US7560107B2
(en)
|
1996-06-26 |
2009-07-14 |
Emory University |
Modified factor VIII
|
US7615622B2
(en)
*
|
2001-01-12 |
2009-11-10 |
University Of Maryland, Baltimore |
Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII
|
EP1572889B1
(de)
|
2001-10-05 |
2008-12-17 |
Expression Therapeutics, LLC |
Faktor-viii-polypeptide auf hohem expressionsniveau codierende nukleinsäure- und aminosäuresequenzen und verwendungsverfahren
|
AU2002364509A1
(en)
*
|
2001-11-30 |
2003-06-17 |
Emory University |
Factor viii c2 domain variants
|
GB0207092D0
(en)
|
2002-03-26 |
2002-05-08 |
Sod Conseils Rech Applic |
Stable pharmaceutical composition containing factor VIII
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
US7485291B2
(en)
*
|
2003-06-03 |
2009-02-03 |
Cell Genesys, Inc. |
Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
|
EP1636360A4
(de)
*
|
2003-06-03 |
2006-11-08 |
Cell Genesys Inc |
Zusammensetzungen und verfahren zur verstärkten expression rekombinanter polypeptide von einem vektor unter verwendung einer peptidspaltstelle
|
ATE368687T1
(de)
*
|
2003-06-26 |
2007-08-15 |
Merck Patent Gmbh |
Thrombopoietinproteine mit verbesserten eigenschaften
|
US20050059023A1
(en)
*
|
2003-09-16 |
2005-03-17 |
Cantor Thomas L. |
Methods and kits for monitoring resistance to therapeutic agents
|
US7211559B2
(en)
*
|
2003-10-31 |
2007-05-01 |
University Of Maryland, Baltimore |
Factor VIII compositions and methods
|
AU2004296768B2
(en)
*
|
2003-12-03 |
2010-06-24 |
University Of Rochester |
Recombinant factor VIII having increased specific activity
|
DK1750733T3
(da)
*
|
2004-05-03 |
2014-01-20 |
Univ Emory |
FREMGANGSMÅDE TIL INDGIVELSE AF SVINE-B-DOMÆNELØS fVIII
|
WO2005123928A1
(en)
*
|
2004-06-08 |
2005-12-29 |
Battelle Memorial Institute |
Production of human coagulation factor viii from plant cells and whole plants
|
HUE033776T2
(en)
*
|
2004-11-12 |
2018-01-29 |
Bayer Healthcare Llc |
FVIII site-specific modification
|
US20100256062A1
(en)
|
2004-12-06 |
2010-10-07 |
Howard Tommy E |
Allelic Variants of Human Factor VIII
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
US20090215025A1
(en)
|
2005-12-07 |
2009-08-27 |
Technische Universitat Munchen |
Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
|
EP1816201A1
(de)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät
|
US20100222554A1
(en)
*
|
2006-04-11 |
2010-09-02 |
Thomas Weimer |
Method of Increasing the In Vivo Recovery of Therapeutic Polypeptides
|
US7939632B2
(en)
*
|
2006-06-14 |
2011-05-10 |
Csl Behring Gmbh |
Proteolytically cleavable fusion proteins with high molar specific activity
|
WO2008077616A1
(en)
*
|
2006-12-22 |
2008-07-03 |
Csl Behring Gmbh |
Modified coagulation factors with prolonged in vivo half-life
|
EP1935430A1
(de)
*
|
2006-12-22 |
2008-06-25 |
CSL Behring GmbH |
Veränderte Koagulationsfaktoren mit verlängerter in vivo Halbwertzeit
|
FR2913020B1
(fr)
*
|
2007-02-23 |
2012-11-23 |
Biomethodes |
Nouveaux facteurs viii pour le traitement des hemophiles de type a
|
EP1988101A1
(de)
|
2007-05-04 |
2008-11-05 |
Novo Nordisk A/S |
Verbesserung von Faktor-VIII-Polypeptid-Titern in Zellkulturen
|
AU2008319183B2
(en)
|
2007-11-01 |
2014-09-04 |
University Of Rochester |
Recombinant factor VIII having increased stability
