FR11C0053I2 - Molecules ctla4 mutantes solubles et leurs utilisations - Google Patents

Molecules ctla4 mutantes solubles et leurs utilisations

Info

Publication number
FR11C0053I2
FR11C0053I2 FR11C0053C FR11C0053C FR11C0053I2 FR 11C0053 I2 FR11C0053 I2 FR 11C0053I2 FR 11C0053 C FR11C0053 C FR 11C0053C FR 11C0053 C FR11C0053 C FR 11C0053C FR 11C0053 I2 FR11C0053 I2 FR 11C0053I2
Authority
FR
France
Prior art keywords
ctla4 molecules
soluble mutant
mutant ctla4
soluble
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR11C0053C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FR11C0053I1 publication Critical patent/FR11C0053I1/fr
Application granted granted Critical
Publication of FR11C0053I2 publication Critical patent/FR11C0053I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR11C0053C 2000-05-26 2011-12-07 Molecules ctla4 mutantes solubles et leurs utilisations Active FR11C0053I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (2)

Publication Number Publication Date
FR11C0053I1 FR11C0053I1 (ru) 2012-01-13
FR11C0053I2 true FR11C0053I2 (fr) 2013-01-11

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
FR11C0053C Active FR11C0053I2 (fr) 2000-05-26 2011-12-07 Molecules ctla4 mutantes solubles et leurs utilisations

Country Status (41)

Country Link
EP (3) EP1248802B9 (ru)
JP (1) JP4328525B2 (ru)
KR (2) KR100889887B1 (ru)
CN (2) CN1309735C (ru)
AR (1) AR031699A1 (ru)
AT (1) ATE271066T1 (ru)
AU (2) AU2001263466C1 (ru)
BE (1) BE2011C041I2 (ru)
BR (1) BRPI0111191B8 (ru)
CA (1) CA2409748C (ru)
CY (2) CY2011019I1 (ru)
CZ (1) CZ304451B6 (ru)
DE (2) DE60104282T2 (ru)
DK (1) DK1248802T3 (ru)
EC (1) ECSP024365A (ru)
EE (2) EE05458B1 (ru)
EG (1) EG24459A (ru)
ES (2) ES2571852T3 (ru)
FR (1) FR11C0053I2 (ru)
GE (1) GEP20053658B (ru)
HK (2) HK1048126B (ru)
HU (2) HU228137B1 (ru)
IL (1) IL152315A (ru)
LT (1) LT5133B (ru)
LU (1) LU91902I2 (ru)
LV (1) LV12994B (ru)
MX (1) MXPA02011534A (ru)
MY (1) MY136113A (ru)
NO (2) NO330797B1 (ru)
PE (1) PE20011338A1 (ru)
PL (1) PL206267B1 (ru)
PT (1) PT1248802E (ru)
RU (1) RU2283847C2 (ru)
SI (1) SI1248802T1 (ru)
SK (1) SK288131B6 (ru)
TR (1) TR200402703T4 (ru)
TW (2) TWI314933B (ru)
UA (1) UA87432C2 (ru)
UY (1) UY26723A1 (ru)
WO (1) WO2001092337A2 (ru)
ZA (1) ZA200208944B (ru)

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US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
AU2001273174B2 (en) * 2000-07-03 2006-05-18 Bristol-Myers Squibb Company Methods for treating rheumatic diseases using a soluble CTLA4 molecule
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
DE60225914T2 (de) 2001-05-23 2009-07-23 Bristol-Myers Squibb Co. Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4-mutationsmolekülen
WO2003088991A1 (en) * 2002-04-19 2003-10-30 Bristol-Myers Squibb Company Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
WO2004058800A2 (en) * 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
AU2003303394B2 (en) * 2002-12-23 2009-02-19 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
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AU2004287431B2 (en) 2003-10-27 2010-03-11 Amgen Inc. Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
US10508144B2 (en) * 2005-12-20 2019-12-17 Bristol-Myers Squibb Company Carbohydrate content of CTLA4 molecules
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
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KR20170091801A (ko) * 2008-10-02 2017-08-09 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Ｃｄ86 길항제 다중-표적 결합 단백질
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TW201134481A (en) * 2010-03-12 2011-10-16 Abbott Biotherapeutics Corp CTLA4 proteins and their uses
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US9758566B2 (en) 2012-03-29 2017-09-12 The General Hospital Corporation Recombinant cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
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US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
KR20150033703A (ko) * 2012-06-27 2015-04-01 오르반 바이오테크 엘엘씨 당뇨병 치료를 위한 ctla4 융합 단백질
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
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Also Published As

