NO912535D0 - Fremgangsmaate for fremstilling av stabile salter av 4''-deoksy-4''-epi-metylamino-avermectin b1a/b1b. - Google Patents

Fremgangsmaate for fremstilling av stabile salter av 4''-deoksy-4''-epi-metylamino-avermectin b1a/b1b.

Info

Publication number
NO912535D0
NO912535D0 NO912535A NO912535A NO912535D0 NO 912535 D0 NO912535 D0 NO 912535D0 NO 912535 A NO912535 A NO 912535A NO 912535 A NO912535 A NO 912535A NO 912535 D0 NO912535 D0 NO 912535D0
Authority
NO
Norway
Prior art keywords
acid salt
epi
deoxy
metylamino
avermectin
Prior art date
Application number
NO912535A
Other languages
English (en)
Other versions
NO178339C (no
NO912535L (no
NO178339B (no
Inventor
Raymond Cvetovich
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO912535D0 publication Critical patent/NO912535D0/no
Publication of NO912535L publication Critical patent/NO912535L/no
Priority to NO952511A priority Critical patent/NO300136B1/no
Publication of NO178339B publication Critical patent/NO178339B/no
Publication of NO178339C publication Critical patent/NO178339C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Fodder In General (AREA)
  • Silicon Polymers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO912535A 1990-06-28 1991-06-27 Stabile salter av 4''-deoksy-4''-epi-metylaminoavermectin B1a/Blb med egenskaper som landbruksinsekticid og preparater inneholdende et slikt salt NO178339C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO952511A NO300136B1 (no) 1990-06-28 1995-06-22 Analogifremgangsmåte for fremstilling av terapeutisk aktive, stabile salter av 4''-deoksy-4''-epi-metylaminoavermectin B1a/B1b

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54522990A 1990-06-28 1990-06-28

Publications (4)

Publication Number Publication Date
NO912535D0 true NO912535D0 (no) 1991-06-27
NO912535L NO912535L (no) 1991-12-30
NO178339B NO178339B (no) 1995-11-27
NO178339C NO178339C (no) 1996-03-06

Family

ID=24175383

Family Applications (2)

Application Number Title Priority Date Filing Date
NO2001007C NO2001007I2 (no) 1990-06-28 1991-06-27 Stabile salter av 4"-deoksy-4"-epimetylaminoavermectin B1a/B1b med egenskaper som landbruksinsekticid og preparater inneholdende et slikt salt
NO912535A NO178339C (no) 1990-06-28 1991-06-27 Stabile salter av 4''-deoksy-4''-epi-metylaminoavermectin B1a/Blb med egenskaper som landbruksinsekticid og preparater inneholdende et slikt salt

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO2001007C NO2001007I2 (no) 1990-06-28 1991-06-27 Stabile salter av 4"-deoksy-4"-epimetylaminoavermectin B1a/B1b med egenskaper som landbruksinsekticid og preparater inneholdende et slikt salt

Country Status (21)

