JPS5142114B1 - - Google Patents

Info

Publication number
JPS5142114B1
JPS5142114B1 JP48082782A JP8278273A JPS5142114B1 JP S5142114 B1 JPS5142114 B1 JP S5142114B1 JP 48082782 A JP48082782 A JP 48082782A JP 8278273 A JP8278273 A JP 8278273A JP S5142114 B1 JPS5142114 B1 JP S5142114B1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP48082782A
Inventor
Jooji Romubaadeino Josefu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS5142114B1 publication Critical patent/JPS5142114B1/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
JP48082782A 1968-08-27 1973-07-24 Pending JPS5142114B1 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76759468A 1968-08-27 1968-08-27

Publications (1)

Publication Number Publication Date
JPS5142114B1 true JPS5142114B1 (ja) 1976-11-13

Family

ID=25079964

Family Applications (2)

Application Number Title Priority Date Filing Date
JP44067265A Pending JPS50677B1 (ja) 1968-08-27 1969-08-27
JP48082782A Pending JPS5142114B1 (ja) 1968-08-27 1973-07-24

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP44067265A Pending JPS50677B1 (ja) 1968-08-27 1969-08-27

Country Status (18)

Country Link
US (1) US3591584A (ja)
JP (2) JPS50677B1 (ja)
AT (2) AT294113B (ja)
BE (1) BE737962A (ja)
BR (1) BR6911817D0 (ja)
CH (1) CH520705A (ja)
DE (2) DE1967325C2 (ja)
DK (1) DK145297C (ja)
ES (1) ES370861A1 (ja)
FI (1) FI51189C (ja)
FR (1) FR2016455B1 (ja)
GB (1) GB1257180A (ja)
IL (1) IL32836A (ja)
MY (1) MY7300310A (ja)
NL (1) NL157013B (ja)
NO (1) NO129746B (ja)
PH (1) PH10029A (ja)
SE (2) SE373854B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59179683U (ja) * 1983-05-19 1984-11-30 寺田毛織株式会社 貼り合わせふとん

Families Citing this family (73)