Publication number Publication date
HUS1300012I1 (hu) 2016-08-29
PL206267B1 (pl) 2010-07-30
HUP0302201A3 (en) 2010-01-28
UY26723A1 (es) 2001-12-28
MY136113A (en) 2008-08-29
CZ20023892A3 (cs) 2003-09-17
UA87432C2 (ru) 2009-07-27
ECSP024365A (es) 2003-03-31
EP1536234A3 (en) 2009-06-03
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
EE05557B1 (et) 2012-08-15
BRPI0111191B8 (pt) 2021-05-25
BE2011C041I2 (ru) 2020-08-20
HUP0302201A2 (hu) 2003-10-28
EP1248802B9 (en) 2005-05-11
NO20025656L (no) 2002-11-25
HK1071931A1 (zh) 2005-08-05
LV12994B (en) 2003-08-20
CY1117625T1 (el) 2017-04-26
EE05458B1 (et) 2011-08-15
PL366231A1 (en) 2005-01-24
CA2409748C (en) 2008-09-16
ES2225549T3 (es) 2005-03-16
TWI319405B (en) 2010-01-11
EG24459A (en) 2009-07-16
EP1536234B1 (en) 2016-03-16
NO330797B1 (no) 2011-07-18
MXPA02011534A (es) 2004-08-12
WO2001092337A2 (en) 2001-12-06
JP2004511213A (ja) 2004-04-15
NO2011027I1 (no) 2012-01-09
TW200906857A (en) 2009-02-16
KR100895134B1 (ko) 2009-05-04
DE122011100063I1 (de) 2012-06-14
ZA200208944B (en) 2004-02-13
HK1048126A1 (en) 2003-03-21
AU6346601A (en) 2001-12-11
EP1248802B1 (en) 2004-07-14
NO20025656D0 (no) 2002-11-25
PT1248802E (pt) 2004-11-30
PE20011338A1 (es) 2002-01-13
JP4328525B2 (ja) 2009-09-09
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
BR0111191A (pt) 2004-07-06
AU2001263466C1 (en) 2006-10-26
CZ304451B6 (cs) 2014-05-14
EE201100050A (et) 2011-10-17
ES2571852T3 (es) 2016-05-27
SI1248802T1 (en) 2005-02-28
IL152315A (en) 2010-04-15
KR20030009502A (ko) 2003-01-29
RU2283847C2 (ru) 2006-09-20
CN101255192A (zh) 2008-09-03
CN1441810A (zh) 2003-09-10
ATE271066T1 (de) 2004-07-15
AR031699A1 (es) 2003-10-01
TWI314933B (en) 2009-09-21
AU2001263466B2 (en) 2006-04-27
IL152315A0 (en) 2003-05-29
DK1248802T3 (da) 2004-11-15
KR100889887B1 (ko) 2009-03-24
TR200402703T4 (tr) 2004-11-22
LT2002114A (en) 2003-12-29
CN1309735C (zh) 2007-04-11
EE200200659A (et) 2004-06-15
DE60104282D1 (de) 2004-08-19
EP3029062A1 (en) 2016-06-08
GEP20053658B (en) 2005-11-10
SK288131B6 (sk) 2013-10-02
WO2001092337A3 (en) 2002-05-10
SK15702002A3 (sk) 2004-01-08
CA2409748A1 (en) 2001-12-06
HK1048126B (zh) 2005-03-04
CY2011019I1 (el) 2016-12-14
BRPI0111191B1 (pt) 2019-12-31
FR11C0053I1 (ru) 2012-01-13
NO2011027I2 (ru) 2011-12-15
LT5133B (lt) 2004-05-25
DE60104282T2 (de) 2005-10-13
EP1536234A2 (en) 2005-06-01
HU228137B1 (en) 2012-12-28

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