FI97890B - Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter - Google Patents

Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter

Info

Publication number
FI97890B
FI97890B FI913137A FI913137A FI97890B FI 97890 B FI97890 B FI 97890B FI 913137 A FI913137 A FI 913137A FI 913137 A FI913137 A FI 913137A FI 97890 B FI97890 B FI 97890B
Authority
FI
Finland
Prior art keywords
acid salt
epi
deoxy
salts
methylaminoavermitine
Prior art date
Application number
FI913137A
Other languages
English (en)
Finnish (fi)
Other versions
FI913137A (sv
FI97890C (sv
FI913137A0 (sv
Inventor
Raymond Cvetovich
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI913137A0 publication Critical patent/FI913137A0/sv
Publication of FI913137A publication Critical patent/FI913137A/sv
Application granted granted Critical
Publication of FI97890B publication Critical patent/FI97890B/sv
Publication of FI97890C publication Critical patent/FI97890C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Fodder In General (AREA)
  • Silicon Polymers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI913137A 1990-06-28 1991-06-27 Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter FI97890C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54522990A 1990-06-28 1990-06-28
US54522990 1990-06-28

Publications (4)

Publication Number Publication Date
FI913137A0 FI913137A0 (sv) 1991-06-27
FI913137A FI913137A (sv) 1991-12-29
FI97890B true FI97890B (sv) 1996-11-29
FI97890C FI97890C (sv) 1997-03-10

Family

ID=24175383

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913137A FI97890C (sv) 1990-06-28 1991-06-27 Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter

Country Status (21)

Country Link
US (1) US5288710A (sv)
EP (1) EP0465121B1 (sv)
JP (1) JPH0822870B2 (sv)
KR (1) KR100224292B1 (sv)
AT (1) ATE134377T1 (sv)
AU (1) AU641777B2 (sv)
CA (1) CA2045864C (sv)
CY (1) CY1949A (sv)
DE (1) DE69117223T2 (sv)
DK (1) DK0465121T3 (sv)
ES (1) ES2084110T3 (sv)
FI (1) FI97890C (sv)
GR (1) GR3019067T3 (sv)
HK (1) HK157096A (sv)
IE (1) IE71175B1 (sv)
IL (1) IL98599A (sv)
LV (1) LV5740B4 (sv)
NO (2) NO2001007I2 (sv)
NZ (1) NZ238705A (sv)
PT (1) PT98117B (sv)
ZA (1) ZA914961B (sv)

