ATE134377T1 - Stabile salze von 4''-desoxy-4''-epimethylamino- avermectin-bla/blb - Google Patents

Stabile salze von 4''-desoxy-4''-epimethylamino- avermectin-bla/blb

Info

Publication number
ATE134377T1
ATE134377T1 AT91305815T AT91305815T ATE134377T1 AT E134377 T1 ATE134377 T1 AT E134377T1 AT 91305815 T AT91305815 T AT 91305815T AT 91305815 T AT91305815 T AT 91305815T AT E134377 T1 ATE134377 T1 AT E134377T1
Authority
AT
Austria
Prior art keywords
acid salt
blb
bla
epimethylamino
desoxy
Prior art date
Application number
AT91305815T
Other languages
English (en)
Inventor
Raymond Cvetovich
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE134377T1 publication Critical patent/ATE134377T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Silicon Polymers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)
AT91305815T 1990-06-28 1991-06-27 Stabile salze von 4''-desoxy-4''-epimethylamino- avermectin-bla/blb ATE134377T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54522990A 1990-06-28 1990-06-28

Publications (1)

Publication Number Publication Date
ATE134377T1 true ATE134377T1 (de) 1996-03-15

Family

ID=24175383

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91305815T ATE134377T1 (de) 1990-06-28 1991-06-27 Stabile salze von 4''-desoxy-4''-epimethylamino- avermectin-bla/blb

Country Status (21)

Country Link
US (1) US5288710A (de)
EP (1) EP0465121B1 (de)
JP (1) JPH0822870B2 (de)
KR (1) KR100224292B1 (de)
AT (1) ATE134377T1 (de)
AU (1) AU641777B2 (de)
CA (1) CA2045864C (de)
CY (1) CY1949A (de)
DE (1) DE69117223T2 (de)
DK (1) DK0465121T3 (de)
ES (1) ES2084110T3 (de)
FI (1) FI97890C (de)
GR (1) GR3019067T3 (de)
HK (1) HK157096A (de)
IE (1) IE71175B1 (de)
IL (1) IL98599A (de)
LV (1) LV5740B4 (de)
NO (2) NO178339C (de)
NZ (1) NZ238705A (de)
PT (1) PT98117B (de)
ZA (1) ZA914961B (de)