|
EP2149603A1
(de)
|
2008-07-28 |
2010-02-03 |
DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH |
Faktor-IX-Varianten mit Gerinnungsaktivität in Abwesenheit ihres Cofaktors und ihre Verwendung zur Behandlung von Blutungsstörungen
|
EA020843B1
(ru)
|
2009-02-03 |
2015-02-27 |
Амуникс Оперейтинг Инк. |
Удлиненные рекомбинантные полипептиды и содержащие их композиции
|
PL2440239T3
(pl)
|
2009-06-09 |
2018-01-31 |
Prolong Pharmaceuticals Llc |
Kompozycje hemoglobiny
|
CA2772051C
(en)
|
2009-08-24 |
2020-08-18 |
Amunix Operating Inc. |
Coagulation factor ix compositions and methods of making and using same
|
WO2011060372A2
(en)
*
|
2009-11-13 |
2011-05-19 |
Puget Sound Blood Center |
Factor viii b cell epitope variants having reduced immunogenicity
|
US9050318B2
(en)
|
2009-12-06 |
2015-06-09 |
Biogen Idec Hemophilia Inc. |
Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
|
WO2011088391A2
(en)
*
|
2010-01-14 |
2011-07-21 |
Haplomics, Inc. |
Predicting and reducing alloimmunogenicity of protein therapeutics
|
AU2011274423B2
(en)
|
2010-07-09 |
2016-02-11 |
Bioverativ Therapeutics Inc. |
Chimeric clotting factors
|
WO2012006623A1
(en)
|
2010-07-09 |
2012-01-12 |
Biogen Idec Hemophilia Inc. |
Systems for factor viii processing and methods thereof
|
SG10201509149VA
(en)
|
2010-11-05 |
2015-12-30 |
Baxter Int |
A new variant of antihemophilic factor viii having increased specific activity
|
KR20140036144A
(ko)
*
|
2011-01-05 |
2014-03-25 |
익스프레션 테라퍼틱스 엘엘씨 |
고수율 현탁세포주, 시스템 및 그 제조방법
|
PT2717898T
(pt)
|
2011-06-10 |
2019-05-20 |
Bioverativ Therapeutics Inc |
Compostos pró-coagulantes e processos para a sua utilização
|
WO2013009627A2
(en)
|
2011-07-08 |
2013-01-17 |
Biogen Idec Hemophilia Inc. |
Factor viii chimeric and hybrid polypeptides, and methods of use thereof
|
WO2013016454A1
(en)
|
2011-07-25 |
2013-01-31 |
Biogen Idec Hemophilia Inc. |
Assays to monitor bleeding disorders
|
CN102277379B
(zh)
*
|
2011-08-18 |
2013-07-24 |
中国科学院遗传与发育生物学研究所 |
表达凝血因子viii的表达载体及其应用
|
PT2802668T
(pt)
|
2012-01-12 |
2018-12-04 |
Puget Sound Blood Center |
Processos para reduzir a imunogenicidade contra o fator viii em indivíduos a receber terapêutica com fator viii
|
SG11201403764XA
(en)
|
2012-01-12 |
2014-07-30 |
Biogen Idec Inc |
Chimeric factor viii polypeptides and uses thereof
|
EP3549953A1
(de)
|
2012-02-15 |
2019-10-09 |
Bioverativ Therapeutics Inc. |
Rekombinante faktor-viii-proteine
|
EP2814840B1
(de)
|
2012-02-15 |
2019-11-13 |
Bioverativ Therapeutics Inc. |
Faktor-viii-zusammensetzungen und verfahren zur herstellung und verwendung davon
|
EP2666782A1
(de)
*
|
2012-05-22 |
2013-11-27 |
Imnate Sarl |
Gerinnungsfaktor VII mit reduzierter Immunogenität
|
JP2015521589A
(ja)
|
2012-06-08 |
2015-07-30 |
バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. |
プロコアグラント化合物
|
EP2863940A4
(de)
|
2012-06-08 |
2016-08-10 |
Biogen Ma Inc |
Chimäre gerinnungsfaktoren
|
EP2870250B2
(de)
|
2012-07-06 |
2022-06-29 |
Bioverativ Therapeutics Inc. |
Einkettige faktor-viii-polypeptide exprimierende zelllinie und verwendungen davon
|
EP3674410A1
(de)
|
2012-07-11 |
2020-07-01 |
Bioverativ Therapeutics Inc. |
Faktor-viii-komplex mit xten und von-willebrand-faktor-protein sowie verwendungen davon
|
WO2014018777A2