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AU687062B2 (en) * 1993-05-26 1998-02-19 Commonwealth Scientific And Industrial Research Organisation Controlled release antiparasitic compositions
NZ266408A (en) * 1993-05-26 1997-09-22 Commw Scient Ind Res Org Antiparasitic, oral particulate composition for ruminants
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HU217769B (hu) * 1993-08-19 2000-04-28 Merck & Co. Inc. 4"-Dezoxi-4"-epi-metil-amino-avermektin-B1a/B1b benzoesavas sójának termodinamikailag stabil kristályformája és eljárás annak előállítására, hatóanyagként ezt tartalmazó kompozíció és eljárás rovarok lekűzdésére
US5362863A (en) * 1993-09-29 1994-11-08 Merck & Co., Inc. Process for the preparation of 4"-amino avermectin compounds
EA002756B1 (ru) * 1995-11-08 2002-08-29 Мерк Энд Ко., Инк. Пестицидная композиция в форме растворимых в воде гранул
AU768262B2 (en) * 1995-11-08 2003-12-04 Merck Sharp & Dohme Corp. Pesticidal formulation
CN1281127C (zh) * 1995-11-08 2006-10-25 麦克公司 农药制剂
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CA2715841A1 (en) * 1997-12-23 1999-07-08 Syngenta Participations Ag Use of macrolides in pest control
US6486128B1 (en) 1999-04-08 2002-11-26 Schering-Plough Veterinary Corporation Method of using emamectin to treat fish parasites
AR006063A4 (es) * 1999-04-17 1999-08-11 Romario S R L Bandeja termica para pizzas
GB9926887D0 (en) 1999-11-12 2000-01-12 Novartis Ag Organic compounds
EG23124A (en) 2001-02-27 2004-04-28 Syngenta Participations Ag Avermectins substituted in the 4-position having pesticidal properties
CR6574A (es) * 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
JP4701538B2 (ja) 2001-05-21 2011-06-15 住友化学株式会社 農業害虫防除剤組成物
AR036486A1 (es) 2001-08-28 2004-09-15 Syngenta Participations Ag Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
DE10203688A1 (de) * 2002-01-31 2003-08-07 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207242A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207241A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
MXPA04009101A (es) * 2002-03-22 2004-12-06 Lg Life Sciences Ltd Sal de acido maleico de (2s) -n-{5- [amino(imino) metil]-2 -tienil} metil-1 -{(2r)- 2-[(carboximetil) amino]-3, 3- difenilpropanoil} -2-pirrolidin carboxamida y un proceso para preparacion de la misma.
AR040073A1 (es) 2002-05-07 2005-03-16 Syngenta Participations Ag Derivados de 4''-desoxi-4''-(s)-amido avermectina y su uso como plaguicidas
GB0302308D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302310D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0320176D0 (en) 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
PE20060693A1 (es) 2004-09-23 2006-09-01 Schering Plough Ltd Nuevos derivados de trifluorometansulfonanilida oxamida eter
EP1811841B1 (en) * 2004-11-19 2009-10-28 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
US20060281695A1 (en) * 2005-06-09 2006-12-14 Schering-Plough Animal Health Corporation Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
TWI422328B (zh) 2006-06-19 2014-01-11 Univ California 結合有殺線蟲之種子塗覆物的生物控制劑
FR2906469B1 (fr) * 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques chez l'homme
CA2672586A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
DE102007002872A1 (de) 2007-01-15 2008-07-17 Alpha-Biocare Gmbh Verwendung von Avermectin-Derivaten zur Behandlung gegen Parasiten von Fischen
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
BRPI0810929B8 (pt) 2007-06-27 2022-12-06 Du Pont uso de um composto de fórmula 1
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
US9345686B2 (en) 2009-03-17 2016-05-24 Intervet Inc. Macrocyclic lactone drug delivery system
IN2012DN00709A (sv) 2009-08-05 2015-06-19 Du Pont
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
HUE028501T2 (en) 2010-05-27 2016-12-28 Du Pont 4- [5- [3-Chloro-5- (trifluoromethyl) phenyl] -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N- [2-oxo-2 - [(2.2, 2-Trifluoroethyl) amino] ethyl] -1-naphthalenecarboxamide crystalline form
AR081970A1 (es) 2010-06-24 2012-10-31 Intervet Int Bv Formulacion inyectable de una lactona macrociclica y levamisol, formulacion y uso veterinario
CA2811924C (en) 2010-10-20 2015-06-16 Galderma S.A. Method of treating hemorrhoids using macrocyclic lactone compound
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN103260620A (zh) 2010-12-27 2013-08-21 英特维特国际股份有限公司 包含三缩四乙二醇的外用局部异噁唑啉制剂
PT2658542T (pt) 2010-12-27 2022-03-10 Intervet Int Bv Formulação de isoxazolina localizada tópica
US9861105B2 (en) 2011-07-28 2018-01-09 Syngenta Participations Ag Methods and compositions for controlling nematode pests
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
US9409920B1 (en) * 2015-06-08 2016-08-09 Rotam Agrochem International Company Limited Method for purifying emamectin benzoate and compositions comprising the same
US9643991B2 (en) * 2015-06-08 2017-05-09 Rotam Agrochem International Company Limited Process for preparing a novel crystalline form of emamectin benzoate and use the same
CN107344954B (zh) * 2017-08-07 2020-08-11 河北蓝泰化工科技有限公司 增效型甲氨基阿维菌素b1或b2的盐及制备方法和应用
CN108840893A (zh) * 2018-07-01 2018-11-20 李万强 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN108864230B (zh) * 2018-07-26 2021-05-14 河北威远生物化工有限公司 一种有机磷基团取代的阿维菌素衍生物及其制备方法和应用

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Also Published As

Publication number Publication date
LV5740A4 (lv) 1996-08-20
AU7939291A (en) 1992-01-02
FI913137A (sv) 1991-12-29
NO178339C (no) 1996-03-06
AU641777B2 (en) 1993-09-30
NO912535L (no) 1991-12-30
JPH0822870B2 (ja) 1996-03-06
FI97890C (sv) 1997-03-10
DE69117223T2 (de) 1996-09-12
IE912251A1 (en) 1992-01-01
US5288710A (en) 1994-02-22
NO178339B (no) 1995-11-27
JPH05306294A (ja) 1993-11-19
CA2045864A1 (en) 1991-12-29
KR100224292B1 (ko) 1999-10-15
DK0465121T3 (da) 1996-03-18
CA2045864C (en) 2001-11-27
GR3019067T3 (en) 1996-05-31
KR920000781A (ko) 1992-01-29
IE71175B1 (en) 1997-01-29
HK157096A (en) 1996-08-23
NO2001007I2 (no) 2007-02-26
DE69117223D1 (de) 1996-03-28
NO912535D0 (no) 1991-06-27
NZ238705A (en) 1993-07-27
ES2084110T3 (es) 1996-05-01
PT98117B (pt) 1998-12-31
ZA914961B (en) 1992-07-29
PT98117A (pt) 1993-10-29
LV5740B4 (lv) 1997-12-20
IL98599A (en) 1995-06-29
CY1949A (en) 1991-06-27
FI913137A0 (sv) 1991-06-27
ATE134377T1 (de) 1996-03-15
EP0465121A1 (en) 1992-01-08
EP0465121B1 (en) 1996-02-21
IL98599A0 (en) 1992-07-15

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Legal Events

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FG Patent granted

Owner name: MERCK & CO., INC.

BB Publication of examined application
SPCF Supplementary protection certificate application filed

Spc suppl protection certif: L20010007

SPCG Supplementary protection certificate granted

Spc suppl protection certif: L193

Extension date: 20150113

PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

Free format text: MERCK SHARP & DOHME CORP.

MA Patent expired