) * | 1983-05-19 | 1984-11-30 | 寺田毛織株式会社 | 貼り合わせふとん |
GR80576B (en) * | 1983-10-17 | 1984-11-29 | Fujisawa Pharmaceutical Co | Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same |
US4551452A (en) * | 1983-12-21 | 1985-11-05 | Pfizer Inc. | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
US4656265A (en) * | 1984-06-21 | 1987-04-07 | Pfizer Inc. | Cyclic prodrugs of antiinflammatory oxicams |
DE3437232A1 (de) * | 1984-10-10 | 1986-04-17 | Mack Chem Pharm | Stabilisierte injektionsloesungen von piroxicam |
US4582831A (en) | 1984-11-16 | 1986-04-15 | Pfizer Inc. | Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor |
CH663899A5 (fr) * | 1985-03-20 | 1988-01-29 | Nestle Sa | Procede pour la preparation d'une composition a base d'un principe actif de faible hydrosolubilite finement divise. |
US4623486A (en) * | 1985-05-29 | 1986-11-18 | Pfizer Inc. | [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity |
US4610982A (en) * | 1985-06-03 | 1986-09-09 | Pfizer Inc. | Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
US4761424A (en) * | 1985-10-01 | 1988-08-02 | Warner-Lambert Company | Enolamides, pharmaceutical compositions and methods for treating inflammation |
MX6506A (es) * | 1986-05-16 | 1993-10-01 | Pfizer | Derivados de dioxido de benzotiazina y procedimiento para su preparacion |
DE3772301D1 (de) * | 1986-08-29 | 1991-09-26 | Pfizer | 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren. |
US5196410A (en) * | 1986-10-31 | 1993-03-23 | Pfizer Inc. | Transdermal flux enhancing compositions |
US4914101A (en) * | 1987-06-10 | 1990-04-03 | Pfizer Inc. | 3,4-Dihydro-2-alkyl-3-oxo-n-aryl-2H-(1)benzo-thieno(3,2-e)-1,2-thiazine-4-carboxamide-1,1-dioxides |
US5081118A (en) * | 1987-10-26 | 1992-01-14 | Pfizer Inc. | Benzothiazine dioxide derivatives |
JPH0629271B2 (ja) * | 1988-03-09 | 1994-04-20 | 株式会社日本ハイポックス | ベンゾチアジン―1,1―ジオキシド誘導体及びそれを含有する医薬組成物 |
HU200926B (en) * | 1988-10-28 | 1990-09-28 | Egyt Gyogyszervegyeszeti Gyar | Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules |
JPH0717589B2 (ja) * | 1990-01-22 | 1995-03-01 | ファイザー製薬株式会社 | 新規1,3―ジカルボニル化合物およびその組成物 |
JP2988739B2 (ja) * | 1990-04-16 | 1999-12-13 | 協和醗酵工業株式会社 | 1,8−ナフチリジン−2−オン誘導体 |
DE4141218A1 (de) * | 1991-12-13 | 1993-06-17 | Luitpold Werk Chem Pharm | Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel |
JP2964195B2 (ja) * | 1992-04-28 | 1999-10-18 | エスエス製薬株式会社 | ピロキシカム錠及びその製造法 |
US5362758A (en) * | 1992-09-18 | 1994-11-08 | Pfizer Inc. | Ophthalmic piroxicam solution |
US5420124A (en) * | 1994-01-12 | 1995-05-30 | Kim; Young S. | Stable, painless piroxicam potassium injectable composition |
US5436241A (en) * | 1994-01-14 | 1995-07-25 | Bristol-Myers Squibb Company | Topical anti-inflammatory compositions containing piroxicam |
US5741798A (en) * | 1996-06-03 | 1998-04-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as antiinflammatory agents |
US5952328A (en) * | 1997-11-12 | 1999-09-14 | Cephalon, Inc. | Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors |
EP1126838A4 (en) | 1998-10-30 | 2005-02-16 | Nitromed Inc | NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
IT1308633B1 (it) | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
US6544556B1 (en) | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
ITMI20020773A1 (it) * | 2002-04-11 | 2003-10-13 | Nicox Sa | Farmaci per il trattamento dell'artrite |