Country Link
US (1) US5288710A (no)
EP (1) EP0465121B1 (no)
JP (1) JPH0822870B2 (no)
KR (1) KR100224292B1 (no)
AT (1) ATE134377T1 (no)
AU (1) AU641777B2 (no)
CA (1) CA2045864C (no)
CY (1) CY1949A (no)
DE (1) DE69117223T2 (no)
DK (1) DK0465121T3 (no)
ES (1) ES2084110T3 (no)
FI (1) FI97890C (no)
GR (1) GR3019067T3 (no)
HK (1) HK157096A (no)
IE (1) IE71175B1 (no)
IL (1) IL98599A (no)
LV (1) LV5740B4 (no)
NO (2) NO2001007I2 (no)
NZ (1) NZ238705A (no)
PT (1) PT98117B (no)
ZA (1) ZA914961B (no)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU687062B2 (en) * 1993-05-26 1998-02-19 Commonwealth Scientific And Industrial Research Organisation Controlled release antiparasitic compositions
NZ266408A (en) * 1993-05-26 1997-09-22 Commw Scient Ind Res Org Antiparasitic, oral particulate composition for ruminants
US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
HU217769B (hu) * 1993-08-19 2000-04-28 Merck & Co. Inc. 4"-Dezoxi-4"-epi-metil-amino-avermektin-B1a/B1b benzoesavas sójának termodinamikailag stabil kristályformája és eljárás annak előállítására, hatóanyagként ezt tartalmazó kompozíció és eljárás rovarok lekűzdésére
US5362863A (en) * 1993-09-29 1994-11-08 Merck & Co., Inc. Process for the preparation of 4"-amino avermectin compounds
EA002756B1 (ru) * 1995-11-08 2002-08-29 Мерк Энд Ко., Инк. Пестицидная композиция в форме растворимых в воде гранул
AU768262B2 (en) * 1995-11-08 2003-12-04 Merck Sharp & Dohme Corp. Pesticidal formulation
CN1281127C (zh) * 1995-11-08 2006-10-25 麦克公司 农药制剂
US20050192319A1 (en) * 1996-09-19 2005-09-01 Albert Boeckh Spot-on formulations for combating parasites
ZA981925B (en) * 1997-03-21 1998-10-23 Biogenesis S A A long acting injectable parasiticidal composition and the process for its preparation
WO1999025187A2 (en) * 1997-11-14 1999-05-27 Novartis Ag Pesticidal compositions of emamectin
CA2715841A1 (en) * 1997-12-23 1999-07-08 Syngenta Participations Ag Use of macrolides in pest control
US6486128B1 (en) 1999-04-08 2002-11-26 Schering-Plough Veterinary Corporation Method of using emamectin to treat fish parasites
AR006063A4 (es) * 1999-04-17 1999-08-11 Romario S R L Bandeja termica para pizzas
GB9926887D0 (en) 1999-11-12 2000-01-12 Novartis Ag Organic compounds
EG23124A (en) 2001-02-27 2004-04-28 Syngenta Participations Ag Avermectins substituted in the 4-position having pesticidal properties
CR6574A (es) * 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
JP4701538B2 (ja) 2001-05-21 2011-06-15 住友化学株式会社 農業害虫防除剤組成物
AR036486A1 (es) 2001-08-28 2004-09-15 Syngenta Participations Ag Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
DE10203688A1 (de) * 2002-01-31 2003-08-07 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207242A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207241A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
MXPA04009101A (es) * 2002-03-22 2004-12-06 Lg Life Sciences Ltd Sal de acido maleico de (2s) -n-{5- [amino(imino) metil]-2 -tienil} metil-1 -{(2r)- 2-[(carboximetil) amino]-3, 3- difenilpropanoil} -2-pirrolidin carboxamida y un proceso para preparacion de la misma.
AR040073A1 (es) 2002-05-07 2005-03-16 Syngenta Participations Ag Derivados de 4''-desoxi-4''-(s)-amido avermectina y su uso como plaguicidas
GB0302308D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302310D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0320176D0 (en) 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
PE20060693A1 (es) 2004-09-23 2006-09-01 Schering Plough Ltd Nuevos derivados de trifluorometansulfonanilida oxamida eter
EP1811841B1 (en) * 2004-11-19 2009-10-28 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
US20060281695A1 (en) * 2005-06-09 2006-12-14 Schering-Plough Animal Health Corporation Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
TWI422328B (zh) 2006-06-19 2014-01-11 Univ California 結合有殺線蟲之種子塗覆物的生物控制劑
FR2906469B1 (fr) * 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques chez l'homme
CA2672586A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
DE102007002872A1 (de) 2007-01-15 2008-07-17 Alpha-Biocare Gmbh Verwendung von Avermectin-Derivaten zur Behandlung gegen Parasiten von Fischen
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
BRPI0810929B8 (pt) 2007-06-27 2022-12-06 Du Pont uso de um composto de fórmula 1
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
US9345686B2 (en) 2009-03-17 2016-05-24 Intervet Inc. Macrocyclic lactone drug delivery system
IN2012DN00709A (no) 2009-08-05 2015-06-19 Du Pont
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
HUE028501T2 (en) 2010-05-27 2016-12-28 Du Pont 4- [5- [3-Chloro-5- (trifluoromethyl) phenyl] -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N- [2-oxo-2 - [(2.2, 2-Trifluoroethyl) amino] ethyl] -1-naphthalenecarboxamide crystalline form
AR081970A1 (es) 2010-06-24 2012-10-31 Intervet Int Bv Formulacion inyectable de una lactona macrociclica y levamisol, formulacion y uso veterinario
CA2811924C (en) 2010-10-20 2015-06-16 Galderma S.A. Method of treating hemorrhoids using macrocyclic lactone compound
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN103260620A (zh) 2010-12-27 2013-08-21 英特维特国际股份有限公司 包含三缩四乙二醇的外用局部异噁唑啉制剂
PT2658542T (pt) 2010-12-27 2022-03-10 Intervet Int Bv Formulação de isoxazolina localizada tópica
US9861105B2 (en) 2011-07-28 2018-01-09 Syngenta Participations Ag Methods and compositions for controlling nematode pests
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
US9409920B1 (en) * 2015-06-08 2016-08-09 Rotam Agrochem International Company Limited Method for purifying emamectin benzoate and compositions comprising the same
US9643991B2 (en) * 2015-06-08 2017-05-09 Rotam Agrochem International Company Limited Process for preparing a novel crystalline form of emamectin benzoate and use the same
CN107344954B (zh) * 2017-08-07 2020-08-11 河北蓝泰化工科技有限公司 增效型甲氨基阿维菌素b1或b2的盐及制备方法和应用
CN108840893A (zh) * 2018-07-01 2018-11-20 李万强 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN108864230B (zh) * 2018-07-26 2021-05-14 河北威远生物化工有限公司 一种有机磷基团取代的阿维菌素衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366309A (en) * 1980-03-14 1982-12-28 Schering Corporation Derivatives of antibiotic AR-5 components
US4321361A (en) * 1980-06-12 1982-03-23 Eli Lilly And Company Demycinosyltylosin and process for its production
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4831016A (en) * 1986-10-31 1989-05-16 Merck & Co., Inc. Reduced avermectin derivatives
US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb

