DE69117223D1 - Stabile Salze von 4"-Desoxy-4"-epimethylamino-Avermectin-Bla/Blb - Google Patents

Stabile Salze von 4"-Desoxy-4"-epimethylamino-Avermectin-Bla/Blb

Info

Publication number
DE69117223D1
DE69117223D1 DE69117223T DE69117223T DE69117223D1 DE 69117223 D1 DE69117223 D1 DE 69117223D1 DE 69117223 T DE69117223 T DE 69117223T DE 69117223 T DE69117223 T DE 69117223T DE 69117223 D1 DE69117223 D1 DE 69117223D1
Authority
DE
Germany
Prior art keywords
acid salt
blb
bla
epimethylamino
desoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69117223T
Other languages
English (en)
Other versions
DE69117223T2 (de
Inventor
Raymond Cvetovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69117223D1 publication Critical patent/DE69117223D1/de
Publication of DE69117223T2 publication Critical patent/DE69117223T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Polymers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Steroid Compounds (AREA)
DE69117223T 1990-06-28 1991-06-27 Stabile Salze von 4"-Desoxy-4"-epimethylamino-Avermectin-Bla/Blb Expired - Lifetime DE69117223T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54522990A 1990-06-28 1990-06-28

Publications (2)

Publication Number Publication Date
DE69117223D1 true DE69117223D1 (de) 1996-03-28
DE69117223T2 DE69117223T2 (de) 1996-09-12

Family

ID=24175383

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69117223T Expired - Lifetime DE69117223T2 (de) 1990-06-28 1991-06-27 Stabile Salze von 4"-Desoxy-4"-epimethylamino-Avermectin-Bla/Blb

Country Status (21)

Country Link
US (1) US5288710A (de)
EP (1) EP0465121B1 (de)
JP (1) JPH0822870B2 (de)
KR (1) KR100224292B1 (de)
AT (1) ATE134377T1 (de)
AU (1) AU641777B2 (de)
CA (1) CA2045864C (de)
CY (1) CY1949A (de)
DE (1) DE69117223T2 (de)
DK (1) DK0465121T3 (de)
ES (1) ES2084110T3 (de)
FI (1) FI97890C (de)
GR (1) GR3019067T3 (de)
HK (1) HK157096A (de)
IE (1) IE71175B1 (de)
IL (1) IL98599A (de)
LV (1) LV5740B4 (de)
NO (2) NO2001007I2 (de)
NZ (1) NZ238705A (de)
PT (1) PT98117B (de)
ZA (1) ZA914961B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU687062B2 (en) * 1993-05-26 1998-02-19 Commonwealth Scientific And Industrial Research Organisation Controlled release antiparasitic compositions
WO1994027598A1 (en) * 1993-05-26 1994-12-08 Commonwealth Scientific And Industrial Research Organisation Antiparasitic compositions
US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
AU684828B2 (en) * 1993-08-19 1998-01-08 Merck Sharp & Dohme Corp. Thermodynamically stable crystal form of 4"-deoxy-4"-(epi)-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
US5362863A (en) * 1993-09-29 1994-11-08 Merck & Co., Inc. Process for the preparation of 4"-amino avermectin compounds
JP3529792B2 (ja) * 1995-11-08 2004-05-24 メルク エンド カムパニー インコーポレーテッド 農薬製剤
CN1281127C (zh) 1995-11-08 2006-10-25 麦克公司 农药制剂
AU768262B2 (en) * 1995-11-08 2003-12-04 Merck Sharp & Dohme Corp. Pesticidal formulation
US20050192319A1 (en) * 1996-09-19 2005-09-01 Albert Boeckh Spot-on formulations for combating parasites
US6054140A (en) * 1997-03-21 2000-04-25 Biogenesis S.A. Long acting injectable parasiticidal composition and the process for its preparation
WO1999025187A2 (en) * 1997-11-14 1999-05-27 Novartis Ag Pesticidal compositions of emamectin
CN100527958C (zh) * 1997-12-23 2009-08-19 辛根塔参与股份公司 大环内酯在害虫防治中的应用
US6486128B1 (en) 1999-04-08 2002-11-26 Schering-Plough Veterinary Corporation Method of using emamectin to treat fish parasites
AR006063A4 (es) * 1999-04-17 1999-08-11 Romario S R L Bandeja termica para pizzas
GB9926887D0 (en) * 1999-11-12 2000-01-12 Novartis Ag Organic compounds
CR6574A (es) * 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
EG23124A (en) 2001-02-27 2004-04-28 Syngenta Participations Ag Avermectins substituted in the 4-position having pesticidal properties
JP4701538B2 (ja) 2001-05-21 2011-06-15 住友化学株式会社 農業害虫防除剤組成物
AR036486A1 (es) 2001-08-28 2004-09-15 Syngenta Participations Ag Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
DE10203688A1 (de) * 2002-01-31 2003-08-07 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207242A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207241A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
IL164045A0 (en) * 2002-03-22 2005-12-18 Lg Life Sciences Ltd Maleic acid salt of (2S)-N-ä5-Äamino(imino)methylÜ--2-thienylümethyl-1-ä(2R)-2Ä(carboxamide)aminoÜ-3,3-diphenylpr
TW200407330A (en) 2002-05-07 2004-05-16 Syngenta Participations Ag 4"-Deoxy-4"-(S)-amido avermectin derivatives
GB0302308D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302310D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0320176D0 (en) 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
ES2314724T3 (es) 2004-09-23 2009-03-16 Schering-Plough Ltd. Control de parasitos en animales mediante el uso de nuevos derivados de eter de trifluorometanosulfonanilida oxima.
CA2587495A1 (en) * 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
MX2007015729A (es) * 2005-06-09 2008-02-21 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP1849363A1 (de) * 2006-03-09 2007-10-31 Cheminova A/S Synergistische Kombinationen aus Glutaminsäure- und GABA-aktivierten Chloridkanälen agonistischen Pestiziden und mindestens eins von Vitamin E und Niacin
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
TWI422328B (zh) 2006-06-19 2014-01-11 Univ California 結合有殺線蟲之種子塗覆物的生物控制劑
FR2906469B1 (fr) * 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques chez l'homme
WO2008076256A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
MX2009006282A (es) * 2006-12-13 2009-06-23 Schering Plough Ltd Profarmacos solubles en agua de florfenicol y sus analogos.
DE102007002872A1 (de) 2007-01-15 2008-07-17 Alpha-Biocare Gmbh Verwendung von Avermectin-Derivaten zur Behandlung gegen Parasiten von Fischen
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
BRPI0810929B8 (pt) 2007-06-27 2022-12-06 Du Pont uso de um composto de fórmula 1
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
US8314252B2 (en) * 2008-07-30 2012-11-20 Intervet Inc. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
US9345686B2 (en) 2009-03-17 2016-05-24 Intervet Inc. Macrocyclic lactone drug delivery system
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
AU2010279574A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
ES2566402T3 (es) 2010-05-27 2016-04-12 E. I. Du Pont De Nemours And Company Forma cristalina de 4-[5-[3-cloro-5-(trifluorometil)fenil]-4,5-dihidro-5-(trifluorometil)-3-isoxazolil]-N-[2-oxo-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenocarboxamida
AR081970A1 (es) 2010-06-24 2012-10-31 Intervet Int Bv Formulacion inyectable de una lactona macrociclica y levamisol, formulacion y uso veterinario
US8912151B2 (en) 2010-10-20 2014-12-16 Galderma S.A. Method of treating hemorrhoids using macrocyclic lactone compound
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
BR112013015503A2 (pt) 2010-12-27 2017-06-27 Intervet Int Bv formulação localizada tópica, uso de uma formulação, e, método para tratamento ou profilaxia de infestação de parasita de um animal
MX348079B (es) 2010-12-27 2017-05-25 Intervet Int Bv Formulacion de isoxazolina topica localizada que comprende glucofurol.
US9861105B2 (en) 2011-07-28 2018-01-09 Syngenta Participations Ag Methods and compositions for controlling nematode pests
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
US9643991B2 (en) * 2015-06-08 2017-05-09 Rotam Agrochem International Company Limited Process for preparing a novel crystalline form of emamectin benzoate and use the same
US9409920B1 (en) * 2015-06-08 2016-08-09 Rotam Agrochem International Company Limited Method for purifying emamectin benzoate and compositions comprising the same
CN107344954B (zh) * 2017-08-07 2020-08-11 河北蓝泰化工科技有限公司 增效型甲氨基阿维菌素b1或b2的盐及制备方法和应用
CN108840893A (zh) * 2018-07-01 2018-11-20 李万强 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN108864230B (zh) * 2018-07-26 2021-05-14 河北威远生物化工有限公司 一种有机磷基团取代的阿维菌素衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366309A (en) * 1980-03-14 1982-12-28 Schering Corporation Derivatives of antibiotic AR-5 components
US4321362A (en) * 1980-06-12 1982-03-23 Eli Lilly And Company De(mycinosyloxy)tylosin and process for its production
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4831016A (en) * 1986-10-31 1989-05-16 Merck & Co., Inc. Reduced avermectin derivatives
US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb

Also Published As

Publication number Publication date
LV5740B4 (lv) 1997-12-20
HK157096A (en) 1996-08-23
IE71175B1 (en) 1997-01-29
ES2084110T3 (es) 1996-05-01
FI97890C (fi) 1997-03-10
NO912535L (no) 1991-12-30
US5288710A (en) 1994-02-22
ZA914961B (en) 1992-07-29
GR3019067T3 (en) 1996-05-31
DE69117223T2 (de) 1996-09-12
EP0465121A1 (de) 1992-01-08
JPH05306294A (ja) 1993-11-19
PT98117B (pt) 1998-12-31
NO178339B (no) 1995-11-27
NZ238705A (en) 1993-07-27
AU7939291A (en) 1992-01-02
NO912535D0 (no) 1991-06-27
CA2045864A1 (en) 1991-12-29
KR100224292B1 (ko) 1999-10-15
NO178339C (no) 1996-03-06
JPH0822870B2 (ja) 1996-03-06
EP0465121B1 (de) 1996-02-21
IE912251A1 (en) 1992-01-01
FI913137A (fi) 1991-12-29
FI913137A0 (fi) 1991-06-27
FI97890B (fi) 1996-11-29
LV5740A4 (lv) 1996-08-20
NO2001007I2 (no) 2007-02-26
DK0465121T3 (da) 1996-03-18
ATE134377T1 (de) 1996-03-15
IL98599A0 (en) 1992-07-15
IL98599A (en) 1995-06-29
CA2045864C (en) 2001-11-27
CY1949A (en) 1991-06-27
KR920000781A (ko) 1992-01-29
AU641777B2 (en) 1993-09-30
PT98117A (pt) 1993-10-29

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US