WO2005016267A2 (en) * | 2003-08-06 | 2005-02-24 | Pfizer Products Inc. | Oxazole compounds for the treatment of neurodegenerative disorders |
US20060047171A1 (en) * | 2003-12-22 | 2006-03-02 | Harold Meckler | Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof |
US20050222227A1 (en) * | 2004-04-01 | 2005-10-06 | Pfizer Inc | Oxazole-amine compounds for the treatment of neurodegenerative disorders |
JP2009529057A (ja) | 2006-03-08 | 2009-08-13 | コートリア・コーポレーシヨン | Cox−関連胃損傷を予防するための非−選択的cox阻害剤との組み合わせ療法 |
FR2942797B1 (fr) * | 2009-03-03 | 2011-04-29 | Pf Medicament | Derives de benzothiazines, leur preparation et leur application a titre de medicaments |
CN101665472B (zh) * | 2009-06-15 | 2011-08-24 | 威海迪素制药有限公司 | 2-甲基-3,4-二氢-4-氧代-2h-1,2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法 |
ITUB20152229A1 (it) * | 2015-07-16 | 2017-01-16 | Edmond Pharma Srl | Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1302858B (xx) * | 1962-09-21 | 1972-05-04 |
-
1968
- 1968-08-27 US US767594*A patent/US3591584A/en not_active Expired - Lifetime
- 1968-12-31 GB GB1257180D patent/GB1257180A/en not_active Expired
-
1969
- 1969-08-12 NO NO03274/69A patent/NO129746B/no unknown
- 1969-08-15 IL IL32836A patent/IL32836A/en unknown
- 1969-08-25 BR BR211817/69A patent/BR6911817D0/pt unknown
- 1969-08-25 FI FI692460A patent/FI51189C/fi active
- 1969-08-25 PH PH10669A patent/PH10029A/en unknown
- 1969-08-26 BE BE737962D patent/BE737962A/xx not_active IP Right Cessation
- 1969-08-26 CH CH1291469A patent/CH520705A/fr not_active IP Right Cessation
- 1969-08-26 AT AT936670A patent/AT298503B/de not_active IP Right Cessation
- 1969-08-26 NL NL6912981.A patent/NL157013B/xx not_active IP Right Cessation
- 1969-08-26 ES ES370861A patent/ES370861A1/es not_active Expired
- 1969-08-26 DE DE1943265A patent/DE1943265C3/de not_active Expired
- 1969-08-26 AT AT814669A patent/AT294113B/de not_active IP Right Cessation
- 1969-08-26 DE DE1967325A patent/DE1967325C2/de not_active Expired
- 1969-08-26 DK DK457069A patent/DK145297C/da not_active IP Right Cessation
- 1969-08-27 FR FR6929284A patent/FR2016455B1/fr not_active Expired
- 1969-08-27 JP JP44067265A patent/JPS50677B1/ja active Pending
- 1969-08-27 SE SE6911871A patent/SE373854B/xx unknown
-
1973
- 1973-01-15 SE SE7300511A patent/SE402459B/xx unknown
- 1973-07-24 JP JP48082782A patent/JPS5142114B1/ja active Pending
- 1973-12-30 MY MY310/73A patent/MY7300310A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AT298503B (de) | 1972-05-10 |
AT294113B (de) | 1971-11-10 |
SE402459B (sv) | 1978-07-03 |
DE1943265A1 (de) | 1970-08-13 |
FR2016455A1 (xx) | 1970-05-08 |
DE1943265B2 (de) | 1981-05-14 |
MY7300310A (en) | 1973-12-31 |
FI51189B (xx) | 1976-08-02 |
NO129746B (xx) | 1974-05-20 |
CH520705A (fr) | 1972-03-31 |
DE1967325C2 (de) | 1982-03-18 |
NL6912981A (xx) | 1970-03-03 |
DE1967325B2 (de) | 1981-08-13 |
BE737962A (xx) | 1970-02-26 |
JPS50677B1 (xx) | 1975-01-10 |
ES370861A1 (es) | 1971-07-01 |
US3591584A (en) | 1971-07-06 |
FI51189C (fi) | 1976-11-10 |
DE1943265C3 (de) | 1982-02-04 |
GB1257180A (xx) | 1971-12-15 |
IL32836A (en) | 1972-08-30 |
IL32836A0 (en) | 1969-11-12 |
DK145297B (da) | 1982-10-25 |
SE373854B (xx) | 1975-02-17 |
BR6911817D0 (pt) | 1973-02-13 |
PH10029A (en) | 1976-07-13 |
FR2016455B1 (xx) | 1974-02-01 |
DK145297C (da) | 1983-03-14 |
JPS5142114B1 (xx) | 1976-11-13 |
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