Also Published As

Publication number Publication date
LV5740A4 (lv) 1996-08-20
AU7939291A (en) 1992-01-02
FI913137A (fi) 1991-12-29
NO178339C (no) 1996-03-06
AU641777B2 (en) 1993-09-30
NO912535L (no) 1991-12-30
JPH0822870B2 (ja) 1996-03-06
FI97890C (fi) 1997-03-10
DE69117223T2 (de) 1996-09-12
IE912251A1 (en) 1992-01-01
US5288710A (en) 1994-02-22
FI97890B (fi) 1996-11-29
NO178339B (no) 1995-11-27
JPH05306294A (ja) 1993-11-19
CA2045864A1 (en) 1991-12-29
KR100224292B1 (ko) 1999-10-15
DK0465121T3 (da) 1996-03-18
CA2045864C (en) 2001-11-27
GR3019067T3 (en) 1996-05-31
KR920000781A (ko) 1992-01-29
IE71175B1 (en) 1997-01-29
HK157096A (en) 1996-08-23
NO2001007I2 (no) 2007-02-26
DE69117223D1 (de) 1996-03-28
NZ238705A (en) 1993-07-27
ES2084110T3 (es) 1996-05-01
PT98117B (pt) 1998-12-31
ZA914961B (en) 1992-07-29
PT98117A (pt) 1993-10-29
LV5740B4 (lv) 1997-12-20
IL98599A (en) 1995-06-29
CY1949A (en) 1991-06-27
FI913137A0 (fi) 1991-06-27
ATE134377T1 (de) 1996-03-15
EP0465121A1 (en) 1992-01-08
EP0465121B1 (en) 1996-02-21
IL98599A0 (en) 1992-07-15

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Legal Events

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SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: EMAMECTIN; NAT. REG. NO/DATE: NO , 99-4254; FIRST REG. NO/DATE: GB , VM 00201/4 20000114

Spc suppl protection certif: 2001007

Filing date: 20010525

Extension date: 20150114

MK1K Patent expired