(en)
|
2012-07-25 |
2014-01-30 |
Biogen Idec Ma Inc. |
Blood factor monitoring assay and uses thereof
|
EP2908847B1
(de)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Verfahren zur verwendung einer festgelegten dosis eines blutgerinnungsfaktors
|
WO2014070953A1
(en)
|
2012-10-30 |
2014-05-08 |
Biogen Idec Ma Inc. |
Methods of Using FVIII Polypeptide
|
BR112015013311A2
(pt)
|
2012-12-07 |
2017-11-14 |
Haplomics Inc |
indução de tolerancia e reparação de mutação do fator 8
|
DK3889173T3
(da)
|
2013-02-15 |
2023-10-09 |
Bioverativ Therapeutics Inc |
Optimeret faktor viii-gen
|
PL3666283T3
(pl)
|
2013-03-15 |
2022-10-03 |
Bioverativ Therapeutics Inc. |
Formulacje polipeptydu czynnika viii
|
TWI828269B
(zh)
|
2013-03-15 |
2024-01-01 |
美商百歐維拉提夫治療公司 |
因子ix多肽調配物
|
SG11201509313PA
(en)
|
2013-06-28 |
2016-01-28 |
Biogen Ma Inc |
Thrombin cleavable linker with xten and its uses thereof
|
US10947269B2
(en)
|
2013-08-08 |
2021-03-16 |
Bioverativ Therapeutics Inc. |
Purification of chimeric FVIII molecules
|
US10548953B2
(en)
|
2013-08-14 |
2020-02-04 |
Bioverativ Therapeutics Inc. |
Factor VIII-XTEN fusions and uses thereof
|
WO2015059121A1
(en)
|
2013-10-22 |
2015-04-30 |
Dbv Technologies |
Method of treating haemophilia by inducing tolerance to blood factors
|
EP3065769A4
(de)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Prokoagulatorische fusionsverbindung
|
WO2015085276A1
(en)
|
2013-12-06 |
2015-06-11 |
Biogen Idec Ma Inc. |
Population pharmacokinetics tools and uses thereof
|
EP2881463A1
(de)
|
2013-12-09 |
2015-06-10 |
DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH |
Faktor-IX-Varianten mit Gerinnungsaktivität in Abwesenheit ihres Cofaktors und/oder mit erhöhter F.IX-Gerinnungsaktivität und ihre Verwendung zur Behandlung von Blutungsstörungen
|
KR102409250B1
(ko)
|
2014-01-10 |
2022-06-14 |
바이오버라티브 테라퓨틱스 인크. |
인자 viii 키메라 단백질 및 이들의 용도
|
EP3102589A1
(de)
|
2014-02-04 |
2016-12-14 |
Biogen MA Inc. |
Verwendung von kationenaustauscherchromatographie im durchflussmodus zur anreicherung von posttranslationalen modifikationen
|
US20170051041A1
(en)
*
|
2014-02-19 |
2017-02-23 |
Kathleen Pratt |
Factor viii b cell epitope variants having reduced immunogenicity
|
EP3114138B1
(de)
|
2014-03-05 |
2021-11-17 |
Pfizer Inc. |
Verbesserte muteine von gerinnungsfaktor viii
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
WO2017024060A1
(en)
|
2015-08-03 |
2017-02-09 |
Biogen Ma Inc. |
Factor ix fusion proteins and methods of making and using same
|
PE20231949A1
(es)
*
|
2015-10-30 |
2023-12-05 |
Spark Therapeutics Inc |
VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA
|
AU2016353353B2
(en)
|
2015-11-13 |
2020-07-09 |
Takeda Pharmaceutical Company Limited |
Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
|
CN108602876B
(zh)
|
2015-11-13 |
2022-07-05 |
武田药品工业株式会社 |
用于血友病a的基因治疗的具有增加的表达的编码重组fviii变体的病毒载体
|
JP7217630B2
(ja)
|
2016-02-01 |
2023-02-03 |
バイオベラティブ セラピューティクス インコーポレイテッド |
最適化第viii因子遺伝子
|
JP6877469B2
(ja)
|
2016-06-24 |
2021-05-26 |
モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research |
Fviiiおよびvwf因子を含むキメラタンパク質、ならびにそれらの使用
|
MX2019006444A
(es)
|
2016-12-02 |
2019-10-30 |
Bioverativ Therapeutics Inc |
Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos.