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AU687062B2 (en) * 1993-05-26 1998-02-19 Commonwealth Scientific And Industrial Research Organisation Controlled release antiparasitic compositions
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US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
US5362863A (en) * 1993-09-29 1994-11-08 Merck & Co., Inc. Process for the preparation of 4"-amino avermectin compounds
AU768262B2 (en) * 1995-11-08 2003-12-04 Merck Sharp & Dohme Corp. Pesticidal formulation
CN1281127C (zh) * 1995-11-08 2006-10-25 麦克公司 农药制剂
SK283851B6 (sk) 1995-11-08 2004-03-02 Merck & Co., Inc. Pesticídny prostriedok obsahujúci benzoát emamectínu a spôsob jeho výroby
US20050192319A1 (en) * 1996-09-19 2005-09-01 Albert Boeckh Spot-on formulations for combating parasites
US6054140A (en) * 1997-03-21 2000-04-25 Biogenesis S.A. Long acting injectable parasiticidal composition and the process for its preparation
AU1665999A (en) * 1997-11-14 1999-06-07 Novartis Ag Pesticidal composition
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US6486128B1 (en) 1999-04-08 2002-11-26 Schering-Plough Veterinary Corporation Method of using emamectin to treat fish parasites
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GB9926887D0 (en) * 1999-11-12 2000-01-12 Novartis Ag Organic compounds
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CR6574A (es) * 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
JP4701538B2 (ja) 2001-05-21 2011-06-15 住友化学株式会社 農業害虫防除剤組成物
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DE10203688A1 (de) * 2002-01-31 2003-08-07 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207242A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207241A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
JP2005526801A (ja) * 2002-03-22 2005-09-08 エルジー・ライフ・サイエンシーズ・リミテッド （２ｓ）−ｎ−｛５−［アミノ（イミノ）メチル］−２−チエニル｝メチル−１−｛［（２ｒ）−２−［（カルボキシルメチル）アミノ］−３，３−ジフェニルプロパノイル］｝−２−ピロリジンカルボキサミドマレイン酸塩及びそれらの製造方法
TW200407330A (en) 2002-05-07 2004-05-16 Syngenta Participations Ag 4"-Deoxy-4"-(S)-amido avermectin derivatives
GB0302308D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302310D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0320176D0 (en) 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
DE602005009381D1 (de) 2004-09-23 2008-10-09 Schering Plough Ltd Bekämpfung von parasiten in tieren durch verwendung neuer trifluormethansulfonanilidoximetherderivate
DE602005017419D1 (de) * 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
AR054380A1 (es) * 2005-06-09 2007-06-20 Schering Plough Ltd Control de parasitos en animales con derivados de n- ((feniloxi) fenil) -1,1,1-trifluorometansulfonamida y de n-(fenilsulfanil) fenil) -1,1,1-trifluorometansulfonamida
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP1849363A1 (de) * 2006-03-09 2007-10-31 Cheminova A/S Synergistische Kombinationen aus Glutaminsäure- und GABA-aktivierten Chloridkanälen agonistischen Pestiziden und mindestens eins von Vitamin E und Niacin
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
TWI422328B (zh) 2006-06-19 2014-01-11 Univ California 結合有殺線蟲之種子塗覆物的生物控制劑
FR2906469B1 (fr) * 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques chez l'homme
MX2009006282A (es) * 2006-12-13 2009-06-23 Schering Plough Ltd Profarmacos solubles en agua de florfenicol y sus analogos.
EP2102154A1 (de) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Wasserlösliche chloramphenicol- und thiamphenicol-prodrugs sowie analoga davon
DE102007002872A1 (de) 2007-01-15 2008-07-17 Alpha-Biocare Gmbh Verwendung von Avermectin-Derivaten zur Behandlung gegen Parasiten von Fischen
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
EP2182945B1 (de) 2007-06-27 2015-08-05 E. I. du Pont de Nemours and Company Verfahren zur bekämpfung von tierischen schädlingen
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
JP2011529895A (ja) * 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
BRPI1009345A2 (pt) 2009-03-17 2016-03-08 Intervet Int Bv sistema de administracao de droga, uso de um sistema de administracao de droga, e, metodo pata tratar doencas
KR20120050467A (ko) 2009-08-05 2012-05-18 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
WO2011017347A2 (en) 2009-08-05 2011-02-10 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA107804C2 (xx) 2009-08-05 2015-02-25 Du Pont Суміші мезоіонних пестицидів
EP2576523B1 (de) 2010-05-27 2016-01-13 E. I. du Pont de Nemours and Company Kristalline form von 4- [5 - [3 -chlor-5 - (trifluormethyl) phenyl]-4, 5 - dihydro - 5 - (trifluormethyl) -3 - isoxazolyl]-n- [2-0x0-2- [ ( 2, 2, 2 - trifluorethyl) amino]ethyl]-1- naphthalencarboxamid
AR081970A1 (es) 2010-06-24 2012-10-31 Intervet Int Bv Formulacion inyectable de una lactona macrociclica y levamisol, formulacion y uso veterinario
EP2629772B1 (de) 2010-10-20 2016-05-18 Galderma S.A. Ivermectin zur behandlung von hämorrhoiden
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
HUE058291T2 (hu) 2010-12-27 2022-07-28 Intervet Int Bv Topikális lokalizált izoxazolin formuláció
KR101992589B1 (ko) 2010-12-27 2019-06-24 인터벳 인터내셔널 비.브이. 글리코푸롤을 포함하는 국소 적용 이속사졸린 제제
WO2013015993A1 (en) 2011-07-28 2013-01-31 Syngenta Participations Ag Methods and compositions for controlling nematode pests
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
US9409920B1 (en) * 2015-06-08 2016-08-09 Rotam Agrochem International Company Limited Method for purifying emamectin benzoate and compositions comprising the same
US9643991B2 (en) * 2015-06-08 2017-05-09 Rotam Agrochem International Company Limited Process for preparing a novel crystalline form of emamectin benzoate and use the same
CN107344954B (zh) * 2017-08-07 2020-08-11 河北蓝泰化工科技有限公司 增效型甲氨基阿维菌素b1或b2的盐及制备方法和应用
CN108840893A (zh) * 2018-07-01 2018-11-20 李万强 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN108864230B (zh) * 2018-07-26 2021-05-14 河北威远生物化工有限公司 一种有机磷基团取代的阿维菌素衍生物及其制备方法和应用

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Also Published As

Publication number Publication date
DE69117223T2 (de) 1996-09-12
FI913137A0 (fi) 1991-06-27
NO178339C (no) 1996-03-06
FI97890C (fi) 1997-03-10
GR3019067T3 (en) 1996-05-31
CA2045864A1 (en) 1991-12-29
IE71175B1 (en) 1997-01-29
ES2084110T3 (es) 1996-05-01
LV5740A4 (lv) 1996-08-20
US5288710A (en) 1994-02-22
KR920000781A (ko) 1992-01-29
FI913137L (fi) 1991-12-29
NZ238705A (en) 1993-07-27
CY1949A (en) 1991-06-27
KR100224292B1 (ko) 1999-10-15
JPH0822870B2 (ja) 1996-03-06
IL98599A0 (en) 1992-07-15
DE69117223D1 (de) 1996-03-28
FI97890B (fi) 1996-11-29
CA2045864C (en) 2001-11-27
AU641777B2 (en) 1993-09-30
PT98117A (pt) 1993-10-29
NO178339B (no) 1995-11-27
NO912535L (no) 1991-12-30
IL98599A (en) 1995-06-29
PT98117B (pt) 1998-12-31
LV5740B4 (lv) 1997-12-20
EP0465121A1 (de) 1992-01-08
ZA914961B (en) 1992-07-29
AU7939291A (en) 1992-01-02
IE912251A1 (en) 1992-01-01
EP0465121B1 (de) 1996-02-21
HK157096A (en) 1996-08-23
NO2001007I2 (no) 2007-02-26
JPH05306294A (ja) 1993-11-19
DK0465121T3 (da) 1996-03-18
NO912535D0 (no) 1991-06-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time