* Cited by examiner, † Cited by third party
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US3692780A (en) * 1970-10-14 1972-09-19 Warner Lambert Pharmaceutical 4-substituted-2-alkyl-3-phenyl-2h-1,2-benzothiazine-1,1-dioxides and processes for their production
US3862319A (en) * 1971-02-09 1975-01-21 Pfizer Benzothiazine dioxides as anti-thromobotic agents
DK153148C (da) * 1971-03-01 1988-10-31 Warner Lambert Co Analogifremgangsmaade til fremstilling af 4-hydroxy-3-(3-isoxazolcarbamyl)-2h-1,2-benzothiazin-1,1-d ioxider eller alkalimetal-, jordalkalimetal- eller aminsalte deraf
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
US3927002A (en) * 1973-04-23 1975-12-16 Pfizer N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives
US3853862A (en) * 1973-04-23 1974-12-10 Pfizer Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
SE411208B (sv) * 1973-06-15 1979-12-10 Merck & Co Inc Forfarande for framstellning av merkaptoalkylpyridiner med en etenylsubstituent
US3891637A (en) * 1974-10-01 1975-06-24 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
DE2539112C2 (de) * 1975-09-03 1983-12-15 Dr. Karl Thomae Gmbh, 7950 Biberach 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SE421792B (sv) * 1976-01-12 1982-02-01 Pfizer Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid
MC1135A1 (fr) * 1976-02-23 1977-11-18 Hoffmann La Roche Derives de thiazine
US4100347A (en) 1976-06-10 1978-07-11 Pfizer Inc. 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
JPS5342370U (ja) * 1976-09-16 1978-04-12
LU78009A1 (de) * 1977-08-22 1979-05-23 Hoffmann La Roche Verfahren zur herstellung von thiazinderivaten
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4213980A (en) * 1978-01-30 1980-07-22 Ciba-Geigy Corporation Azathianaphthalenes
US4246263A (en) 1979-10-15 1981-01-20 Pfizer Inc. Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
JPS5714589A (en) * 1980-06-27 1982-01-25 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation and drug composition
GB2078738B (en) * 1980-06-27 1983-11-30 Mitsui Toatsu Chemicals Benzothiazine derivatives
JPS57140785A (en) * 1981-02-24 1982-08-31 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation, and pharmaceutical composition containing the same
US4289879A (en) * 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
US4434164A (en) 1981-06-01 1984-02-28 Pfizer Inc. Crystalline benzothiazine dioxide salts
US4474955A (en) * 1981-06-17 1984-10-02 Vincenzo Iannella Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester
GT198276334A (es) * 1981-08-03 1984-01-10 Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina.
IN159273B (ja) * 1981-10-05 1987-04-25 Pfizer
CA1197244A (en) * 1982-04-16 1985-11-26 Medichem, S.A. Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides
SU1306476A3 (ru) * 1982-06-17 1987-04-23 Пфайзер,Инк (Фирма) Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида
DE3374865D1 (en) * 1982-07-07 1988-01-21 Siegfried Ag Process for preparing 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide
JPS5913714A (ja) * 1982-07-13 1984-01-24 Taito Pfizer Kk 外用消炎鎮痛剤
US4483982A (en) * 1982-09-02 1984-11-20 Pfizer Inc. Processes for preparing piroxicam and intermediates leading thereto
DE3237473A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel
IT1153293B (it) * 1982-10-22 1987-01-14 Francia Famaceutici S R L Derivati del 4-idrossi-2-metil-2h-1, 2-benzotiazina-3-carbossamide 1, 1-biossido e procedimento per la loro preparazione
JPS59193879A (ja) * 1983-03-31 1984-11-02 Fujisawa Pharmaceut Co Ltd トロポン誘導体
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
DE3437232A1 (de) * 1984-10-10 1986-04-17 Mack Chem Pharm Stabilisierte injektionsloesungen von piroxicam
US4582831A (en) 1984-11-16 1986-04-15 Pfizer Inc. Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
CH663899A5 (fr) * 1985-03-20 1988-01-29 Nestle Sa Procede pour la preparation d'une composition a base d'un principe actif de faible hydrosolubilite finement divise.
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4761424A (en) * 1985-10-01 1988-08-02 Warner-Lambert Company Enolamides, pharmaceutical compositions and methods for treating inflammation
HU199833B (en) * 1986-05-16 1990-03-28 Pfizer Process for producing benzothiazine dioxide derivatives
EP0259085B1 (en) * 1986-08-29 1991-08-21 Pfizer Inc. 2-guanidino-4-arylthiazoles for treatment of peptic ulcers
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
US4914101A (en) * 1987-06-10 1990-04-03 Pfizer Inc. 3,4-Dihydro-2-alkyl-3-oxo-n-aryl-2H-(1)benzo-thieno(3,2-e)-1,2-thiazine-4-carboxamide-1,1-dioxides
WO1989003682A1 (en) * 1987-10-26 1989-05-05 Pfizer Inc. Benzothiazine dioxide derivatives
JPH0629271B2 (ja) * 1988-03-09 1994-04-20 株式会社日本ハイポックス ベンゾチアジン―１，１―ジオキシド誘導体及びそれを含有する医薬組成物
HU200926B (en) * 1988-10-28 1990-09-28 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules
JPH0717589B2 (ja) * 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規１，３―ジカルボニル化合物およびその組成物
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
DE4141218A1 (de) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
JP2964195B2 (ja) * 1992-04-28 1999-10-18 エスエス製薬株式会社 ピロキシカム錠及びその製造法
US5362758A (en) * 1992-09-18 1994-11-08 Pfizer Inc. Ophthalmic piroxicam solution
US5420124A (en) * 1994-01-12 1995-05-30 Kim; Young S. Stable, painless piroxicam potassium injectable composition
US5436241A (en) * 1994-01-14 1995-07-25 Bristol-Myers Squibb Company Topical anti-inflammatory compositions containing piroxicam
US5741798A (en) * 1996-06-03 1998-04-21 Boehringer Ingelheim Pharmaceuticals, Inc. 2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as antiinflammatory agents
US5952328A (en) * 1997-11-12 1999-09-14 Cephalon, Inc. Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
ITMI20020773A1 (it) * 2002-04-11 2003-10-13 Nicox Sa Farmaci per il trattamento dell'artrite
WO2005016267A2 (en) * 2003-08-06 2005-02-24 Pfizer Products Inc. Oxazole compounds for the treatment of neurodegenerative disorders
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
US20050222227A1 (en) * 2004-04-01 2005-10-06 Pfizer Inc Oxazole-amine compounds for the treatment of neurodegenerative disorders
AU2007223787A1 (en) 2006-03-08 2007-09-13 Pharmena North America Inc. Combination therapy with non-selective COX inhibitors to prevent COX-related gastric injuries
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments
CN101665472B (zh) * 2009-06-15 2011-08-24 威海迪素制药有限公司 2-甲基-3，4-二氢-4-氧代-2h-1，2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法
ITUB20152229A1 (it) * 2015-07-16 2017-01-16 Edmond Pharma Srl Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302858B (ja) * 1962-09-21 1972-05-04

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59179683U (ja) * 1983-05-19 1984-11-30 寺田毛織株式会社 貼り合わせふとん

Also Published As

Publication number Publication date
SE402459B (sv) 1978-07-03
NO129746B (ja) 1974-05-20
GB1257180A (ja) 1971-12-15
DK145297B (da) 1982-10-25
AT298503B (de) 1972-05-10
NL157013B (nl) 1978-06-15
PH10029A (en) 1976-07-13
BE737962A (ja) 1970-02-26
DE1943265B2 (de) 1981-05-14
FI51189B (ja) 1976-08-02
FR2016455B1 (ja) 1974-02-01
IL32836A (en) 1972-08-30
CH520705A (fr) 1972-03-31
DE1967325B2 (de) 1981-08-13
MY7300310A (en) 1973-12-31
DE1943265A1 (de) 1970-08-13
JPS50677B1 (ja) 1975-01-10
NL6912981A (ja) 1970-03-03
DE1943265C3 (de) 1982-02-04
DE1967325C2 (de) 1982-03-18
FR2016455A1 (ja) 1970-05-08
FI51189C (fi) 1976-11-10
BR6911817D0 (pt) 1973-02-13
US3591584A (en) 1971-07-06
DK145297C (da) 1983-03-14
SE373854B (ja) 1975-02-17
IL32836A0 (en) 1969-11-12
ES370861A1 (es) 1971-07-01
AT294113B (de) 1971-11-10

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