|
JP2019536794A
(ja)
|
2016-12-02 |
2019-12-19 |
バイオベラティブ セラピューティクス インコーポレイテッド |
凝固因子に対する免疫寛容を誘導する方法
|
JP2020519272A
(ja)
*
|
2017-05-09 |
2020-07-02 |
エモリー ユニバーシティー |
凝固因子変異体及びその使用
|
KR20200035130A
(ko)
|
2017-08-09 |
2020-04-01 |
바이오버라티브 테라퓨틱스 인크. |
핵산 분자 및 이의 용도
|
KR20200118089A
(ko)
|
2018-02-01 |
2020-10-14 |
바이오버라티브 테라퓨틱스 인크. |
인자 viii을 발현하는 렌티바이러스 벡터의 용도
|
TW202014181A
(zh)
|
2018-04-04 |
2020-04-16 |
美商希吉隆醫療公司 |
可植入顆粒及相關方法
|
TW202015723A
(zh)
|
2018-05-18 |
2020-05-01 |
美商百歐維拉提夫治療公司 |
治療a型血友病的方法
|
CN112449640A
(zh)
|
2018-07-16 |
2021-03-05 |
百深公司 |
使用编码具有增加的表达的重组fviii变体的病毒载体的a型血友病的基因疗法
|
WO2020033863A1
(en)
|
2018-08-09 |
2020-02-13 |
Bioverativ Therapeutics Inc. |
Nucleic acid molecules and uses thereof for non-viral gene therapy
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
TW202039546A
(zh)
|
2019-01-16 |
2020-11-01 |
美商巴克斯歐塔公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
|
CA3144630A1
(en)
|
2019-06-19 |
2020-12-24 |
Bioverativ Therapeutics Inc. |
Methods and compositions for treating hemophilia and low bone mineral density with factor viiifc protein
|
EP3986481A2
(de)
|
2019-06-20 |
2022-04-27 |
Takeda Pharmaceutical Company Limited |
Verfahren zur behandlung mit einer auf viren basierenden gentherapie
|
WO2021119357A2
(en)
|
2019-12-12 |
2021-06-17 |
Baxalta Incorporated |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
TW202246505A
(zh)
*
|
2021-03-05 |
2022-12-01 |
俄羅斯聯邦商亞那拜恩有限公司 |
編碼凝血因子ix蛋白的密碼子優化的核酸及其用途
|
WO2022212162A1
(en)
*
|
2021-03-31 |
2022-10-06 |
Haemonetics Corporation |
Hemostasis measurement device quality control formulations
|
WO2022264040A1
(en)
|
2021-06-14 |
2022-12-22 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
IL310997A
(en)
|
2021-08-23 |
2024-04-01 |
Bioverativ Therapeutics Inc |
Factor VIII gene optimization
|
AU2022355088A1
(en)
|
2021-09-30 |
2024-05-16 |
Bioverativ Therapeutics Inc. |
Nucleic acids encoding factor viii polypeptides with reduced immunogenicity
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|